NP-MRD: Showing NP-Card for methyl 3,16-dihydroxy-15-methyl-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1¹⁵,¹⁸.0²,⁶.0⁷,²⁷.0⁸,¹³.0¹⁹,²⁶.0²⁰,²⁵]octacosa-1(26),2(6),3,7(27),8(13),9,11,20(25),21,23-decaene-16-carboxylate (NP0280579)

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Record Information

Version

2.0

Created at

2022-09-09 06:26:51 UTC

Updated at

2022-09-09 06:26:51 UTC

NP-MRD ID

NP0280579

Secondary Accession Numbers

None

Natural Product Identification

Common Name

methyl 3,16-dihydroxy-15-methyl-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1¹⁵,¹⁸.0²,⁶.0⁷,²⁷.0⁸,¹³.0¹⁹,²⁶.0²⁰,²⁵]octacosa-1(26),2(6),3,7(27),8(13),9,11,20(25),21,23-decaene-16-carboxylate

Description

K-252a, also known as 3'-(S)-epi-K-252a or staurosporinone, belongs to the class of organic compounds known as indolocarbazoles. These are polycyclic aromatic compounds containing an indole fused to a carbazole. K-252a is an extremely weak basic (essentially neutral) compound (based on its pKa).

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1533004161521002D          

 35 42  0  0  0  0            999 V2000
    3.4344   -1.5471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3446   -0.7270    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5894   -0.3948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9241   -0.8826    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4996    0.4253    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6953    0.2417    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3689    0.4200    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6636    1.2484    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9342    1.3304    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2085    1.2491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4193    1.0087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9870    2.1103    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2168    2.4613    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4731    2.1042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2081    2.5696    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1455    3.3922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5981    3.7494    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2793    3.2840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0887    3.5142    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5319    4.2299    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2803    5.0156    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9498    5.4977    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6152    5.0099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4009    5.2615    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3569    4.2264    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7921    3.5048    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6029    3.2832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2835    3.7493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0276    3.3930    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0910    2.5704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4104    2.1042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6663    2.4606    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8860    2.1096    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3607    2.7911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5104    2.7927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  5 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 13 18  2  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 20 25  2  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 28 29  1  0  0  0  0
 29 30  2  0  0  0  0
 30 31  1  0  0  0  0
 31 32  2  0  0  0  0
 27 32  1  0  0  0  0
 32 33  1  0  0  0  0
  8 33  1  0  0  0  0
 33 34  1  0  0  0  0
 26 34  2  0  0  0  0
 34 35  1  0  0  0  0
 12 35  1  0  0  0  0
 19 35  2  0  0  0  0
M  END

     RDKit          3D

 56 63  0  0  0  0  0  0  0  0999 V2000
   -4.2127    1.0825   -2.2511 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9439    0.1030   -1.2352 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6795   -0.1385   -0.7800 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7410    0.5524   -1.3038 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3958   -1.1430    0.2632 C   0  0  1  0  0  0  0  0  0  0  0  0
   -3.6087   -1.7286    0.6359 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5214   -2.2668   -0.2414 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5372   -2.4287    0.8824 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.8656   -1.6013    1.9117 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6691   -0.5408    1.4409 C   0  0  2  0  0  0  0  0  0  0  0  0
   -2.7048   -0.2319    2.4880 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8515    0.5693    1.0086 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270    1.8838    1.0956 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2258    2.6053    1.5414 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1668    3.9773    1.4720 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0816    4.6545    0.9858 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0166    3.9206    0.5533 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0131    2.5444    0.5964 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9353    1.6351    0.2023 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1879    1.6641   -0.3577 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9297    0.5103   -0.6718 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3736   -0.7285   -0.4057 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7895   -2.0363   -0.5934 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9353   -2.5978   -1.1070 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9965   -3.9967   -1.1368 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9566   -4.7715   -0.6730 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8354   -4.1873   -0.1704 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7423   -2.8192   -0.1264 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7723   -2.0374    0.3087 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1036   -0.7474    0.1632 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3951    0.3973    0.4652 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1844    0.9223   -1.2365 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1263    0.2496   -1.6463 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2035    2.3615   -1.2655 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9828    2.8547   -0.7310 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9373    0.5958   -2.9404 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6960    1.9734   -1.8191 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2836    1.4069   -2.7483 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4837   -2.6578    0.9706 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0880   -3.2001   -0.4244 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0870   -1.9518   -1.1895 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4991   -3.4838    1.1531 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3520    0.4523    3.2778 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7251   -0.0770    2.1079 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8775   -1.1900    3.1247 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0815    2.0709    1.9017 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0377    4.5351    1.8267 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0491    5.7523    0.9368 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.8768    4.4047    0.1550 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.7488   -2.0208   -1.4699 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.9117   -4.4376   -1.5470 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.0441   -5.8664   -0.7140 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.9831   -4.7643    0.2098 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.9816    2.9522   -1.6191 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4230    3.5134   -1.4493 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.1401    3.5060    0.1756 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  1  1
  5  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  1
 10 12  1  0
 12 13  1  0
 13 18  2  0
 18 17  1  0
 17 16  2  0
 16 15  1  0
 15 14  2  0
 18 19  1  0
 19 31  1  0
 31 30  2  0
 30 22  1  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 22 21  2  0
 21 20  1  0
 20 35  1  0
 35 34  1  0
 34 32  1  0
 32 33  2  0
 10  5  1  0
 31 12  1  0
 29 30  1  0
 32 21  1  0
 29  8  1  0
 14 13  1  0
 20 19  2  0
 28 23  1  0
  1 36  1  0
  1 37  1  0
  1 38  1  0
  6 39  1  0
  7 40  1  0
  7 41  1  0
  8 42  1  1
 11 43  1  0
 11 44  1  0
 11 45  1  0
 17 49  1  0
 16 48  1  0
 15 47  1  0
 14 46  1  0
 24 50  1  0
 25 51  1  0
 26 52  1  0
 27 53  1  0
 35 55  1  0
 35 56  1  0
 34 54  1  0
M  END


