NP-MRD: Showing NP-Card for 2-{3a,6,10-trimethyl-1h,2h,3h,4h,7h,8h,11h,12h,12ah-cyclopenta[11]annulen-1-yl}propan-2-ol (NP0263353)

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Record Information

Version

2.0

Created at

2022-09-08 06:30:56 UTC

Updated at

2022-09-08 06:30:57 UTC

NP-MRD ID

NP0263353

Secondary Accession Numbers

None

Natural Product Identification

Common Name

2-{3a,6,10-trimethyl-1h,2h,3h,4h,7h,8h,11h,12h,12ah-cyclopenta[11]annulen-1-yl}propan-2-ol

Description

2-{3A,6,10-trimethyl-1H,2H,3H,3aH,4H,7H,8H,11H,12H,12aH-cyclopenta[11]annulen-1-yl}propan-2-ol belongs to the class of organic compounds known as dolabellane and neodolabellane diterpenoids. These are diterpenoids with a structure based on the dolabellane skeleton (3a,6,10-trimethyl-1-(propan-2-yl)-cyclopenta[11]annulene) or the neodolabellane skeleton. 2-{3a,6,10-trimethyl-1h,2h,3h,4h,7h,8h,11h,12h,12ah-cyclopenta[11]annulen-1-yl}propan-2-ol is found in Aglaia odorata, Dictyota dichotoma, Dictyota spiralis and Plagiomnium acutum. 2-{3A,6,10-trimethyl-1H,2H,3H,3aH,4H,7H,8H,11H,12H,12aH-cyclopenta[11]annulen-1-yl}propan-2-ol is an extremely weak basic (essentially neutral) compound (based on its pKa).

Structure

MOL SDF PDB SMILES InChI


  Mrv1533004171511272D          

 21 22  0  0  0  0            999 V2000
    2.9126   -1.2248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5001   -0.5103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6751   -0.5103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1902    0.2512    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4056    0.5062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4056   -0.3188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3791    0.2512    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8640    0.9187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3791    1.5861    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4056    1.3312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1902    1.5861    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6751    2.3476    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5001    2.3476    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9126    1.6331    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5001    0.9187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9126    0.2042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9126    3.0621    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6340    2.3707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8889    3.1553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1506    2.6256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4186    2.1158    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  4  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  5 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  4  0  0  0
 15 16  1  0  0  0  0
  2 16  1  0  0  0  0
 13 17  1  0  0  0  0
  9 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0263353

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CC1=CCC2(C)CCC(C2CCC(C)=CCC1)C(C)(C)O

> <INCHI_IDENTIFIER>
InChI=1S/C20H34O/c1-15-7-6-8-16(2)11-13-20(5)14-12-17(19(3,4)21)18(20)10-9-15/h7,11,17-18,21H,6,8-10,12-14H2,1-5H3

> <INCHI_KEY>
OEBBSSBZPLXOHC-UHFFFAOYSA-N

> <FORMULA>
C20H34O

> <MOLECULAR_WEIGHT>
290.491

> <EXACT_MASS>
290.260965715

> <JCHEM_ACCEPTOR_COUNT>
1

> <JCHEM_ATOM_COUNT>
55

> <JCHEM_AVERAGE_POLARIZABILITY>
36.53770068258635

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
2-{3a,6,10-trimethyl-1H,2H,3H,3aH,4H,7H,8H,11H,12H,12aH-cyclopenta[11]annulen-1-yl}propan-2-ol

> <ALOGPS_LOGP>
5.85

> <JCHEM_LOGP>
5.133508522666667

> <ALOGPS_LOGS>
-4.70

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
2

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_ACIDIC>
19.47748449613722

> <JCHEM_PKA_STRONGEST_BASIC>
-0.8403482813895805

> <JCHEM_POLAR_SURFACE_AREA>
20.23

> <JCHEM_REFRACTIVITY>
93.2366

> <JCHEM_ROTATABLE_BOND_COUNT>
1

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
5.81e-03 g/l

> <JCHEM_TRADITIONAL_IUPAC>
2-{3a,6,10-trimethyl-1H,2H,3H,4H,7H,8H,11H,12H,12aH-cyclopenta[11]annulen-1-yl}propan-2-ol

> <JCHEM_VEBER_RULE>
1

$$$$

HEADER    PROTEIN                                 17-APR-15   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   17-APR-15         0                                  
HETATM    1  C   UNK     0       5.437  -2.286   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       4.667  -0.953   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       3.127  -0.953   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       2.222   0.469   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       0.757   0.945   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       0.757  -0.595   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      -0.708   0.469   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      -1.613   1.715   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      -0.708   2.961   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       0.757   2.485   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       2.222   2.961   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       3.127   4.382   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       4.667   4.382   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       5.437   3.048   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       4.667   1.715   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       5.437   0.381   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       5.437   5.716   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      -1.183   4.425   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0      -1.659   5.890   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       0.281   4.901   0.000  0.00  0.00           C+0
HETATM   21  O   UNK     0      -2.648   3.949   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3   16                                                  
CONECT    3    2    4                                                       
CONECT    4    3    5                                                       
CONECT    5    4    6    7   10                                             
CONECT    6    5                                                            
CONECT    7    5    8                                                       
CONECT    8    7    9                                                       
CONECT    9    8   10   18                                                  
CONECT   10    9    5   11                                                  
CONECT   11   10   12                                                       
CONECT   12   11   13                                                       
CONECT   13   12   14   17                                                  
CONECT   14   13   15                                                       
CONECT   15   14   16                                                       
CONECT   16   15    2                                                       
CONECT   17   13                                                            
CONECT   18    9   19   20   21                                             
CONECT   19   18                                                            
CONECT   20   18                                                            
CONECT   21   18                                                            
MASTER        0    0    0    0    0    0    0    0   21    0   44    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₀H₃₄O

