NP-MRD: Showing NP-Card for (1as,2s,2as,5r,5as,6s,7ar)-2-(acetyloxy)-5-hydroxy-5-isopropyl-2a,7a-dimethyl-hexahydro-1ah-azuleno[5,6-b]oxiren-6-yl (2e)-2-methylbut-2-enoate (NP0248962)

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Record Information

Version

2.0

Created at

2022-09-07 11:23:41 UTC

Updated at

2022-09-07 11:23:41 UTC

NP-MRD ID

NP0248962

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(1as,2s,2as,5r,5as,6s,7ar)-2-(acetyloxy)-5-hydroxy-5-isopropyl-2a,7a-dimethyl-hexahydro-1ah-azuleno[5,6-b]oxiren-6-yl (2e)-2-methylbut-2-enoate

Description

Lapiferin belongs to the class of organic compounds known as fatty acid esters. These are carboxylic ester derivatives of a fatty acid. (1as,2s,2as,5r,5as,6s,7ar)-2-(acetyloxy)-5-hydroxy-5-isopropyl-2a,7a-dimethyl-hexahydro-1ah-azuleno[5,6-b]oxiren-6-yl (2e)-2-methylbut-2-enoate is found in Ferula communis. (1as,2s,2as,5r,5as,6s,7ar)-2-(acetyloxy)-5-hydroxy-5-isopropyl-2a,7a-dimethyl-hexahydro-1ah-azuleno[5,6-b]oxiren-6-yl (2e)-2-methylbut-2-enoate was first documented in 2005 (PMID: 15852493). Based on a literature review a small amount of articles have been published on Lapiferin (PMID: 28489375) (PMID: 33907850) (PMID: 32901688) (PMID: 20140803).

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309072213232D          

 28 30  0  0  1  0            999 V2000
    3.1135    4.5343    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4491    3.7806    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9642    3.1131    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1437    3.1993    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2998    2.3595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1203    2.2733    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8149    1.6920    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1505    0.9384    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.9752    0.9137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4701    0.2537    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.0913    0.7965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0578   -0.3253    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2626   -0.5448    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.5089   -0.8804    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.4843   -1.7051    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1861   -2.1387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9126   -1.7477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1615   -2.9633    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7766   -0.5005    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.7890   -1.3254    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0561   -0.9023    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4513   -0.3412    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7980    0.4074    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.9816    1.2118    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0173    0.6740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8578    1.4835    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3960    0.1312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6171    0.3090    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  0  0  0  0
  3  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  8  7  1  1  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  6  0  0  0
 10 12  1  0  0  0  0
 13 12  1  1  0  0  0
 10 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  1  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  2  0  0  0  0
 14 19  1  0  0  0  0
 19 20  1  6  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  6  0  0  0
 23 25  1  1  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 28 23  1  6  0  0  0
  8 28  1  0  0  0  0
 19 28  1  0  0  0  0
M  END

