NP-MRD: Showing NP-Card for 1-[1-(3,4-dimethyloxolan-2-yl)-1,2-dihydroxypropan-2-yl]-3a,7,8-trihydroxy-9a,11a-dimethyl-1h,2h,3h,5ah,6h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-5-one (NP0246011)

Jump To Section:

Identification Spectra BioTaxonomy ChemoTaxonomy Physical properties Links References XML

Record Information

Version

2.0

Created at

2022-09-07 07:18:49 UTC

Updated at

2022-09-07 07:18:49 UTC

NP-MRD ID

NP0246011

Secondary Accession Numbers

None

Natural Product Identification

Common Name

1-[1-(3,4-dimethyloxolan-2-yl)-1,2-dihydroxypropan-2-yl]-3a,7,8-trihydroxy-9a,11a-dimethyl-1h,2h,3h,5ah,6h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-5-one

Description

14-[1-(3,4-Dimethyloxolan-2-yl)-1,2-dihydroxypropan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]Heptadec-9-en-8-one belongs to the class of organic compounds known as pentahydroxy bile acids, alcohols and derivatives. These are bile acids, alcohols or derivatives bearing five hydroxyl groups. 1-[1-(3,4-dimethyloxolan-2-yl)-1,2-dihydroxypropan-2-yl]-3a,7,8-trihydroxy-9a,11a-dimethyl-1h,2h,3h,5ah,6h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-5-one is found in Polyporus umbellatus. 14-[1-(3,4-Dimethyloxolan-2-yl)-1,2-dihydroxypropan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]Heptadec-9-en-8-one is an extremely weak basic (essentially neutral) compound (based on its pKa).

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1533004251508032D          

 35 39  0  0  0  0            999 V2000
   -0.8032   -4.3033    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0757   -3.9143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0371   -3.0970    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8492   -2.9518    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2383   -3.6793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0556   -3.7922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3665   -4.5563    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5619   -3.1408    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2132   -3.6472    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9106   -2.6345    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0683   -2.4895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8390   -1.6970    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5218   -1.2340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1731   -1.7404    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3708   -0.9394    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9853   -1.5952    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2655   -0.8192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0777   -0.6740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3580    0.1019    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6095   -1.3047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4216   -1.1595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9534   -1.7902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7655   -1.6450    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.6731   -2.5662    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2049   -3.1969    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.8610   -2.7114    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3292   -2.0807    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0489   -2.8566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5171   -2.2259    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2368   -3.0018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4247   -3.1470    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8928   -2.5163    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5330   -3.2587    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6667   -4.2741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8119   -5.0863    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 20 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
 16 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 11 32  1  0  0  0  0
 14 32  1  0  0  0  0
 32 33  1  0  0  0  0
  5 34  1  0  0  0  0
  2 34  1  0  0  0  0
 34 35  1  0  0  0  0
M  END

