NP-MRD: Showing NP-Card for (2z)-n-[(1s,3br,7s,9ar,9bs,11ar)-1-[(1s)-1-(dimethylamino)ethyl]-9a,11a-dimethyl-6-oxo-1h,2h,3bh,4h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-yl]-2-methylbut-2-enimidic acid (NP0263979)

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Record Information

Version

2.0

Created at

2022-09-08 07:20:28 UTC

Updated at

2022-09-08 07:20:28 UTC

NP-MRD ID

NP0263979

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(2z)-n-[(1s,3br,7s,9ar,9bs,11ar)-1-[(1s)-1-(dimethylamino)ethyl]-9a,11a-dimethyl-6-oxo-1h,2h,3bh,4h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-yl]-2-methylbut-2-enimidic acid

Description

(2Z)-N-[(1S,2R,5S,10R,14S,15R)-14-[(1S)-1-(dimethylamino)ethyl]-2,15-dimethyl-6-oxotetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]Heptadeca-7,11-dien-5-yl]-2-methylbut-2-enimidic acid belongs to the class of organic compounds known as oxosteroids. These are steroid derivatives carrying a C=O group attached to steroid skeleton. (2z)-n-[(1s,3br,7s,9ar,9bs,11ar)-1-[(1s)-1-(dimethylamino)ethyl]-9a,11a-dimethyl-6-oxo-1h,2h,3bh,4h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-yl]-2-methylbut-2-enimidic acid is found in Sarcococca saligna. Based on a literature review very few articles have been published on (2Z)-N-[(1S,2R,5S,10R,14S,15R)-14-[(1S)-1-(dimethylamino)ethyl]-2,15-dimethyl-6-oxotetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]Heptadeca-7,11-dien-5-yl]-2-methylbut-2-enimidic acid.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309082209202D          

 32 35  0  0  1  0            999 V2000
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M  END

     RDKit          3D

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M  END


  Mrv1652309082209202D          

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 21 22  1  6  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 20 26  1  0  0  0  0
 17 26  1  0  0  0  0
 26 27  1  6  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 30 29  1  6  0  0  0
 16 30  1  0  0  0  0
 11 30  1  0  0  0  0
 13 31  1  0  0  0  0
  8 31  1  0  0  0  0
 31 32  2  0  0  0  0
M  END
> <DATABASE_ID>
NP0263979

> <DATABASE_NAME>
NP-MRD

> <SMILES>
C\C=C(\C)C(O)=N[C@H]1CC[C@]2(C)[C@H]3CC[C@]4(C)[C@H](CC=C4[C@@H]3CC=C2C1=O)[C@H](C)N(C)C

> <INCHI_IDENTIFIER>
InChI=1S/C28H42N2O2/c1-8-17(2)26(32)29-24-14-16-28(5)22-13-15-27(4)20(18(3)30(6)7)11-12-21(27)19(22)9-10-23(28)25(24)31/h8,10,12,18-20,22,24H,9,11,13-16H2,1-7H3,(H,29,32)/b17-8-/t18-,19-,20+,22-,24-,27+,28+/m0/s1

> <INCHI_KEY>
GCHGDPVSONOHQE-GETOESACSA-N

> <FORMULA>
C28H42N2O2

> <MOLECULAR_WEIGHT>
438.656

> <EXACT_MASS>
438.3246286

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_ATOM_COUNT>
74

> <JCHEM_AVERAGE_POLARIZABILITY>
52.988531837827466

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(2Z)-N-[(1S,2R,5S,10R,14S,15R)-14-[(1S)-1-(dimethylamino)ethyl]-2,15-dimethyl-6-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-7,11-dien-5-yl]-2-methylbut-2-enimidic acid

> <JCHEM_LOGP>
2.9603257799788625

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
1

> <JCHEM_PKA_STRONGEST_ACIDIC>
6.456976812010375

> <JCHEM_PKA_STRONGEST_BASIC>
9.708930537089408

> <JCHEM_POLAR_SURFACE_AREA>
52.900000000000006

> <JCHEM_REFRACTIVITY>
134.17879999999997

> <JCHEM_ROTATABLE_BOND_COUNT>
4

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
(2Z)-N-[(1S,2R,5S,10R,14S,15R)-14-[(1S)-1-(dimethylamino)ethyl]-2,15-dimethyl-6-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-7,11-dien-5-yl]-2-methylbut-2-enimidic acid

