NP-MRD: Showing NP-Card for 5-(hex-4-enoyl)-3,6-dihydroxy-1,3-dimethyl-7-(prop-1-en-1-yl)-8-(2,4,5-trihydroxy-3,5-dimethyl-6-oxocyclohexa-1,3-diene-1-carbonyl)bicyclo[2.2.2]oct-5-en-2-one (NP0250958)

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Record Information

Version

2.0

Created at

2022-09-07 13:58:42 UTC

Updated at

2022-09-07 13:58:42 UTC

NP-MRD ID

NP0250958

Secondary Accession Numbers

None

Natural Product Identification

Common Name

5-(hex-4-enoyl)-3,6-dihydroxy-1,3-dimethyl-7-(prop-1-en-1-yl)-8-(2,4,5-trihydroxy-3,5-dimethyl-6-oxocyclohexa-1,3-diene-1-carbonyl)bicyclo[2.2.2]oct-5-en-2-one

Description

5-(Hex-4-enoyl)-3,6-dihydroxy-1,3-dimethyl-7-(prop-1-en-1-yl)-8-(2,4,5-trihydroxy-3,5-dimethyl-6-oxocyclohexa-1,3-diene-1-carbonyl)bicyclo[2.2.2]Oct-5-en-2-one belongs to the class of organic compounds known as cyclohexenones. Cyclohexenones are compounds containing a cylohexenone moiety, which is a six-membered aliphatic ring that carries a ketone and has one endocyclic double bond. Based on a literature review very few articles have been published on 5-(hex-4-enoyl)-3,6-dihydroxy-1,3-dimethyl-7-(prop-1-en-1-yl)-8-(2,4,5-trihydroxy-3,5-dimethyl-6-oxocyclohexa-1,3-diene-1-carbonyl)bicyclo[2.2.2]Oct-5-en-2-one.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309072215582D          

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M  END

     RDKit          3D

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M  END


  Mrv1652309072215582D          

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  6  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
  8 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  2  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  2  0  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  1  0  0  0  0
 29 32  1  0  0  0  0
 22 32  1  0  0  0  0
 32 33  2  0  0  0  0
 19 34  1  0  0  0  0
 11 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  2  0  0  0  0
 36 37  1  4  0  0  0
M  END
> <DATABASE_ID>
NP0250958

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CC=CCCC(=O)C1=C(O)C2(C)C(C=CC)C(C1C(C)(O)C2=O)C(=O)C1=C(O)C(C)=C(O)C(C)(O)C1=O

> <INCHI_IDENTIFIER>
InChI=1S/C28H34O9/c1-7-9-10-12-15(29)17-19-16(14(11-8-2)26(4,23(17)33)25(35)27(19,5)36)21(31)18-20(30)13(3)22(32)28(6,37)24(18)34/h7-9,11,14,16,19,30,32-33,36-37H,10,12H2,1-6H3

> <INCHI_KEY>
SJEJDTOPDKRRDN-UHFFFAOYSA-N

> <FORMULA>
C28H34O9

> <MOLECULAR_WEIGHT>
514.571

> <EXACT_MASS>
514.220282675

> <JCHEM_ACCEPTOR_COUNT>
9

> <JCHEM_ATOM_COUNT>
71

> <JCHEM_AVERAGE_POLARIZABILITY>
53.16904580044324

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
5

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
5-(hex-4-enoyl)-3,6-dihydroxy-1,3-dimethyl-7-(prop-1-en-1-yl)-8-(2,4,5-trihydroxy-3,5-dimethyl-6-oxocyclohexa-1,3-diene-1-carbonyl)bicyclo[2.2.2]oct-5-en-2-one

> <JCHEM_LOGP>
2.374937362

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-2

> <JCHEM_PKA>
5.803178429795768

> <JCHEM_PKA_STRONGEST_ACIDIC>
3.7731567710742455

> <JCHEM_PKA_STRONGEST_BASIC>
-3.716484821415791

> <JCHEM_POLAR_SURFACE_AREA>
169.42999999999998

> <JCHEM_REFRACTIVITY>
140.96769999999998

> <JCHEM_ROTATABLE_BOND_COUNT>
7

> <JCHEM_RULE_OF_FIVE>
0

> <JCHEM_TRADITIONAL_IUPAC>
5-(hex-4-enoyl)-3,6-dihydroxy-1,3-dimethyl-7-(prop-1-en-1-yl)-8-(2,4,5-trihydroxy-3,5-dimethyl-6-oxocyclohexa-1,3-diene-1-carbonyl)bicyclo[2.2.2]oct-5-en-2-one

