NP-MRD: Showing NP-Card for (3as,4as,6s,8r,8as,9ar)-6,8-dihydroxy-8a-methyl-3,5-dimethylidene-octahydronaphtho[2,3-b]furan-2-one (NP0282626)

Jump To Section:

Identification Spectra BioTaxonomy ChemoTaxonomy Physical properties Links References XML

Record Information

Version

2.0

Created at

2022-09-09 09:31:51 UTC

Updated at

2022-09-09 09:31:51 UTC

NP-MRD ID

NP0282626

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(3as,4as,6s,8r,8as,9ar)-6,8-dihydroxy-8a-methyl-3,5-dimethylidene-octahydronaphtho[2,3-b]furan-2-one

Description

ZINC238766945 belongs to the class of organic compounds known as eudesmanolides, secoeudesmanolides, and derivatives. These are terpenoids with a structure based on the eudesmanolide (a 3,5a,9-trimethyl-naphtho[1,2-b]furan-2-one derivative) or secoeudesmanolide (a 3,6-dimethyl-5-(pentan-2-yl)-1-benzofuran-2-one derivative) skeleton. (3as,4as,6s,8r,8as,9ar)-6,8-dihydroxy-8a-methyl-3,5-dimethylidene-octahydronaphtho[2,3-b]furan-2-one is found in Inula grandis. Based on a literature review very few articles have been published on ZINC238766945.

Structure

MOL SDF PDB SMILES InChI


  Mrv1652309092211312D          

 19 21  0  0  1  0            999 V2000
    1.5983   -3.3875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8532   -2.6029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3683   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5433   -1.9354    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8532   -1.2680    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.0668   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.7812   -0.2854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -2.3479    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    6.2102   -2.7604    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -2.3479    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.3523   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  6  5  1  6  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  1  0  0  0
  8 10  1  0  0  0  0
 10 11  1  6  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  6  0  0  0
 13 15  1  0  0  0  0
 15 16  2  0  0  0  0
 17 15  1  6  0  0  0
  8 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19  2  1  1  0  0  0
  6 19  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0282626

> <DATABASE_NAME>
NP-MRD

> <SMILES>
C[C@]12C[C@H]3OC(=O)C(=C)[C@@H]3C[C@H]1C(=C)[C@@H](O)C[C@H]2O

> <INCHI_IDENTIFIER>
InChI=1S/C15H20O4/c1-7-9-4-10-8(2)11(16)5-13(17)15(10,3)6-12(9)19-14(7)18/h9-13,16-17H,1-2,4-6H2,3H3/t9-,10-,11-,12+,13+,15-/m0/s1

> <INCHI_KEY>
ZEIYNPAINVEWGP-YTTQYIQMSA-N

> <FORMULA>
C15H20O4

> <MOLECULAR_WEIGHT>
264.321

> <EXACT_MASS>
264.136159124

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_ATOM_COUNT>
39

> <JCHEM_AVERAGE_POLARIZABILITY>
27.903413204606643

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(3aS,4aS,6S,8R,8aS,9aR)-6,8-dihydroxy-8a-methyl-3,5-dimethylidene-dodecahydronaphtho[2,3-b]furan-2-one

> <JCHEM_LOGP>
0.8235591820000003

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
14.97015204767904

> <JCHEM_PKA_STRONGEST_ACIDIC>
14.264701297380867

> <JCHEM_PKA_STRONGEST_BASIC>
-2.9767066928764256

> <JCHEM_POLAR_SURFACE_AREA>
66.76

> <JCHEM_REFRACTIVITY>
69.18480000000001

> <JCHEM_ROTATABLE_BOND_COUNT>
0

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
(3aS,4aS,6S,8R,8aS,9aR)-6,8-dihydroxy-8a-methyl-3,5-dimethylidene-octahydronaphtho[2,3-b]furan-2-one

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 09-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   09-SEP-22         0                                  
HETATM    1  C   UNK     0       2.983  -6.323   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       3.459  -4.859   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       2.554  -3.613   0.000  0.00  0.00           C+0
HETATM    4  O   UNK     0       1.014  -3.613   0.000  0.00  0.00           O+0
HETATM    5  O   UNK     0       3.459  -2.367   0.000  0.00  0.00           O+0
HETATM    6  C   UNK     0       4.924  -2.843   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       6.258  -2.073   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       7.591  -2.843   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       7.591  -1.303   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       8.925  -2.073   0.000  0.00  0.00           C+0
HETATM   11  O   UNK     0       8.925  -0.533   0.000  0.00  0.00           O+0
HETATM   12  C   UNK     0      10.259  -2.843   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      10.259  -4.383   0.000  0.00  0.00           C+0
HETATM   14  O   UNK     0      11.592  -5.153   0.000  0.00  0.00           O+0
HETATM   15  C   UNK     0       8.925  -5.153   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       8.925  -6.693   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       7.591  -4.383   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       6.258  -5.153   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       4.924  -4.383   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3   19                                                  
CONECT    3    2    4    5                                                  
CONECT    4    3                                                            
CONECT    5    3    6                                                       
CONECT    6    5    7   19                                                  
CONECT    7    6    8                                                       
CONECT    8    7    9   10   17                                             
CONECT    9    8                                                            
CONECT   10    8   11   12                                                  
CONECT   11   10                                                            
CONECT   12   10   13                                                       
CONECT   13   12   14   15                                                  
CONECT   14   13                                                            
CONECT   15   13   16   17                                                  
CONECT   16   15                                                            
CONECT   17   15    8   18                                                  
CONECT   18   17   19                                                       
CONECT   19   18    2    6                                                  
MASTER        0    0    0    0    0    0    0    0   19    0   42    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₁₅H₂₀O₄

