NP-MRD: Showing NP-Card for (+)-11-isolupanine (NP0256624)

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Record Information

Version

2.0

Created at

2022-09-07 21:30:55 UTC

Updated at

2022-09-07 21:30:55 UTC

NP-MRD ID

NP0256624

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(+)-11-isolupanine

Description

Isolupanine, also known as alpha-isolupanine, belongs to the class of organic compounds known as sparteine, lupanine, and related alkaloids. These are alkaloids with a structure based on either sparteine, lupanine, or derivatives thereof. These are tetracyclic compounds made of two fused quinolizidine ring systems. (+)-11-isolupanine is found in Aspalathus perfoliata, Cytisophyllum sessilifolium, Leontice leontopetalum, Liparia hirsuta, Lupinus mexicanus, Pearsonia grandifolia, Petteria ramentacea and Robynsiophyton vanderystii. Based on a literature review very few articles have been published on Isolupanine.

Structure

MOL 3D MOL SDF PDB SMILES InChI

     RDKit          3D

 42 45  0  0  0  0  0  0  0  0999 V2000
   -2.6574    2.8570    0.0007 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7162    1.6379    0.2071 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9137    1.0678    0.8616 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9221   -0.4175    0.9568 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5510   -1.0585    0.8935 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8835   -0.5895   -0.3461 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.6872   -1.3511   -0.7946 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.2038   -0.6241   -2.0594 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4687    0.6314   -1.5270 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.3028    1.3258   -0.4543 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6136    0.8244   -0.1996 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7550    0.1010   -0.8702 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.6005    1.2802   -0.5494 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7741    0.9996    0.3317 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5750   -0.0953    1.3175 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6077   -1.1567    0.8742 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3915   -0.5890    0.3183 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3720   -1.5583    0.2040 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7952    1.4159    0.2519 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0436    1.5777    1.8505 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4843   -0.8091    0.0587 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5070   -0.7709    1.8326 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0144   -0.7778    1.8231 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7146   -2.1539    0.9367 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6396   -0.6619   -1.1799 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0391   -2.3513   -1.1689 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0844   -0.3881   -2.6712 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.5356   -1.2757   -2.5412 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.7376    1.3022   -2.3678 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3376    2.4263   -0.7064 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.2285    1.3207    0.5447 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.3073   -0.5498   -1.5823 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9652    2.1024   -0.1719 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.0096    1.6663   -1.5301 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.9665    1.9449    0.9218 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.6991    0.8628   -0.2746 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2928    0.2493    2.3251 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.5700   -0.6108    1.4481 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4152   -1.8283    1.7215 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.1007   -1.7436    0.0618 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1164   -1.6671    1.2169 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.8549   -2.5657    0.0364 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
  9 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 11  2  1  0
 17 12  1  0
 11  6  1  0
 18  7  1  0
  3 19  1  0
  3 20  1  0
  4 21  1  0
  4 22  1  0
  5 23  1  0
  5 24  1  0
  6 25  1  6
  7 26  1  6
  8 27  1  0
  8 28  1  0
  9 29  1  6
 10 30  1  0
 10 31  1  0
 12 32  1  6
 13 33  1  0
 13 34  1  0
 14 35  1  0
 14 36  1  0
 15 37  1  0
 15 38  1  0
 16 39  1  0
 16 40  1  0
 18 41  1  0
 18 42  1  0
M  END


  Mrv1652309072223302D          

 18 21  0  0  1  0            999 V2000
    6.1269   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1269   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8413    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8413    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1269    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4124    0.8250    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.8290    1.4084    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.6655    0.3094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0040   -0.5834    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.8290   -0.5834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4124   -0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4207   -0.0000    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.7062   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9917    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9917    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7062    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4207    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0040    1.4084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  6  0  0  0
  9  8  1  6  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  2 11  1  0  0  0  0
  6 11  1  1  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  1  0  0  0
 17 18  1  0  0  0  0
  7 18  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0256624