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 07-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   07-SEP-22         0                                  
HETATM    1  C   UNK     0      -6.269  -7.775   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -5.550  -6.348   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      -3.967  -5.682   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      -3.335  -4.116   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      -1.732  -2.965   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      -1.696  -1.380   0.000  0.00  0.00           C+0
HETATM    7  O   UNK     0      -3.425  -0.646   0.000  0.00  0.00           O+0
HETATM    8  C   UNK     0      -0.163  -0.143   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      -0.032   1.649   0.000  0.00  0.00           C+0
HETATM   10  O   UNK     0      -1.875   2.390   0.000  0.00  0.00           O+0
HETATM   11  C   UNK     0       1.349   2.306   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       2.455   3.568   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       2.675   1.523   0.000  0.00  0.00           C+0
HETATM   14  O   UNK     0       4.201   2.141   0.000  0.00  0.00           O+0
HETATM   15  C   UNK     0       2.660  -0.017   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       4.336  -0.010   0.000  0.00  0.00           C+0
HETATM   17  O   UNK     0       3.477  -1.420   0.000  0.00  0.00           O+0
HETATM   18  C   UNK     0       1.318  -0.774   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       1.585   0.250   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0      -0.097   0.811   0.000  0.00  0.00           C+0
HETATM   21  O   UNK     0      -0.661   2.709   0.000  0.00  0.00           O+0
HETATM   22  C   UNK     0      -0.881  -0.767   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0      -0.143  -2.118   0.000  0.00  0.00           C+0
HETATM   24  O   UNK     0       1.349  -2.913   0.000  0.00  0.00           O+0
HETATM   25  C   UNK     0      -0.944  -3.433   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0      -0.377  -5.063   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0      -2.484  -3.397   0.000  0.00  0.00           C+0
HETATM   28  O   UNK     0      -2.605  -5.212   0.000  0.00  0.00           O+0
HETATM   29  C   UNK     0      -3.222  -2.045   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0      -4.708  -2.827   0.000  0.00  0.00           C+0
HETATM   31  O   UNK     0      -4.826  -1.498   0.000  0.00  0.00           O+0
HETATM   32  C   UNK     0      -2.420  -0.730   0.000  0.00  0.00           C+0
HETATM   33  O   UNK     0      -3.238   0.783   0.000  0.00  0.00           O+0
HETATM   34  C   UNK     0       1.596   1.277   0.000  0.00  0.00           C+0
HETATM   35  C   UNK     0       0.465   2.862   0.000  0.00  0.00           C+0
HETATM   36  C   UNK     0       0.493   4.621   0.000  0.00  0.00           C+0
HETATM   37  C   UNK     0      -0.403   6.003   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4                                                       
CONECT    4    3    5                                                       
CONECT    5    4    6                                                       
CONECT    6    5    7    8                                                  
CONECT    7    6                                                            
CONECT    8    6    9   18                                                  
CONECT    9    8   10   11                                                  
CONECT   10    9                                                            
CONECT   11    9   12   13   34                                             
CONECT   12   11                                                            
CONECT   13   11   14   15                                                  
CONECT   14   13                                                            
CONECT   15   13   16   17   18                                             
CONECT   16   15                                                            
CONECT   17   15                                                            
CONECT   18   15    8   19                                                  
CONECT   19   18   20   34                                                  
CONECT   20   19   21   22                                                  
CONECT   21   20                                                            
CONECT   22   20   23   32                                                  
CONECT   23   22   24   25                                                  
CONECT   24   23                                                            
CONECT   25   23   26   27                                                  
CONECT   26   25                                                            
CONECT   27   25   28   29                                                  
CONECT   28   27                                                            
CONECT   29   27   30   31   32                                             
CONECT   30   29                                                            
CONECT   31   29                                                            
CONECT   32   29   22   33                                                  
CONECT   33   32                                                            
CONECT   34   19   11   35                                                  
CONECT   35   34   36                                                       
CONECT   36   35   37                                                       
CONECT   37   36                                                            
MASTER        0    0    0    0    0    0    0    0   37    0   78    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₈H₃₄O₉

Average Mass

514.5710 Da

Monoisotopic Mass

514.22028 Da

IUPAC Name

5-(hex-4-enoyl)-3,6-dihydroxy-1,3-dimethyl-7-(prop-1-en-1-yl)-8-(2,4,5-trihydroxy-3,5-dimethyl-6-oxocyclohexa-1,3-diene-1-carbonyl)bicyclo[2.2.2]oct-5-en-2-one

Traditional Name

5-(hex-4-enoyl)-3,6-dihydroxy-1,3-dimethyl-7-(prop-1-en-1-yl)-8-(2,4,5-trihydroxy-3,5-dimethyl-6-oxocyclohexa-1,3-diene-1-carbonyl)bicyclo[2.2.2]oct-5-en-2-one

CAS Registry Number

Not Available

SMILES

CC=CCCC(=O)C1=C(O)C2(C)C(C=CC)C(C1C(C)(O)C2=O)C(=O)C1=C(O)C(C)=C(O)C(C)(O)C1=O

InChI Identifier

InChI=1S/C28H34O9/c1-7-9-10-12-15(29)17-19-16(14(11-8-2)26(4,23(17)33)25(35)27(19,5)36)21(31)18-20(30)13(3)22(32)28(6,37)24(18)34/h7-9,11,14,16,19,30,32-33,36-37H,10,12H2,1-6H3

InChI Key

SJEJDTOPDKRRDN-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Not Available

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as cyclohexenones. Cyclohexenones are compounds containing a cylohexenone moiety, which is a six-membered aliphatic ring that carries a ketone and has one endocyclic double bond.