     RDKit          3D

 79 83  0  0  0  0  0  0  0  0999 V2000
    7.2165    1.7054    1.6831 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7271    0.5700    0.8393 C   0  0  2  0  0  0  0  0  0  0  0  0
    6.4211    1.0961   -0.5357 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0737    0.9694   -0.7280 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6463   -0.1374   -0.0070 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.1545   -0.1764    0.1763 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.7246    0.9250    0.8330 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5133   -0.4736   -1.1579 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.8449    0.5737   -2.1603 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2198   -1.6404   -1.5791 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1128   -0.9368   -1.0718 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.5899   -1.2208   -2.4597 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7004   -0.3867   -2.5228 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1793   -0.6439   -1.1091 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.3689   -1.9971   -0.9707 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2769    0.1957   -0.6623 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1087    0.8480   -1.4511 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1523    1.6433   -0.8361 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6584    2.5979   -1.4507 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6357    1.3288    0.5441 C   0  0  1  0  0  0  0  0  0  0  0  0
   -6.1204    1.1744    0.5608 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4953   -0.0450   -0.2470 C   0  0  2  0  0  0  0  0  0  0  0  0
   -7.8841   -0.1241   -0.3164 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9176   -1.2472    0.4632 C   0  0  1  0  0  0  0  0  0  0  0  0
   -6.2935   -2.3764   -0.2822 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4294   -1.1736    0.4944 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9168    0.1015    1.0905 C   0  0  2  0  0  0  0  0  0  0  0  0
   -4.1141    0.1149    2.6046 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4579    0.3125    0.8335 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.5973   -0.7573    1.4402 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1686   -0.6728    1.0673 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0839   -0.1696   -0.3487 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.0656    1.2918   -0.3899 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3765    0.0399    1.3088 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.5387   -1.2939    1.9823 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4427    1.9138    2.4639 H   0  0  0  0  0  0  0  0  0  0  0  0
    8.1991    1.5178    2.1560 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.3230    2.6575    1.0985 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.4720   -0.2466    0.7302 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.9863    0.5857   -1.3370 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.6908    2.1838   -0.6294 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.0414   -1.0900   -0.4350 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.9564   -1.0648    0.8462 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.3229    1.7030    0.6986 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.7999    0.3691   -2.7237 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.0918    0.7301   -2.9656 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.0739    1.5608   -1.6519 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.0994   -1.8042   -2.5324 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.1475   -1.9459   -0.5512 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.2688   -1.0517   -3.2776 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.2225   -2.2697   -2.5621 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3590   -0.8107   -3.2893 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4998    0.6609   -2.7312 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8805   -2.2986   -1.7870 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9833    0.7672   -2.5107 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3257    2.1801    1.1848 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.5521    2.0499    0.0318 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.5088    1.1467    1.5834 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0470    0.0349   -1.2390 H   0  0  0  0  0  0  0  0  0  0  0  0
   -8.3157    0.7688   -0.1310 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3615   -1.3520    1.4865 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9438   -2.2047   -1.2073 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0331   -1.3337   -0.5069 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0734   -2.0095    1.1578 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1482    0.3443    2.8733 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4770    0.9590    2.9749 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7328   -0.8241    3.0665 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1987    1.3072    1.2056 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6874   -0.6313    2.5605 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0525   -1.7655    1.2513 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.3748   -0.0964    1.8264 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.2604   -1.7166    1.0891 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.8267    1.8216   -0.9423 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.1026    1.6972    0.6663 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9104    1.7258   -0.7716 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.8185    0.7779    1.8961 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.7261   -1.5063    2.7137 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.4917   -1.3485    2.5768 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.5179   -2.1076    1.2076 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  6  8  1  0
  8  9  1  0
  8 10  1  6
  8 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  6
 14 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 18 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 22 24  1  0
 24 25  1  0
 24 26  1  0
 26 27  1  0
 27 28  1  1
 27 29  1  0
 29 30  1  0
 30 31  1  0
 31 32  1  0
 32 33  1  1
  5 34  1  0
 34 35  1  0
 34  2  1  0
 32 11  1  0
 32 14  1  0
 29 16  1  0
 27 20  1  0
  1 36  1  0
  1 37  1  0
  1 38  1  0
  2 39  1  6
  3 40  1  0
  3 41  1  0
  5 42  1  6
  6 43  1  1
  7 44  1  0
  9 45  1  0
  9 46  1  0
  9 47  1  0
 10 48  1  0
 11 49  1  1
 12 50  1  0
 12 51  1  0
 13 52  1  0
 13 53  1  0
 15 54  1  0
 17 55  1  0
 20 56  1  1
 21 57  1  0
 21 58  1  0
 22 59  1  6
 23 60  1  0
 24 61  1  1
 25 62  1  0
 26 63  1  0
 26 64  1  0
 28 65  1  0
 28 66  1  0
 28 67  1  0
 29 68  1  1
 30 69  1  0
 30 70  1  0
 31 71  1  0
 31 72  1  0
 33 73  1  0
 33 74  1  0
 33 75  1  0
 34 76  1  1
 35 77  1  0
 35 78  1  0
 35 79  1  0
M  END


