NP-MRD: Showing NP-Card for (1s,12s)-23,23-dimethyl-5,7,17-trioxa-23-azahexacyclo[10.10.1.0²,¹⁰.0⁴,⁸.0¹³,²¹.0¹⁵,¹⁹]tricosa-2,4(8),9,13,15(19),20-hexaen-23-ium (NP0256162)

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Record Information

Version

2.0

Created at

2022-09-07 20:53:48 UTC

Updated at

2022-09-07 20:53:48 UTC

NP-MRD ID

NP0256162

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(1s,12s)-23,23-dimethyl-5,7,17-trioxa-23-azahexacyclo[10.10.1.0²,¹⁰.0⁴,⁸.0¹³,²¹.0¹⁵,¹⁹]tricosa-2,4(8),9,13,15(19),20-hexaen-23-ium

Description

Carlifornidine belongs to the class of organic compounds known as pavine alkaloids. These are alkaloids with a structure based on the pavine skeleton. (1s,12s)-23,23-dimethyl-5,7,17-trioxa-23-azahexacyclo[10.10.1.0²,¹⁰.0⁴,⁸.0¹³,²¹.0¹⁵,¹⁹]tricosa-2,4(8),9,13,15(19),20-hexaen-23-ium is found in Eschscholzia californica. Based on a literature review very few articles have been published on Carlifornidine.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309072222532D          

 25 30  0  0  1  0            999 V2000
    2.5685    1.7321    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1213    2.4254    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.9278    2.5995    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4599    1.5327    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.2849    1.5327    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8682    2.1161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5827    1.7036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2972    2.1161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2972    2.9411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5827    3.3536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8682    2.9411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2849    3.5244    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.4599    3.5244    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8765    2.9411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1620    3.3536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5524    2.9411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5524    2.1161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1620    1.7036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8765    2.1161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3371    1.8611    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8220    2.5286    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3371    3.1960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0818    3.1960    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5667    2.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0818    1.8611    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  1  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
  6 11  1  0  0  0  0
 12 11  1  1  0  0  0
  2 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 14 19  1  0  0  0  0
  4 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 16 22  1  0  0  0  0
  9 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
  8 25  1  0  0  0  0
M  CHG  1   2   1
M  END

     RDKit          3D

 47 52  0  0  0  0  0  0  0  0999 V2000
   -1.1677   -2.1390   -1.0829 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1655   -1.4264   -0.3212 N   0  0  0  0  0  4  0  0  0  0  0  0
    0.8003   -2.4020    0.1155 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4209   -0.4232   -1.1893 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.5257    0.6808   -1.4792 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8360    0.5664   -0.8385 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9159    1.1943   -1.4183 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1454    1.0718   -0.7982 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3084    0.3381    0.3808 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2150   -0.2889    0.9546 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0171   -0.1560    0.3300 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7418   -0.7828    0.8444 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.0730    0.3425    1.3983 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4497    0.4459    0.8618 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5029    0.9070    1.6372 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7573    0.9863    1.0782 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9106    0.6024   -0.2317 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8697    0.1388   -1.0221 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6377    0.0654   -0.4585 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3427    0.7934   -0.5647 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8272    1.6435    0.4235 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0980    1.4098    1.5592 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6320    0.3834    0.7774 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3769    0.7978   -0.3577 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4265    1.5540   -1.0846 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0318   -2.4463   -0.4667 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7168   -3.0720   -1.4763 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5212   -1.5860   -1.9759 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.2285   -3.3394    0.3507 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.3429   -2.1353    1.0202 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.5211   -2.6657   -0.6621 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.7620   -0.9286   -2.1104 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0663    1.6450   -1.1534 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6405    0.7800   -2.5875 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8483    1.7733   -2.3274 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2723   -0.8705    1.8640 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9774   -1.5421    1.6199 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962    0.3057    2.5302 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3855    1.3601    1.2067 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.3365    1.1977    2.6612 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.0062   -0.1615   -2.0574 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.3882    1.3493   -1.5253 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.9035   -0.1355   -0.6586 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.5381    0.5036    2.0645 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.0674    2.2450    2.2596 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7329   -0.0271   -0.9744 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.2136    1.4473    0.0031 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 23  1  0
 23 24  1  0
 24 25  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 20  1  0
 20 21  1  0
 21 22  1  0
 17 18  1  0
 18 19  2  0
 12  2  1  0
 19 14  1  0
 19  4  1  0
 11  6  1  0
 22 16  1  0
 25  8  1  0
  1 26  1  0
  1 27  1  0
  1 28  1  0
  3 29  1  0
  3 30  1  0
  3 31  1  0
  4 32  1  6
  5 33  1  0
  5 34  1  0
  7 35  1  0
 24 46  1  0
 24 47  1  0
 10 36  1  0
 12 37  1  1
 13 38  1  0
 13 39  1  0
 15 40  1  0
 20 42  1  0
 20 43  1  0
 22 44  1  0
 22 45  1  0
 18 41  1  0
M  CHG  1   2   1
M  END


