NP-MRD: Showing NP-Card for (4s,11s,14s,17s)-14-[(1r)-1-hydroxyethyl]-4,11,17-triisopropyl-19-oxa-6-thia-3,10,13,16,21,22-hexaazatricyclo[16.2.1.1⁵,⁸]docosa-1(20),2,5(22),7,9,12,15,18(21)-octaene-2,9,12,15-tetrol (NP0248226)

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Record Information

Version

2.0

Created at

2022-09-07 10:23:41 UTC

Updated at

2022-09-07 10:23:41 UTC

NP-MRD ID

NP0248226

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(4s,11s,14s,17s)-14-[(1r)-1-hydroxyethyl]-4,11,17-triisopropyl-19-oxa-6-thia-3,10,13,16,21,22-hexaazatricyclo[16.2.1.1⁵,⁸]docosa-1(20),2,5(22),7,9,12,15,18(21)-octaene-2,9,12,15-tetrol

Description

Bistratamide I belongs to the class of organic compounds known as cyclic peptides. Cyclic peptides are compounds containing a cyclic moiety bearing a peptide backbone. Bistratamide I is a secondary metabolite. Secondary metabolites are metabolically or physiologically non-essential metabolites that may serve a role as defense or signalling molecules. In some cases they are simply molecules that arise from the incomplete metabolism of other secondary metabolites. (4s,11s,14s,17s)-14-[(1r)-1-hydroxyethyl]-4,11,17-triisopropyl-19-oxa-6-thia-3,10,13,16,21,22-hexaazatricyclo[16.2.1.1⁵,⁸]docosa-1(20),2,5(22),7,9,12,15,18(21)-octaene-2,9,12,15-tetrol is found in Lissoclinum bistratum. Based on a literature review very few articles have been published on bistratamide I.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309072212232D          

 38 40  0  0  1  0            999 V2000
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M  END

     RDKit          3D

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M  END


  Mrv1652309072212232D          

 38 40  0  0  1  0            999 V2000
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    5.4164   -4.7909    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    6.1342   -5.1976    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7053   -5.2093    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1207   -3.5476    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.8385   -3.9543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8453   -4.7792    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  4  0  0  0
  6  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
  8 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  1  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  2  0  0  0  0
 18 19  1  4  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 20 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  1  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
 25 29  1  0  0  0  0
 29 30  2  0  0  0  0
 30 31  1  4  0  0  0
 30 32  1  0  0  0  0
 32 33  1  1  0  0  0
 33 34  1  0  0  0  0
 33 35  1  1  0  0  0
 32 36  1  0  0  0  0
 36 37  2  0  0  0  0
  4 37  1  0  0  0  0
 37 38  1  4  0  0  0
M  END
> <DATABASE_ID>
NP0248226

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CC(C)[C@@H]1N=C(O)[C@@H](N=C(O)[C@@H](N=C(O)C2=CSC(=N2)[C@@H](N=C(O)C2=COC1=N2)C(C)C)C(C)C)[C@@H](C)O

> <INCHI_IDENTIFIER>
InChI=1S/C25H36N6O6S/c1-10(2)16-22(35)31-19(13(7)32)23(36)29-17(11(3)4)24-26-14(8-37-24)20(33)30-18(12(5)6)25-27-15(9-38-25)21(34)28-16/h8-13,16-19,32H,1-7H3,(H,28,34)(H,29,36)(H,30,33)(H,31,35)/t13-,16+,17+,18+,19+/m1/s1

> <INCHI_KEY>
LDXCESZYUWPDOR-RUZYHRDJSA-N

> <FORMULA>
C25H36N6O6S

> <MOLECULAR_WEIGHT>
548.66

> <EXACT_MASS>
548.241704077

> <JCHEM_ACCEPTOR_COUNT>
11

> <JCHEM_ATOM_COUNT>
74

> <JCHEM_AVERAGE_POLARIZABILITY>
57.35300877847309

> <JCHEM_BIOAVAILABILITY>
0

> <JCHEM_DONOR_COUNT>
5

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(4S,11S,14S,17S)-14-[(1R)-1-hydroxyethyl]-4,11,17-tris(propan-2-yl)-19-oxa-6-thia-3,10,13,16,21,22-hexaazatricyclo[16.2.1.1^{5,8}]docosa-1(20),2,5(22),7,9,12,15,18(21)-octaene-2,9,12,15-tetrol