  Mrv1533004251508032D          

 35 39  0  0  0  0            999 V2000
   -0.8032   -4.3033    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0757   -3.9143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0371   -3.0970    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8492   -2.9518    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2383   -3.6793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0556   -3.7922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3665   -4.5563    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5619   -3.1408    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2132   -3.6472    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9106   -2.6345    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0683   -2.4895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8390   -1.6970    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5218   -1.2340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1731   -1.7404    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3708   -0.9394    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9853   -1.5952    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2655   -0.8192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0777   -0.6740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3580    0.1019    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6095   -1.3047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4216   -1.1595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9534   -1.7902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7655   -1.6450    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.6731   -2.5662    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2049   -3.1969    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.8610   -2.7114    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3292   -2.0807    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0489   -2.8566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5171   -2.2259    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2368   -3.0018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4247   -3.1470    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8928   -2.5163    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5330   -3.2587    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6667   -4.2741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8119   -5.0863    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 20 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
 16 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 11 32  1  0  0  0  0
 14 32  1  0  0  0  0
 32 33  1  0  0  0  0
  5 34  1  0  0  0  0
  2 34  1  0  0  0  0
 34 35  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0246011

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CC1COC(C(O)C(C)(O)C2CCC3(O)C4=CC(=O)C5CC(O)C(O)CC5(C)C4CCC23C)C1C

> <INCHI_IDENTIFIER>
InChI=1S/C28H44O7/c1-14-13-35-23(15(14)2)24(32)27(5,33)22-7-9-28(34)17-10-19(29)18-11-20(30)21(31)12-25(18,3)16(17)6-8-26(22,28)4/h10,14-16,18,20-24,30-34H,6-9,11-13H2,1-5H3

> <INCHI_KEY>
HHPPCGSBRMCORM-UHFFFAOYSA-N

> <FORMULA>
C28H44O7

> <MOLECULAR_WEIGHT>
492.653

> <EXACT_MASS>
492.308703757

> <JCHEM_ACCEPTOR_COUNT>
7

> <JCHEM_ATOM_COUNT>
79

> <JCHEM_AVERAGE_POLARIZABILITY>
54.22862552948377

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
5

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
14-[1-(3,4-dimethyloxolan-2-yl)-1,2-dihydroxypropan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-9-en-8-one

> <ALOGPS_LOGP>
1.28

> <JCHEM_LOGP>
1.1740247946666653

> <ALOGPS_LOGS>
-3.18

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
5

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
13.57328213245843

> <JCHEM_PKA_STRONGEST_ACIDIC>
12.868205942290036

> <JCHEM_PKA_STRONGEST_BASIC>
-3.153288443303487

> <JCHEM_POLAR_SURFACE_AREA>
127.45000000000002

> <JCHEM_REFRACTIVITY>
131.21439999999998

> <JCHEM_ROTATABLE_BOND_COUNT>
3

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
3.25e-01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
14-[1-(3,4-dimethyloxolan-2-yl)-1,2-dihydroxypropan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-9-en-8-one