  Mrv1652309072222532D          

 25 30  0  0  1  0            999 V2000
    2.5685    1.7321    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1213    2.4254    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.9278    2.5995    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4599    1.5327    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.2849    1.5327    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8682    2.1161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5827    1.7036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2972    2.1161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2972    2.9411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5827    3.3536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8682    2.9411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2849    3.5244    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.4599    3.5244    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8765    2.9411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1620    3.3536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5524    2.9411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5524    2.1161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1620    1.7036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8765    2.1161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3371    1.8611    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8220    2.5286    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3371    3.1960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0818    3.1960    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5667    2.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0818    1.8611    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  1  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
  6 11  1  0  0  0  0
 12 11  1  1  0  0  0
  2 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 14 19  1  0  0  0  0
  4 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 16 22  1  0  0  0  0
  9 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
  8 25  1  0  0  0  0
M  CHG  1   2   1
M  END
> <DATABASE_ID>
NP0256162

> <DATABASE_NAME>
NP-MRD

> <SMILES>
C[N+]1(C)[C@H]2CC3=CC4=C(OCO4)C=C3[C@@H]1CC1=CC3=C(COC3)C=C21

> <INCHI_IDENTIFIER>
InChI=1S/C21H22NO3/c1-22(2)18-6-13-7-20-21(25-11-24-20)8-17(13)19(22)5-12-3-14-9-23-10-15(14)4-16(12)18/h3-4,7-8,18-19H,5-6,9-11H2,1-2H3/q+1/t18-,19-/m0/s1

> <INCHI_KEY>
UKXXQEQKOSUQKT-OALUTQOASA-N

> <FORMULA>
C21H22NO3

> <MOLECULAR_WEIGHT>
336.41

> <EXACT_MASS>
336.159419993

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_ATOM_COUNT>
47

> <JCHEM_AVERAGE_POLARIZABILITY>
37.13375168820876

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
0

> <JCHEM_FORMAL_CHARGE>
1

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(1S,12S)-23,23-dimethyl-5,7,17-trioxa-23-azahexacyclo[10.10.1.0^{2,10}.0^{4,8}.0^{13,21}.0^{15,19}]tricosa-2,4(8),9,13,15(19),20-hexaen-23-ium

> <JCHEM_LOGP>
-1.073672258138412

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
6

> <JCHEM_PHYSIOLOGICAL_CHARGE>
1

> <JCHEM_PKA_STRONGEST_ACIDIC>
19.345965246825344

> <JCHEM_PKA_STRONGEST_BASIC>
-4.079522879443018

> <JCHEM_POLAR_SURFACE_AREA>
27.69

> <JCHEM_REFRACTIVITY>
106.9751

> <JCHEM_ROTATABLE_BOND_COUNT>
0

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
(1S,12S)-23,23-dimethyl-5,7,17-trioxa-23-azahexacyclo[10.10.1.0^{2,10}.0^{4,8}.0^{13,21}.0^{15,19}]tricosa-2,4(8),9,13,15(19),20-hexaen-23-ium

