NP-MRD: Showing NP-Card for (2r,4r,5r,6s)-18-hydroxy-5-methoxy-6-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1²,⁶.0⁷,²⁸.0⁸,¹³.0¹⁵,¹⁹.0²⁰,²⁷.0²¹,²⁶]nonacosa-8(13),9,11,14(28),15(19),17,20(27),21(26),22,24-decaen-16-one (NP0254443)

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Record Information

Version

2.0

Created at

2022-09-07 18:36:25 UTC

Updated at

2022-09-07 18:36:25 UTC

NP-MRD ID

NP0254443

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(2r,4r,5r,6s)-18-hydroxy-5-methoxy-6-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1²,⁶.0⁷,²⁸.0⁸,¹³.0¹⁵,¹⁹.0²⁰,²⁷.0²¹,²⁶]nonacosa-8(13),9,11,14(28),15(19),17,20(27),21(26),22,24-decaen-16-one

Description

7-Oxostaurosporine belongs to the class of organic compounds known as indolocarbazoles. These are polycyclic aromatic compounds containing an indole fused to a carbazole. (2r,4r,5r,6s)-18-hydroxy-5-methoxy-6-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1²,⁶.0⁷,²⁸.0⁸,¹³.0¹⁵,¹⁹.0²⁰,²⁷.0²¹,²⁶]nonacosa-8(13),9,11,14(28),15(19),17,20(27),21(26),22,24-decaen-16-one is found in Streptomyces platensis. (2r,4r,5r,6s)-18-hydroxy-5-methoxy-6-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1²,⁶.0⁷,²⁸.0⁸,¹³.0¹⁵,¹⁹.0²⁰,²⁷.0²¹,²⁶]nonacosa-8(13),9,11,14(28),15(19),17,20(27),21(26),22,24-decaen-16-one was first documented in 2013 (PMID: 23986809). Based on a literature review a small amount of articles have been published on 7-oxostaurosporine (PMID: 34786807) (PMID: 32466301) (PMID: 32344693) (PMID: 31627366).

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309072220362D          

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M  END

     RDKit          3D

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M  END


  Mrv1652309072220362D          

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  5 29  1  0  0  0  0
 29 30  1  0  0  0  0
 22 30  2  0  0  0  0
 30 31  1  0  0  0  0
 19 31  2  0  0  0  0
 12 31  1  0  0  0  0
 21 32  1  0  0  0  0
 32 33  1  0  0  0  0
 32 34  2  0  0  0  0
 34 35  1  0  0  0  0
 20 35  1  0  0  0  0
 35 36  2  0  0  0  0
M  END
> <DATABASE_ID>
NP0254443

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)N1C3=C(C=CC=C3)C3=C1C1=C(C4=CC=CC=C4N21)C1=C3C(=O)N=C1O

> <INCHI_IDENTIFIER>
InChI=1S/C28H24N4O4/c1-28-25(35-3)15(29-2)12-18(36-28)31-16-10-6-4-8-13(16)19-21-22(27(34)30-26(21)33)20-14-9-5-7-11-17(14)32(28)24(20)23(19)31/h4-11,15,18,25,29H,12H2,1-3H3,(H,30,33,34)/t15-,18-,25-,28+/m1/s1

> <INCHI_KEY>
POTTVLREWUNNRO-UGZRAAABSA-N

> <FORMULA>
C28H24N4O4

> <MOLECULAR_WEIGHT>
480.524

> <EXACT_MASS>
480.179755269

> <JCHEM_ACCEPTOR_COUNT>
6

> <JCHEM_ATOM_COUNT>
60

> <JCHEM_AVERAGE_POLARIZABILITY>
50.598345849036605

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(2R,4R,5R,6S)-18-hydroxy-5-methoxy-6-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),17,20(27),21,23,25-decaen-16-one

