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Showing NP-Card for hitachimycin (NP0245768)

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Record Information
Version2.0
Created at2022-09-07 06:58:19 UTC
Updated at2022-09-07 06:58:19 UTC
NP-MRD IDNP0245768
Secondary Accession NumbersNone
Natural Product Identification
Common Namehitachimycin
Description(+)-Hitachimycin belongs to the class of organic compounds known as benzene and substituted derivatives. These are aromatic compounds containing one monocyclic ring system consisting of benzene. hitachimycin was first documented in 2004 (PMID: 15023978). Based on a literature review a small amount of articles have been published on (+)-Hitachimycin (PMID: 35403858) (PMID: 33625847) (PMID: 29464421) (PMID: 25786909).
Structure
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MOLSDFPDBSMILESInChI

MOL for NP0245768 (hitachimycin)


  Mrv1652309072208582D          

 35 37  0  0  1  0            999 V2000
   -1.8661   -2.1690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4536   -1.4545    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6286   -1.4545    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.1437   -0.7871    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6410   -1.0420    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.9088   -0.2617    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4156    0.3893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8568    0.9963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1062    0.8405    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9060    1.0431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7282    0.9749    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4837    0.6435    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0906    0.0848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7417    0.5915    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4833   -0.6408    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6191   -1.4545    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    6.4441   -1.4545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8566   -0.7401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6816   -0.7401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0941   -1.4545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6816   -2.1690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8566   -2.1690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4833   -2.2683    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0906   -2.9939    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4837   -3.5526    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7282   -3.8840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9060   -3.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1062   -3.7496    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.7748   -4.5051    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4156   -3.2984    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9088   -2.6473    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1833   -3.0400    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6410   -1.8670    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1437   -2.1220    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3986   -2.9066    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  3  2  1  1  0  0  0
  3  4  1  0  0  0  0
  5  4  1  6  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  4  0  0  0
 13 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  6  0  0  0
 17 18  2  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 17 22  1  0  0  0  0
 16 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  6  0  0  0
 28 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  2  0  0  0  0
 31 33  1  0  0  0  0
  5 33  1  0  0  0  0
 33 34  2  0  0  0  0
  3 34  1  0  0  0  0
 34 35  1  0  0  0  0
M  END
Download

3D MOL for NP0245768 (hitachimycin)

Download
3D SDF for NP0245768 (hitachimycin)

  Mrv1652309072208582D          

 35 37  0  0  1  0            999 V2000
   -1.8661   -2.1690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4536   -1.4545    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6286   -1.4545    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.1437   -0.7871    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6410   -1.0420    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.9088   -0.2617    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4156    0.3893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8568    0.9963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1062    0.8405    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9060    1.0431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7282    0.9749    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4837    0.6435    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0906    0.0848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7417    0.5915    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4833   -0.6408    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6191   -1.4545    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    6.4441   -1.4545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8566   -0.7401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6816   -0.7401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0941   -1.4545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6816   -2.1690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8566   -2.1690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4833   -2.2683    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0906   -2.9939    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4837   -3.5526    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7282   -3.8840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9060   -3.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1062   -3.7496    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.7748   -4.5051    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4156   -3.2984    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9088   -2.6473    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1833   -3.0400    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6410   -1.8670    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1437   -2.1220    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3986   -2.9066    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  3  2  1  1  0  0  0
  3  4  1  0  0  0  0
  5  4  1  6  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  4  0  0  0
 13 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  6  0  0  0
 17 18  2  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 17 22  1  0  0  0  0
 16 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  6  0  0  0
 28 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  2  0  0  0  0
 31 33  1  0  0  0  0
  5 33  1  0  0  0  0
 33 34  2  0  0  0  0
  3 34  1  0  0  0  0
 34 35  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0245768

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CO[C@H]1C[C@@H]2\C=C(\C)/C=C\C=C/C(O)=N[C@@H](C\C=C/CC[C@H](O)CC(=O)C2=C1O)C1=CC=CC=C1