> <JCHEM_LOGP>
1.333268661306812

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
3.090297242715903

> <JCHEM_PKA_STRONGEST_ACIDIC>
1.130957156751939

> <JCHEM_PKA_STRONGEST_BASIC>
5.172474857740587

> <JCHEM_POLAR_SURFACE_AREA>
189.50999999999996

> <JCHEM_REFRACTIVITY>
139.62190000000004

> <JCHEM_ROTATABLE_BOND_COUNT>
4

> <JCHEM_RULE_OF_FIVE>
0

> <JCHEM_TRADITIONAL_IUPAC>
(4S,11S,14S,17S)-14-[(1R)-1-hydroxyethyl]-4,11,17-triisopropyl-19-oxa-6-thia-3,10,13,16,21,22-hexaazatricyclo[16.2.1.1^{5,8}]docosa-1(20),2,5(22),7,9,12,15,18(21)-octaene-2,9,12,15-tetrol

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 07-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   07-SEP-22         0                                  
HETATM    1  C   UNK     0      15.445  -8.899   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      15.432  -7.359   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      16.760  -6.578   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      14.093  -6.600   0.000  0.00  0.00           C+0
HETATM    5  N   UNK     0      14.080  -5.060   0.000  0.00  0.00           N+0
HETATM    6  C   UNK     0      15.407  -4.279   0.000  0.00  0.00           C+0
HETATM    7  O   UNK     0      16.747  -5.039   0.000  0.00  0.00           O+0
HETATM    8  C   UNK     0      15.395  -2.740   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      16.416  -1.587   0.000  0.00  0.00           C+0
HETATM   10  S   UNK     0      15.635  -0.259   0.000  0.00  0.00           S+0
HETATM   11  C   UNK     0      14.042  -0.441   0.000  0.00  0.00           C+0
HETATM   12  N   UNK     0      14.055  -1.981   0.000  0.00  0.00           N+0
HETATM   13  C   UNK     0      12.702   0.318   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      12.689   1.858   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      14.017   2.639   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      11.349   2.617   0.000  0.00  0.00           C+0
HETATM   17  N   UNK     0      11.375  -0.462   0.000  0.00  0.00           N+0
HETATM   18  C   UNK     0      10.035   0.297   0.000  0.00  0.00           C+0
HETATM   19  O   UNK     0      10.022   1.837   0.000  0.00  0.00           O+0
HETATM   20  C   UNK     0       8.707  -0.484   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       7.199  -0.176   0.000  0.00  0.00           C+0
HETATM   22  O   UNK     0       6.439  -1.516   0.000  0.00  0.00           O+0
HETATM   23  C   UNK     0       7.393  -2.805   0.000  0.00  0.00           C+0
HETATM   24  N   UNK     0       8.720  -2.024   0.000  0.00  0.00           N+0
HETATM   25  C   UNK     0       7.405  -4.345   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0       6.078  -5.126   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0       6.091  -6.666   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0       4.738  -4.367   0.000  0.00  0.00           C+0
HETATM   29  N   UNK     0       8.745  -5.104   0.000  0.00  0.00           N+0
HETATM   30  C   UNK     0       8.758  -6.644   0.000  0.00  0.00           C+0
HETATM   31  O   UNK     0       7.431  -7.425   0.000  0.00  0.00           O+0
HETATM   32  C   UNK     0      10.098  -7.403   0.000  0.00  0.00           C+0
HETATM   33  C   UNK     0      10.111  -8.943   0.000  0.00  0.00           C+0
HETATM   34  C   UNK     0      11.451  -9.702   0.000  0.00  0.00           C+0
HETATM   35  O   UNK     0       8.783  -9.724   0.000  0.00  0.00           O+0
HETATM   36  N   UNK     0      11.425  -6.622   0.000  0.00  0.00           N+0
HETATM   37  C   UNK     0      12.765  -7.381   0.000  0.00  0.00           C+0
HETATM   38  O   UNK     0      12.778  -8.921   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3    4                                                  
CONECT    3    2                                                            
CONECT    4    2    5   37                                                  
CONECT    5    4    6                                                       
CONECT    6    5    7    8                                                  
CONECT    7    6                                                            
CONECT    8    6    9   12                                                  
CONECT    9    8   10                                                       
CONECT   10    9   11                                                       
CONECT   11   10   12   13                                                  
CONECT   12   11    8                                                       
CONECT   13   11   14   17                                                  
CONECT   14   13   15   16                                                  
CONECT   15   14                                                            
CONECT   16   14                                                            
CONECT   17   13   18                                                       
CONECT   18   17   19   20                                                  
CONECT   19   18                                                            
CONECT   20   18   21   24                                                  
CONECT   21   20   22                                                       
CONECT   22   21   23                                                       
CONECT   23   22   24   25                                                  
CONECT   24   23   20                                                       
CONECT   25   23   26   29                                                  
CONECT   26   25   27   28                                                  
CONECT   27   26                                                            
CONECT   28   26                                                            
CONECT   29   25   30                                                       
CONECT   30   29   31   32                                                  
CONECT   31   30                                                            
CONECT   32   30   33   36                                                  
CONECT   33   32   34   35                                                  
CONECT   34   33                                                            
CONECT   35   33                                                            
CONECT   36   32   37                                                       
CONECT   37   36    4   38                                                  
CONECT   38   37                                                            
MASTER        0    0    0    0    0    0    0    0   38    0   80    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₅H₃₆N₆O₆S

