NP-MRD: Showing NP-Card for (1s,2s,3r,4r,5s,7s,8r,11s,17s)-4-hydroxy-4,8,11-trimethyl-15-methylidene-10,18-dioxatetracyclo[9.7.0.0²,⁷.0³,¹⁷]octadecan-5-yl octanoate (NP0246947)

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Record Information

Version

2.0

Created at

2022-09-07 08:34:54 UTC

Updated at

2022-09-07 08:34:54 UTC

NP-MRD ID

NP0246947

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(1s,2s,3r,4r,5s,7s,8r,11s,17s)-4-hydroxy-4,8,11-trimethyl-15-methylidene-10,18-dioxatetracyclo[9.7.0.0²,⁷.0³,¹⁷]octadecan-5-yl octanoate

Description

(1S,2S,3R,4R,5S,7S,8R,11S,17S)-4-hydroxy-4,8,11-trimethyl-15-methylidene-10,18-dioxatetracyclo[9.7.0.0²,⁷.0³,¹⁷]Octadecan-5-yl octanoate belongs to the class of organic compounds known as oxepanes. Oxepanes are compounds containing an oxepane ring, which is a seven-member saturated aliphatic heterocycle with one oxygen and six carbon atoms. (1s,2s,3r,4r,5s,7s,8r,11s,17s)-4-hydroxy-4,8,11-trimethyl-15-methylidene-10,18-dioxatetracyclo[9.7.0.0²,⁷.0³,¹⁷]octadecan-5-yl octanoate is found in Briareum asbestinum. Based on a literature review very few articles have been published on (1S,2S,3R,4R,5S,7S,8R,11S,17S)-4-hydroxy-4,8,11-trimethyl-15-methylidene-10,18-dioxatetracyclo[9.7.0.0²,⁷.0³,¹⁷]Octadecan-5-yl octanoate.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309072210342D          

 33 36  0  0  1  0            999 V2000
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   -1.6977   -4.0967    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1738   -3.4350    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.9970   -3.3804    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 33 32  1  1  0  0  0
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M  END

     RDKit          3D

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M  END


  Mrv1652309072210342D          

 33 36  0  0  1  0            999 V2000
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    0.1866   -4.0330    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3418   -3.4216    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.2667   -2.9253    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  1  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  6  0  0  0
 10 12  1  0  0  0  0
 12 13  1  6  0  0  0
 13 14  1  0  0  0  0
 14 15  1  6  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 14 25  1  0  0  0  0
 25 26  1  1  0  0  0
 25 27  1  6  0  0  0
 25 28  1  0  0  0  0
 28 29  1  1  0  0  0
 29 30  1  0  0  0  0
  2 30  1  0  0  0  0
 29 31  1  1  0  0  0
 32 31  1  6  0  0  0
  6 32  1  0  0  0  0
 33 32  1  1  0  0  0
 12 33  1  0  0  0  0
 28 33  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0246947

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CCCCCCCC(=O)O[C@H]1C[C@@H]2[C@@H]3[C@@H]4O[C@@H](CC(=C)CCC[C@]4(C)OC[C@@H]2C)[C@@H]3[C@@]1(C)O

> <INCHI_IDENTIFIER>
InChI=1S/C28H46O5/c1-6-7-8-9-10-13-23(29)33-22-16-20-19(3)17-31-27(4)14-11-12-18(2)15-21-25(28(22,5)30)24(20)26(27)32-21/h19-22,24-26,30H,2,6-17H2,1,3-5H3/t19-,20-,21-,22-,24-,25-,26-,27-,28-/m0/s1

> <INCHI_KEY>
GGABJCIMEQXKJD-PLDABBGUSA-N

> <FORMULA>
C28H46O5

> <MOLECULAR_WEIGHT>
462.671

> <EXACT_MASS>
462.334524581

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_ATOM_COUNT>
79

> <JCHEM_AVERAGE_POLARIZABILITY>
54.1413044698015

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(1S,2S,3R,4R,5S,7S,8R,11S,17S)-4-hydroxy-4,8,11-trimethyl-15-methylidene-10,18-dioxatetracyclo[9.7.0.0^{2,7}.0^{3,17}]octadecan-5-yl octanoate