  Mrv1533004161521002D          

 35 42  0  0  0  0            999 V2000
    3.4344   -1.5471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3446   -0.7270    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5894   -0.3948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9241   -0.8826    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4996    0.4253    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6953    0.2417    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3689    0.4200    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6636    1.2484    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9342    1.3304    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2085    1.2491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4193    1.0087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9870    2.1103    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2168    2.4613    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4731    2.1042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2081    2.5696    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1455    3.3922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5981    3.7494    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2793    3.2840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0887    3.5142    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5319    4.2299    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2803    5.0156    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9498    5.4977    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6152    5.0099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4009    5.2615    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3569    4.2264    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7921    3.5048    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6029    3.2832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2835    3.7493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0276    3.3930    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0910    2.5704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4104    2.1042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6663    2.4606    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8860    2.1096    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3607    2.7911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5104    2.7927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  5 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 13 18  2  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 20 25  2  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 28 29  1  0  0  0  0
 29 30  2  0  0  0  0
 30 31  1  0  0  0  0
 31 32  2  0  0  0  0
 27 32  1  0  0  0  0
 32 33  1  0  0  0  0
  8 33  1  0  0  0  0
 33 34  1  0  0  0  0
 26 34  2  0  0  0  0
 34 35  1  0  0  0  0
 12 35  1  0  0  0  0
 19 35  2  0  0  0  0
M  END
> <DATABASE_ID>
NP0280579

> <DATABASE_NAME>
NP-MRD

> <SMILES>
COC(=O)C1(O)CC2OC1(C)N1C3=C(C=CC=C3)C3=C1C1=C(C4=CC=CC=C4N21)C1=C3CNC1=O

> <INCHI_IDENTIFIER>
InChI=1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)

> <INCHI_KEY>
KOZFSFOOLUUIGY-UHFFFAOYSA-N

> <FORMULA>
C27H21N3O5

> <MOLECULAR_WEIGHT>
467.481

> <EXACT_MASS>
467.148120788

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_ATOM_COUNT>
56

> <JCHEM_AVERAGE_POLARIZABILITY>
49.42953607042839

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
methyl 16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1¹⁵,¹⁸.0²,⁶.0⁷,²⁷.0⁸,¹³.0¹⁹,²⁶.0²⁰,²⁵]octacosa-1(26),2(6),7(27),8(13),9,11,20,22,24-nonaene-16-carboxylate

> <ALOGPS_LOGP>
2.91

> <JCHEM_LOGP>
3.483207518999999

> <ALOGPS_LOGS>
-3.89

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
8

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
13.421357436034487

> <JCHEM_PKA_STRONGEST_ACIDIC>
10.7134719981546

> <JCHEM_PKA_STRONGEST_BASIC>
-1.4854353256789063

> <JCHEM_POLAR_SURFACE_AREA>
94.72

> <JCHEM_REFRACTIVITY>
126.11979999999998

> <JCHEM_ROTATABLE_BOND_COUNT>
2

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
5.97e-02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
staurosporinone