> <JCHEM_LOGP>
1.9104676726683023

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
8

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_ACIDIC>
6.701347164707052

> <JCHEM_PKA_STRONGEST_BASIC>
9.454388274188204

> <JCHEM_POLAR_SURFACE_AREA>
90.00999999999999

> <JCHEM_REFRACTIVITY>
133.4209

> <JCHEM_ROTATABLE_BOND_COUNT>
2

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
(2R,4R,5R,6S)-18-hydroxy-5-methoxy-6-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),17,20(27),21,23,25-decaen-16-one

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 07-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   07-SEP-22         0                                  
HETATM    1  C   UNK     0       3.500  -2.818   0.000  0.00  0.00           C+0
HETATM    2  N   UNK     0       4.886  -2.148   0.000  0.00  0.00           N+0
HETATM    3  C   UNK     0       4.999  -0.612   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       6.411   0.157   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       6.597   1.877   0.000  0.00  0.00           C+0
HETATM    6  O   UNK     0       5.195   2.043   0.000  0.00  0.00           O+0
HETATM    7  C   UNK     0       3.807   2.016   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       2.269   1.921   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       3.729   0.345   0.000  0.00  0.00           C+0
HETATM   10  O   UNK     0       2.335  -0.310   0.000  0.00  0.00           O+0
HETATM   11  C   UNK     0       2.205  -1.844   0.000  0.00  0.00           C+0
HETATM   12  N   UNK     0       3.518   3.691   0.000  0.00  0.00           N+0
HETATM   13  C   UNK     0       2.023   4.273   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       0.639   3.596   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      -0.638   4.456   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      -0.532   5.993   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       0.851   6.669   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       2.129   5.809   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       3.674   6.255   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       4.514   7.576   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       6.054   7.581   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       6.917   6.204   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       8.461   5.783   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0       9.723   6.667   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0      11.118   6.016   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0      11.253   4.482   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0       9.991   3.599   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0       8.596   4.249   0.000  0.00  0.00           C+0
HETATM   29  N   UNK     0       7.067   3.562   0.000  0.00  0.00           N+0
HETATM   30  C   UNK     0       6.093   4.876   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0       4.516   4.950   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0       6.526   9.047   0.000  0.00  0.00           C+0
HETATM   33  O   UNK     0       7.989   9.527   0.000  0.00  0.00           O+0
HETATM   34  N   UNK     0       5.277   9.948   0.000  0.00  0.00           N+0
HETATM   35  C   UNK     0       4.034   9.039   0.000  0.00  0.00           C+0
HETATM   36  O   UNK     0       2.568   9.511   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4    9                                                  
CONECT    4    3    5                                                       
CONECT    5    4    6   29                                                  
CONECT    6    5    7                                                       
CONECT    7    6    8    9   12                                             
CONECT    8    7                                                            
CONECT    9    7    3   10                                                  
CONECT   10    9   11                                                       
CONECT   11   10                                                            
CONECT   12    7   13   31                                                  
CONECT   13   12   14   18                                                  
CONECT   14   13   15                                                       
CONECT   15   14   16                                                       
CONECT   16   15   17                                                       
CONECT   17   16   18                                                       
CONECT   18   17   13   19                                                  
CONECT   19   18   20   31                                                  
CONECT   20   19   21   35                                                  
CONECT   21   20   22   32                                                  
CONECT   22   21   23   30                                                  
CONECT   23   22   24   28                                                  
CONECT   24   23   25                                                       
CONECT   25   24   26                                                       
CONECT   26   25   27                                                       
CONECT   27   26   28                                                       
CONECT   28   27   23   29                                                  
CONECT   29   28    5   30                                                  
CONECT   30   29   22   31                                                  
CONECT   31   30   19   12                                                  
CONECT   32   21   33   34                                                  
CONECT   33   32                                                            
CONECT   34   32   35                                                       
CONECT   35   34   20   36                                                  
CONECT   36   35                                                            
MASTER        0    0    0    0    0    0    0    0   36    0   86    0
END

