NP-MRD: Showing NP-Card for 3,4a,5-trimethyl-9-oxo-4h,5h,6h,7h-naphtho[2,3-b]furan-4-yl acetate (NP0280738)

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Record Information

Version

2.0

Created at

2022-09-09 06:41:52 UTC

Updated at

2022-09-09 06:41:52 UTC

NP-MRD ID

NP0280738

Secondary Accession Numbers

None

Natural Product Identification

Common Name

3,4a,5-trimethyl-9-oxo-4h,5h,6h,7h-naphtho[2,3-b]furan-4-yl acetate

Description

Decompostin belongs to the class of organic compounds known as eremophilane, 8,9-secoeremophilane and furoeremophilane sesquiterpenoids. These are sesquiterpenoids with a structure based either on the eremophilane skeleton, its 8,9-seco derivative, or the furoeremophilane skeleton. Eremophilanes have been shown to be derived from eudesmanes by migration of the methyl group at C-10 to C-5. 3,4a,5-trimethyl-9-oxo-4h,5h,6h,7h-naphtho[2,3-b]furan-4-yl acetate was first documented in 2001 (PMID: 11325222). Based on a literature review very few articles have been published on Decompostin.

Structure

MOL 3D MOL SDF PDB SMILES InChI

     RDKit          3D

 41 43  0  0  0  0  0  0  0  0999 V2000
    2.7728    2.7657   -0.1170 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9270    1.6797   -0.6763 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7159    1.5189   -1.8902 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3433    0.7994    0.2151 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5168   -0.2800   -0.1535 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.0756   -1.5872    0.1881 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3495   -2.0381    0.4503 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5967   -1.2472    0.4720 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2695   -3.4027    0.6994 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0074   -3.7235    0.5863 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2673   -2.6935    0.2880 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1937   -2.5964    0.0704 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9608   -3.5744    0.1485 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6885   -1.2454   -0.2505 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7606   -1.1282   -0.9814 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3682    0.1381   -1.3805 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9708    1.1816   -0.3534 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4550    1.1583   -0.2689 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.9749    2.4087    0.3756 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9225   -0.1134    0.2966 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.0463   -0.1840    1.8029 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2754    2.4653    0.8266 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.0931    3.6225    0.1447 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.5016    3.0676   -0.9017 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.4637   -0.2282   -1.2857 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.7720   -0.7290   -0.4995 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.4724   -1.9068    0.6236 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.6156   -0.5162    1.3281 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.0794   -4.0747    0.9394 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2813   -2.0371   -1.3467 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4842    0.0759   -1.3358 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0966    0.4814   -2.3958 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4633    1.0060    0.6030 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2504    2.1656   -0.7838 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1096    1.1957   -1.3452 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8341    2.9059    0.8805 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6220    3.1730   -0.3798 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2154    2.2685    1.1729 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9660    0.7689    2.3181 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0873   -0.5672    2.0177 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3633   -0.9738    2.1519 H   0  0  0  0  0  0  0  0  0  0  0  0
 19 18  1  0
 18 17  1  0
 17 16  1  0
 16 15  1  0
 15 14  2  0
 14 12  1  0
 12 13  2  0
 12 11  1  0
 11  6  2  0
  6  5  1  0
  5  4  1  0
  4  2  1  0
  2  1  1  0
  2  3  2  0
  5 20  1  0
 20 21  1  1
  6  7  1  0
  7  8  1  0
  7  9  2  0
  9 10  1  0
 20 18  1  0
 20 14  1  0
 10 11  1  0
 19 36  1  0
 19 37  1  0
 19 38  1  0
 18 35  1  6
 17 33  1  0
 17 34  1  0
 16 31  1  0
 16 32  1  0
 15 30  1  0
  5 25  1  6
  1 22  1  0
  1 23  1  0
  1 24  1  0
 21 39  1  0
 21 40  1  0
 21 41  1  0
  8 26  1  0
  8 27  1  0
  8 28  1  0
  9 29  1  0
M  END