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 16-APR-15   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   16-APR-15         0                                  
HETATM    1  C   UNK     0       6.411  -2.888   0.000  0.00  0.00           C+0
HETATM    2  O   UNK     0       6.243  -1.357   0.000  0.00  0.00           O+0
HETATM    3  C   UNK     0       4.834  -0.737   0.000  0.00  0.00           C+0
HETATM    4  O   UNK     0       3.592  -1.648   0.000  0.00  0.00           O+0
HETATM    5  C   UNK     0       4.666   0.794   0.000  0.00  0.00           C+0
HETATM    6  O   UNK     0       3.164   0.451   0.000  0.00  0.00           O+0
HETATM    7  C   UNK     0       6.289   0.784   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       6.839   2.330   0.000  0.00  0.00           C+0
HETATM    9  O   UNK     0       5.477   2.483   0.000  0.00  0.00           O+0
HETATM   10  C   UNK     0       4.122   2.332   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       2.649   1.883   0.000  0.00  0.00           C+0
HETATM   12  N   UNK     0       3.709   3.939   0.000  0.00  0.00           N+0
HETATM   13  C   UNK     0       2.271   4.594   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       0.883   3.928   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      -0.388   4.797   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      -0.272   6.332   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       1.117   6.999   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       2.388   6.130   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       3.899   6.560   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       4.726   7.896   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       4.257   9.363   0.000  0.00  0.00           C+0
HETATM   22  N   UNK     0       5.506  10.262   0.000  0.00  0.00           N+0
HETATM   23  C   UNK     0       6.748   9.352   0.000  0.00  0.00           C+0
HETATM   24  O   UNK     0       8.215   9.821   0.000  0.00  0.00           O+0
HETATM   25  C   UNK     0       6.266   7.889   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0       7.079   6.542   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0       8.592   6.129   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0       9.863   6.999   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0      11.252   6.334   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0      11.370   4.798   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0      10.099   3.928   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0       8.710   4.593   0.000  0.00  0.00           C+0
HETATM   33  N   UNK     0       7.254   3.938   0.000  0.00  0.00           N+0
HETATM   34  C   UNK     0       6.273   5.210   0.000  0.00  0.00           C+0
HETATM   35  C   UNK     0       4.686   5.213   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4    5                                                  
CONECT    4    3                                                            
CONECT    5    3    6    7   10                                             
CONECT    6    5                                                            
CONECT    7    5    8                                                       
CONECT    8    7    9   33                                                  
CONECT    9    8   10                                                       
CONECT   10    9    5   11   12                                             
CONECT   11   10                                                            
CONECT   12   10   13   35                                                  
CONECT   13   12   14   18                                                  
CONECT   14   13   15                                                       
CONECT   15   14   16                                                       
CONECT   16   15   17                                                       
CONECT   17   16   18                                                       
CONECT   18   17   13   19                                                  
CONECT   19   18   20   35                                                  
CONECT   20   19   21   25                                                  
CONECT   21   20   22                                                       
CONECT   22   21   23                                                       
CONECT   23   22   24   25                                                  
CONECT   24   23                                                            
CONECT   25   23   20   26                                                  
CONECT   26   25   27   34                                                  
CONECT   27   26   28   32                                                  
CONECT   28   27   29                                                       
CONECT   29   28   30                                                       
CONECT   30   29   31                                                       
CONECT   31   30   32                                                       
CONECT   32   31   27   33                                                  
CONECT   33   32    8   34                                                  
CONECT   34   33   26   35                                                  
CONECT   35   34   12   19                                                  
MASTER        0    0    0    0    0    0    0    0   35    0   84    0
END

View in JSmol

Synonyms

Value	Source
3'-(S)-Epi-K-252a	MeSH
Staurosporine aglycone	MeSH
Staurosporinone	MeSH

Chemical Formula

C₂₇H₂₁N₃O₅

Average Mass

467.4810 Da

Monoisotopic Mass

467.14812 Da

IUPAC Name

methyl 16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1¹⁵,¹⁸.0²,⁶.0⁷,²⁷.0⁸,¹³.0¹⁹,²⁶.0²⁰,²⁵]octacosa-1(26),2(6),7(27),8(13),9,11,20,22,24-nonaene-16-carboxylate

Traditional Name

staurosporinone

CAS Registry Number

Not Available

SMILES

COC(=O)C1(O)CC2OC1(C)N1C3=C(C=CC=C3)C3=C1C1=C(C4=CC=CC=C4N21)C1=C3CNC1=O

InChI Identifier

InChI=1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)

InChI Key

KOZFSFOOLUUIGY-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Not Available

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as indolocarbazoles. These are polycyclic aromatic compounds containing an indole fused to a carbazole.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Indoles and derivatives

Sub Class

Carbazoles

Direct Parent

Indolocarbazoles

Alternative Parents

Substituents

Indolocarbazole
Pyrrolo[2,3-a]carbazole
Pyrroloindole
Isoindolone
Indole
Isoindoline
Isoindole or derivatives
Benzenoid
Pyrrole
Heteroaromatic compound
Tertiary alcohol
Tetrahydrofuran
Methyl ester
Secondary carboxylic acid amide
Carboxamide group
Lactam
Carboxylic acid ester
Azacycle
Oxacycle
Carboxylic acid derivative
Monocarboxylic acid or derivatives
Alcohol
Organic oxide
Organopnictogen compound
Organic oxygen compound
Organic nitrogen compound
Hydrocarbon derivative
Carbonyl group
Organonitrogen compound
Organooxygen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

a chloroaromatic compound (CPD-11887 )
an indolocarbazole alkaloid (CPD-11887 )

