NP-MRD: Showing NP-Card for dictazoline a (NP0279320)

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Record Information

Version

2.0

Created at

2022-09-09 04:40:06 UTC

Updated at

2022-09-09 04:40:06 UTC

NP-MRD ID

NP0279320

Secondary Accession Numbers

None

Natural Product Identification

Common Name

dictazoline a

Description

Not Available

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309092206402D          

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 18 19  2  0  0  0  0
 10 19  1  0  0  0  0
 13 19  1  0  0  0  0
 11 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  2  0  0  0  0
 26 27  1  0  0  0  0
 25 28  1  0  0  0  0
 20 28  1  6  0  0  0
 28 29  1  0  0  0  0
 20 30  1  0  0  0  0
  8 30  1  0  0  0  0
 30 31  1  1  0  0  0
 31 32  2  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  2  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 36 38  2  0  0  0  0
 38 39  1  0  0  0  0
 39 40  2  0  0  0  0
 31 40  1  0  0  0  0
 34 40  1  0  0  0  0
  8 41  1  1  0  0  0
  3 41  1  0  0  0  0
 41 42  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0279320

> <DATABASE_NAME>
NP-MRD

> <SMILES>
[H]N=C1N(C)C(=O)[C@]2(CC3=C(NC4=CC(Br)=CC=C34)[C@]3([C@@H]2C2=CNC4=CC(Br)=CC=C24)N(C)C(=N[H])N(C)C3=O)N1C

> <INCHI_IDENTIFIER>
InChI=1S/C28H26Br2N8O2/c1-35-23(39)27(37(3)25(35)31)11-17-15-7-5-14(30)10-20(15)34-22(17)28(24(40)36(2)26(32)38(28)4)21(27)18-12-33-19-9-13(29)6-8-16(18)19/h5-10,12,21,31-34H,11H2,1-4H3/b31-25+,32-26-/t21-,27-,28+/m1/s1

> <INCHI_KEY>
YXJMPPIPGTWBHE-YYHWTIAUSA-N

> <FORMULA>
C28H26Br2N8O2

> <MOLECULAR_WEIGHT>
666.378

> <EXACT_MASS>
664.054548

> <JCHEM_ACCEPTOR_COUNT>
6

> <JCHEM_ATOM_COUNT>
66

> <JCHEM_AVERAGE_POLARIZABILITY>
61.76218344536486

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
4

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(2'R,3'R,4S)-7'-bromo-2'-(6-bromo-1H-indol-3-yl)-2,2''-diimino-1,1'',3,3''-tetramethyl-4',9'-dihydro-2'H-dispiro[imidazolidine-4,1'-carbazole-3',4''-imidazolidine]-5,5''-dione

