NP-MRD: Showing NP-Card for 3-[(3-methoxy-4-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)methyl]-4-[(3,4,5-trimethoxyphenyl)methyl]oxolan-2-one (NP0267022)

Jump To Section:

Identification Spectra BioTaxonomy ChemoTaxonomy Physical properties Links References XML

Record Information

Version

2.0

Created at

2022-09-08 11:39:55 UTC

Updated at

2022-09-08 11:39:55 UTC

NP-MRD ID

NP0267022

Secondary Accession Numbers

None

Natural Product Identification

Common Name

3-[(3-methoxy-4-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)methyl]-4-[(3,4,5-trimethoxyphenyl)methyl]oxolan-2-one

Description

3-[(3-Methoxy-4-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)methyl]-4-[(3,4,5-trimethoxyphenyl)methyl]oxolan-2-one belongs to the class of organic compounds known as lignan glycosides. These are aromatic polycyclic compounds containing a carbohydrate component glycosidically linked to a lignan moiety. They include 1-aryltetralin lactones. 3-[(3-methoxy-4-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)methyl]-4-[(3,4,5-trimethoxyphenyl)methyl]oxolan-2-one is found in Torreya nucifera and Trachelospermum axillare. 3-[(3-Methoxy-4-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)methyl]-4-[(3,4,5-trimethoxyphenyl)methyl]oxolan-2-one is an extremely weak basic (essentially neutral) compound (based on its pKa).

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv0541 04121518232D          

 40 43  0  0  0  0            999 V2000
    7.0380    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235    1.8777    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091   -0.1848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946   -0.5973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946   -1.4223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5620   -1.9072    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3467   -1.6523    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9597   -2.2043    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7444   -1.9494    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3575   -2.5014    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1421   -2.2465    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.7552   -2.7985    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1859   -3.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7990   -3.8604    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.6275   -4.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4013   -3.5633    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2298   -4.3703    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4452   -4.6253    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7882   -3.0113    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3071   -2.6919    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4821   -2.6919    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2272   -1.9072    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4425   -1.6523    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235   -0.5973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380   -0.1848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525    1.0527    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814    1.0527    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.8959    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6104    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6104    1.8777    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.8959   -0.1848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6104   -0.5973    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814   -0.5973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814   -1.4223    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669   -0.1848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525   -0.5973    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 12 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 18 21  2  0  0  0  0
 10 21  1  0  0  0  0
  8 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
  7 24  1  0  0  0  0
 24 25  2  0  0  0  0
  5 26  2  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
  3 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 32 35  1  0  0  0  0
 35 36  1  0  0  0  0
 35 37  1  0  0  0  0
 37 38  1  0  0  0  0
 37 39  1  0  0  0  0
 30 39  1  0  0  0  0
 39 40  1  0  0  0  0
M  END