  Mrv1652309092208412D          

 21 23  0  0  0  0            999 V2000
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6425    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8974    1.8646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1274    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6425   -0.2549    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  6 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 14 20  1  0  0  0  0
  5 20  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0280738

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CC1CCC=C2C(=O)C3=C(C(OC(C)=O)C12C)C(C)=CO3

> <INCHI_IDENTIFIER>
InChI=1S/C17H20O4/c1-9-8-20-15-13(9)16(21-11(3)18)17(4)10(2)6-5-7-12(17)14(15)19/h7-8,10,16H,5-6H2,1-4H3

> <INCHI_KEY>
FAZNZOQAEBFDJI-UHFFFAOYSA-N

> <FORMULA>
C17H20O4

> <MOLECULAR_WEIGHT>
288.343

> <EXACT_MASS>
288.136159124

> <JCHEM_ACCEPTOR_COUNT>
2

> <JCHEM_ATOM_COUNT>
41

> <JCHEM_AVERAGE_POLARIZABILITY>
30.563709158442837

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
0

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
3,4a,5-trimethyl-9-oxo-4H,4aH,5H,6H,7H,9H-naphtho[2,3-b]furan-4-yl acetate

> <JCHEM_LOGP>
2.9138852240000004

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_BASIC>
-2.940820504932101

> <JCHEM_POLAR_SURFACE_AREA>
56.51

> <JCHEM_REFRACTIVITY>
78.69430000000001

> <JCHEM_ROTATABLE_BOND_COUNT>
2

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
3,4a,5-trimethyl-9-oxo-4H,5H,6H,7H-naphtho[2,3-b]furan-4-yl acetate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 09-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   09-SEP-22         0                                  
HETATM    1  C   UNK     0       6.668   3.850   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       5.335   4.620   0.000  0.00  0.00           C+0
HETATM    3  O   UNK     0       5.335   6.160   0.000  0.00  0.00           O+0
HETATM    4  O   UNK     0       4.001   3.850   0.000  0.00  0.00           O+0
HETATM    5  C   UNK     0       4.001   2.310   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       5.335   1.540   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       6.799   2.016   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       7.275   3.481   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       7.705   0.770   0.000  0.00  0.00           C+0
HETATM   10  O   UNK     0       6.799  -0.476   0.000  0.00  0.00           O+0
HETATM   11  C   UNK     0       5.335   0.000   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       4.001  -0.770   0.000  0.00  0.00           C+0
HETATM   13  O   UNK     0       4.001  -2.310   0.000  0.00  0.00           O+0
HETATM   14  C   UNK     0       2.667   0.000   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       1.334  -0.770   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       0.000   1.540   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       1.334   2.310   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       1.334   3.850   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       2.667   1.540   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       2.667   3.080   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3    4                                                  
CONECT    3    2                                                            
CONECT    4    2    5                                                       
CONECT    5    4    6   20                                                  
CONECT    6    5    7   11                                                  
CONECT    7    6    8    9                                                  
CONECT    8    7                                                            
CONECT    9    7   10                                                       
CONECT   10    9   11                                                       
CONECT   11   10    6   12                                                  
CONECT   12   11   13   14                                                  
CONECT   13   12                                                            
CONECT   14   12   15   20                                                  
CONECT   15   14   16                                                       
CONECT   16   15   17                                                       
CONECT   17   16   18                                                       
CONECT   18   17   19   20                                                  
CONECT   19   18                                                            
CONECT   20   18   14    5   21                                             
CONECT   21   20                                                            
MASTER        0    0    0    0    0    0    0    0   21    0   46    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₁₇H₂₀O₄