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 25-APR-15   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   25-APR-15         0                                  
HETATM    1  C   UNK     0      -1.499  -8.033   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -0.141  -7.307   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       0.069  -5.781   0.000  0.00  0.00           C+0
HETATM    4  O   UNK     0       1.585  -5.510   0.000  0.00  0.00           O+0
HETATM    5  C   UNK     0       2.312  -6.868   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       3.837  -7.079   0.000  0.00  0.00           C+0
HETATM    7  O   UNK     0       4.417  -8.505   0.000  0.00  0.00           O+0
HETATM    8  C   UNK     0       4.782  -5.863   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       5.998  -6.808   0.000  0.00  0.00           C+0
HETATM   10  O   UNK     0       3.566  -4.918   0.000  0.00  0.00           O+0
HETATM   11  C   UNK     0       5.727  -4.647   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       5.299  -3.168   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       6.574  -2.304   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       7.790  -3.249   0.000  0.00  0.00           C+0
HETATM   15  O   UNK     0       8.159  -1.754   0.000  0.00  0.00           O+0
HETATM   16  C   UNK     0       9.306  -2.978   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       9.829  -1.529   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      11.345  -1.258   0.000  0.00  0.00           C+0
HETATM   19  O   UNK     0      11.868   0.190   0.000  0.00  0.00           O+0
HETATM   20  C   UNK     0      12.338  -2.436   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0      13.854  -2.164   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0      14.846  -3.342   0.000  0.00  0.00           C+0
HETATM   23  O   UNK     0      16.362  -3.071   0.000  0.00  0.00           O+0
HETATM   24  C   UNK     0      14.323  -4.790   0.000  0.00  0.00           C+0
HETATM   25  O   UNK     0      15.316  -5.967   0.000  0.00  0.00           O+0
HETATM   26  C   UNK     0      12.807  -5.061   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0      11.814  -3.884   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0      11.291  -5.332   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0      10.299  -4.155   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0       9.775  -5.603   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0       8.259  -5.874   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0       7.267  -4.697   0.000  0.00  0.00           C+0
HETATM   33  C   UNK     0       6.595  -6.083   0.000  0.00  0.00           C+0
HETATM   34  C   UNK     0       1.244  -7.978   0.000  0.00  0.00           C+0
HETATM   35  C   UNK     0       1.515  -9.494   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3   34                                                  
CONECT    3    2    4                                                       
CONECT    4    3    5                                                       
CONECT    5    4    6   34                                                  
CONECT    6    5    7    8                                                  
CONECT    7    6                                                            
CONECT    8    6    9   10   11                                             
CONECT    9    8                                                            
CONECT   10    8                                                            
CONECT   11    8   12   32                                                  
CONECT   12   11   13                                                       
CONECT   13   12   14                                                       
CONECT   14   13   15   16   32                                             
CONECT   15   14                                                            
CONECT   16   14   17   29                                                  
CONECT   17   16   18                                                       
CONECT   18   17   19   20                                                  
CONECT   19   18                                                            
CONECT   20   18   21   27                                                  
CONECT   21   20   22                                                       
CONECT   22   21   23   24                                                  
CONECT   23   22                                                            
CONECT   24   22   25   26                                                  
CONECT   25   24                                                            
CONECT   26   24   27                                                       
CONECT   27   26   20   28   29                                             
CONECT   28   27                                                            
CONECT   29   27   16   30                                                  
CONECT   30   29   31                                                       
CONECT   31   30   32                                                       
CONECT   32   31   11   14   33                                             
CONECT   33   32                                                            
CONECT   34    5    2   35                                                  
CONECT   35   34                                                            
MASTER        0    0    0    0    0    0    0    0   35    0   78    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₈H₄₄O₇

Average Mass

492.6530 Da

Monoisotopic Mass

492.30870 Da

IUPAC Name

14-[1-(3,4-dimethyloxolan-2-yl)-1,2-dihydroxypropan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-9-en-8-one

Traditional Name

14-[1-(3,4-dimethyloxolan-2-yl)-1,2-dihydroxypropan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-9-en-8-one

CAS Registry Number

Not Available

SMILES

CC1COC(C(O)C(C)(O)C2CCC3(O)C4=CC(=O)C5CC(O)C(O)CC5(C)C4CCC23C)C1C

InChI Identifier

InChI=1S/C28H44O7/c1-14-13-35-23(15(14)2)24(32)27(5,33)22-7-9-28(34)17-10-19(29)18-11-20(30)21(31)12-25(18,3)16(17)6-8-26(22,28)4/h10,14-16,18,20-24,30-34H,6-9,11-13H2,1-5H3

InChI Key

HHPPCGSBRMCORM-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Polyporus umbellatus	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as pentahydroxy bile acids, alcohols and derivatives. These are bile acids, alcohols or derivatives bearing five hydroxyl groups.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Steroids and steroid derivatives