> <INCHI_IDENTIFIER>
InChI=1S/C29H35NO5/c1-20-11-9-10-16-27(33)30-24(21-12-5-3-6-13-21)15-8-4-7-14-23(31)19-25(32)28-22(17-20)18-26(35-2)29(28)34/h3-6,8-13,16-17,22-24,26,31,34H,7,14-15,18-19H2,1-2H3,(H,30,33)/b8-4-,11-9-,16-10-,20-17-/t22-,23-,24-,26-/m0/s1

> <INCHI_KEY>
PLQKHNPZPRTISL-ULKJNZDWSA-N

> <FORMULA>
C29H35NO5

> <MOLECULAR_WEIGHT>
477.601

> <EXACT_MASS>
477.251523231

> <JCHEM_ACCEPTOR_COUNT>
6

> <JCHEM_ATOM_COUNT>
70

> <JCHEM_AVERAGE_POLARIZABILITY>
51.94688505537204

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(9S,15S,19S,20aR)-7,15,18-trihydroxy-19-methoxy-2-methyl-9-phenyl-9H,10H,13H,14H,15H,16H,17H,19H,20H,20aH-cyclopenta[i]azacyclononadecan-17-one

> <JCHEM_LOGP>
4.396291700333332

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
9.370414285544904

> <JCHEM_PKA_STRONGEST_ACIDIC>
6.457400570424646

> <JCHEM_PKA_STRONGEST_BASIC>
4.047835512153342

> <JCHEM_POLAR_SURFACE_AREA>
99.35000000000001

> <JCHEM_REFRACTIVITY>
143.31520000000003

> <JCHEM_ROTATABLE_BOND_COUNT>
2

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
(9S,15S,19S,20aR)-7,15,18-trihydroxy-19-methoxy-2-methyl-9-phenyl-9H,10H,13H,14H,15H,16H,19H,20H,20aH-cyclopenta[i]azacyclononadecan-17-one

> <JCHEM_VEBER_RULE>
0

$$$$

Download
3D-SDF for NP0245768 (hitachimycin)
Download
PDB for NP0245768 (hitachimycin)
HEADER    PROTEIN                                 07-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   07-SEP-22         0                                  
HETATM    1  C   UNK     0      -3.483  -4.049   0.000  0.00  0.00           C+0
HETATM    2  O   UNK     0      -2.713  -2.715   0.000  0.00  0.00           O+0
HETATM    3  C   UNK     0      -1.173  -2.715   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      -0.268  -1.469   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       1.196  -1.945   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       1.696  -0.489   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       2.642   0.727   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       1.599   1.860   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       3.932   1.569   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       5.424   1.947   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       6.959   1.820   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       8.370   1.201   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       9.503   0.158   0.000  0.00  0.00           C+0
HETATM   14  O   UNK     0      10.718   1.104   0.000  0.00  0.00           O+0
HETATM   15  N   UNK     0      10.235  -1.196   0.000  0.00  0.00           N+0
HETATM   16  C   UNK     0      10.489  -2.715   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      12.029  -2.715   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      12.799  -1.381   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0      14.339  -1.381   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0      15.109  -2.715   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0      14.339  -4.049   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0      12.799  -4.049   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0      10.235  -4.234   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0       9.503  -5.589   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0       8.370  -6.632   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0       6.959  -7.250   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0       5.424  -7.377   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0       3.932  -6.999   0.000  0.00  0.00           C+0
HETATM   29  O   UNK     0       3.313  -8.410   0.000  0.00  0.00           O+0
HETATM   30  C   UNK     0       2.642  -6.157   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0       1.696  -4.942   0.000  0.00  0.00           C+0
HETATM   32  O   UNK     0       0.342  -5.675   0.000  0.00  0.00           O+0
HETATM   33  C   UNK     0       1.196  -3.485   0.000  0.00  0.00           C+0
HETATM   34  C   UNK     0      -0.268  -3.961   0.000  0.00  0.00           C+0
HETATM   35  O   UNK     0      -0.744  -5.426   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4   34                                                  
CONECT    4    3    5                                                       
CONECT    5    4    6   33                                                  
CONECT    6    5    7                                                       
CONECT    7    6    8    9                                                  
CONECT    8    7                                                            
CONECT    9    7   10                                                       
CONECT   10    9   11                                                       
CONECT   11   10   12                                                       
CONECT   12   11   13                                                       
CONECT   13   12   14   15                                                  
CONECT   14   13                                                            
CONECT   15   13   16                                                       
CONECT   16   15   17   23                                                  
CONECT   17   16   18   22                                                  
CONECT   18   17   19                                                       
CONECT   19   18   20                                                       
CONECT   20   19   21                                                       
CONECT   21   20   22                                                       
CONECT   22   21   17                                                       
CONECT   23   16   24                                                       
CONECT   24   23   25                                                       
CONECT   25   24   26                                                       
CONECT   26   25   27                                                       
CONECT   27   26   28                                                       
CONECT   28   27   29   30                                                  
CONECT   29   28                                                            
CONECT   30   28   31                                                       
CONECT   31   30   32   33                                                  
CONECT   32   31                                                            
CONECT   33   31    5   34                                                  
CONECT   34   33    3   35                                                  
CONECT   35   34                                                            
MASTER        0    0    0    0    0    0    0    0   35    0   74    0
END