     RDKit          3D

 62 64  0  0  0  0  0  0  0  0999 V2000
    4.8509    2.2309    2.1646 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6649    1.4175    1.7300 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8727    0.2526    1.1446 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2471   -0.2154    0.9344 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7018   -0.5144    0.7346 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8229   -1.6389    0.1678 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4070   -0.0644    0.9380 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3102   -0.8215    0.5344 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.5267   -1.2873    1.7355 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2126   -2.5728    1.4963 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.5042   -3.7946    2.0529 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6471   -2.5851    1.8889 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1783   -2.7155    0.5109 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.5490   -1.5932   -0.3898 C   0  0  1  0  0  0  0  0  0  0  0  0
   -3.1113   -0.4919    0.3000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3783    0.0019    0.0197 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9247    1.1555    0.7669 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0500   -0.5713   -0.8996 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3825   -1.0807   -1.2261 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.5555   -2.2589   -1.6222 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8243   -0.3499   -2.4509 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1418    1.0195   -2.3709 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0129    0.8152   -1.3513 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.0380    0.2280   -2.0313 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3936    2.1589   -0.8697 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8722    2.9501   -2.0970 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6907    2.9634   -0.2366 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6399   -0.0812   -0.3660 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.5321    3.2259    2.5223 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.4240    1.6687    2.9307 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.5380    2.4167    1.3087 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.6761    1.8269    1.9182 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.5287   -0.3150   -0.1376 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.9910    0.4309    1.4125 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.4126   -1.2415    1.3747 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.6786   -1.7569    0.0669 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.2065   -1.3646    2.5789 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2297   -0.4525    1.9593 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1219   -3.5362    3.0769 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.3126   -4.1211    1.3964 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2209   -4.6251    2.1765 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4366   -3.7246    0.1182 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3207   -1.9208   -1.1405 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8624    1.0340    1.8600 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4409    2.0974    0.4038 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0053    1.2325    0.5191 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0650   -2.7256   -2.5162 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.4619   -2.0346   -1.9422 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6009   -3.0605   -0.8403 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9018   -0.2740   -2.5899 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4142   -0.8234   -3.3895 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7692    1.3546   -3.3395 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8930    1.7001   -1.9117 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.8660    0.6688   -1.7767 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.2833    2.1279   -0.1929 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.5199    3.7651   -1.7397 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0480    3.4208   -2.5231 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.3124    2.3054   -2.8590 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3659    3.4455   -0.9886 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2126    3.8256    0.3129 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3107    2.4478    0.4884 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3762    0.4252    0.2549 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  3  5  1  0
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  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  1
 10 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 16 18  2  0
 14 19  1  0
 19 20  1  6
 19 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  6
 23 25  1  0
 25 26  1  0
 25 27  1  0
 23 28  1  0
 28  8  1  0
 13 10  1  0
 28 19  1  0
  1 29  1  0
  1 30  1  0
  1 31  1  0
  2 32  1  0
  4 33  1  0
  4 34  1  0
  4 35  1  0
  8 36  1  6
  9 37  1  0
  9 38  1  0
 11 39  1  0
 11 40  1  0
 11 41  1  0
 13 42  1  6
 14 43  1  6
 17 44  1  0
 17 45  1  0
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 20 47  1  0
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 21 50  1  0
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 22 52  1  0
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 25 55  1  0
 26 56  1  0
 26 57  1  0
 26 58  1  0
 27 59  1  0
 27 60  1  0
 27 61  1  0
 28 62  1  1
M  END


  Mrv1652309072213232D          

 28 30  0  0  1  0            999 V2000
    3.1135    4.5343    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4491    3.7806    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9642    3.1131    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1437    3.1993    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2998    2.3595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1203    2.2733    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8149    1.6920    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1505    0.9384    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.9752    0.9137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4701    0.2537    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.0913    0.7965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0578   -0.3253    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2626   -0.5448    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.5089   -0.8804    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.4843   -1.7051    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1861   -2.1387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9126   -1.7477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1615   -2.9633    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7766   -0.5005    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.7890   -1.3254    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0561   -0.9023    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4513   -0.3412    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7980    0.4074    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.9816    1.2118    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0173    0.6740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8578    1.4835    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3960    0.1312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6171    0.3090    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  0  0  0  0
  3  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  8  7  1  1  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  6  0  0  0
 10 12  1  0  0  0  0
 13 12  1  1  0  0  0
 10 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  1  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  2  0  0  0  0
 14 19  1  0  0  0  0
 19 20  1  6  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  6  0  0  0
 23 25  1  1  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 28 23  1  6  0  0  0
  8 28  1  0  0  0  0
 19 28  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0248962

> <DATABASE_NAME>
NP-MRD

> <SMILES>
C\C=C(/C)C(=O)O[C@H]1C[C@@]2(C)O[C@H]2[C@@H](OC(C)=O)[C@@]2(C)CC[C@@](O)(C(C)C)[C@H]12

> <INCHI_IDENTIFIER>
InChI=1S/C22H34O6/c1-8-13(4)19(24)27-15-11-21(7)18(28-21)17(26-14(5)23)20(6)9-10-22(25,12(2)3)16(15)20/h8,12,15-18,25H,9-11H2,1-7H3/b13-8+/t15-,16+,17+,18-,20-,21+,22+/m0/s1

