NP-MRD: Showing NP-Card for (1ar,2s,3r,7r,7ar,7bs)-2,3-dihydroxy-1,1,7,7a-tetramethyl-1ah,2h,3h,6h,7h,7bh-cyclopropa[a]naphthalen-5-one (NP0254232)

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Record Information

Version

1.0

Created at

2022-09-07 18:19:41 UTC

Updated at

2022-09-07 18:19:41 UTC

NP-MRD ID

NP0254232

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(1ar,2s,3r,7r,7ar,7bs)-2,3-dihydroxy-1,1,7,7a-tetramethyl-1ah,2h,3h,6h,7h,7bh-cyclopropa[a]naphthalen-5-one

Description

Rulepidadiol belongs to the class of organic compounds known as aristolane sesquiterpenoids. These are sesquiterpenoids with a structure based on the aristolane skeleton. Aristolanes arise from the C6,C11 cyclization of the bicyclic eremophilane skeleton. (1ar,2s,3r,7r,7ar,7bs)-2,3-dihydroxy-1,1,7,7a-tetramethyl-1ah,2h,3h,6h,7h,7bh-cyclopropa[a]naphthalen-5-one is found in Russula lepida. It was first documented in 2002 (PMID: 35412727). Based on a literature review a significant number of articles have been published on Rulepidadiol (PMID: 36099392) (PMID: 31661213) (PMID: 31593386) (PMID: 29589881).

Structure

MOL SDF PDB SMILES InChI


  Mrv1652309072220192D          

 18 20  0  0  1  0            999 V2000
    2.0846   -2.3391    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7568   -1.5821    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.9372   -1.4874    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6094   -0.7304    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2102   -0.6357    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1011   -0.0679    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9207   -0.1626    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4124    0.4999    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.0846    1.2569    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2320    0.4052    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.7237    1.0677    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5598   -0.3518    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.0681   -1.0143    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.8876   -1.1089    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1482   -1.8917    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7123   -1.1317    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2485   -0.9196    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.5763   -1.6767    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  6  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  8  7  1  0  0  0  0
  8  9  1  1  0  0  0
 10  8  1  0  0  0  0
 10 11  1  1  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  1  0  0  0
 12 14  1  1  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 13 17  1  0  0  0  0
 17  7  1  0  0  0  0
 17  2  1  0  0  0  0
 17 18  1  6  0  0  0
M  END
> <DATABASE_ID>
NP0254232

> <DATABASE_NAME>
NP-MRD

> <SMILES>
C[C@@H]1CC(=O)C=C2[C@@H](O)[C@@H](O)[C@@H]3[C@@H](C3(C)C)[C@@]12C

> <INCHI_IDENTIFIER>
InChI=1S/C15H22O3/c1-7-5-8(16)6-9-11(17)12(18)10-13(14(10,2)3)15(7,9)4/h6-7,10-13,17-18H,5H2,1-4H3/t7-,10-,11-,12+,13+,15+/m1/s1

> <INCHI_KEY>
GQUVWWKDAFPDRH-TZJKVICWSA-N

> <FORMULA>
C15H22O3

> <MOLECULAR_WEIGHT>
250.338

> <EXACT_MASS>
250.156894568

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_ATOM_COUNT>
40

> <JCHEM_AVERAGE_POLARIZABILITY>
27.485994121680143

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(1aS,1bR,2R,6R,7S,7aR)-6,7-dihydroxy-1,1,1b,2-tetramethyl-1H,1aH,1bH,2H,3H,4H,6H,7H,7aH-cyclopropa[a]naphthalen-4-one

> <JCHEM_LOGP>
1.053924663333333

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
14.862315492525521

> <JCHEM_PKA_STRONGEST_ACIDIC>
13.380336158145614

> <JCHEM_PKA_STRONGEST_BASIC>
-3.2955011630904094

> <JCHEM_POLAR_SURFACE_AREA>
57.53

> <JCHEM_REFRACTIVITY>
69.1125

> <JCHEM_ROTATABLE_BOND_COUNT>
0

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
(1aS,1bR,2R,6R,7S,7aR)-6,7-dihydroxy-1,1,1b,2-tetramethyl-1aH,2H,3H,6H,7H,7aH-cyclopropa[a]naphthalen-4-one

