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Record Information
Version1.0
Created at2022-09-09 01:58:45 UTC
Updated at2022-09-09 01:58:45 UTC
NP-MRD IDNP0277364
Secondary Accession NumbersNone
Natural Product Identification
Common Namehistidine
DescriptionL-Histidine, also known as histidina, belongs to the class of organic compounds known as histidine and derivatives. Histidine and derivatives are compounds containing cysteine or a derivative thereof resulting from reaction of cysteine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. An alpha-amino acid that is propanoic acid bearing an amino substituent at position 2 and a 1H-imidazol-4-yl group at position 3. L-Histidine is a very strong basic compound (based on its pKa). In humans, L-histidine is involved in methylhistidine metabolism. L-Histidine is a bitter and odorless tasting compound. Outside of the human body, L-Histidine is found, on average, in the highest concentration within a few different foods, such as beluga whales, caseins, and bearded seals and in a lower concentration in other bread products, baked beans, and allium (onion). L-Histidine has also been detected, but not quantified in, several different foods, such as carp breams, black chokeberries, peach (var.), Acerola, and winter savories. histidine is found in Abutilon indicum, Arabidopsis thaliana, Caenorhabditis elegans, Castanea sativa, Catha edulis, Claviceps purpurea, Coprinopsis atramentaria, Hippospongia communis, Lupinus albus, Mycoplasma bovis, Pseudostellaria heterophylla, Puccinia graminis, Scolopendra subspinipes, Solanum lycopersicum and Stellaria media. It was first documented in 2007 (PMID: 17190852). This could make L-histidine a potential biomarker for the consumption of these foods (PMID: 22770225) (PMID: 22264337) (PMID: 29286160).
Structure
Thumb
Synonyms
ValueSource
alpha-Amino-1H-imidazole-4-propionic acidChEBI
DL-HistidineChEBI
HistidinChEBI
HistidinaChEBI
a-Amino-1H-imidazole-4-propionateGenerator
a-Amino-1H-imidazole-4-propionic acidGenerator
alpha-Amino-1H-imidazole-4-propionateGenerator
Α-amino-1H-imidazole-4-propionateGenerator
Α-amino-1H-imidazole-4-propionic acidGenerator
Chemical FormulaC6H9N3O2
Average Mass155.1546 Da
Monoisotopic Mass155.06948 Da
IUPAC Name2-amino-3-(1H-imidazol-5-yl)propanoic acid
Traditional Namehistidine
CAS Registry NumberNot Available
SMILES
NC(CC1=CN=CN1)C(O)=O
InChI Identifier
InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)
InChI KeyHNDVDQJCIGZPNO-UHFFFAOYSA-N
Experimental Spectra
Spectrum TypeDescriptionDepositor EmailDepositor OrganizationDepositorDeposition DateView
1D NMR13C NMR Spectrum (1D, 22.53 MHz, D2O, experimental)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
Predicted Spectra
Not Available
Chemical Shift Submissions
Not Available
Species
Species of Origin
Species NameSourceReference
Abutilon indicumLOTUS Database
Arabidopsis thalianaLOTUS Database
Caenorhabditis elegansLOTUS Database
Castanea sativaLOTUS Database
Catha edulisLOTUS Database
Claviceps purpureaLOTUS Database
Coprinopsis atramentariaLOTUS Database
Hippospongia communisLOTUS Database
Lupinus albusLOTUS Database
Mycoplasmopsis bovisLOTUS Database
Pseudostellaria heterophyllaLOTUS Database
Puccinia graminisLOTUS Database
Scolopendra subspinipesLOTUS Database
Solanum lycopersicumLOTUS Database
Stellaria mediaLOTUS Database
Chemical Taxonomy
Description Belongs to the class of organic compounds known as histidine and derivatives. Histidine and derivatives are compounds containing cysteine or a derivative thereof resulting from reaction of cysteine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentHistidine and derivatives
Alternative Parents
Substituents
  • Histidine or derivatives
  • Alpha-amino acid
  • Imidazolyl carboxylic acid derivative
  • Aralkylamine
  • Azole
  • Imidazole
  • Heteroaromatic compound
  • Amino acid
  • Azacycle
  • Organoheterocyclic compound
  • Monocarboxylic acid or derivatives
  • Carboxylic acid
  • Organic nitrogen compound
  • Primary amine
  • Organooxygen compound
  • Organonitrogen compound
  • Primary aliphatic amine
  • Organic oxide
  • Organopnictogen compound
  • Carbonyl group
  • Organic oxygen compound
  • Amine
  • Hydrocarbon derivative
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Physical Properties
StateNot Available
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP-3.1ALOGPS
logP-3.6ChemAxon
logS-0.4ALOGPS
pKa (Strongest Acidic)1.85ChemAxon
pKa (Strongest Basic)9.44ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area92 ŲChemAxon
Rotatable Bond Count3ChemAxon
Refractivity38.06 m³·mol⁻¹ChemAxon
Polarizability14.8 ųChemAxon
Number of Rings1ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
HMDB IDNot Available
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FoodDB IDFDB011856
KNApSAcK IDC00001363
Chemspider IDNot Available
KEGG Compound IDC00768
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkHistidine
METLIN IDNot Available
PubChem Compound773
PDB IDNot Available
ChEBI ID27570
Good Scents IDNot Available
References
General References
  1. Roux A, Xu Y, Heilier JF, Olivier MF, Ezan E, Tabet JC, Junot C: Annotation of the human adult urinary metabolome and metabolite identification using ultra high performance liquid chromatography coupled to a linear quadrupole ion trap-Orbitrap mass spectrometer. Anal Chem. 2012 Aug 7;84(15):6429-37. doi: 10.1021/ac300829f. Epub 2012 Jul 17. [PubMed:22770225 ]
  2. Castro C, Sar F, Shaw WR, Mishima M, Miska EA, Griffin JL: A metabolomic strategy defines the regulation of lipid content and global metabolism by Delta9 desaturases in Caenorhabditis elegans. BMC Genomics. 2012 Jan 20;13:36. doi: 10.1186/1471-2164-13-36. [PubMed:22264337 ]
  3. Salek RM, Maguire ML, Bentley E, Rubtsov DV, Hough T, Cheeseman M, Nunez D, Sweatman BC, Haselden JN, Cox RD, Connor SC, Griffin JL: A metabolomic comparison of urinary changes in type 2 diabetes in mouse, rat, and human. Physiol Genomics. 2007 Apr 24;29(2):99-108. doi: 10.1152/physiolgenomics.00194.2006. Epub 2006 Dec 26. [PubMed:17190852 ]
  4. Li Y, Hu H, Qi Z, Sun J, Li Y, Feng Q, Guo C, Wang H, Zhao P, Liu Y, Zhao X, Wang G, Zhang H, Liu L, Hu J: Identification and characterization of epitopes from influenza A virus hemagglutinin that induce broadly cross-reactive antibodies. Int J Mol Med. 2018 Mar;41(3):1673-1682. doi: 10.3892/ijmm.2017.3344. Epub 2017 Dec 22. [PubMed:29286160 ]
  5. LOTUS database [Link]