Kingdom

Organic compounds

Super Class

Organic oxygen compounds

Class

Organooxygen compounds

Sub Class

Carbonyl compounds

Direct Parent

Cyclohexenones

Alternative Parents

Substituents

Cyclohexenone
Acyloin
Vinylogous acid
Tertiary alcohol
Cyclic alcohol
Polyol
Enol
Organic oxide
Hydrocarbon derivative
Alcohol
Aliphatic homopolycyclic compound

Molecular Framework

Aliphatic homopolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	2.37	ChemAxon
pKa (Strongest Acidic)	3.77	ChemAxon
pKa (Strongest Basic)	-3.7	ChemAxon
Physiological Charge	-2	ChemAxon
Hydrogen Acceptor Count	9	ChemAxon
Hydrogen Donor Count	5	ChemAxon
Polar Surface Area	169.43 Å²	ChemAxon
Rotatable Bond Count	7	ChemAxon
Refractivity	140.97 m³·mol⁻¹	ChemAxon
Polarizability	53.17 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

73311267

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for 5-(hex-4-enoyl)-3,6-dihydroxy-1,3-dimethyl-7-(prop-1-en-1-yl)-8-(2,4,5-trihydroxy-3,5-dimethyl-6-oxocyclohexa-1,3-diene-1-carbonyl)bicyclo[2.2.2]oct-5-en-2-one (NP0250958)

MOL for NP0250958 (5-(hex-4-enoyl)-3,6-dihydroxy-1,3-dimethyl-7-(prop-1-en-1-yl)-8-(2,4,5-trihydroxy-3,5-dimethyl-6-oxocyclohexa-1,3-diene-1-carbonyl)bicyclo[2.2.2]oct-5-en-2-one)

3D MOL for NP0250958 (5-(hex-4-enoyl)-3,6-dihydroxy-1,3-dimethyl-7-(prop-1-en-1-yl)-8-(2,4,5-trihydroxy-3,5-dimethyl-6-oxocyclohexa-1,3-diene-1-carbonyl)bicyclo[2.2.2]oct-5-en-2-one)

3D SDF for NP0250958 (5-(hex-4-enoyl)-3,6-dihydroxy-1,3-dimethyl-7-(prop-1-en-1-yl)-8-(2,4,5-trihydroxy-3,5-dimethyl-6-oxocyclohexa-1,3-diene-1-carbonyl)bicyclo[2.2.2]oct-5-en-2-one)

3D-SDF for NP0250958 (5-(hex-4-enoyl)-3,6-dihydroxy-1,3-dimethyl-7-(prop-1-en-1-yl)-8-(2,4,5-trihydroxy-3,5-dimethyl-6-oxocyclohexa-1,3-diene-1-carbonyl)bicyclo[2.2.2]oct-5-en-2-one)

PDB for NP0250958 (5-(hex-4-enoyl)-3,6-dihydroxy-1,3-dimethyl-7-(prop-1-en-1-yl)-8-(2,4,5-trihydroxy-3,5-dimethyl-6-oxocyclohexa-1,3-diene-1-carbonyl)bicyclo[2.2.2]oct-5-en-2-one)

3D PDB for NP0250958 (5-(hex-4-enoyl)-3,6-dihydroxy-1,3-dimethyl-7-(prop-1-en-1-yl)-8-(2,4,5-trihydroxy-3,5-dimethyl-6-oxocyclohexa-1,3-diene-1-carbonyl)bicyclo[2.2.2]oct-5-en-2-one)

SMILES for NP0250958 (5-(hex-4-enoyl)-3,6-dihydroxy-1,3-dimethyl-7-(prop-1-en-1-yl)-8-(2,4,5-trihydroxy-3,5-dimethyl-6-oxocyclohexa-1,3-diene-1-carbonyl)bicyclo[2.2.2]oct-5-en-2-one)

INCHI for NP0250958 (5-(hex-4-enoyl)-3,6-dihydroxy-1,3-dimethyl-7-(prop-1-en-1-yl)-8-(2,4,5-trihydroxy-3,5-dimethyl-6-oxocyclohexa-1,3-diene-1-carbonyl)bicyclo[2.2.2]oct-5-en-2-one)

Structure for NP0250958 (5-(hex-4-enoyl)-3,6-dihydroxy-1,3-dimethyl-7-(prop-1-en-1-yl)-8-(2,4,5-trihydroxy-3,5-dimethyl-6-oxocyclohexa-1,3-diene-1-carbonyl)bicyclo[2.2.2]oct-5-en-2-one)

3D Structure for NP0250958 (5-(hex-4-enoyl)-3,6-dihydroxy-1,3-dimethyl-7-(prop-1-en-1-yl)-8-(2,4,5-trihydroxy-3,5-dimethyl-6-oxocyclohexa-1,3-diene-1-carbonyl)bicyclo[2.2.2]oct-5-en-2-one)