View in JSmol

Synonyms

Value	Source
7-oxo-Staurosporine	MeSH

Chemical Formula

C₂₈H₂₄N₄O₄

Average Mass

480.5240 Da

Monoisotopic Mass

480.17976 Da

IUPAC Name

Not Available

Traditional Name

Not Available

CAS Registry Number

Not Available

SMILES

CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)N1C3=C(C=CC=C3)C3=C1C1=C(C4=CC=CC=C4N21)C1=C3C(=O)N=C1O

InChI Identifier

InChI=1S/C28H24N4O4/c1-28-25(35-3)15(29-2)12-18(36-28)31-16-10-6-4-8-13(16)19-21-22(27(34)30-26(21)33)20-14-9-5-7-11-17(14)32(28)24(20)23(19)31/h4-11,15,18,25,29H,12H2,1-3H3,(H,30,33,34)/t15-,18-,25-,28+/m1/s1

InChI Key

POTTVLREWUNNRO-UGZRAAABSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Streptomyces platensis	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as indolocarbazoles. These are polycyclic aromatic compounds containing an indole fused to a carbazole.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Indoles and derivatives

Sub Class

Carbazoles

Direct Parent

Indolocarbazoles

Alternative Parents

Substituents

Indolocarbazole
Pyrrolo[2,3-a]carbazole
Pyrroloindole
Phthalimide
Isoindolone
Indole
Isoindoline
Isoindole or derivatives
Benzenoid
Oxane
Carboxylic acid imide
Heteroaromatic compound
Pyrrole
Carboxylic acid imide, n-unsubstituted
Amino acid or derivatives
Carboxylic acid derivative
Dialkyl ether
Secondary aliphatic amine
Ether
Oxacycle
Azacycle
Secondary amine
Amine
Organic oxide
Hydrocarbon derivative
Organic oxygen compound
Organic nitrogen compound
Organooxygen compound
Organonitrogen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

C00017237

Chemspider ID

9082216

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

10906957

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Seo K, Jang SH, Rhee YH: Sequential Metal Catalysis towards 7-Oxostaurosporine and Its Non-Natural Septanose Analogue. Angew Chem Int Ed Engl. 2022 Jan 17;61(3):e202112524. doi: 10.1002/anie.202112524. Epub 2021 Nov 30. [PubMed:34786807 ]
Rizo-Liendo A, Sifaoui I, Cartuche L, Arberas-Jimenez I, Reyes-Batlle M, Fernandez JJ, Pinero JE, Diaz-Marrero AR, Lorenzo-Morales J: Evaluation of Indolocarbazoles from Streptomyces sanyensis as a Novel Source of Therapeutic Agents against the Brain-Eating Amoeba Naegleria fowleri. Microorganisms. 2020 May 25;8(5):789. doi: 10.3390/microorganisms8050789. [PubMed:32466301 ]
Cartuche L, Sifaoui I, Lopez-Arencibia A, Bethencourt-Estrella CJ, San Nicolas-Hernandez D, Lorenzo-Morales J, Pinero JE, Diaz-Marrero AR, Fernandez JJ: Antikinetoplastid Activity of Indolocarbazoles from Streptomyces sanyensis. Biomolecules. 2020 Apr 24;10(4):657. doi: 10.3390/biom10040657. [PubMed:32344693 ]
Cartuche L, Reyes-Batlle M, Sifaoui I, Arberas-Jimenez I, Pinero JE, Fernandez JJ, Lorenzo-Morales J, Diaz-Marrero AR: Antiamoebic Activities of Indolocarbazole Metabolites Isolated from Streptomyces sanyensis Cultures. Mar Drugs. 2019 Oct 17;17(10):588. doi: 10.3390/md17100588. [PubMed:31627366 ]
Cho KJ, Park JH, Hancock JF: Staurosporine: A new tool for studying phosphatidylserine trafficking. Commun Integr Biol. 2013 Jul 1;6(4):e24746. doi: 10.4161/cib.24746. Epub 2013 May 10. [PubMed:23986809 ]
LOTUS database [Link]

