NP-MRD: Showing NP-Card for n-{5-[(1r,2r)-1,2-dihydroxypropyl]-2-methoxyphenyl}ethanimidic acid (NP0254624)

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Record Information

Version

2.0

Created at

2022-09-07 18:50:45 UTC

Updated at

2022-09-07 18:50:45 UTC

NP-MRD ID

NP0254624

Secondary Accession Numbers

None

Natural Product Identification

Common Name

n-{5-[(1r,2r)-1,2-dihydroxypropyl]-2-methoxyphenyl}ethanimidic acid

Description

(-)-Agaridiol belongs to the class of organic compounds known as acetanilides. These are organic compounds containing an acetamide group conjugated to a phenyl group. Based on a literature review very few articles have been published on (-)-Agaridiol.

Structure

MOL 3D MOL SDF PDB SMILES InChI

     RDKit          3D

 34 34  0  0  0  0  0  0  0  0999 V2000
   -3.2408    0.5909    2.6246 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5664    0.9346    1.4172 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2466    0.4905    1.2240 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6019   -0.2640    2.1736 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6866   -0.6869    1.9643 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3895   -0.3763    0.7987 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7571   -0.8559    0.6157 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.8527   -2.2435    0.9061 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3793   -0.6664   -0.7115 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.7781   -1.5370   -1.7950 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4250    0.6342   -1.1654 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7301    0.3755   -0.1347 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5902    0.8111    0.0757 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2329    1.5873   -0.9178 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3349    1.1825   -1.4294 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0609    1.9531   -2.4786 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9082   -0.0089   -1.0219 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3171   -0.5159    2.6932 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2620    1.0526    2.5584 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7278    0.9891    3.5086 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1369   -0.5192    3.0973 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.2094   -1.2783    2.6946 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.4632   -0.3908    1.3699 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5113   -2.7694    0.1475 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.4422   -1.0501   -0.6143 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.6981   -1.5928   -1.6711 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.0371   -1.0566   -2.7608 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2523   -2.5425   -1.8111 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.5678    1.2240   -0.3599 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.1783    0.6688   -1.0750 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9155    2.4666   -1.9961 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4095    1.2590   -3.2753 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4193    2.7129   -2.9560 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3875   -0.5781   -1.6953 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 15 17  1  0
  6  7  1  0
  7  8  1  0
  7  9  1  0
  9 10  1  0
  9 11  1  0
 13  3  1  0
  1 18  1  0
  1 19  1  0
  1 20  1  0
  4 21  1  0
  5 22  1  0
 12 30  1  0
 16 31  1  0
 16 32  1  0
 16 33  1  0
 17 34  1  0
  7 23  1  1
  8 24  1  0
  9 25  1  1
 10 26  1  0
 10 27  1  0
 10 28  1  0
 11 29  1  0
M  END


  Mrv1652309072220502D          

 17 17  0  0  1  0            999 V2000
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.6500    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  1  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  1  0  0  0
  6 12  1  0  0  0  0
 12 13  2  0  0  0  0
  3 13  1  0  0  0  0
 14 13  1  4  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0254624

> <DATABASE_NAME>
NP-MRD

> <SMILES>
COC1=CC=C(C=C1N=C(C)O)[C@@H](O)[C@@H](C)O

> <INCHI_IDENTIFIER>
InChI=1S/C12H17NO4/c1-7(14)12(16)9-4-5-11(17-3)10(6-9)13-8(2)15/h4-7,12,14,16H,1-3H3,(H,13,15)/t7-,12+/m1/s1

> <INCHI_KEY>
FAVNXOVMWUMJAK-KRTXAFLBSA-N

> <FORMULA>
C12H17NO4

> <MOLECULAR_WEIGHT>
239.271

> <EXACT_MASS>
239.115758031

> <JCHEM_ACCEPTOR_COUNT>
5

> <JCHEM_ATOM_COUNT>
34

> <JCHEM_AVERAGE_POLARIZABILITY>
25.20326860426548

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
N-{5-[(1R,2R)-1,2-dihydroxypropyl]-2-methoxyphenyl}ethanimidic acid

> <JCHEM_LOGP>
0.7996319033333336

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
1

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
13.466222739163737

> <JCHEM_PKA_STRONGEST_ACIDIC>
5.502757190926917

> <JCHEM_PKA_STRONGEST_BASIC>
-0.1520883076341183

> <JCHEM_POLAR_SURFACE_AREA>
82.28000000000002

> <JCHEM_REFRACTIVITY>
65.3365

> <JCHEM_ROTATABLE_BOND_COUNT>
4

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
N-{5-[(1R,2R)-1,2-dihydroxypropyl]-2-methoxyphenyl}ethanimidic acid