> <INCHI_KEY>
WVPPLOSRTXOZAP-GTRIHBNGSA-N

> <FORMULA>
C22H34O6

> <MOLECULAR_WEIGHT>
394.508

> <EXACT_MASS>
394.235538815

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_ATOM_COUNT>
62

> <JCHEM_AVERAGE_POLARIZABILITY>
42.72265983121552

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(1aS,2S,2aS,5R,5aS,6S,7aR)-2-(acetyloxy)-5-hydroxy-2a,7a-dimethyl-5-(propan-2-yl)-decahydroazuleno[5,6-b]oxiren-6-yl (2E)-2-methylbut-2-enoate

> <JCHEM_LOGP>
3.1239846213333324

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_ACIDIC>
14.265399678853392

> <JCHEM_PKA_STRONGEST_BASIC>
-3.1201141804695265

> <JCHEM_POLAR_SURFACE_AREA>
85.36

> <JCHEM_REFRACTIVITY>
103.6794

> <JCHEM_ROTATABLE_BOND_COUNT>
6

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
(1aS,2S,2aS,5R,5aS,6S,7aR)-2-(acetyloxy)-5-hydroxy-5-isopropyl-2a,7a-dimethyl-hexahydro-1aH-azuleno[5,6-b]oxiren-6-yl (2E)-2-methylbut-2-enoate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 07-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   07-SEP-22         0                                  
HETATM    1  C   UNK     0       5.812   8.464   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       6.438   7.057   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       5.533   5.811   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       4.002   5.972   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       6.160   4.404   0.000  0.00  0.00           C+0
HETATM    6  O   UNK     0       7.691   4.243   0.000  0.00  0.00           O+0
HETATM    7  O   UNK     0       5.255   3.158   0.000  0.00  0.00           O+0
HETATM    8  C   UNK     0       5.881   1.752   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       7.420   1.706   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       8.344   0.473   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       9.504   1.487   0.000  0.00  0.00           C+0
HETATM   12  O   UNK     0       9.441  -0.607   0.000  0.00  0.00           O+0
HETATM   13  C   UNK     0       7.957  -1.017   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       6.550  -1.643   0.000  0.00  0.00           C+0
HETATM   15  O   UNK     0       6.504  -3.183   0.000  0.00  0.00           O+0
HETATM   16  C   UNK     0       7.814  -3.992   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       9.170  -3.262   0.000  0.00  0.00           C+0
HETATM   18  O   UNK     0       7.768  -5.532   0.000  0.00  0.00           O+0
HETATM   19  C   UNK     0       5.183  -0.934   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       5.206  -2.474   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       3.838  -1.684   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       2.709  -0.637   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       3.356   0.761   0.000  0.00  0.00           C+0
HETATM   24  O   UNK     0       3.699   2.262   0.000  0.00  0.00           O+0
HETATM   25  C   UNK     0       1.899   1.258   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0       1.601   2.769   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0       0.739   0.245   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0       4.885   0.577   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4    5                                                  
CONECT    4    3                                                            
CONECT    5    3    6    7                                                  
CONECT    6    5                                                            
CONECT    7    5    8                                                       
CONECT    8    7    9   28                                                  
CONECT    9    8   10                                                       
CONECT   10    9   11   12   13                                             
CONECT   11   10                                                            
CONECT   12   10   13                                                       
CONECT   13   12   10   14                                                  
CONECT   14   13   15   19                                                  
CONECT   15   14   16                                                       
CONECT   16   15   17   18                                                  
CONECT   17   16                                                            
CONECT   18   16                                                            
CONECT   19   14   20   21   28                                             
CONECT   20   19                                                            
CONECT   21   19   22                                                       
CONECT   22   21   23                                                       
CONECT   23   22   24   25   28                                             
CONECT   24   23                                                            
CONECT   25   23   26   27                                                  
CONECT   26   25                                                            
CONECT   27   25                                                            
CONECT   28   23    8   19                                                  
MASTER        0    0    0    0    0    0    0    0   28    0   60    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₂H₃₄O₆