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 07-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   07-SEP-22         0                                  
HETATM    1  C   UNK     0       3.891  -4.366   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       3.279  -2.953   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       1.749  -2.777   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       1.138  -1.363   0.000  0.00  0.00           C+0
HETATM    5  O   UNK     0      -0.392  -1.187   0.000  0.00  0.00           O+0
HETATM    6  C   UNK     0       2.055  -0.127   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       3.585  -0.303   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       4.503   0.933   0.000  0.00  0.00           C+0
HETATM    9  O   UNK     0       3.891   2.346   0.000  0.00  0.00           O+0
HETATM   10  C   UNK     0       6.033   0.756   0.000  0.00  0.00           C+0
HETATM   11  O   UNK     0       6.951   1.993   0.000  0.00  0.00           O+0
HETATM   12  C   UNK     0       6.645  -0.657   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       5.727  -1.893   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       7.257  -2.070   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       7.743  -3.531   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       8.796  -2.113   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       4.197  -1.717   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       4.809  -3.130   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3   17                                                  
CONECT    3    2    4                                                       
CONECT    4    3    5    6                                                  
CONECT    5    4                                                            
CONECT    6    4    7                                                       
CONECT    7    6    8   17                                                  
CONECT    8    7    9   10                                                  
CONECT    9    8                                                            
CONECT   10    8   11   12                                                  
CONECT   11   10                                                            
CONECT   12   10   13   14                                                  
CONECT   13   12   14   17                                                  
CONECT   14   13   12   15   16                                             
CONECT   15   14                                                            
CONECT   16   14                                                            
CONECT   17   13    7    2   18                                             
CONECT   18   17                                                            
MASTER        0    0    0    0    0    0    0    0   18    0   40    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₁₅H₂₂O₃

Average Mass

250.3380 Da

Monoisotopic Mass

250.15689 Da

IUPAC Name

(1aS,1bR,2R,6R,7S,7aR)-6,7-dihydroxy-1,1,1b,2-tetramethyl-1H,1aH,1bH,2H,3H,4H,6H,7H,7aH-cyclopropa[a]naphthalen-4-one

Traditional Name

(1aS,1bR,2R,6R,7S,7aR)-6,7-dihydroxy-1,1,1b,2-tetramethyl-1aH,2H,3H,6H,7H,7aH-cyclopropa[a]naphthalen-4-one

CAS Registry Number

Not Available

SMILES

C[C@@H]1CC(=O)C=C2[C@@H](O)[C@@H](O)[C@@H]3[C@@H](C3(C)C)[C@@]12C

InChI Identifier

InChI=1S/C15H22O3/c1-7-5-8(16)6-9-11(17)12(18)10-13(14(10,2)3)15(7,9)4/h6-7,10-13,17-18H,5H2,1-4H3/t7-,10-,11-,12+,13+,15+/m1/s1

InChI Key

GQUVWWKDAFPDRH-TZJKVICWSA-N

Experimental Spectra

Not Available

Predicted Spectra

Not Available

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Russula lepida	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as aristolane sesquiterpenoids. These are sesquiterpenoids with a structure based on the aristolane skeleton. Aristolanes arise from the C6,C11 cyclization of the bicyclic eremophilane skeleton.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Sesquiterpenoids

Direct Parent

Aristolane sesquiterpenoids

Alternative Parents

Substituents

Aristolane sesquiterpenoid
Cyclohexenone
Cyclic alcohol
Cyclic ketone
Secondary alcohol
Ketone
1,2-diol
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Organooxygen compound
Carbonyl group
Alcohol
Aliphatic homopolycyclic compound