> <JCHEM_VEBER_RULE>
1

$$$$

HEADER    PROTEIN                                 07-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   07-SEP-22         0                                  
HETATM    1  C   UNK     0       4.795   3.233   0.000  0.00  0.00           C+0
HETATM    2  N   UNK     0       3.960   4.527   0.000  0.00  0.00           N+1
HETATM    3  C   UNK     0       5.465   4.852   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       2.725   2.861   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       4.265   2.861   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       5.354   3.950   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       6.688   3.180   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       8.021   3.950   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       8.021   5.490   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       6.688   6.260   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       5.354   5.490   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       4.265   6.579   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       2.725   6.579   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       1.636   5.490   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       0.302   6.260   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      -1.031   5.490   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      -1.031   3.950   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       0.302   3.180   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       1.636   3.950   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0      -2.496   3.474   0.000  0.00  0.00           C+0
HETATM   21  O   UNK     0      -3.401   4.720   0.000  0.00  0.00           O+0
HETATM   22  C   UNK     0      -2.496   5.966   0.000  0.00  0.00           C+0
HETATM   23  O   UNK     0       9.486   5.966   0.000  0.00  0.00           O+0
HETATM   24  C   UNK     0      10.391   4.720   0.000  0.00  0.00           C+0
HETATM   25  O   UNK     0       9.486   3.474   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3    4   12                                             
CONECT    3    2                                                            
CONECT    4    2    5   19                                                  
CONECT    5    4    6                                                       
CONECT    6    5    7   11                                                  
CONECT    7    6    8                                                       
CONECT    8    7    9   25                                                  
CONECT    9    8   10   23                                                  
CONECT   10    9   11                                                       
CONECT   11   10    6   12                                                  
CONECT   12   11    2   13                                                  
CONECT   13   12   14                                                       
CONECT   14   13   15   19                                                  
CONECT   15   14   16                                                       
CONECT   16   15   17   22                                                  
CONECT   17   16   18   20                                                  
CONECT   18   17   19                                                       
CONECT   19   18   14    4                                                  
CONECT   20   17   21                                                       
CONECT   21   20   22                                                       
CONECT   22   21   16                                                       
CONECT   23    9   24                                                       
CONECT   24   23   25                                                       
CONECT   25   24    8                                                       
MASTER        0    0    0    0    0    0    0    0   25    0   60    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₁H₂₂NO₃

Average Mass

336.4100 Da

Monoisotopic Mass

336.15942 Da

IUPAC Name

(1S,12S)-23,23-dimethyl-5,7,17-trioxa-23-azahexacyclo[10.10.1.0^{2,10}.0^{4,8}.0^{13,21}.0^{15,19}]tricosa-2,4(8),9,13,15(19),20-hexaen-23-ium

Traditional Name

(1S,12S)-23,23-dimethyl-5,7,17-trioxa-23-azahexacyclo[10.10.1.0^{2,10}.0^{4,8}.0^{13,21}.0^{15,19}]tricosa-2,4(8),9,13,15(19),20-hexaen-23-ium

CAS Registry Number

Not Available

SMILES

C[N+]1(C)[C@H]2CC3=CC4=C(OCO4)C=C3[C@@H]1CC1=CC3=C(COC3)C=C21

InChI Identifier

InChI=1S/C21H22NO3/c1-22(2)18-6-13-7-20-21(25-11-24-20)8-17(13)19(22)5-12-3-14-9-23-10-15(14)4-16(12)18/h3-4,7-8,18-19H,5-6,9-11H2,1-2H3/q+1/t18-,19-/m0/s1

InChI Key

UKXXQEQKOSUQKT-OALUTQOASA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Eschscholzia californica	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as pavine alkaloids. These are alkaloids with a structure based on the pavine skeleton.