Sub Class

Bile acids, alcohols and derivatives

Direct Parent

Pentahydroxy bile acids, alcohols and derivatives

Alternative Parents

Substituents

Pentahydroxy bile acid, alcohol, or derivatives
Cholesterol-skeleton
Cholestane-skeleton
Ecdysteroid
22-hydroxysteroid
20-hydroxysteroid
2-hydroxysteroid
14-hydroxysteroid
Hydroxysteroid
3-hydroxy-delta-7-steroid
Oxosteroid
3-hydroxysteroid
6-oxosteroid
Delta-7-steroid
Cyclohexenone
Tertiary alcohol
Tetrahydrofuran
Cyclic alcohol
Secondary alcohol
Ketone
Oxacycle
Organoheterocyclic compound
Dialkyl ether
Ether
Polyol
Organic oxygen compound
Hydrocarbon derivative
Organic oxide
Alcohol
Carbonyl group
Organooxygen compound
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	1.28	ALOGPS
logP	1.17	ChemAxon
logS	-3.2	ALOGPS
pKa (Strongest Acidic)	12.87	ChemAxon
pKa (Strongest Basic)	-3.2	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	7	ChemAxon
Hydrogen Donor Count	5	ChemAxon
Polar Surface Area	127.45 Å²	ChemAxon
Rotatable Bond Count	3	ChemAxon
Refractivity	131.21 m³·mol⁻¹	ChemAxon
Polarizability	54.23 Å³	ChemAxon
Number of Rings	5	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

75028481

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for 1-[1-(3,4-dimethyloxolan-2-yl)-1,2-dihydroxypropan-2-yl]-3a,7,8-trihydroxy-9a,11a-dimethyl-1h,2h,3h,5ah,6h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-5-one (NP0246011)

MOL for NP0246011 (1-[1-(3,4-dimethyloxolan-2-yl)-1,2-dihydroxypropan-2-yl]-3a,7,8-trihydroxy-9a,11a-dimethyl-1h,2h,3h,5ah,6h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-5-one)

3D MOL for NP0246011 (1-[1-(3,4-dimethyloxolan-2-yl)-1,2-dihydroxypropan-2-yl]-3a,7,8-trihydroxy-9a,11a-dimethyl-1h,2h,3h,5ah,6h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-5-one)

3D SDF for NP0246011 (1-[1-(3,4-dimethyloxolan-2-yl)-1,2-dihydroxypropan-2-yl]-3a,7,8-trihydroxy-9a,11a-dimethyl-1h,2h,3h,5ah,6h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-5-one)

3D-SDF for NP0246011 (1-[1-(3,4-dimethyloxolan-2-yl)-1,2-dihydroxypropan-2-yl]-3a,7,8-trihydroxy-9a,11a-dimethyl-1h,2h,3h,5ah,6h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-5-one)

PDB for NP0246011 (1-[1-(3,4-dimethyloxolan-2-yl)-1,2-dihydroxypropan-2-yl]-3a,7,8-trihydroxy-9a,11a-dimethyl-1h,2h,3h,5ah,6h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-5-one)

3D PDB for NP0246011 (1-[1-(3,4-dimethyloxolan-2-yl)-1,2-dihydroxypropan-2-yl]-3a,7,8-trihydroxy-9a,11a-dimethyl-1h,2h,3h,5ah,6h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-5-one)

SMILES for NP0246011 (1-[1-(3,4-dimethyloxolan-2-yl)-1,2-dihydroxypropan-2-yl]-3a,7,8-trihydroxy-9a,11a-dimethyl-1h,2h,3h,5ah,6h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-5-one)

INCHI for NP0246011 (1-[1-(3,4-dimethyloxolan-2-yl)-1,2-dihydroxypropan-2-yl]-3a,7,8-trihydroxy-9a,11a-dimethyl-1h,2h,3h,5ah,6h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-5-one)

Structure for NP0246011 (1-[1-(3,4-dimethyloxolan-2-yl)-1,2-dihydroxypropan-2-yl]-3a,7,8-trihydroxy-9a,11a-dimethyl-1h,2h,3h,5ah,6h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-5-one)

3D Structure for NP0246011 (1-[1-(3,4-dimethyloxolan-2-yl)-1,2-dihydroxypropan-2-yl]-3a,7,8-trihydroxy-9a,11a-dimethyl-1h,2h,3h,5ah,6h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-5-one)