> <DATABASE_NAME>
NP-MRD

> <SMILES>
O=C1CCC[C@@H]2[C@H]3C[C@@H](CN12)[C@H]1CCCCN1C3

> <INCHI_IDENTIFIER>
InChI=1S/C15H24N2O/c18-15-6-3-5-14-11-8-12(10-17(14)15)13-4-1-2-7-16(13)9-11/h11-14H,1-10H2/t11-,12-,13+,14+/m0/s1

> <INCHI_KEY>
JYIJIIVLEOETIQ-IGQOVBAYSA-N

> <FORMULA>
C15H24N2O

> <MOLECULAR_WEIGHT>
248.37

> <EXACT_MASS>
248.188863401

> <JCHEM_ACCEPTOR_COUNT>
2

> <JCHEM_ATOM_COUNT>
42

> <JCHEM_AVERAGE_POLARIZABILITY>
28.00603070481256

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
0

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(1S,2R,9S,10R)-7,15-diazatetracyclo[7.7.1.0^{2,7}.0^{10,15}]heptadecan-6-one

> <JCHEM_LOGP>
1.0759273119999997

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
1

> <JCHEM_PKA_STRONGEST_BASIC>
9.75154362875031

> <JCHEM_POLAR_SURFACE_AREA>
23.550000000000004

> <JCHEM_REFRACTIVITY>
71.4485

> <JCHEM_ROTATABLE_BOND_COUNT>
0

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
(1S,2R,9S,10R)-7,15-diazatetracyclo[7.7.1.0^{2,7}.0^{10,15}]heptadecan-6-one

> <JCHEM_VEBER_RULE>
1

$$$$

HEADER    PROTEIN                                 07-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   07-SEP-22         0                                  
HETATM    1  O   UNK     0      11.437  -2.310   0.000  0.00  0.00           O+0
HETATM    2  C   UNK     0      11.437  -0.770   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      12.770   0.000   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      12.770   1.540   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      11.437   2.310   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      10.103   1.540   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       9.014   2.629   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       8.709   0.577   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       7.474  -1.089   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       9.014  -1.089   0.000  0.00  0.00           C+0
HETATM   11  N   UNK     0      10.103  -0.000   0.000  0.00  0.00           N+0
HETATM   12  C   UNK     0       6.385  -0.000   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       5.052  -0.770   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       3.718   0.000   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       3.718   1.540   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       5.052   2.310   0.000  0.00  0.00           C+0
HETATM   17  N   UNK     0       6.385   1.540   0.000  0.00  0.00           N+0
HETATM   18  C   UNK     0       7.474   2.629   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3   11                                                  
CONECT    3    2    4                                                       
CONECT    4    3    5                                                       
CONECT    5    4    6                                                       
CONECT    6    5    7   11                                                  
CONECT    7    6    8   18                                                  
CONECT    8    7    9                                                       
CONECT    9    8   10   12                                                  
CONECT   10    9   11                                                       
CONECT   11   10    2    6                                                  
CONECT   12    9   13   17                                                  
CONECT   13   12   14                                                       
CONECT   14   13   15                                                       
CONECT   15   14   16                                                       
CONECT   16   15   17                                                       
CONECT   17   16   12   18                                                  
CONECT   18   17    7                                                       
MASTER        0    0    0    0    0    0    0    0   18    0   42    0
END