     RDKit          3D

 76 79  0  0  0  0  0  0  0  0999 V2000
    2.9257   -3.0407   -1.8945 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6325   -2.0049   -1.2472 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9001   -0.9560   -0.7001 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5198   -0.9384   -0.7934 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7157    0.0532   -0.2845 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7637    0.0474   -0.4001 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4180   -0.6535    0.7669 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.1261   -2.1184    0.6977 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2267   -2.7743    1.2862 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0740   -2.6364   -0.1739 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1296   -1.7135   -0.4069 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9177   -0.6657    0.6618 C   0  0  2  0  0  0  0  0  0  0  0  0
   -3.5242    0.6382    0.3036 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0011    0.4705    0.2376 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7536    0.6716    1.3788 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1415    0.5235    1.3496 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.9350    0.7158    2.4709 O   0  0  0  0  0  0  0  0  0  0  0  0
   -7.2974    1.0747    3.6807 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7564    0.1735    0.1667 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.1343    0.0255    0.1333 O   0  0  0  0  0  0  0  0  0  0  0  0
   -9.9110    1.1674   -0.1768 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0373   -0.0350   -0.9909 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.6832   -0.3868   -2.1676 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.8867   -0.5866   -3.3200 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6665    0.1216   -0.9196 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3866    1.0812    0.3558 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7521    1.1049    0.4718 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5478    0.0747   -0.0600 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8814    0.1863    0.1039 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9862   -0.5501   -0.2365 C   0  0  1  0  0  0  0  0  0  0  0  0
    6.8216    0.1504   -1.1262 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.2256    1.3123   -0.5069 C   0  0  2  0  0  0  0  0  0  0  0  0
    7.8203    2.2909   -1.5029 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2214    3.4516   -0.8713 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.3051    0.9202    0.5004 C   0  0  2  0  0  0  0  0  0  0  0  0
    9.3484    0.3022   -0.1432 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.6515    0.0505    1.5482 C   0  0  1  0  0  0  0  0  0  0  0  0
    6.9740    0.8276    2.5001 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.7851   -1.0271    0.9680 C   0  0  2  0  0  0  0  0  0  0  0  0
    7.4982   -2.1600    0.6283 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2755   -2.6268   -2.6894 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.6249   -3.7858   -2.3346 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.2616   -3.5143   -1.1293 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.0489   -1.7643   -1.3026 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1003    1.0746   -0.5316 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0447   -0.5045   -1.3292 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1286   -0.2667    1.7414 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1310   -2.1585   -0.2373 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0999   -1.3009   -1.4303 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3225   -0.9998    1.6230 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3099    1.3802    1.0971 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2139    1.0283   -0.6884 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2862    0.9466    2.3149 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.9200    2.1092    3.6598 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4405    0.4033    3.9122 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.9983    1.0040    4.5443 H   0  0  0  0  0  0  0  0  0  0  0  0
  -10.5850    1.4397    0.6813 H   0  0  0  0  0  0  0  0  0  0  0  0
  -10.5671    1.0287   -1.0477 H   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2709    2.0755   -0.3457 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0763   -1.3317   -3.1316 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.5241   -0.9938   -4.1380 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4793    0.3718   -3.7115 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0990   -0.0446   -1.8424 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.8327    1.9146    0.7929 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2714    1.9104    0.9732 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.7103   -1.4675   -0.7797 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.3944    1.7877    0.0230 H   0  0  0  0  0  0  0  0  0  0  0  0
    8.7197    1.8431   -1.9882 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.0673    2.4537   -2.2959 H   0  0  0  0  0  0  0  0  0  0  0  0
    9.1223    3.7580   -1.1735 H   0  0  0  0  0  0  0  0  0  0  0  0
    8.6299    1.8551    0.9898 H   0  0  0  0  0  0  0  0  0  0  0  0
    9.8420   -0.2749    0.5212 H   0  0  0  0  0  0  0  0  0  0  0  0
    8.4762   -0.4506    2.1019 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.7609    1.6866    2.1036 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.0365   -1.3079    1.7474 H   0  0  0  0  0  0  0  0  0  0  0  0
    8.0081   -2.4666    1.4224 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 16 19  2  0
 19 20  1  0
 20 21  1  0
 19 22  1  0
 22 23  1  0
 23 24  1  0
 22 25  2  0
 12 11  1  0
 11 10  1  0
 10  8  1  0
  8  9  2  0
  5 26  2  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 29 30  1  0
 30 31  1  0
 31 32  1  0
 32 33  1  0
 33 34  1  0
 32 35  1  0
 35 36  1  0
 35 37  1  0
 37 38  1  0
 37 39  1  0
 39 40  1  0
 28  3  1  0
 39 30  1  0
  8  7  1  0
 25 14  1  0
  1 41  1  0
  1 42  1  0
  1 43  1  0
  4 44  1  0
  6 45  1  0
  6 46  1  0
  7 47  1  1
 12 50  1  1
 13 51  1  0
 13 52  1  0
 15 53  1  0
 18 54  1  0
 18 55  1  0
 18 56  1  0
 21 57  1  0
 21 58  1  0
 21 59  1  0
 24 60  1  0
 24 61  1  0
 24 62  1  0
 25 63  1  0
 11 48  1  0
 11 49  1  0
 26 64  1  0
 27 65  1  0
 30 66  1  6
 32 67  1  1
 33 68  1  0
 33 69  1  0
 34 70  1  0
 35 71  1  1
 36 72  1  0
 37 73  1  1
 38 74  1  0
 39 75  1  1
 40 76  1  0
M  END


