NP-MRD: Showing NP-Card for ethyl 2-[(1r,2r,5r,7r,8s,11s,12r)-11-(acetyloxy)-2,8-dihydroxy-7-methoxy-2,8,12-trimethyl-15-oxabicyclo[10.2.1]pentadecan-5-yl]prop-2-enoate (NP0267539)

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Record Information

Version

2.0

Created at

2022-09-08 12:21:01 UTC

Updated at

2022-09-08 12:21:01 UTC

NP-MRD ID

NP0267539

Secondary Accession Numbers

None

Natural Product Identification

Common Name

ethyl 2-[(1r,2r,5r,7r,8s,11s,12r)-11-(acetyloxy)-2,8-dihydroxy-7-methoxy-2,8,12-trimethyl-15-oxabicyclo[10.2.1]pentadecan-5-yl]prop-2-enoate

Description

Ethyl 2-[(1R,2R,5R,7R,8S,11S,12R)-11-(acetyloxy)-2,8-dihydroxy-7-methoxy-2,8,12-trimethyl-15-oxabicyclo[10.2.1]Pentadecan-5-yl]prop-2-enoate belongs to the class of organic compounds known as sesquiterpenoids. These are terpenes with three consecutive isoprene units. Based on a literature review very few articles have been published on ethyl 2-[(1R,2R,5R,7R,8S,11S,12R)-11-(acetyloxy)-2,8-dihydroxy-7-methoxy-2,8,12-trimethyl-15-oxabicyclo[10.2.1]Pentadecan-5-yl]prop-2-enoate.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309082214212D          

 33 34  0  0  1  0            999 V2000
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M  END

     RDKit          3D

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M  END


  Mrv1652309082214212D          

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 22 24  2  0  0  0  0
 20 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  1  0  0  0
 27 29  1  6  0  0  0
 27 30  1  0  0  0  0
 30 31  1  6  0  0  0
 31 32  1  0  0  0  0
 30 33  1  0  0  0  0
  8 33  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0267539

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CCOC(=O)C(=C)[C@@H]1CC[C@@](C)(O)[C@H]2CC[C@@](C)(O2)[C@H](CC[C@](C)(O)[C@@H](C1)OC)OC(C)=O

> <INCHI_IDENTIFIER>
InChI=1S/C25H42O8/c1-8-31-22(27)16(2)18-9-12-23(4,28)19-11-14-25(6,33-19)20(32-17(3)26)10-13-24(5,29)21(15-18)30-7/h18-21,28-29H,2,8-15H2,1,3-7H3/t18-,19-,20+,21-,23-,24+,25-/m1/s1

> <INCHI_KEY>
DNCNDFBVUIHHRL-GPXXFDTLSA-N

> <FORMULA>
C25H42O8

> <MOLECULAR_WEIGHT>
470.603

> <EXACT_MASS>
470.287968312

> <JCHEM_ACCEPTOR_COUNT>
6

> <JCHEM_ATOM_COUNT>
75

> <JCHEM_AVERAGE_POLARIZABILITY>
50.827635728939754

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
ethyl 2-[(1R,2R,5R,7R,8S,11S,12R)-11-(acetyloxy)-2,8-dihydroxy-7-methoxy-2,8,12-trimethyl-15-oxabicyclo[10.2.1]pentadecan-5-yl]prop-2-enoate