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 07-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   07-SEP-22         0                                  
HETATM    1  C   UNK     0       0.000   4.620   0.000  0.00  0.00           C+0
HETATM    2  O   UNK     0       1.334   3.850   0.000  0.00  0.00           O+0
HETATM    3  C   UNK     0       1.334   2.310   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       2.667   1.540   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       2.667  -0.000   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       1.334  -0.770   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       1.334  -2.310   0.000  0.00  0.00           C+0
HETATM    8  O   UNK     0       2.667  -3.080   0.000  0.00  0.00           O+0
HETATM    9  C   UNK     0      -0.000  -3.080   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      -0.000  -4.620   0.000  0.00  0.00           C+0
HETATM   11  O   UNK     0      -1.334  -2.310   0.000  0.00  0.00           O+0
HETATM   12  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       0.000   1.540   0.000  0.00  0.00           C+0
HETATM   14  N   UNK     0      -1.334   2.310   0.000  0.00  0.00           N+0
HETATM   15  C   UNK     0      -2.667   1.540   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      -4.001   2.310   0.000  0.00  0.00           C+0
HETATM   17  O   UNK     0      -2.667   0.000   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4   13                                                  
CONECT    4    3    5                                                       
CONECT    5    4    6                                                       
CONECT    6    5    7   12                                                  
CONECT    7    6    8    9                                                  
CONECT    8    7                                                            
CONECT    9    7   10   11                                                  
CONECT   10    9                                                            
CONECT   11    9                                                            
CONECT   12    6   13                                                       
CONECT   13   12    3   14                                                  
CONECT   14   13   15                                                       
CONECT   15   14   16   17                                                  
CONECT   16   15                                                            
CONECT   17   15                                                            
MASTER        0    0    0    0    0    0    0    0   17    0   34    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₁₂H₁₇NO₄

Average Mass

239.2710 Da

Monoisotopic Mass

239.11576 Da

IUPAC Name

N-{5-[(1R,2R)-1,2-dihydroxypropyl]-2-methoxyphenyl}ethanimidic acid

Traditional Name

N-{5-[(1R,2R)-1,2-dihydroxypropyl]-2-methoxyphenyl}ethanimidic acid

CAS Registry Number

Not Available

SMILES

COC1=CC=C(C=C1N=C(C)O)[C@@H](O)[C@@H](C)O

InChI Identifier

InChI=1S/C12H17NO4/c1-7(14)12(16)9-4-5-11(17-3)10(6-9)13-8(2)15/h4-7,12,14,16H,1-3H3,(H,13,15)/t7-,12+/m1/s1

InChI Key

FAVNXOVMWUMJAK-KRTXAFLBSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Not Available

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as acetanilides. These are organic compounds containing an acetamide group conjugated to a phenyl group.

Kingdom

Organic compounds

Super Class

Benzenoids

Class

Benzene and substituted derivatives

Sub Class

Anilides

Direct Parent

Acetanilides

Alternative Parents

Substituents

Acetanilide
N-acetylarylamine
Phenylpropane
Methoxyaniline
Phenoxy compound
Anisole
Phenol ether
Methoxybenzene
N-arylamide
Alkyl aryl ether
Acetamide
1,2-diol
Carboxamide group
Secondary alcohol
Secondary carboxylic acid amide
Ether
Carboxylic acid derivative
Organic oxide
Organooxygen compound
Organonitrogen compound
Alcohol
Carbonyl group
Organopnictogen compound
Hydrocarbon derivative
Organic nitrogen compound
Organic oxygen compound
Aromatic alcohol
Aromatic homomonocyclic compound

Molecular Framework

Aromatic homomonocyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	0.8	ChemAxon
pKa (Strongest Acidic)	5.5	ChemAxon
pKa (Strongest Basic)	-0.15	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	82.28 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	65.34 m³·mol⁻¹	ChemAxon
Polarizability	25.2 Å³	ChemAxon
Number of Rings	1	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

78442532

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

139584337

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for n-{5-[(1r,2r)-1,2-dihydroxypropyl]-2-methoxyphenyl}ethanimidic acid (NP0254624)

MOL for NP0254624 (n-{5-[(1r,2r)-1,2-dihydroxypropyl]-2-methoxyphenyl}ethanimidic acid)

3D MOL for NP0254624 (n-{5-[(1r,2r)-1,2-dihydroxypropyl]-2-methoxyphenyl}ethanimidic acid)

3D SDF for NP0254624 (n-{5-[(1r,2r)-1,2-dihydroxypropyl]-2-methoxyphenyl}ethanimidic acid)

3D-SDF for NP0254624 (n-{5-[(1r,2r)-1,2-dihydroxypropyl]-2-methoxyphenyl}ethanimidic acid)

PDB for NP0254624 (n-{5-[(1r,2r)-1,2-dihydroxypropyl]-2-methoxyphenyl}ethanimidic acid)

3D PDB for NP0254624 (n-{5-[(1r,2r)-1,2-dihydroxypropyl]-2-methoxyphenyl}ethanimidic acid)

SMILES for NP0254624 (n-{5-[(1r,2r)-1,2-dihydroxypropyl]-2-methoxyphenyl}ethanimidic acid)

INCHI for NP0254624 (n-{5-[(1r,2r)-1,2-dihydroxypropyl]-2-methoxyphenyl}ethanimidic acid)

Structure for NP0254624 (n-{5-[(1r,2r)-1,2-dihydroxypropyl]-2-methoxyphenyl}ethanimidic acid)

3D Structure for NP0254624 (n-{5-[(1r,2r)-1,2-dihydroxypropyl]-2-methoxyphenyl}ethanimidic acid)