Average Mass

548.6600 Da

Monoisotopic Mass

548.24170 Da

IUPAC Name

(4S,11S,14S,17S)-14-[(1R)-1-hydroxyethyl]-4,11,17-tris(propan-2-yl)-19-oxa-6-thia-3,10,13,16,21,22-hexaazatricyclo[16.2.1.1^{5,8}]docosa-1(20),2,5(22),7,9,12,15,18(21)-octaene-2,9,12,15-tetrol

Traditional Name

(4S,11S,14S,17S)-14-[(1R)-1-hydroxyethyl]-4,11,17-triisopropyl-19-oxa-6-thia-3,10,13,16,21,22-hexaazatricyclo[16.2.1.1^{5,8}]docosa-1(20),2,5(22),7,9,12,15,18(21)-octaene-2,9,12,15-tetrol

CAS Registry Number

Not Available

SMILES

CC(C)[C@@H]1N=C(O)[C@@H](N=C(O)[C@@H](N=C(O)C2=CSC(=N2)[C@@H](N=C(O)C2=COC1=N2)C(C)C)C(C)C)[C@@H](C)O

InChI Identifier

InChI=1S/C25H36N6O6S/c1-10(2)16-22(35)31-19(13(7)32)23(36)29-17(11(3)4)24-26-14(8-37-24)20(33)30-18(12(5)6)25-27-15(9-38-25)21(34)28-16/h8-13,16-19,32H,1-7H3,(H,28,34)(H,29,36)(H,30,33)(H,31,35)/t13-,16+,17+,18+,19+/m1/s1

InChI Key

LDXCESZYUWPDOR-RUZYHRDJSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Lissoclinum bistratum	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as cyclic peptides. Cyclic peptides are compounds containing a cyclic moiety bearing a peptide backbone.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

Cyclic peptides

Alternative Parents

Substituents

Alpha-dipeptide
Cyclic alpha peptide
Macrolactam
Alpha-amino acid or derivatives
2-heteroaryl carboxamide
Thiazolecarboxylic acid or derivatives
Azole
Oxazole
Thiazole
Heteroaromatic compound
Secondary carboxylic acid amide
Secondary alcohol
Carboxamide group
Lactam
Organoheterocyclic compound
Oxacycle
Azacycle
Hydrocarbon derivative
Organonitrogen compound
Organopnictogen compound
Organooxygen compound
Organic oxygen compound
Organic nitrogen compound
Carbonyl group
Organic oxide
Alcohol
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

homodetic cyclic peptide (CHEBI:65508 )
macrocycle (CHEBI:65508 )

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	1.33	ChemAxon
pKa (Strongest Acidic)	1.13	ChemAxon
pKa (Strongest Basic)	5.17	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	11	ChemAxon
Hydrogen Donor Count	5	ChemAxon
Polar Surface Area	189.51 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	139.62 m³·mol⁻¹	ChemAxon
Polarizability	57.35 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