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 08-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   08-SEP-22         0                                  
HETATM    1  C   UNK     0       0.733   3.347   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -0.260   2.170   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       0.264   0.722   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      -0.729  -0.456   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       1.780   0.451   0.000  0.00  0.00           C+0
HETATM    6  O   UNK     0       2.772   1.628   0.000  0.00  0.00           O+0
HETATM    7  N   UNK     0       2.303  -0.998   0.000  0.00  0.00           N+0
HETATM    8  C   UNK     0       3.819  -1.269   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       4.342  -2.717   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       5.858  -2.988   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       6.851  -1.811   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       7.374  -3.259   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       6.327  -0.363   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       7.320   0.815   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       8.836   0.544   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       9.359  -0.905   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      10.875  -1.176   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      12.091  -0.231   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0      13.366  -1.095   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0      12.938  -2.574   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0      13.883  -3.790   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0      15.408  -3.579   0.000  0.00  0.00           C+0
HETATM   23  N   UNK     0      13.303  -5.217   0.000  0.00  0.00           N+0
HETATM   24  C   UNK     0      14.248  -6.432   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0      11.777  -5.427   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0      11.399  -2.624   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0      12.070  -4.010   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0      10.406  -3.802   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0       8.890  -3.531   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0       8.367  -2.082   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0       4.811  -0.092   0.000  0.00  0.00           C+0
HETATM   32  O   UNK     0       4.288   1.357   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4    5                                                  
CONECT    4    3                                                            
CONECT    5    3    6    7                                                  
CONECT    6    5                                                            
CONECT    7    5    8                                                       
CONECT    8    7    9   31                                                  
CONECT    9    8   10                                                       
CONECT   10    9   11                                                       
CONECT   11   10   12   13   30                                             
CONECT   12   11                                                            
CONECT   13   11   14   31                                                  
CONECT   14   13   15                                                       
CONECT   15   14   16                                                       
CONECT   16   15   17   30                                                  
CONECT   17   16   18   26                                                  
CONECT   18   17   19                                                       
CONECT   19   18   20                                                       
CONECT   20   19   21   26                                                  
CONECT   21   20   22   23                                                  
CONECT   22   21                                                            
CONECT   23   21   24   25                                                  
CONECT   24   23                                                            
CONECT   25   23                                                            
CONECT   26   20   17   27   28                                             
CONECT   27   26                                                            
CONECT   28   26   29                                                       
CONECT   29   28   30                                                       
CONECT   30   29   16   11                                                  
CONECT   31   13    8   32                                                  
CONECT   32   31                                                            
MASTER        0    0    0    0    0    0    0    0   32    0   70    0
END

View in JSmol

Synonyms

Value	Source
(2Z)-N-[(1S,2R,5S,10R,14S,15R)-14-[(1S)-1-(Dimethylamino)ethyl]-2,15-dimethyl-6-oxotetracyclo[8.7.0.0,.0,]heptadeca-7,11-dien-5-yl]-2-methylbut-2-enimidate	Generator

Chemical Formula

C₂₈H₄₂N₂O₂

Average Mass

438.6560 Da

Monoisotopic Mass

438.32463 Da

IUPAC Name

(2Z)-N-[(1S,2R,5S,10R,14S,15R)-14-[(1S)-1-(dimethylamino)ethyl]-2,15-dimethyl-6-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-7,11-dien-5-yl]-2-methylbut-2-enimidic acid

Traditional Name

(2Z)-N-[(1S,2R,5S,10R,14S,15R)-14-[(1S)-1-(dimethylamino)ethyl]-2,15-dimethyl-6-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-7,11-dien-5-yl]-2-methylbut-2-enimidic acid

CAS Registry Number

Not Available

SMILES

C\C=C(\C)C(O)=N[C@H]1CC[C@]2(C)[C@H]3CC[C@]4(C)[C@H](CC=C4[C@@H]3CC=C2C1=O)[C@H](C)N(C)C

InChI Identifier

InChI=1S/C28H42N2O2/c1-8-17(2)26(32)29-24-14-16-28(5)22-13-15-27(4)20(18(3)30(6)7)11-12-21(27)19(22)9-10-23(28)25(24)31/h8,10,12,18-20,22,24H,9,11,13-16H2,1-7H3,(H,29,32)/b17-8-/t18-,19-,20+,22-,24-,27+,28+/m0/s1