Average Mass

264.3210 Da

Monoisotopic Mass

264.13616 Da

IUPAC Name

Not Available

Traditional Name

Not Available

CAS Registry Number

Not Available

SMILES

C[C@]12C[C@H]3OC(=O)C(=C)[C@@H]3C[C@H]1C(=C)[C@@H](O)C[C@H]2O

InChI Identifier

InChI=1S/C15H20O4/c1-7-9-4-10-8(2)11(16)5-13(17)15(10,3)6-12(9)19-14(7)18/h9-13,16-17H,1-2,4-6H2,3H3/t9-,10-,11-,12+,13+,15-/m0/s1

InChI Key

ZEIYNPAINVEWGP-YTTQYIQMSA-N

Experimental Spectra

Not Available

Predicted Spectra

Not Available

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Inula grandis	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as eudesmanolides, secoeudesmanolides, and derivatives. These are terpenoids with a structure based on the eudesmanolide (a 3,5a,9-trimethyl-naphtho[1,2-b]furan-2-one derivative) or secoeudesmanolide (a 3,6-dimethyl-5-(pentan-2-yl)-1-benzofuran-2-one derivative) skeleton.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Terpene lactones

Direct Parent

Eudesmanolides, secoeudesmanolides, and derivatives

Alternative Parents

Substituents

Eudesmanolide
Sesquiterpenoid
Naphthofuran
Gamma butyrolactone
Cyclic alcohol
Tetrahydrofuran
Enoate ester
Alpha,beta-unsaturated carboxylic ester
Secondary alcohol
Lactone
Carboxylic acid ester
Oxacycle
Monocarboxylic acid or derivatives
Carboxylic acid derivative
Organoheterocyclic compound
Organooxygen compound
Hydrocarbon derivative
Organic oxide
Organic oxygen compound
Alcohol
Carbonyl group
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

124708150

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for (3as,4as,6s,8r,8as,9ar)-6,8-dihydroxy-8a-methyl-3,5-dimethylidene-octahydronaphtho[2,3-b]furan-2-one (NP0282626)

MOL for NP0282626 ((3as,4as,6s,8r,8as,9ar)-6,8-dihydroxy-8a-methyl-3,5-dimethylidene-octahydronaphtho[2,3-b]furan-2-one)

3D MOL for NP0282626 ((3as,4as,6s,8r,8as,9ar)-6,8-dihydroxy-8a-methyl-3,5-dimethylidene-octahydronaphtho[2,3-b]furan-2-one)

3D SDF for NP0282626 ((3as,4as,6s,8r,8as,9ar)-6,8-dihydroxy-8a-methyl-3,5-dimethylidene-octahydronaphtho[2,3-b]furan-2-one)

3D-SDF for NP0282626 ((3as,4as,6s,8r,8as,9ar)-6,8-dihydroxy-8a-methyl-3,5-dimethylidene-octahydronaphtho[2,3-b]furan-2-one)

PDB for NP0282626 ((3as,4as,6s,8r,8as,9ar)-6,8-dihydroxy-8a-methyl-3,5-dimethylidene-octahydronaphtho[2,3-b]furan-2-one)

3D PDB for NP0282626 ((3as,4as,6s,8r,8as,9ar)-6,8-dihydroxy-8a-methyl-3,5-dimethylidene-octahydronaphtho[2,3-b]furan-2-one)

SMILES for NP0282626 ((3as,4as,6s,8r,8as,9ar)-6,8-dihydroxy-8a-methyl-3,5-dimethylidene-octahydronaphtho[2,3-b]furan-2-one)

INCHI for NP0282626 ((3as,4as,6s,8r,8as,9ar)-6,8-dihydroxy-8a-methyl-3,5-dimethylidene-octahydronaphtho[2,3-b]furan-2-one)

Structure for NP0282626 ((3as,4as,6s,8r,8as,9ar)-6,8-dihydroxy-8a-methyl-3,5-dimethylidene-octahydronaphtho[2,3-b]furan-2-one)

3D Structure for NP0282626 ((3as,4as,6s,8r,8as,9ar)-6,8-dihydroxy-8a-methyl-3,5-dimethylidene-octahydronaphtho[2,3-b]furan-2-one)