> <JCHEM_LOGP>
5.180957982

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_ACIDIC>
13.714421262545219

> <JCHEM_PKA_STRONGEST_BASIC>
-3.36111213976272

> <JCHEM_POLAR_SURFACE_AREA>
64.99000000000001

> <JCHEM_REFRACTIVITY>
128.9013

> <JCHEM_ROTATABLE_BOND_COUNT>
8

> <JCHEM_RULE_OF_FIVE>
0

> <JCHEM_TRADITIONAL_IUPAC>
(1S,2S,3R,4R,5S,7S,8R,11S,17S)-4-hydroxy-4,8,11-trimethyl-15-methylidene-10,18-dioxatetracyclo[9.7.0.0^{2,7}.0^{3,17}]octadecan-5-yl octanoate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 07-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   07-SEP-22         0                                  
HETATM    1  C   UNK     0      -0.192 -12.091   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -0.554 -10.594   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      -2.148 -10.393   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      -3.178  -9.222   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      -3.169  -7.647   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      -2.191  -6.412   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      -3.728  -6.310   0.000  0.00  0.00           C+0
HETATM    8  O   UNK     0      -3.007  -5.042   0.000  0.00  0.00           O+0
HETATM    9  C   UNK     0      -2.531  -3.569   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      -1.051  -3.078   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0      -0.885  -1.546   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       0.344  -3.906   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       1.755  -3.204   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       3.104  -3.981   0.000  0.00  0.00           C+0
HETATM   15  O   UNK     0       4.438  -3.211   0.000  0.00  0.00           O+0
HETATM   16  C   UNK     0       5.772  -3.981   0.000  0.00  0.00           C+0
HETATM   17  O   UNK     0       5.772  -5.521   0.000  0.00  0.00           O+0
HETATM   18  C   UNK     0       7.105  -3.211   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       8.439  -3.981   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       9.773  -3.211   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0      11.107  -3.981   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0      12.440  -3.211   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0      13.774  -3.981   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0      15.108  -3.211   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0       3.103  -5.545   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0       4.612  -5.239   0.000  0.00  0.00           C+0
HETATM   27  O   UNK     0       3.704  -6.963   0.000  0.00  0.00           O+0
HETATM   28  C   UNK     0       1.838  -6.415   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0       1.428  -8.109   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0       0.806  -9.664   0.000  0.00  0.00           C+0
HETATM   31  O   UNK     0       0.348  -7.528   0.000  0.00  0.00           O+0
HETATM   32  C   UNK     0      -0.638  -6.387   0.000  0.00  0.00           C+0
HETATM   33  C   UNK     0       0.498  -5.461   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3   30                                                  
CONECT    3    2    4                                                       
CONECT    4    3    5                                                       
CONECT    5    4    6                                                       
CONECT    6    5    7    8   32                                             
CONECT    7    6                                                            
CONECT    8    6    9                                                       
CONECT    9    8   10                                                       
CONECT   10    9   11   12                                                  
CONECT   11   10                                                            
CONECT   12   10   13   33                                                  
CONECT   13   12   14                                                       
CONECT   14   13   15   25                                                  
CONECT   15   14   16                                                       
CONECT   16   15   17   18                                                  
CONECT   17   16                                                            
CONECT   18   16   19                                                       
CONECT   19   18   20                                                       
CONECT   20   19   21                                                       
CONECT   21   20   22                                                       
CONECT   22   21   23                                                       
CONECT   23   22   24                                                       
CONECT   24   23                                                            
CONECT   25   14   26   27   28                                             
CONECT   26   25                                                            
CONECT   27   25                                                            
CONECT   28   25   29   33                                                  
CONECT   29   28   30   31                                                  
CONECT   30   29    2                                                       
CONECT   31   29   32                                                       
CONECT   32   31    6   33                                                  
CONECT   33   32   12   28                                                  
MASTER        0    0    0    0    0    0    0    0   33    0   72    0
END

View in JSmol

Synonyms

Value	Source
(1S,2S,3R,4R,5S,7S,8R,11S,17S)-4-Hydroxy-4,8,11-trimethyl-15-methylidene-10,18-dioxatetracyclo[9.7.0.0,.0,]octadecan-5-yl octanoic acid	Generator

Chemical Formula

C₂₈H₄₆O₅

Average Mass

462.6710 Da

Monoisotopic Mass

462.33452 Da

IUPAC Name

(1S,2S,3R,4R,5S,7S,8R,11S,17S)-4-hydroxy-4,8,11-trimethyl-15-methylidene-10,18-dioxatetracyclo[9.7.0.0^{2,7}.0^{3,17}]octadecan-5-yl octanoate

Traditional Name

(1S,2S,3R,4R,5S,7S,8R,11S,17S)-4-hydroxy-4,8,11-trimethyl-15-methylidene-10,18-dioxatetracyclo[9.7.0.0^{2,7}.0^{3,17}]octadecan-5-yl octanoate

CAS Registry Number

Not Available

SMILES

CCCCCCCC(=O)O[C@H]1C[C@@H]2[C@@H]3[C@@H]4O[C@@H](CC(=C)CCC[C@]4(C)OC[C@@H]2C)[C@@H]3[C@@]1(C)O

InChI Identifier

InChI=1S/C28H46O5/c1-6-7-8-9-10-13-23(29)33-22-16-20-19(3)17-31-27(4)14-11-12-18(2)15-21-25(28(22,5)30)24(20)26(27)32-21/h19-22,24-26,30H,2,6-17H2,1,3-5H3/t19-,20-,21-,22-,24-,25-,26-,27-,28-/m0/s1