InChI Key

GCHGDPVSONOHQE-GETOESACSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Sarcococca saligna	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as oxosteroids. These are steroid derivatives carrying a C=O group attached to steroid skeleton.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Steroids and steroid derivatives

Sub Class

Oxosteroids

Direct Parent

Oxosteroids

Alternative Parents

Substituents

22-azasteroid
4-oxosteroid
Oxosteroid
Azasteroid
Delta-5-steroid
N-acyl-amine
Amino acid or derivatives
Carboxamide group
Tertiary aliphatic amine
Tertiary amine
Secondary carboxylic acid amide
Ketone
Carboxylic acid derivative
Amine
Organonitrogen compound
Organooxygen compound
Hydrocarbon derivative
Carbonyl group
Organic oxide
Organic oxygen compound
Organic nitrogen compound
Aliphatic homopolycyclic compound

Molecular Framework

Aliphatic homopolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	2.96	ChemAxon
pKa (Strongest Acidic)	6.46	ChemAxon
pKa (Strongest Basic)	9.71	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	52.9 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	134.18 m³·mol⁻¹	ChemAxon
Polarizability	52.99 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

8893224

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

10717885

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for (2z)-n-[(1s,3br,7s,9ar,9bs,11ar)-1-[(1s)-1-(dimethylamino)ethyl]-9a,11a-dimethyl-6-oxo-1h,2h,3bh,4h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-yl]-2-methylbut-2-enimidic acid (NP0263979)

MOL for NP0263979 ((2z)-n-[(1s,3br,7s,9ar,9bs,11ar)-1-[(1s)-1-(dimethylamino)ethyl]-9a,11a-dimethyl-6-oxo-1h,2h,3bh,4h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-yl]-2-methylbut-2-enimidic acid)

3D MOL for NP0263979 ((2z)-n-[(1s,3br,7s,9ar,9bs,11ar)-1-[(1s)-1-(dimethylamino)ethyl]-9a,11a-dimethyl-6-oxo-1h,2h,3bh,4h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-yl]-2-methylbut-2-enimidic acid)

3D SDF for NP0263979 ((2z)-n-[(1s,3br,7s,9ar,9bs,11ar)-1-[(1s)-1-(dimethylamino)ethyl]-9a,11a-dimethyl-6-oxo-1h,2h,3bh,4h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-yl]-2-methylbut-2-enimidic acid)

3D-SDF for NP0263979 ((2z)-n-[(1s,3br,7s,9ar,9bs,11ar)-1-[(1s)-1-(dimethylamino)ethyl]-9a,11a-dimethyl-6-oxo-1h,2h,3bh,4h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-yl]-2-methylbut-2-enimidic acid)

PDB for NP0263979 ((2z)-n-[(1s,3br,7s,9ar,9bs,11ar)-1-[(1s)-1-(dimethylamino)ethyl]-9a,11a-dimethyl-6-oxo-1h,2h,3bh,4h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-yl]-2-methylbut-2-enimidic acid)

3D PDB for NP0263979 ((2z)-n-[(1s,3br,7s,9ar,9bs,11ar)-1-[(1s)-1-(dimethylamino)ethyl]-9a,11a-dimethyl-6-oxo-1h,2h,3bh,4h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-yl]-2-methylbut-2-enimidic acid)

SMILES for NP0263979 ((2z)-n-[(1s,3br,7s,9ar,9bs,11ar)-1-[(1s)-1-(dimethylamino)ethyl]-9a,11a-dimethyl-6-oxo-1h,2h,3bh,4h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-yl]-2-methylbut-2-enimidic acid)

INCHI for NP0263979 ((2z)-n-[(1s,3br,7s,9ar,9bs,11ar)-1-[(1s)-1-(dimethylamino)ethyl]-9a,11a-dimethyl-6-oxo-1h,2h,3bh,4h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-yl]-2-methylbut-2-enimidic acid)

Structure for NP0263979 ((2z)-n-[(1s,3br,7s,9ar,9bs,11ar)-1-[(1s)-1-(dimethylamino)ethyl]-9a,11a-dimethyl-6-oxo-1h,2h,3bh,4h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-yl]-2-methylbut-2-enimidic acid)

3D Structure for NP0263979 ((2z)-n-[(1s,3br,7s,9ar,9bs,11ar)-1-[(1s)-1-(dimethylamino)ethyl]-9a,11a-dimethyl-6-oxo-1h,2h,3bh,4h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-yl]-2-methylbut-2-enimidic acid)