Showing NP-Card for (2r,4r,5r,6s)-18-hydroxy-5-methoxy-6-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1²,⁶.0⁷,²⁸.0⁸,¹³.0¹⁵,¹⁹.0²⁰,²⁷.0²¹,²⁶]nonacosa-8(13),9,11,14(28),15(19),17,20(27),21(26),22,24-decaen-16-one (NP0254443)

MOL for NP0254443 ((2r,4r,5r,6s)-18-hydroxy-5-methoxy-6-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1²,⁶.0⁷,²⁸.0⁸,¹³.0¹⁵,¹⁹.0²⁰,²⁷.0²¹,²⁶]nonacosa-8(13),9,11,14(28),15(19),17,20(27),21(26),22,24-decaen-16-one)

3D MOL for NP0254443 ((2r,4r,5r,6s)-18-hydroxy-5-methoxy-6-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1²,⁶.0⁷,²⁸.0⁸,¹³.0¹⁵,¹⁹.0²⁰,²⁷.0²¹,²⁶]nonacosa-8(13),9,11,14(28),15(19),17,20(27),21(26),22,24-decaen-16-one)

3D SDF for NP0254443 ((2r,4r,5r,6s)-18-hydroxy-5-methoxy-6-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1²,⁶.0⁷,²⁸.0⁸,¹³.0¹⁵,¹⁹.0²⁰,²⁷.0²¹,²⁶]nonacosa-8(13),9,11,14(28),15(19),17,20(27),21(26),22,24-decaen-16-one)

3D-SDF for NP0254443 ((2r,4r,5r,6s)-18-hydroxy-5-methoxy-6-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1²,⁶.0⁷,²⁸.0⁸,¹³.0¹⁵,¹⁹.0²⁰,²⁷.0²¹,²⁶]nonacosa-8(13),9,11,14(28),15(19),17,20(27),21(26),22,24-decaen-16-one)

PDB for NP0254443 ((2r,4r,5r,6s)-18-hydroxy-5-methoxy-6-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1²,⁶.0⁷,²⁸.0⁸,¹³.0¹⁵,¹⁹.0²⁰,²⁷.0²¹,²⁶]nonacosa-8(13),9,11,14(28),15(19),17,20(27),21(26),22,24-decaen-16-one)

3D PDB for NP0254443 ((2r,4r,5r,6s)-18-hydroxy-5-methoxy-6-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1²,⁶.0⁷,²⁸.0⁸,¹³.0¹⁵,¹⁹.0²⁰,²⁷.0²¹,²⁶]nonacosa-8(13),9,11,14(28),15(19),17,20(27),21(26),22,24-decaen-16-one)

SMILES for NP0254443 ((2r,4r,5r,6s)-18-hydroxy-5-methoxy-6-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1²,⁶.0⁷,²⁸.0⁸,¹³.0¹⁵,¹⁹.0²⁰,²⁷.0²¹,²⁶]nonacosa-8(13),9,11,14(28),15(19),17,20(27),21(26),22,24-decaen-16-one)

INCHI for NP0254443 ((2r,4r,5r,6s)-18-hydroxy-5-methoxy-6-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1²,⁶.0⁷,²⁸.0⁸,¹³.0¹⁵,¹⁹.0²⁰,²⁷.0²¹,²⁶]nonacosa-8(13),9,11,14(28),15(19),17,20(27),21(26),22,24-decaen-16-one)

Structure for NP0254443 ((2r,4r,5r,6s)-18-hydroxy-5-methoxy-6-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1²,⁶.0⁷,²⁸.0⁸,¹³.0¹⁵,¹⁹.0²⁰,²⁷.0²¹,²⁶]nonacosa-8(13),9,11,14(28),15(19),17,20(27),21(26),22,24-decaen-16-one)

3D Structure for NP0254443 ((2r,4r,5r,6s)-18-hydroxy-5-methoxy-6-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1²,⁶.0⁷,²⁸.0⁸,¹³.0¹⁵,¹⁹.0²⁰,²⁷.0²¹,²⁶]nonacosa-8(13),9,11,14(28),15(19),17,20(27),21(26),22,24-decaen-16-one)