InChI Key

GGABJCIMEQXKJD-PLDABBGUSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Briareum asbestinum	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as oxepanes. Oxepanes are compounds containing an oxepane ring, which is a seven-member saturated aliphatic heterocycle with one oxygen and six carbon atoms.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Oxepanes

Sub Class

Not Available

Direct Parent

Oxepanes

Alternative Parents

Substituents

Fatty acid ester
Oxepane
Fatty acyl
Cyclic alcohol
Tertiary alcohol
Tetrahydrofuran
Carboxylic acid ester
Monocarboxylic acid or derivatives
Ether
Dialkyl ether
Carboxylic acid derivative
Oxacycle
Hydrocarbon derivative
Organooxygen compound
Organic oxide
Organic oxygen compound
Alcohol
Carbonyl group
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	5.18	ChemAxon
pKa (Strongest Acidic)	13.71	ChemAxon
pKa (Strongest Basic)	-3.4	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	64.99 Å²	ChemAxon
Rotatable Bond Count	8	ChemAxon
Refractivity	128.9 m³·mol⁻¹	ChemAxon
Polarizability	54.14 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

8965553

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

10790241

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for (1s,2s,3r,4r,5s,7s,8r,11s,17s)-4-hydroxy-4,8,11-trimethyl-15-methylidene-10,18-dioxatetracyclo[9.7.0.0²,⁷.0³,¹⁷]octadecan-5-yl octanoate (NP0246947)

MOL for NP0246947 ((1s,2s,3r,4r,5s,7s,8r,11s,17s)-4-hydroxy-4,8,11-trimethyl-15-methylidene-10,18-dioxatetracyclo[9.7.0.0²,⁷.0³,¹⁷]octadecan-5-yl octanoate)

3D MOL for NP0246947 ((1s,2s,3r,4r,5s,7s,8r,11s,17s)-4-hydroxy-4,8,11-trimethyl-15-methylidene-10,18-dioxatetracyclo[9.7.0.0²,⁷.0³,¹⁷]octadecan-5-yl octanoate)

3D SDF for NP0246947 ((1s,2s,3r,4r,5s,7s,8r,11s,17s)-4-hydroxy-4,8,11-trimethyl-15-methylidene-10,18-dioxatetracyclo[9.7.0.0²,⁷.0³,¹⁷]octadecan-5-yl octanoate)

3D-SDF for NP0246947 ((1s,2s,3r,4r,5s,7s,8r,11s,17s)-4-hydroxy-4,8,11-trimethyl-15-methylidene-10,18-dioxatetracyclo[9.7.0.0²,⁷.0³,¹⁷]octadecan-5-yl octanoate)

PDB for NP0246947 ((1s,2s,3r,4r,5s,7s,8r,11s,17s)-4-hydroxy-4,8,11-trimethyl-15-methylidene-10,18-dioxatetracyclo[9.7.0.0²,⁷.0³,¹⁷]octadecan-5-yl octanoate)

3D PDB for NP0246947 ((1s,2s,3r,4r,5s,7s,8r,11s,17s)-4-hydroxy-4,8,11-trimethyl-15-methylidene-10,18-dioxatetracyclo[9.7.0.0²,⁷.0³,¹⁷]octadecan-5-yl octanoate)

SMILES for NP0246947 ((1s,2s,3r,4r,5s,7s,8r,11s,17s)-4-hydroxy-4,8,11-trimethyl-15-methylidene-10,18-dioxatetracyclo[9.7.0.0²,⁷.0³,¹⁷]octadecan-5-yl octanoate)

INCHI for NP0246947 ((1s,2s,3r,4r,5s,7s,8r,11s,17s)-4-hydroxy-4,8,11-trimethyl-15-methylidene-10,18-dioxatetracyclo[9.7.0.0²,⁷.0³,¹⁷]octadecan-5-yl octanoate)

Structure for NP0246947 ((1s,2s,3r,4r,5s,7s,8r,11s,17s)-4-hydroxy-4,8,11-trimethyl-15-methylidene-10,18-dioxatetracyclo[9.7.0.0²,⁷.0³,¹⁷]octadecan-5-yl octanoate)

3D Structure for NP0246947 ((1s,2s,3r,4r,5s,7s,8r,11s,17s)-4-hydroxy-4,8,11-trimethyl-15-methylidene-10,18-dioxatetracyclo[9.7.0.0²,⁷.0³,¹⁷]octadecan-5-yl octanoate)