> <JCHEM_LOGP>
3.815169103666666

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
7

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
15.954401234190957

> <JCHEM_PKA_STRONGEST_ACIDIC>
15.284372019557516

> <JCHEM_PKA_STRONGEST_BASIC>
4.41811798839408

> <JCHEM_POLAR_SURFACE_AREA>
126.38000000000001

> <JCHEM_REFRACTIVITY>
179.46509999999992

> <JCHEM_ROTATABLE_BOND_COUNT>
1

> <JCHEM_RULE_OF_FIVE>
0

> <JCHEM_TRADITIONAL_IUPAC>
dictazoline A

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 09-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   09-SEP-22         0                                  
HETATM    1  H   UNK     0      12.665  -1.520   0.000  0.00  0.00           H+0
HETATM    2  N   UNK     0      11.292  -0.822   0.000  0.00  0.00           N+0
HETATM    3  C   UNK     0       9.925  -1.713   0.000  0.00  0.00           C+0
HETATM    4  N   UNK     0       9.605  -3.219   0.000  0.00  0.00           N+0
HETATM    5  C   UNK     0      11.237  -3.966   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       8.074  -3.380   0.000  0.00  0.00           C+0
HETATM    7  O   UNK     0       7.713  -4.550   0.000  0.00  0.00           O+0
HETATM    8  C   UNK     0       7.447  -1.973   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       6.971  -0.508   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       5.465  -0.188   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       4.434  -1.333   0.000  0.00  0.00           C+0
HETATM   12  N   UNK     0       3.028  -0.706   0.000  0.00  0.00           N+0
HETATM   13  C   UNK     0       3.189   0.825   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       2.158   1.970   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       2.634   3.434   0.000  0.00  0.00           C+0
HETATM   16 Br   UNK     0       1.673   4.701   0.000  0.00  0.00          Br+0
HETATM   17  C   UNK     0       4.140   3.755   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       5.171   2.610   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       4.695   1.146   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       4.910  -2.797   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       5.231  -4.304   0.000  0.00  0.00           C+0
HETATM   22  O   UNK     0       6.186  -5.032   0.000  0.00  0.00           O+0
HETATM   23  N   UNK     0       3.897  -5.074   0.000  0.00  0.00           N+0
HETATM   24  C   UNK     0       2.925  -6.380   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0       2.752  -4.043   0.000  0.00  0.00           C+0
HETATM   26  N   UNK     0       1.209  -4.482   0.000  0.00  0.00           N+0
HETATM   27  H   UNK     0       0.103  -3.409   0.000  0.00  0.00           H+0
HETATM   28  N   UNK     0       3.379  -2.636   0.000  0.00  0.00           N+0
HETATM   29  C   UNK     0       2.113  -1.759   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0       6.417  -3.117   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0       6.893  -4.582   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0       5.987  -5.828   0.000  0.00  0.00           C+0
HETATM   33  N   UNK     0       6.893  -7.074   0.000  0.00  0.00           N+0
HETATM   34  C   UNK     0       8.357  -6.598   0.000  0.00  0.00           C+0
HETATM   35  C   UNK     0       9.691  -7.368   0.000  0.00  0.00           C+0
HETATM   36  C   UNK     0      11.025  -6.598   0.000  0.00  0.00           C+0
HETATM   37 Br   UNK     0      12.358  -7.368   0.000  0.00  0.00          Br+0
HETATM   38  C   UNK     0      11.025  -5.058   0.000  0.00  0.00           C+0
HETATM   39  C   UNK     0       9.691  -4.288   0.000  0.00  0.00           C+0
HETATM   40  C   UNK     0       8.357  -5.058   0.000  0.00  0.00           C+0
HETATM   41  N   UNK     0       8.592  -0.943   0.000  0.00  0.00           N+0
HETATM   42  C   UNK     0       9.349   0.519   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4   41                                                  
CONECT    4    3    5    6                                                  
CONECT    5    4                                                            
CONECT    6    4    7    8                                                  
CONECT    7    6                                                            
CONECT    8    6    9   30   41                                             
CONECT    9    8   10                                                       
CONECT   10    9   11   19                                                  
CONECT   11   10   12   20                                                  
CONECT   12   11   13                                                       
CONECT   13   12   14   19                                                  
CONECT   14   13   15                                                       
CONECT   15   14   16   17                                                  
CONECT   16   15                                                            
CONECT   17   15   18                                                       
CONECT   18   17   19                                                       
CONECT   19   18   10   13                                                  
CONECT   20   11   21   28   30                                             
CONECT   21   20   22   23                                                  
CONECT   22   21                                                            
CONECT   23   21   24   25                                                  
CONECT   24   23                                                            
CONECT   25   23   26   28                                                  
CONECT   26   25   27                                                       
CONECT   27   26                                                            
CONECT   28   25   20   29                                                  
CONECT   29   28                                                            
CONECT   30   20    8   31                                                  
CONECT   31   30   32   40                                                  
CONECT   32   31   33                                                       
CONECT   33   32   34                                                       
CONECT   34   33   35   40                                                  
CONECT   35   34   36                                                       
CONECT   36   35   37   38                                                  
CONECT   37   36                                                            
CONECT   38   36   39                                                       
CONECT   39   38   40                                                       
CONECT   40   39   31   34                                                  
CONECT   41    8    3   42                                                  
CONECT   42   41                                                            
MASTER        0    0    0    0    0    0    0    0   42    0   96    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₈H₂₆Br₂N₈O₂

Average Mass

666.3780 Da

Monoisotopic Mass

664.05455 Da

IUPAC Name

(2'R,3'R,4S)-7'-bromo-2'-(6-bromo-1H-indol-3-yl)-2,2''-diimino-1,1'',3,3''-tetramethyl-4',9'-dihydro-2'H-dispiro[imidazolidine-4,1'-carbazole-3',4''-imidazolidine]-5,5''-dione

Traditional Name

dictazoline A

CAS Registry Number

Not Available

SMILES

[H]N=C1N(C)C(=O)[C@]2(CC3=C(NC4=CC(Br)=CC=C34)[C@]3([C@@H]2C2=CNC4=CC(Br)=CC=C24)N(C)C(=N[H])N(C)C3=O)N1C

InChI Identifier

InChI=1S/C28H26Br2N8O2/c1-35-23(39)27(37(3)25(35)31)11-17-15-7-5-14(30)10-20(15)34-22(17)28(24(40)36(2)26(32)38(28)4)21(27)18-12-33-19-9-13(29)6-8-16(18)19/h5-10,12,21,31-34H,11H2,1-4H3/b31-25+,32-26-/t21-,27-,28+/m1/s1

InChI Key

YXJMPPIPGTWBHE-YYHWTIAUSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Not Available

Chemical Taxonomy

Classification

Not classified

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	3.82	ChemAxon
pKa (Strongest Acidic)	15.28	ChemAxon
pKa (Strongest Basic)	4.42	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	6	ChemAxon
Hydrogen Donor Count	4	ChemAxon
Polar Surface Area	126.38 Å²	ChemAxon
Rotatable Bond Count	1	ChemAxon
Refractivity	179.47 m³·mol⁻¹	ChemAxon
Polarizability	61.76 Å³	ChemAxon
Number of Rings	7	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for dictazoline a (NP0279320)

MOL for NP0279320 (dictazoline a)

3D MOL for NP0279320 (dictazoline a)

3D SDF for NP0279320 (dictazoline a)

3D-SDF for NP0279320 (dictazoline a)

PDB for NP0279320 (dictazoline a)

3D PDB for NP0279320 (dictazoline a)

SMILES for NP0279320 (dictazoline a)

INCHI for NP0279320 (dictazoline a)

Structure for NP0279320 (dictazoline a)

3D Structure for NP0279320 (dictazoline a)