  Mrv0541 04121518232D          

 40 43  0  0  0  0            999 V2000
    7.0380    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235    1.8777    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091   -0.1848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946   -0.5973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946   -1.4223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5620   -1.9072    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3467   -1.6523    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9597   -2.2043    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7444   -1.9494    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3575   -2.5014    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1421   -2.2465    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.7552   -2.7985    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1859   -3.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7990   -3.8604    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.6275   -4.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4013   -3.5633    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2298   -4.3703    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4452   -4.6253    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7882   -3.0113    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3071   -2.6919    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4821   -2.6919    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2272   -1.9072    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4425   -1.6523    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235   -0.5973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380   -0.1848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525    1.0527    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814    1.0527    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.8959    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6104    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6104    1.8777    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.8959   -0.1848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6104   -0.5973    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814   -0.5973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814   -1.4223    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669   -0.1848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525   -0.5973    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 12 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 18 21  2  0  0  0  0
 10 21  1  0  0  0  0
  8 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
  7 24  1  0  0  0  0
 24 25  2  0  0  0  0
  5 26  2  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
  3 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 32 35  1  0  0  0  0
 35 36  1  0  0  0  0
 35 37  1  0  0  0  0
 37 38  1  0  0  0  0
 37 39  1  0  0  0  0
 30 39  1  0  0  0  0
 39 40  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0267022

> <DATABASE_NAME>
NP-MRD

> <SMILES>
COC1=CC(CC2C(CC3=CC(OC)=C(OC)C(OC)=C3)COC2=O)=CC=C1OC1OC(CO)C(O)C(O)C1O

> <INCHI_IDENTIFIER>
InChI=1S/C28H36O12/c1-34-19-9-14(5-6-18(19)39-28-25(32)24(31)23(30)22(12-29)40-28)8-17-16(13-38-27(17)33)7-15-10-20(35-2)26(37-4)21(11-15)36-3/h5-6,9-11,16-17,22-25,28-32H,7-8,12-13H2,1-4H3

> <INCHI_KEY>
IPSLAOALYPCJBD-UHFFFAOYSA-N

> <FORMULA>
C28H36O12

> <MOLECULAR_WEIGHT>
564.584

> <EXACT_MASS>
564.220676599

> <JCHEM_ACCEPTOR_COUNT>
11

> <JCHEM_ATOM_COUNT>
76

> <JCHEM_AVERAGE_POLARIZABILITY>
57.211841393141555

> <JCHEM_BIOAVAILABILITY>
0

> <JCHEM_DONOR_COUNT>
4

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
3-[(3-methoxy-4-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)methyl]-4-[(3,4,5-trimethoxyphenyl)methyl]oxolan-2-one

> <ALOGPS_LOGP>
1.66

> <JCHEM_LOGP>
1.0119372080000009

> <ALOGPS_LOGS>
-3.45

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
13.196043729445432

> <JCHEM_PKA_STRONGEST_ACIDIC>
12.20001489976324

> <JCHEM_PKA_STRONGEST_BASIC>
-2.981092354907191

> <JCHEM_POLAR_SURFACE_AREA>
162.6

> <JCHEM_REFRACTIVITY>
138.72430000000003

> <JCHEM_ROTATABLE_BOND_COUNT>
11

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
2.02e-01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
3-[(3-methoxy-4-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)methyl]-4-[(3,4,5-trimethoxyphenyl)methyl]oxolan-2-one