Average Mass

288.3430 Da

Monoisotopic Mass

288.13616 Da

IUPAC Name

3,4a,5-trimethyl-9-oxo-4H,4aH,5H,6H,7H,9H-naphtho[2,3-b]furan-4-yl acetate

Traditional Name

3,4a,5-trimethyl-9-oxo-4H,5H,6H,7H-naphtho[2,3-b]furan-4-yl acetate

CAS Registry Number

Not Available

SMILES

CC1CCC=C2C(=O)C3=C(C(OC(C)=O)C12C)C(C)=CO3

InChI Identifier

InChI=1S/C17H20O4/c1-9-8-20-15-13(9)16(21-11(3)18)17(4)10(2)6-5-7-12(17)14(15)19/h7-8,10,16H,5-6H2,1-4H3

InChI Key

FAZNZOQAEBFDJI-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Not Available

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as eremophilane, 8,9-secoeremophilane and furoeremophilane sesquiterpenoids. These are sesquiterpenoids with a structure based either on the eremophilane skeleton, its 8,9-seco derivative, or the furoeremophilane skeleton. Eremophilanes have been shown to be derived from eudesmanes by migration of the methyl group at C-10 to C-5.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Sesquiterpenoids

Direct Parent

Eremophilane, 8,9-secoeremophilane and furoeremophilane sesquiterpenoids

Alternative Parents

Substituents

Furoeremophilane sesquiterpenoid
Naphthofuran
Benzofuran
Aryl ketone
Furan
Heteroaromatic compound
Carboxylic acid ester
Ketone
Carboxylic acid derivative
Oxacycle
Monocarboxylic acid or derivatives
Organoheterocyclic compound
Hydrocarbon derivative
Organic oxide
Organic oxygen compound
Carbonyl group
Organooxygen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	2.91	ChemAxon
pKa (Strongest Basic)	-2.9	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	2	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	56.51 Å²	ChemAxon
Rotatable Bond Count	2	ChemAxon
Refractivity	78.69 m³·mol⁻¹	ChemAxon
Polarizability	30.56 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

C00017423

Chemspider ID

534636

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

615079

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Garduno-Ramirez ML, Trejo A, Navarro V, Bye R, Linares E, Delgado G: New modified eremophilanes from the roots of Psacalium radulifolium. J Nat Prod. 2001 Apr;64(4):432-5. doi: 10.1021/np000385z. [PubMed:11325222 ]
LOTUS database [Link]

Showing NP-Card for 3,4a,5-trimethyl-9-oxo-4h,5h,6h,7h-naphtho[2,3-b]furan-4-yl acetate (NP0280738)

MOL for NP0280738 (3,4a,5-trimethyl-9-oxo-4h,5h,6h,7h-naphtho[2,3-b]furan-4-yl acetate)

3D MOL for NP0280738 (3,4a,5-trimethyl-9-oxo-4h,5h,6h,7h-naphtho[2,3-b]furan-4-yl acetate)

3D SDF for NP0280738 (3,4a,5-trimethyl-9-oxo-4h,5h,6h,7h-naphtho[2,3-b]furan-4-yl acetate)

3D-SDF for NP0280738 (3,4a,5-trimethyl-9-oxo-4h,5h,6h,7h-naphtho[2,3-b]furan-4-yl acetate)

PDB for NP0280738 (3,4a,5-trimethyl-9-oxo-4h,5h,6h,7h-naphtho[2,3-b]furan-4-yl acetate)

3D PDB for NP0280738 (3,4a,5-trimethyl-9-oxo-4h,5h,6h,7h-naphtho[2,3-b]furan-4-yl acetate)

SMILES for NP0280738 (3,4a,5-trimethyl-9-oxo-4h,5h,6h,7h-naphtho[2,3-b]furan-4-yl acetate)

INCHI for NP0280738 (3,4a,5-trimethyl-9-oxo-4h,5h,6h,7h-naphtho[2,3-b]furan-4-yl acetate)

Structure for NP0280738 (3,4a,5-trimethyl-9-oxo-4h,5h,6h,7h-naphtho[2,3-b]furan-4-yl acetate)

3D Structure for NP0280738 (3,4a,5-trimethyl-9-oxo-4h,5h,6h,7h-naphtho[2,3-b]furan-4-yl acetate)