Average Mass

394.5080 Da

Monoisotopic Mass

394.23554 Da

IUPAC Name

(1aS,2S,2aS,5R,5aS,6S,7aR)-2-(acetyloxy)-5-hydroxy-2a,7a-dimethyl-5-(propan-2-yl)-decahydroazuleno[5,6-b]oxiren-6-yl (2E)-2-methylbut-2-enoate

Traditional Name

(1aS,2S,2aS,5R,5aS,6S,7aR)-2-(acetyloxy)-5-hydroxy-5-isopropyl-2a,7a-dimethyl-hexahydro-1aH-azuleno[5,6-b]oxiren-6-yl (2E)-2-methylbut-2-enoate

CAS Registry Number

Not Available

SMILES

C\C=C(/C)C(=O)O[C@H]1C[C@@]2(C)O[C@H]2[C@@H](OC(C)=O)[C@@]2(C)CC[C@@](O)(C(C)C)[C@H]12

InChI Identifier

InChI=1S/C22H34O6/c1-8-13(4)19(24)27-15-11-21(7)18(28-21)17(26-14(5)23)20(6)9-10-22(25,12(2)3)16(15)20/h8,12,15-18,25H,9-11H2,1-7H3/b13-8+/t15-,16+,17+,18-,20-,21+,22+/m0/s1

InChI Key

WVPPLOSRTXOZAP-GTRIHBNGSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Ferula communis	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as fatty acid esters. These are carboxylic ester derivatives of a fatty acid.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Fatty Acyls

Sub Class

Fatty acid esters

Direct Parent

Fatty acid esters

Alternative Parents

Substituents

Fatty acid ester
Dicarboxylic acid or derivatives
Cyclic alcohol
Tertiary alcohol
Enoate ester
Alpha,beta-unsaturated carboxylic ester
Carboxylic acid ester
Ether
Oxirane
Dialkyl ether
Carboxylic acid derivative
Organoheterocyclic compound
Oxacycle
Carbonyl group
Organooxygen compound
Organic oxide
Organic oxygen compound
Alcohol
Hydrocarbon derivative
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	3.12	ChemAxon
pKa (Strongest Acidic)	14.27	ChemAxon
pKa (Strongest Basic)	-3.1	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	85.36 Å²	ChemAxon
Rotatable Bond Count	6	ChemAxon
Refractivity	103.68 m³·mol⁻¹	ChemAxon
Polarizability	42.72 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

26616816

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

14239538

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Popovic V, Goeman JL, Bougarne N, Eyckerman S, Heyerick A, De Bosscher K, Van der Eycken J: Involvement of the Glucocorticoid Receptor in Pro-inflammatory Transcription Factor Inhibition by Daucane Esters from Laserpitium zernyi. J Nat Prod. 2017 May 26;80(5):1505-1513. doi: 10.1021/acs.jnatprod.7b00012. Epub 2017 May 10. [PubMed:28489375 ]
Liu L, Peng C, Ruan Y, Zhang Q: The natural product lapiferin inhibits cell proliferation and promotes cell apoptosis in gingival squamous cell carcinoma via P21 regulation. Mol Med Rep. 2021 Jul;24(1):482. doi: 10.3892/mmr.2021.12121. Epub 2021 Apr 28. [PubMed:33907850 ]
Pei L, Gao X, Liu W, Feng X, Zhao Z, Lai Y: Lapiferin protects against H1N1 virus-induced pulmonary inflammation by negatively regulating NF-kB signaling. Braz J Med Biol Res. 2020;53(10):e9183. doi: 10.1590/1414-431X20209183. Epub 2020 Sep 7. [PubMed:32901688 ]
Gamal-Eldeen AM, Hegazy ME: A crystal lapiferin derived from Ferula vesceritensis induces apoptosis pathway in MCF-7 breast cancer cells. Nat Prod Res. 2010 Feb;24(3):246-57. doi: 10.1080/14786410802685398. [PubMed:20140803 ]
Poli F, Appendino G, Sacchetti G, Ballero M, Maggiano N, Ranelletti FO: Antiproliferative effects of daucane esters from Ferula communis and F. arrigonii on human colon cancer cell lines. Phytother Res. 2005 Feb;19(2):152-7. doi: 10.1002/ptr.1443. [PubMed:15852493 ]
LOTUS database [Link]