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	2.91	ALOGPS
logP	3.48	ChemAxon
logS	-3.9	ALOGPS
pKa (Strongest Acidic)	10.71	ChemAxon
pKa (Strongest Basic)	-1.5	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	94.72 Å²	ChemAxon
Rotatable Bond Count	2	ChemAxon
Refractivity	126.12 m³·mol⁻¹	ChemAxon
Polarizability	49.43 Å³	ChemAxon
Number of Rings	8	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

3813

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for methyl 3,16-dihydroxy-15-methyl-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1¹⁵,¹⁸.0²,⁶.0⁷,²⁷.0⁸,¹³.0¹⁹,²⁶.0²⁰,²⁵]octacosa-1(26),2(6),3,7(27),8(13),9,11,20(25),21,23-decaene-16-carboxylate (NP0280579)

MOL for NP0280579 (methyl 3,16-dihydroxy-15-methyl-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1¹⁵,¹⁸.0²,⁶.0⁷,²⁷.0⁸,¹³.0¹⁹,²⁶.0²⁰,²⁵]octacosa-1(26),2(6),3,7(27),8(13),9,11,20(25),21,23-decaene-16-carboxylate)

3D MOL for NP0280579 (methyl 3,16-dihydroxy-15-methyl-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1¹⁵,¹⁸.0²,⁶.0⁷,²⁷.0⁸,¹³.0¹⁹,²⁶.0²⁰,²⁵]octacosa-1(26),2(6),3,7(27),8(13),9,11,20(25),21,23-decaene-16-carboxylate)

3D SDF for NP0280579 (methyl 3,16-dihydroxy-15-methyl-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1¹⁵,¹⁸.0²,⁶.0⁷,²⁷.0⁸,¹³.0¹⁹,²⁶.0²⁰,²⁵]octacosa-1(26),2(6),3,7(27),8(13),9,11,20(25),21,23-decaene-16-carboxylate)

3D-SDF for NP0280579 (methyl 3,16-dihydroxy-15-methyl-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1¹⁵,¹⁸.0²,⁶.0⁷,²⁷.0⁸,¹³.0¹⁹,²⁶.0²⁰,²⁵]octacosa-1(26),2(6),3,7(27),8(13),9,11,20(25),21,23-decaene-16-carboxylate)

PDB for NP0280579 (methyl 3,16-dihydroxy-15-methyl-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1¹⁵,¹⁸.0²,⁶.0⁷,²⁷.0⁸,¹³.0¹⁹,²⁶.0²⁰,²⁵]octacosa-1(26),2(6),3,7(27),8(13),9,11,20(25),21,23-decaene-16-carboxylate)

3D PDB for NP0280579 (methyl 3,16-dihydroxy-15-methyl-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1¹⁵,¹⁸.0²,⁶.0⁷,²⁷.0⁸,¹³.0¹⁹,²⁶.0²⁰,²⁵]octacosa-1(26),2(6),3,7(27),8(13),9,11,20(25),21,23-decaene-16-carboxylate)

SMILES for NP0280579 (methyl 3,16-dihydroxy-15-methyl-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1¹⁵,¹⁸.0²,⁶.0⁷,²⁷.0⁸,¹³.0¹⁹,²⁶.0²⁰,²⁵]octacosa-1(26),2(6),3,7(27),8(13),9,11,20(25),21,23-decaene-16-carboxylate)

INCHI for NP0280579 (methyl 3,16-dihydroxy-15-methyl-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1¹⁵,¹⁸.0²,⁶.0⁷,²⁷.0⁸,¹³.0¹⁹,²⁶.0²⁰,²⁵]octacosa-1(26),2(6),3,7(27),8(13),9,11,20(25),21,23-decaene-16-carboxylate)

Structure for NP0280579 (methyl 3,16-dihydroxy-15-methyl-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1¹⁵,¹⁸.0²,⁶.0⁷,²⁷.0⁸,¹³.0¹⁹,²⁶.0²⁰,²⁵]octacosa-1(26),2(6),3,7(27),8(13),9,11,20(25),21,23-decaene-16-carboxylate)

3D Structure for NP0280579 (methyl 3,16-dihydroxy-15-methyl-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1¹⁵,¹⁸.0²,⁶.0⁷,²⁷.0⁸,¹³.0¹⁹,²⁶.0²⁰,²⁵]octacosa-1(26),2(6),3,7(27),8(13),9,11,20(25),21,23-decaene-16-carboxylate)