Molecular Framework

Aliphatic homopolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	1.05	ChemAxon
pKa (Strongest Acidic)	13.38	ChemAxon
pKa (Strongest Basic)	-3.3	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	57.53 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	69.11 m³·mol⁻¹	ChemAxon
Polarizability	27.49 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

4475291

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

5316179

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Freebody J: "The Root of All Evil is Inactivity": The Response of French Psychiatrists to New Approaches to Patient Work and Occupation, 1918-1939. 2021. [PubMed:36099392 ]
Authors unspecified: Childhood Pulmonary Inflammatory Myofibroblastic Tumors Treatment (PDQ(R)): Health Professional Version. 2002. [PubMed:35412727 ]
Authors unspecified: Childhood Adrenocortical Carcinoma Treatment (PDQ(R)): Health Professional Version. 2002. [PubMed:31661213 ]
Authors unspecified: Childhood Breast Tumors Treatment (PDQ(R)): Health Professional Version. 2002. [PubMed:31593386 ]
Authors unspecified: Cognitive Impairment in Adults with Non-Central Nervous System Cancers (PDQ(R)): Patient Version. 2002. [PubMed:29589881 ]
LOTUS database [Link]

Showing NP-Card for (1ar,2s,3r,7r,7ar,7bs)-2,3-dihydroxy-1,1,7,7a-tetramethyl-1ah,2h,3h,6h,7h,7bh-cyclopropa[a]naphthalen-5-one (NP0254232)

MOL for NP0254232 ((1ar,2s,3r,7r,7ar,7bs)-2,3-dihydroxy-1,1,7,7a-tetramethyl-1ah,2h,3h,6h,7h,7bh-cyclopropa[a]naphthalen-5-one)

3D MOL for NP0254232 ((1ar,2s,3r,7r,7ar,7bs)-2,3-dihydroxy-1,1,7,7a-tetramethyl-1ah,2h,3h,6h,7h,7bh-cyclopropa[a]naphthalen-5-one)

3D SDF for NP0254232 ((1ar,2s,3r,7r,7ar,7bs)-2,3-dihydroxy-1,1,7,7a-tetramethyl-1ah,2h,3h,6h,7h,7bh-cyclopropa[a]naphthalen-5-one)

3D-SDF for NP0254232 ((1ar,2s,3r,7r,7ar,7bs)-2,3-dihydroxy-1,1,7,7a-tetramethyl-1ah,2h,3h,6h,7h,7bh-cyclopropa[a]naphthalen-5-one)

PDB for NP0254232 ((1ar,2s,3r,7r,7ar,7bs)-2,3-dihydroxy-1,1,7,7a-tetramethyl-1ah,2h,3h,6h,7h,7bh-cyclopropa[a]naphthalen-5-one)

3D PDB for NP0254232 ((1ar,2s,3r,7r,7ar,7bs)-2,3-dihydroxy-1,1,7,7a-tetramethyl-1ah,2h,3h,6h,7h,7bh-cyclopropa[a]naphthalen-5-one)

SMILES for NP0254232 ((1ar,2s,3r,7r,7ar,7bs)-2,3-dihydroxy-1,1,7,7a-tetramethyl-1ah,2h,3h,6h,7h,7bh-cyclopropa[a]naphthalen-5-one)

INCHI for NP0254232 ((1ar,2s,3r,7r,7ar,7bs)-2,3-dihydroxy-1,1,7,7a-tetramethyl-1ah,2h,3h,6h,7h,7bh-cyclopropa[a]naphthalen-5-one)

Structure for NP0254232 ((1ar,2s,3r,7r,7ar,7bs)-2,3-dihydroxy-1,1,7,7a-tetramethyl-1ah,2h,3h,6h,7h,7bh-cyclopropa[a]naphthalen-5-one)

3D Structure for NP0254232 ((1ar,2s,3r,7r,7ar,7bs)-2,3-dihydroxy-1,1,7,7a-tetramethyl-1ah,2h,3h,6h,7h,7bh-cyclopropa[a]naphthalen-5-one)