Showing NP-Card for (1as,2s,2as,5r,5as,6s,7ar)-2-(acetyloxy)-5-hydroxy-5-isopropyl-2a,7a-dimethyl-hexahydro-1ah-azuleno[5,6-b]oxiren-6-yl (2e)-2-methylbut-2-enoate (NP0248962)

MOL for NP0248962 ((1as,2s,2as,5r,5as,6s,7ar)-2-(acetyloxy)-5-hydroxy-5-isopropyl-2a,7a-dimethyl-hexahydro-1ah-azuleno[5,6-b]oxiren-6-yl (2e)-2-methylbut-2-enoate)

3D MOL for NP0248962 ((1as,2s,2as,5r,5as,6s,7ar)-2-(acetyloxy)-5-hydroxy-5-isopropyl-2a,7a-dimethyl-hexahydro-1ah-azuleno[5,6-b]oxiren-6-yl (2e)-2-methylbut-2-enoate)

3D SDF for NP0248962 ((1as,2s,2as,5r,5as,6s,7ar)-2-(acetyloxy)-5-hydroxy-5-isopropyl-2a,7a-dimethyl-hexahydro-1ah-azuleno[5,6-b]oxiren-6-yl (2e)-2-methylbut-2-enoate)

3D-SDF for NP0248962 ((1as,2s,2as,5r,5as,6s,7ar)-2-(acetyloxy)-5-hydroxy-5-isopropyl-2a,7a-dimethyl-hexahydro-1ah-azuleno[5,6-b]oxiren-6-yl (2e)-2-methylbut-2-enoate)

PDB for NP0248962 ((1as,2s,2as,5r,5as,6s,7ar)-2-(acetyloxy)-5-hydroxy-5-isopropyl-2a,7a-dimethyl-hexahydro-1ah-azuleno[5,6-b]oxiren-6-yl (2e)-2-methylbut-2-enoate)

3D PDB for NP0248962 ((1as,2s,2as,5r,5as,6s,7ar)-2-(acetyloxy)-5-hydroxy-5-isopropyl-2a,7a-dimethyl-hexahydro-1ah-azuleno[5,6-b]oxiren-6-yl (2e)-2-methylbut-2-enoate)

SMILES for NP0248962 ((1as,2s,2as,5r,5as,6s,7ar)-2-(acetyloxy)-5-hydroxy-5-isopropyl-2a,7a-dimethyl-hexahydro-1ah-azuleno[5,6-b]oxiren-6-yl (2e)-2-methylbut-2-enoate)

INCHI for NP0248962 ((1as,2s,2as,5r,5as,6s,7ar)-2-(acetyloxy)-5-hydroxy-5-isopropyl-2a,7a-dimethyl-hexahydro-1ah-azuleno[5,6-b]oxiren-6-yl (2e)-2-methylbut-2-enoate)

Structure for NP0248962 ((1as,2s,2as,5r,5as,6s,7ar)-2-(acetyloxy)-5-hydroxy-5-isopropyl-2a,7a-dimethyl-hexahydro-1ah-azuleno[5,6-b]oxiren-6-yl (2e)-2-methylbut-2-enoate)

3D Structure for NP0248962 ((1as,2s,2as,5r,5as,6s,7ar)-2-(acetyloxy)-5-hydroxy-5-isopropyl-2a,7a-dimethyl-hexahydro-1ah-azuleno[5,6-b]oxiren-6-yl (2e)-2-methylbut-2-enoate)