Download
3D PDB for NP0245768 (hitachimycin)
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SMILES for NP0245768 (hitachimycin)
CO[C@H]1C[C@@H]2\C=C(\C)/C=C\C=C/C(O)=N[C@@H](C\C=C/CC[C@H](O)CC(=O)C2=C1O)C1=CC=CC=C1
Download
INCHI for NP0245768 (hitachimycin)
InChI=1S/C29H35NO5/c1-20-11-9-10-16-27(33)30-24(21-12-5-3-6-13-21)15-8-4-7-14-23(31)19-25(32)28-22(17-20)18-26(35-2)29(28)34/h3-6,8-13,16-17,22-24,26,31,34H,7,14-15,18-19H2,1-2H3,(H,30,33)/b8-4-,11-9-,16-10-,20-17-/t22-,23-,24-,26-/m0/s1
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View in JSmol
SynonymsNot Available
Chemical FormulaC29H35NO5
Average Mass477.6010 Da
Monoisotopic Mass477.25152 Da
IUPAC Name(9S,15S,19S,20aR)-7,15,18-trihydroxy-19-methoxy-2-methyl-9-phenyl-9H,10H,13H,14H,15H,16H,17H,19H,20H,20aH-cyclopenta[i]azacyclononadecan-17-one
Traditional Name(9S,15S,19S,20aR)-7,15,18-trihydroxy-19-methoxy-2-methyl-9-phenyl-9H,10H,13H,14H,15H,16H,19H,20H,20aH-cyclopenta[i]azacyclononadecan-17-one
CAS Registry NumberNot Available
SMILES
CO[C@H]1C[C@@H]2\C=C(\C)/C=C\C=C/C(O)=N[C@@H](C\C=C/CC[C@H](O)CC(=O)C2=C1O)C1=CC=CC=C1
InChI Identifier
InChI=1S/C29H35NO5/c1-20-11-9-10-16-27(33)30-24(21-12-5-3-6-13-21)15-8-4-7-14-23(31)19-25(32)28-22(17-20)18-26(35-2)29(28)34/h3-6,8-13,16-17,22-24,26,31,34H,7,14-15,18-19H2,1-2H3,(H,30,33)/b8-4-,11-9-,16-10-,20-17-/t22-,23-,24-,26-/m0/s1
InChI KeyPLQKHNPZPRTISL-ULKJNZDWSA-N
Experimental Spectra
Not Available
Predicted Spectra
Not Available
Chemical Shift Submissions
Not Available
Species
Species of OriginNot Available
Chemical Taxonomy
Description Belongs to the class of organic compounds known as benzene and substituted derivatives. These are aromatic compounds containing one monocyclic ring system consisting of benzene.
KingdomOrganic compounds  
Super ClassBenzenoids  
ClassBenzene and substituted derivatives  
Sub ClassNot Available
Direct ParentBenzene and substituted derivatives  
Alternative Parents
Substituents
  • Monocyclic benzene moiety
    • 