View in JSmol

Synonyms

Value	Source
alpha-Isolupanine	MeSH
Lupanine	MeSH
Lupanine sulfate (1:1), (7S-(7alpha,7abeta,14alpha,14aalpha))-isomer	MeSH
Lupanine, (7S-(7alpha,7aalpha,14alpha,14aalpha))-isomer	MeSH
Lupanine monohydrochloride, (7S-(7alpha,7aalpha,14alpha,14aalpha))-isomer	MeSH
Lupanine monohydrochloride, (7S-(7alpha,7abeta,14alpha,14aalpha))-isomer	MeSH
Lupanine monoperchlorate, (7S-(7alpha,7abeta,14alpha,14aalpha))-isomer	MeSH
Lupanine, (7R-(7alpha,7abeta,14alpha,14aalpha))-isomer	MeSH
Lupanine, (7S-(7alpha,7aalpha,14alpha,14abeta))-isomer	MeSH
Lupanine monohydrobromide, (7S-(7alpha,7abeta,14alpha,14aalpha))-isomer	MeSH

Chemical Formula

C₁₅H₂₄N₂O

Average Mass

248.3700 Da

Monoisotopic Mass

248.18886 Da

IUPAC Name

(1S,2R,9S,10R)-7,15-diazatetracyclo[7.7.1.0^{2,7}.0^{10,15}]heptadecan-6-one

Traditional Name

(1S,2R,9S,10R)-7,15-diazatetracyclo[7.7.1.0^{2,7}.0^{10,15}]heptadecan-6-one

CAS Registry Number

Not Available

SMILES

O=C1CCC[C@@H]2[C@H]3C[C@@H](CN12)[C@H]1CCCCN1C3

InChI Identifier

InChI=1S/C15H24N2O/c18-15-6-3-5-14-11-8-12(10-17(14)15)13-4-1-2-7-16(13)9-11/h11-14H,1-10H2/t11-,12-,13+,14+/m0/s1

InChI Key

JYIJIIVLEOETIQ-IGQOVBAYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Aspalathus perfoliata	LOTUS Database	35616633
Cytisophyllum sessilifolium	LOTUS Database	35616633
Leontice leontopetalum	LOTUS Database	35616633
Liparia hirsuta	LOTUS Database	35616633
Lupinus mexicanus	LOTUS Database	35616633
Pearsonia grandifolia	LOTUS Database	35616633
Petteria ramentacea	LOTUS Database	35616633
Robynsiophyton vanderystii	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as sparteine, lupanine, and related alkaloids. These are alkaloids with a structure based on either sparteine, lupanine, or derivatives thereof. These are tetracyclic compounds made of two fused quinolizidine ring systems.

Kingdom

Organic compounds

Super Class

Alkaloids and derivatives

Class

Lupin alkaloids

Sub Class

Sparteine, lupanine, and related alkaloids

Direct Parent

Sparteine, lupanine, and related alkaloids

Alternative Parents

Substituents

Sparteine-lupanine skeleton
Quinolizidinone
Quinolizidine
Delta-lactam
Piperidinone
Piperidine
Tertiary carboxylic acid amide
Tertiary aliphatic amine
Tertiary amine
Amino acid or derivatives
Carboxamide group
Lactam
Organoheterocyclic compound
Azacycle
Carboxylic acid derivative
Hydrocarbon derivative
Organonitrogen compound
Organooxygen compound
Amine
Organic nitrogen compound
Carbonyl group
Organic oxygen compound
Organic oxide
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	1.08	ChemAxon
pKa (Strongest Basic)	9.75	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	2	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	23.55 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	71.45 m³·mol⁻¹	ChemAxon
Polarizability	28.01 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

C00007694

Chemspider ID

10194147

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

15939852

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for (+)-11-isolupanine (NP0256624)

MOL for NP0256624 ((+)-11-isolupanine)

3D MOL for NP0256624 ((+)-11-isolupanine)

3D SDF for NP0256624 ((+)-11-isolupanine)

3D-SDF for NP0256624 ((+)-11-isolupanine)

PDB for NP0256624 ((+)-11-isolupanine)

3D PDB for NP0256624 ((+)-11-isolupanine)

SMILES for NP0256624 ((+)-11-isolupanine)

INCHI for NP0256624 ((+)-11-isolupanine)

Structure for NP0256624 ((+)-11-isolupanine)

3D Structure for NP0256624 ((+)-11-isolupanine)