Average Mass

290.4910 Da

Monoisotopic Mass

290.26097 Da

IUPAC Name

2-{3a,6,10-trimethyl-1H,2H,3H,3aH,4H,7H,8H,11H,12H,12aH-cyclopenta[11]annulen-1-yl}propan-2-ol

Traditional Name

2-{3a,6,10-trimethyl-1H,2H,3H,4H,7H,8H,11H,12H,12aH-cyclopenta[11]annulen-1-yl}propan-2-ol

CAS Registry Number

Not Available

SMILES

CC1=CCC2(C)CCC(C2CCC(C)=CCC1)C(C)(C)O

InChI Identifier

InChI=1S/C20H34O/c1-15-7-6-8-16(2)11-13-20(5)14-12-17(19(3,4)21)18(20)10-9-15/h7,11,17-18,21H,6,8-10,12-14H2,1-5H3

InChI Key

OEBBSSBZPLXOHC-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Not Available

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Aglaia odorata	LOTUS Database	35616633
Dictyota dichotoma	LOTUS Database	35616633
Dictyota spiralis	LOTUS Database	35616633
Plagiomnium acutum	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as dolabellane and neodolabellane diterpenoids. These are diterpenoids with a structure based on the dolabellane skeleton (3a,6,10-trimethyl-1-(propan-2-yl)-cyclopenta[11]annulene) or the neodolabellane skeleton.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Diterpenoids

Direct Parent

Dolabellane and neodolabellane diterpenoids

Alternative Parents

Substituents

Dolabellane diterpenoid
Tertiary alcohol
Organic oxygen compound
Hydrocarbon derivative
Organooxygen compound
Alcohol
Aliphatic homopolycyclic compound

Molecular Framework

Aliphatic homopolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	5.85	ALOGPS
logP	5.13	ChemAxon
logS	-4.7	ALOGPS
pKa (Strongest Acidic)	19.48	ChemAxon
pKa (Strongest Basic)	-0.84	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	1	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	20.23 Å²	ChemAxon
Rotatable Bond Count	1	ChemAxon
Refractivity	93.24 m³·mol⁻¹	ChemAxon
Polarizability	36.54 Å³	ChemAxon
Number of Rings	2	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

75604187

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for 2-{3a,6,10-trimethyl-1h,2h,3h,4h,7h,8h,11h,12h,12ah-cyclopenta[11]annulen-1-yl}propan-2-ol (NP0263353)

MOL for NP0263353 (2-{3a,6,10-trimethyl-1h,2h,3h,4h,7h,8h,11h,12h,12ah-cyclopenta[11]annulen-1-yl}propan-2-ol)

3D MOL for NP0263353 (2-{3a,6,10-trimethyl-1h,2h,3h,4h,7h,8h,11h,12h,12ah-cyclopenta[11]annulen-1-yl}propan-2-ol)

3D SDF for NP0263353 (2-{3a,6,10-trimethyl-1h,2h,3h,4h,7h,8h,11h,12h,12ah-cyclopenta[11]annulen-1-yl}propan-2-ol)

3D-SDF for NP0263353 (2-{3a,6,10-trimethyl-1h,2h,3h,4h,7h,8h,11h,12h,12ah-cyclopenta[11]annulen-1-yl}propan-2-ol)

PDB for NP0263353 (2-{3a,6,10-trimethyl-1h,2h,3h,4h,7h,8h,11h,12h,12ah-cyclopenta[11]annulen-1-yl}propan-2-ol)

3D PDB for NP0263353 (2-{3a,6,10-trimethyl-1h,2h,3h,4h,7h,8h,11h,12h,12ah-cyclopenta[11]annulen-1-yl}propan-2-ol)

SMILES for NP0263353 (2-{3a,6,10-trimethyl-1h,2h,3h,4h,7h,8h,11h,12h,12ah-cyclopenta[11]annulen-1-yl}propan-2-ol)

INCHI for NP0263353 (2-{3a,6,10-trimethyl-1h,2h,3h,4h,7h,8h,11h,12h,12ah-cyclopenta[11]annulen-1-yl}propan-2-ol)

Structure for NP0263353 (2-{3a,6,10-trimethyl-1h,2h,3h,4h,7h,8h,11h,12h,12ah-cyclopenta[11]annulen-1-yl}propan-2-ol)

3D Structure for NP0263353 (2-{3a,6,10-trimethyl-1h,2h,3h,4h,7h,8h,11h,12h,12ah-cyclopenta[11]annulen-1-yl}propan-2-ol)