  • Vinylogous acid
    • 

  • Cyclic carboximidic acid
    • 

  • Secondary alcohol
    • 

  • Ketone
    • 

  • Azacycle
    • 

  • Organoheterocyclic compound
    • 

  • Organic 1,3-dipolar compound
    • 

  • Propargyl-type 1,3-dipolar organic compound
    • 

  • Polyol
    • 

  • Ether
    • 

  • Enol
    • 

  • Dialkyl ether
    • 

  • Organic nitrogen compound
    • 

  • Organic oxygen compound
    • 

  • Organopnictogen compound
    • 

  • Organic oxide
    • 

  • Hydrocarbon derivative
    • 

  • Organooxygen compound
    • 

  • Organonitrogen compound
    • 

  • Carbonyl group
    • 

  • Alcohol
    • 

  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External DescriptorsNot Available
Physical Properties
StateNot Available
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP4.4ChemAxon
pKa (Strongest Acidic)6.46ChemAxon
pKa (Strongest Basic)4.05ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area99.35 ŲChemAxon
Rotatable Bond Count2ChemAxon
Refractivity143.32 m³·mol⁻¹ChemAxon
Polarizability51.95 ųChemAxon
Number of Rings3ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
HMDB IDNot Available
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FoodDB IDNot Available
KNApSAcK IDNot Available
Chemspider IDNot Available
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem Compound101529348  
PDB IDNot Available
ChEBI IDNot Available
Good Scents IDNot Available
References
General References
  1. Rodriguez-Pena K, Gomez-Roman MP, Macias-Rubalcava ML, Rocha-Zavaleta L, Rodriguez-Sanoja R, Sanchez S: Bioinformatic comparison of three Embleya species and description of steffimycins production by Embleya sp. NF3. Appl Microbiol Biotechnol. 2022 Apr;106(8):3173-3190. doi:  10.1007/s00253-022-11915-0. Epub 2022 Apr 11. [PubMed:35403858  ] 
  2. Kudo F, Takahashi S, Miyanaga A, Nakazawa Y, Nishino K, Hayakawa Y, Kawamura K, Ishikawa F, Tanabe G, Iwai N, Nagumo Y, Usui T, Eguchi T: Mutational Biosynthesis of Hitachimycin Analogs Controlled by the beta-Amino Acid-Selective Adenylation Enzyme HitB. ACS Chem Biol. 2021 Mar 19;16(3):539-547. doi: 10.1021/acschembio.1c00003. Epub  2021 Feb 24. [PubMed:33625847  ] 
  3. Ottilie S, Goldgof GM, Cheung AL, Walker JL, Vigil E, Allen KE, Antonova-Koch Y, Slayman CW, Suzuki Y, Durrant JD: Two inhibitors of yeast plasma membrane ATPase 1 (ScPma1p): toward the development of novel antifungal therapies. J Cheminform. 2018 Feb 20;10(1):6. doi: 10.1186/s13321-018-0261-3. [PubMed:29464421  ] 
  4. Kudo F, Kawamura K, Uchino A, Miyanaga A, Numakura M, Takayanagi R, Eguchi T: Genome mining of the hitachimycin biosynthetic gene cluster: involvement of a phenylalanine-2,3-aminomutase in biosynthesis. Chembiochem. 2015 Apr 13;16(6):909-14. doi: 10.1002/cbic.201500040. Epub 2015 Mar  18. [PubMed:25786909  ] 
  5. Ping X, Takahashi Y, Seino A, Iwai Y, Omura S: Streptomyces scabrisporus sp. nov. Int J Syst Evol Microbiol. 2004 Mar;54(Pt 2):577-581. doi: 10.1099/ijs.0.02692-0. [PubMed:15023978  ] 
  6. LOTUS database [Link]