9267985

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

11092841

PDB ID

Not Available

ChEBI ID

65508

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for (4s,11s,14s,17s)-14-[(1r)-1-hydroxyethyl]-4,11,17-triisopropyl-19-oxa-6-thia-3,10,13,16,21,22-hexaazatricyclo[16.2.1.1⁵,⁸]docosa-1(20),2,5(22),7,9,12,15,18(21)-octaene-2,9,12,15-tetrol (NP0248226)

MOL for NP0248226 ((4s,11s,14s,17s)-14-[(1r)-1-hydroxyethyl]-4,11,17-triisopropyl-19-oxa-6-thia-3,10,13,16,21,22-hexaazatricyclo[16.2.1.1⁵,⁸]docosa-1(20),2,5(22),7,9,12,15,18(21)-octaene-2,9,12,15-tetrol)

3D MOL for NP0248226 ((4s,11s,14s,17s)-14-[(1r)-1-hydroxyethyl]-4,11,17-triisopropyl-19-oxa-6-thia-3,10,13,16,21,22-hexaazatricyclo[16.2.1.1⁵,⁸]docosa-1(20),2,5(22),7,9,12,15,18(21)-octaene-2,9,12,15-tetrol)

3D SDF for NP0248226 ((4s,11s,14s,17s)-14-[(1r)-1-hydroxyethyl]-4,11,17-triisopropyl-19-oxa-6-thia-3,10,13,16,21,22-hexaazatricyclo[16.2.1.1⁵,⁸]docosa-1(20),2,5(22),7,9,12,15,18(21)-octaene-2,9,12,15-tetrol)

3D-SDF for NP0248226 ((4s,11s,14s,17s)-14-[(1r)-1-hydroxyethyl]-4,11,17-triisopropyl-19-oxa-6-thia-3,10,13,16,21,22-hexaazatricyclo[16.2.1.1⁵,⁸]docosa-1(20),2,5(22),7,9,12,15,18(21)-octaene-2,9,12,15-tetrol)

PDB for NP0248226 ((4s,11s,14s,17s)-14-[(1r)-1-hydroxyethyl]-4,11,17-triisopropyl-19-oxa-6-thia-3,10,13,16,21,22-hexaazatricyclo[16.2.1.1⁵,⁸]docosa-1(20),2,5(22),7,9,12,15,18(21)-octaene-2,9,12,15-tetrol)

3D PDB for NP0248226 ((4s,11s,14s,17s)-14-[(1r)-1-hydroxyethyl]-4,11,17-triisopropyl-19-oxa-6-thia-3,10,13,16,21,22-hexaazatricyclo[16.2.1.1⁵,⁸]docosa-1(20),2,5(22),7,9,12,15,18(21)-octaene-2,9,12,15-tetrol)

SMILES for NP0248226 ((4s,11s,14s,17s)-14-[(1r)-1-hydroxyethyl]-4,11,17-triisopropyl-19-oxa-6-thia-3,10,13,16,21,22-hexaazatricyclo[16.2.1.1⁵,⁸]docosa-1(20),2,5(22),7,9,12,15,18(21)-octaene-2,9,12,15-tetrol)

INCHI for NP0248226 ((4s,11s,14s,17s)-14-[(1r)-1-hydroxyethyl]-4,11,17-triisopropyl-19-oxa-6-thia-3,10,13,16,21,22-hexaazatricyclo[16.2.1.1⁵,⁸]docosa-1(20),2,5(22),7,9,12,15,18(21)-octaene-2,9,12,15-tetrol)

Structure for NP0248226 ((4s,11s,14s,17s)-14-[(1r)-1-hydroxyethyl]-4,11,17-triisopropyl-19-oxa-6-thia-3,10,13,16,21,22-hexaazatricyclo[16.2.1.1⁵,⁸]docosa-1(20),2,5(22),7,9,12,15,18(21)-octaene-2,9,12,15-tetrol)

3D Structure for NP0248226 ((4s,11s,14s,17s)-14-[(1r)-1-hydroxyethyl]-4,11,17-triisopropyl-19-oxa-6-thia-3,10,13,16,21,22-hexaazatricyclo[16.2.1.1⁵,⁸]docosa-1(20),2,5(22),7,9,12,15,18(21)-octaene-2,9,12,15-tetrol)