> <JCHEM_LOGP>
2.5254693889999995

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
2

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
14.354701727567559

> <JCHEM_PKA_STRONGEST_ACIDIC>
13.752638430397027

> <JCHEM_PKA_STRONGEST_BASIC>
-3.2122022558584895

> <JCHEM_POLAR_SURFACE_AREA>
111.52000000000001

> <JCHEM_REFRACTIVITY>
122.52479999999997

> <JCHEM_ROTATABLE_BOND_COUNT>
7

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
ethyl 2-[(1R,2R,5R,7R,8S,11S,12R)-11-(acetyloxy)-2,8-dihydroxy-7-methoxy-2,8,12-trimethyl-15-oxabicyclo[10.2.1]pentadecan-5-yl]prop-2-enoate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 08-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   08-SEP-22         0                                  
HETATM    1  C   UNK     0      -0.000  -3.080   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -0.000  -4.620   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       1.334  -5.390   0.000  0.00  0.00           C+0
HETATM    4  O   UNK     0       1.334  -6.930   0.000  0.00  0.00           O+0
HETATM    5  O   UNK     0       2.667  -4.620   0.000  0.00  0.00           O+0
HETATM    6  C   UNK     0       4.001  -5.390   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       5.335  -4.620   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      -1.334  -5.390   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      -1.334  -6.930   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      -2.755  -7.835   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0      -3.231  -9.300   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      -1.725  -9.620   0.000  0.00  0.00           C+0
HETATM   13  O   UNK     0      -3.392 -10.831   0.000  0.00  0.00           O+0
HETATM   14  C   UNK     0      -4.771  -9.300   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      -3.925  -8.013   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      -4.888  -6.811   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      -6.668  -6.930   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      -7.720  -8.055   0.000  0.00  0.00           C+0
HETATM   19  O   UNK     0      -5.247  -7.835   0.000  0.00  0.00           O+0
HETATM   20  C   UNK     0      -6.668  -5.390   0.000  0.00  0.00           C+0
HETATM   21  O   UNK     0      -8.002  -4.620   0.000  0.00  0.00           O+0
HETATM   22  C   UNK     0      -8.002  -3.080   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0      -9.336  -2.310   0.000  0.00  0.00           C+0
HETATM   24  O   UNK     0      -6.668  -2.310   0.000  0.00  0.00           O+0
HETATM   25  C   UNK     0      -5.335  -4.620   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0      -5.335  -3.080   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0      -4.001  -2.310   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0      -3.011  -1.130   0.000  0.00  0.00           C+0
HETATM   29  O   UNK     0      -4.991  -1.130   0.000  0.00  0.00           O+0
HETATM   30  C   UNK     0      -2.667  -3.080   0.000  0.00  0.00           C+0
HETATM   31  O   UNK     0      -1.334  -2.310   0.000  0.00  0.00           O+0
HETATM   32  C   UNK     0      -1.334  -0.770   0.000  0.00  0.00           C+0
HETATM   33  C   UNK     0      -2.667  -4.620   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3    8                                                  
CONECT    3    2    4    5                                                  
CONECT    4    3                                                            
CONECT    5    3    6                                                       
CONECT    6    5    7                                                       
CONECT    7    6                                                            
CONECT    8    2    9   33                                                  
CONECT    9    8   10                                                       
CONECT   10    9   11                                                       
CONECT   11   10   12   13   14                                             
CONECT   12   11                                                            
CONECT   13   11                                                            
CONECT   14   11   15   19                                                  
CONECT   15   14   16                                                       
CONECT   16   15   17                                                       
CONECT   17   16   18   19   20                                             
CONECT   18   17                                                            
CONECT   19   17   14                                                       
CONECT   20   17   21   25                                                  
CONECT   21   20   22                                                       
CONECT   22   21   23   24                                                  
CONECT   23   22                                                            
CONECT   24   22                                                            
CONECT   25   20   26                                                       
CONECT   26   25   27                                                       
CONECT   27   26   28   29   30                                             
CONECT   28   27                                                            
CONECT   29   27                                                            
CONECT   30   27   31   33                                                  
CONECT   31   30   32                                                       
CONECT   32   31                                                            
CONECT   33   30    8                                                       
MASTER        0    0    0    0    0    0    0    0   33    0   68    0
END

View in JSmol

Synonyms

Value	Source
Ethyl 2-[(1R,2R,5R,7R,8S,11S,12R)-11-(acetyloxy)-2,8-dihydroxy-7-methoxy-2,8,12-trimethyl-15-oxabicyclo[10.2.1]pentadecan-5-yl]prop-2-enoic acid	Generator

Chemical Formula

C₂₅H₄₂O₈

Average Mass

470.6030 Da

Monoisotopic Mass

470.28797 Da

IUPAC Name

ethyl 2-[(1R,2R,5R,7R,8S,11S,12R)-11-(acetyloxy)-2,8-dihydroxy-7-methoxy-2,8,12-trimethyl-15-oxabicyclo[10.2.1]pentadecan-5-yl]prop-2-enoate

Traditional Name

ethyl 2-[(1R,2R,5R,7R,8S,11S,12R)-11-(acetyloxy)-2,8-dihydroxy-7-methoxy-2,8,12-trimethyl-15-oxabicyclo[10.2.1]pentadecan-5-yl]prop-2-enoate

CAS Registry Number

Not Available

SMILES

CCOC(=O)C(=C)[C@@H]1CC[C@@](C)(O)[C@H]2CC[C@@](C)(O2)[C@H](CC[C@](C)(O)[C@@H](C1)OC)OC(C)=O

InChI Identifier

InChI=1S/C25H42O8/c1-8-31-22(27)16(2)18-9-12-23(4,28)19-11-14-25(6,33-19)20(32-17(3)26)10-13-24(5,29)21(15-18)30-7/h18-21,28-29H,2,8-15H2,1,3-7H3/t18-,19-,20+,21-,23-,24+,25-/m1/s1