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 12-APR-15   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   12-APR-15         0                                  
HETATM    1  C   UNK     0      13.138   4.275   0.000  0.00  0.00           C+0
HETATM    2  O   UNK     0      11.804   3.505   0.000  0.00  0.00           O+0
HETATM    3  C   UNK     0      11.804   1.965   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      10.470   1.195   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      10.470  -0.345   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       9.137  -1.115   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       9.137  -2.655   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      10.382  -3.560   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      11.847  -3.084   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      12.992  -4.115   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0      14.456  -3.639   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      15.601  -4.669   0.000  0.00  0.00           C+0
HETATM   13  O   UNK     0      17.065  -4.193   0.000  0.00  0.00           O+0
HETATM   14  C   UNK     0      18.210  -5.224   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      15.280  -6.176   0.000  0.00  0.00           C+0
HETATM   16  O   UNK     0      16.425  -7.206   0.000  0.00  0.00           O+0
HETATM   17  C   UNK     0      16.105  -8.712   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      13.816  -6.652   0.000  0.00  0.00           C+0
HETATM   19  O   UNK     0      13.496  -8.158   0.000  0.00  0.00           O+0
HETATM   20  C   UNK     0      12.031  -8.634   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0      12.671  -5.621   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       9.907  -5.025   0.000  0.00  0.00           C+0
HETATM   23  O   UNK     0       8.367  -5.025   0.000  0.00  0.00           O+0
HETATM   24  C   UNK     0       7.891  -3.560   0.000  0.00  0.00           C+0
HETATM   25  O   UNK     0       6.426  -3.084   0.000  0.00  0.00           O+0
HETATM   26  C   UNK     0      11.804  -1.115   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0      13.138  -0.345   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0      13.138   1.195   0.000  0.00  0.00           C+0
HETATM   29  O   UNK     0      14.471   1.965   0.000  0.00  0.00           O+0
HETATM   30  C   UNK     0      15.805   1.195   0.000  0.00  0.00           C+0
HETATM   31  O   UNK     0      17.139   1.965   0.000  0.00  0.00           O+0
HETATM   32  C   UNK     0      18.472   1.195   0.000  0.00  0.00           C+0
HETATM   33  C   UNK     0      19.806   1.965   0.000  0.00  0.00           C+0
HETATM   34  O   UNK     0      19.806   3.505   0.000  0.00  0.00           O+0
HETATM   35  C   UNK     0      18.472  -0.345   0.000  0.00  0.00           C+0
HETATM   36  O   UNK     0      19.806  -1.115   0.000  0.00  0.00           O+0
HETATM   37  C   UNK     0      17.139  -1.115   0.000  0.00  0.00           C+0
HETATM   38  O   UNK     0      17.139  -2.655   0.000  0.00  0.00           O+0
HETATM   39  C   UNK     0      15.805  -0.345   0.000  0.00  0.00           C+0
HETATM   40  O   UNK     0      14.471  -1.115   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4   28                                                  
CONECT    4    3    5                                                       
CONECT    5    4    6   26                                                  
CONECT    6    5    7                                                       
CONECT    7    6    8   24                                                  
CONECT    8    7    9   22                                                  
CONECT    9    8   10                                                       
CONECT   10    9   11   21                                                  
CONECT   11   10   12                                                       
CONECT   12   11   13   15                                                  
CONECT   13   12   14                                                       
CONECT   14   13                                                            
CONECT   15   12   16   18                                                  
CONECT   16   15   17                                                       
CONECT   17   16                                                            
CONECT   18   15   19   21                                                  
CONECT   19   18   20                                                       
CONECT   20   19                                                            
CONECT   21   18   10                                                       
CONECT   22    8   23                                                       
CONECT   23   22   24                                                       
CONECT   24   23    7   25                                                  
CONECT   25   24                                                            
CONECT   26    5   27                                                       
CONECT   27   26   28                                                       
CONECT   28   27    3   29                                                  
CONECT   29   28   30                                                       
CONECT   30   29   31   39                                                  
CONECT   31   30   32                                                       
CONECT   32   31   33   35                                                  
CONECT   33   32   34                                                       
CONECT   34   33                                                            
CONECT   35   32   36   37                                                  
CONECT   36   35                                                            
CONECT   37   35   38   39                                                  
CONECT   38   37                                                            
CONECT   39   37   30   40                                                  
CONECT   40   39                                                            
MASTER        0    0    0    0    0    0    0    0   40    0   86    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₈H₃₆O₁₂

Average Mass

564.5840 Da

Monoisotopic Mass

564.22068 Da

IUPAC Name

3-[(3-methoxy-4-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)methyl]-4-[(3,4,5-trimethoxyphenyl)methyl]oxolan-2-one

Traditional Name

3-[(3-methoxy-4-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)methyl]-4-[(3,4,5-trimethoxyphenyl)methyl]oxolan-2-one