Kingdom

Organic compounds

Super Class

Alkaloids and derivatives

Class

Pavine alkaloids

Sub Class

Not Available

Direct Parent

Pavine alkaloids

Alternative Parents

Substituents

Pavine skeleton
Tetrahydroisoquinoline
Benzodioxole
Isocoumaran
Aralkylamine
Benzenoid
Quaternary ammonium salt
Tetraalkylammonium salt
Acetal
Dialkyl ether
Ether
Oxacycle
Organoheterocyclic compound
Azacycle
Organic oxygen compound
Organooxygen compound
Organonitrogen compound
Organopnictogen compound
Hydrocarbon derivative
Organic nitrogen compound
Amine
Organic cation
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	-1.1	ChemAxon
pKa (Strongest Acidic)	19.35	ChemAxon
pKa (Strongest Basic)	-4.1	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	27.69 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	106.98 m³·mol⁻¹	ChemAxon
Polarizability	37.13 Å³	ChemAxon
Number of Rings	6	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

23106590

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

44575218

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for (1s,12s)-23,23-dimethyl-5,7,17-trioxa-23-azahexacyclo[10.10.1.0²,¹⁰.0⁴,⁸.0¹³,²¹.0¹⁵,¹⁹]tricosa-2,4(8),9,13,15(19),20-hexaen-23-ium (NP0256162)

MOL for NP0256162 ((1s,12s)-23,23-dimethyl-5,7,17-trioxa-23-azahexacyclo[10.10.1.0²,¹⁰.0⁴,⁸.0¹³,²¹.0¹⁵,¹⁹]tricosa-2,4(8),9,13,15(19),20-hexaen-23-ium)

3D MOL for NP0256162 ((1s,12s)-23,23-dimethyl-5,7,17-trioxa-23-azahexacyclo[10.10.1.0²,¹⁰.0⁴,⁸.0¹³,²¹.0¹⁵,¹⁹]tricosa-2,4(8),9,13,15(19),20-hexaen-23-ium)

3D SDF for NP0256162 ((1s,12s)-23,23-dimethyl-5,7,17-trioxa-23-azahexacyclo[10.10.1.0²,¹⁰.0⁴,⁸.0¹³,²¹.0¹⁵,¹⁹]tricosa-2,4(8),9,13,15(19),20-hexaen-23-ium)

3D-SDF for NP0256162 ((1s,12s)-23,23-dimethyl-5,7,17-trioxa-23-azahexacyclo[10.10.1.0²,¹⁰.0⁴,⁸.0¹³,²¹.0¹⁵,¹⁹]tricosa-2,4(8),9,13,15(19),20-hexaen-23-ium)

PDB for NP0256162 ((1s,12s)-23,23-dimethyl-5,7,17-trioxa-23-azahexacyclo[10.10.1.0²,¹⁰.0⁴,⁸.0¹³,²¹.0¹⁵,¹⁹]tricosa-2,4(8),9,13,15(19),20-hexaen-23-ium)

3D PDB for NP0256162 ((1s,12s)-23,23-dimethyl-5,7,17-trioxa-23-azahexacyclo[10.10.1.0²,¹⁰.0⁴,⁸.0¹³,²¹.0¹⁵,¹⁹]tricosa-2,4(8),9,13,15(19),20-hexaen-23-ium)

SMILES for NP0256162 ((1s,12s)-23,23-dimethyl-5,7,17-trioxa-23-azahexacyclo[10.10.1.0²,¹⁰.0⁴,⁸.0¹³,²¹.0¹⁵,¹⁹]tricosa-2,4(8),9,13,15(19),20-hexaen-23-ium)

INCHI for NP0256162 ((1s,12s)-23,23-dimethyl-5,7,17-trioxa-23-azahexacyclo[10.10.1.0²,¹⁰.0⁴,⁸.0¹³,²¹.0¹⁵,¹⁹]tricosa-2,4(8),9,13,15(19),20-hexaen-23-ium)

Structure for NP0256162 ((1s,12s)-23,23-dimethyl-5,7,17-trioxa-23-azahexacyclo[10.10.1.0²,¹⁰.0⁴,⁸.0¹³,²¹.0¹⁵,¹⁹]tricosa-2,4(8),9,13,15(19),20-hexaen-23-ium)

3D Structure for NP0256162 ((1s,12s)-23,23-dimethyl-5,7,17-trioxa-23-azahexacyclo[10.10.1.0²,¹⁰.0⁴,⁸.0¹³,²¹.0¹⁵,¹⁹]tricosa-2,4(8),9,13,15(19),20-hexaen-23-ium)