InChI Key

DNCNDFBVUIHHRL-GPXXFDTLSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Not Available

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as sesquiterpenoids. These are terpenes with three consecutive isoprene units.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Sesquiterpenoids

Direct Parent

Sesquiterpenoids

Alternative Parents

Substituents

Sesquiterpenoid
Dicarboxylic acid or derivatives
Tertiary alcohol
Tetrahydrofuran
Enoate ester
Alpha,beta-unsaturated carboxylic ester
Carboxylic acid ester
Ether
Dialkyl ether
Carboxylic acid derivative
Organoheterocyclic compound
Oxacycle
Carbonyl group
Alcohol
Organic oxide
Organooxygen compound
Organic oxygen compound
Hydrocarbon derivative
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	2.53	ChemAxon
pKa (Strongest Acidic)	13.75	ChemAxon
pKa (Strongest Basic)	-3.2	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	6	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	111.52 Å²	ChemAxon
Rotatable Bond Count	7	ChemAxon
Refractivity	122.52 m³·mol⁻¹	ChemAxon
Polarizability	50.83 Å³	ChemAxon
Number of Rings	2	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

27023711

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

163033365

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for ethyl 2-[(1r,2r,5r,7r,8s,11s,12r)-11-(acetyloxy)-2,8-dihydroxy-7-methoxy-2,8,12-trimethyl-15-oxabicyclo[10.2.1]pentadecan-5-yl]prop-2-enoate (NP0267539)

MOL for NP0267539 (ethyl 2-[(1r,2r,5r,7r,8s,11s,12r)-11-(acetyloxy)-2,8-dihydroxy-7-methoxy-2,8,12-trimethyl-15-oxabicyclo[10.2.1]pentadecan-5-yl]prop-2-enoate)

3D MOL for NP0267539 (ethyl 2-[(1r,2r,5r,7r,8s,11s,12r)-11-(acetyloxy)-2,8-dihydroxy-7-methoxy-2,8,12-trimethyl-15-oxabicyclo[10.2.1]pentadecan-5-yl]prop-2-enoate)

3D SDF for NP0267539 (ethyl 2-[(1r,2r,5r,7r,8s,11s,12r)-11-(acetyloxy)-2,8-dihydroxy-7-methoxy-2,8,12-trimethyl-15-oxabicyclo[10.2.1]pentadecan-5-yl]prop-2-enoate)

3D-SDF for NP0267539 (ethyl 2-[(1r,2r,5r,7r,8s,11s,12r)-11-(acetyloxy)-2,8-dihydroxy-7-methoxy-2,8,12-trimethyl-15-oxabicyclo[10.2.1]pentadecan-5-yl]prop-2-enoate)

PDB for NP0267539 (ethyl 2-[(1r,2r,5r,7r,8s,11s,12r)-11-(acetyloxy)-2,8-dihydroxy-7-methoxy-2,8,12-trimethyl-15-oxabicyclo[10.2.1]pentadecan-5-yl]prop-2-enoate)

3D PDB for NP0267539 (ethyl 2-[(1r,2r,5r,7r,8s,11s,12r)-11-(acetyloxy)-2,8-dihydroxy-7-methoxy-2,8,12-trimethyl-15-oxabicyclo[10.2.1]pentadecan-5-yl]prop-2-enoate)

SMILES for NP0267539 (ethyl 2-[(1r,2r,5r,7r,8s,11s,12r)-11-(acetyloxy)-2,8-dihydroxy-7-methoxy-2,8,12-trimethyl-15-oxabicyclo[10.2.1]pentadecan-5-yl]prop-2-enoate)

INCHI for NP0267539 (ethyl 2-[(1r,2r,5r,7r,8s,11s,12r)-11-(acetyloxy)-2,8-dihydroxy-7-methoxy-2,8,12-trimethyl-15-oxabicyclo[10.2.1]pentadecan-5-yl]prop-2-enoate)

Structure for NP0267539 (ethyl 2-[(1r,2r,5r,7r,8s,11s,12r)-11-(acetyloxy)-2,8-dihydroxy-7-methoxy-2,8,12-trimethyl-15-oxabicyclo[10.2.1]pentadecan-5-yl]prop-2-enoate)

3D Structure for NP0267539 (ethyl 2-[(1r,2r,5r,7r,8s,11s,12r)-11-(acetyloxy)-2,8-dihydroxy-7-methoxy-2,8,12-trimethyl-15-oxabicyclo[10.2.1]pentadecan-5-yl]prop-2-enoate)