CAS Registry Number

Not Available

SMILES

COC1=CC(CC2C(CC3=CC(OC)=C(OC)C(OC)=C3)COC2=O)=CC=C1OC1OC(CO)C(O)C(O)C1O

InChI Identifier

InChI=1S/C28H36O12/c1-34-19-9-14(5-6-18(19)39-28-25(32)24(31)23(30)22(12-29)40-28)8-17-16(13-38-27(17)33)7-15-10-20(35-2)26(37-4)21(11-15)36-3/h5-6,9-11,16-17,22-25,28-32H,7-8,12-13H2,1-4H3

InChI Key

IPSLAOALYPCJBD-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Torreya nucifera	LOTUS Database	35616633
Trachelospermum axillare	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as lignan glycosides. These are aromatic polycyclic compounds containing a carbohydrate component glycosidically linked to a lignan moiety. They include 1-aryltetralin lactones.

Kingdom

Organic compounds

Super Class

Lignans, neolignans and related compounds

Class

Lignan glycosides

Sub Class

Not Available

Direct Parent

Lignan glycosides

Alternative Parents

Substituents

Lignan glycoside
Dibenzylbutyrolactone
Lignan lactone
Tetrahydrofuran lignan
9,9p-epoxylignan
Furanoid lignan
Fatty acyl glycoside
Phenolic glycoside
Fatty acyl glycoside of mono- or disaccharide
Alkyl glycoside
Glycosyl compound
O-glycosyl compound
Anisole
Phenoxy compound
Methoxybenzene
Phenol ether
Alkyl aryl ether
Fatty acyl
Oxane
Monosaccharide
Benzenoid
Monocyclic benzene moiety
Gamma butyrolactone
Tetrahydrofuran
Secondary alcohol
Carboxylic acid ester
Lactone
Acetal
Oxacycle
Carboxylic acid derivative
Monocarboxylic acid or derivatives
Organoheterocyclic compound
Ether
Polyol
Primary alcohol
Carbonyl group
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Alcohol
Organooxygen compound
Aromatic heteromonocyclic compound

Molecular Framework

Aromatic heteromonocyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	1.66	ALOGPS
logP	1.01	ChemAxon
logS	-3.4	ALOGPS
pKa (Strongest Acidic)	12.2	ChemAxon
pKa (Strongest Basic)	-3	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	11	ChemAxon
Hydrogen Donor Count	4	ChemAxon
Polar Surface Area	162.6 Å²	ChemAxon
Rotatable Bond Count	11	ChemAxon
Refractivity	138.72 m³·mol⁻¹	ChemAxon
Polarizability	57.21 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

85097674

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for 3-[(3-methoxy-4-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)methyl]-4-[(3,4,5-trimethoxyphenyl)methyl]oxolan-2-one (NP0267022)

MOL for NP0267022 (3-[(3-methoxy-4-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)methyl]-4-[(3,4,5-trimethoxyphenyl)methyl]oxolan-2-one)

3D MOL for NP0267022 (3-[(3-methoxy-4-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)methyl]-4-[(3,4,5-trimethoxyphenyl)methyl]oxolan-2-one)

3D SDF for NP0267022 (3-[(3-methoxy-4-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)methyl]-4-[(3,4,5-trimethoxyphenyl)methyl]oxolan-2-one)

3D-SDF for NP0267022 (3-[(3-methoxy-4-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)methyl]-4-[(3,4,5-trimethoxyphenyl)methyl]oxolan-2-one)

PDB for NP0267022 (3-[(3-methoxy-4-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)methyl]-4-[(3,4,5-trimethoxyphenyl)methyl]oxolan-2-one)

3D PDB for NP0267022 (3-[(3-methoxy-4-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)methyl]-4-[(3,4,5-trimethoxyphenyl)methyl]oxolan-2-one)

SMILES for NP0267022 (3-[(3-methoxy-4-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)methyl]-4-[(3,4,5-trimethoxyphenyl)methyl]oxolan-2-one)

INCHI for NP0267022 (3-[(3-methoxy-4-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)methyl]-4-[(3,4,5-trimethoxyphenyl)methyl]oxolan-2-one)

Structure for NP0267022 (3-[(3-methoxy-4-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)methyl]-4-[(3,4,5-trimethoxyphenyl)methyl]oxolan-2-one)

3D Structure for NP0267022 (3-[(3-methoxy-4-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)methyl]-4-[(3,4,5-trimethoxyphenyl)methyl]oxolan-2-one)