NP-MRD: Showing NP-Card for minovincine (NP0245131)

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Record Information

Version

1.0

Created at

2022-09-07 06:05:59 UTC

Updated at

2022-09-07 06:05:59 UTC

NP-MRD ID

NP0245131

Secondary Accession Numbers

None

Natural Product Identification

Common Name

minovincine

Description

Methyl 12-acetyl-5-methoxy-8,16-diazapentacyclo[10.6.1.0¹,⁹.0²,⁷.0¹⁶,¹⁹]Nonadeca-2(7),3,5,9-tetraene-10-carboxylate belongs to the class of organic compounds known as phenolic glycosides. These are organic compounds containing a phenolic structure attached to a glycosyl moiety. Some examples of phenolic structures include lignans, and flavonoids. Among the sugar units found in natural glycosides are D-glucose, L-Fructose, and L rhamnose. minovincine is found in Catharanthus trichophyllus and Vinca minor. Methyl 12-acetyl-5-methoxy-8,16-diazapentacyclo[10.6.1.0¹,⁹.0²,⁷.0¹⁶,¹⁹]Nonadeca-2(7),3,5,9-tetraene-10-carboxylate is a very strong basic compound (based on its pKa).

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1533004201502272D          

 28 32  0  0  0  0            999 V2000
    2.0785    5.7235    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9486    4.9088    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5892    4.3890    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3597    4.6838    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4593    3.5743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0999    3.0544    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9149    3.1826    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2886    2.4471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0853    2.2327    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2980    1.4356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0946    1.2213    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6786    1.8040    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7140    0.8529    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9173    1.0673    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7047    1.8644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9700    2.2397    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4885    1.5980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0384    0.9066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0695    1.1301    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    0.8353    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6584    1.3552    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7883    2.1699    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5589    2.4647    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6888    3.2794    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1995    1.9448    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9183    2.9846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0482    3.7993    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1477    2.6897    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 10 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
  8 15  1  0  0  0  0
 15 16  1  0  0  0  0
  6 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
  5 24  1  0  0  0  0
 23 25  1  0  0  0  0
 16 25  1  0  0  0  0
 19 25  1  0  0  0  0
 23 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
M  END

     RDKit          3D

 54 58  0  0  0  0  0  0  0  0999 V2000
   -0.7259    5.3460   -0.4797 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5030    3.9888   -0.1558 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5913    3.1317   -0.1220 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7213    3.6254   -0.3855 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4427    1.7262    0.2019 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2420    1.2595    0.4706 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0562    1.8435    0.5163 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0142    0.7729    0.3011 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3775    0.8257    0.0239 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0131   -0.3349   -0.4112 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3706   -0.3126   -0.6950 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1808    0.8149   -0.5769 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2937   -1.4969   -0.5577 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9226   -1.5275   -0.2681 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2786   -0.3891    0.1682 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0229   -0.1108    0.7596 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.1597   -0.5361    2.2313 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0607   -2.0522    2.0265 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6731   -2.2133    0.6830 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7553   -3.1658    0.6855 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1195   -2.5388    0.7159 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3521   -1.5048   -0.3637 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1958   -0.5310   -0.4594 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.7309   -0.3678   -1.8368 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2136   -1.5084   -2.6369 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7617    0.7325   -2.3612 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6574    0.8661    0.1014 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2074   -0.9291    0.5356 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.2610    5.8211   -0.7246 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3490    5.4321   -1.3852 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1338    5.9085    0.3911 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.3217    2.8379    0.6682 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.9408    1.7245    0.1356 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.3515    1.0440    0.4894 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.1626    0.6041   -1.0481 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.7068    1.6790   -1.0830 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.8118   -2.3755   -0.8988 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.4083   -2.4435   -0.3962 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6878   -0.1286    2.8004 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.1545   -0.3056    2.6174 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.9440   -2.5087    2.0083 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7166   -2.4426    2.8073 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6747   -3.7505   -0.2712 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7028   -3.8938    1.4952 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3428   -2.1514    1.7243 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8516   -3.3634    0.5122 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2690   -0.9372   -0.0500 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6047   -1.9651   -1.3325 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3457   -1.1650   -3.2526 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9709   -1.8888   -3.3517 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7996   -2.3245   -1.9918 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1210    0.7001    1.0793 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3606    1.2817   -0.6005 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8225   -0.8030    1.5468 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 10 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  1  1
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 27  1  0
 23 28  1  0
 23 24  1  6
 24 25  1  0
 24 26  2  0
 27  5  1  0
 16  6  1  0
 28 16  1  0
 15  8  1  0
 28 19  1  0
  1 29  1  0
  1 30  1  0
  1 31  1  0
  7 32  1  0
  9 33  1  0
 12 34  1  0
 12 35  1  0
 12 36  1  0
 13 37  1  0
 14 38  1  0
 17 39  1  0
 17 40  1  0
 18 41  1  0
 18 42  1  0
 20 43  1  0
 20 44  1  0
 21 45  1  0
 21 46  1  0
 22 47  1  0
 22 48  1  0
 27 52  1  0
 27 53  1  0
 28 54  1  1
 25 49  1  0
 25 50  1  0
 25 51  1  0
M  END


  Mrv1533004201502272D          

 28 32  0  0  0  0            999 V2000
    2.0785    5.7235    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9486    4.9088    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5892    4.3890    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3597    4.6838    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4593    3.5743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0999    3.0544    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9149    3.1826    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2886    2.4471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0853    2.2327    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2980    1.4356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0946    1.2213    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6786    1.8040    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7140    0.8529    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9173    1.0673    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7047    1.8644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9700    2.2397    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4885    1.5980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0384    0.9066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0695    1.1301    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    0.8353    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6584    1.3552    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7883    2.1699    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5589    2.4647    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6888    3.2794    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1995    1.9448    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9183    2.9846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0482    3.7993    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1477    2.6897    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 10 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
  8 15  1  0  0  0  0
 15 16  1  0  0  0  0
  6 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
  5 24  1  0  0  0  0
 23 25  1  0  0  0  0
 16 25  1  0  0  0  0
 19 25  1  0  0  0  0
 23 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0245131

> <DATABASE_NAME>
NP-MRD

> <SMILES>
COC(=O)C1=C2NC3=CC(OC)=CC=C3C22CCN3CCCC(C1)(C23)C(C)=O

> <INCHI_IDENTIFIER>
InChI=1S/C22H26N2O4/c1-13(25)21-7-4-9-24-10-8-22(20(21)24)16-6-5-14(27-2)11-17(16)23-18(22)15(12-21)19(26)28-3/h5-6,11,20,23H,4,7-10,12H2,1-3H3

> <INCHI_KEY>
UPEIYBJSTNGANI-UHFFFAOYSA-N

> <FORMULA>
C22H26N2O4

> <MOLECULAR_WEIGHT>
382.46

> <EXACT_MASS>
382.189257325

> <JCHEM_ACCEPTOR_COUNT>
5

> <JCHEM_ATOM_COUNT>
54

> <JCHEM_AVERAGE_POLARIZABILITY>
41.6182322230887

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
methyl 12-acetyl-5-methoxy-8,16-diazapentacyclo[10.6.1.0¹,⁹.0²,⁷.0¹⁶,¹⁹]nonadeca-2,4,6,9-tetraene-10-carboxylate

> <ALOGPS_LOGP>
2.41

> <JCHEM_LOGP>
1.7129098636666673

> <ALOGPS_LOGS>
-3.15

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
5

> <JCHEM_PHYSIOLOGICAL_CHARGE>
1

> <JCHEM_PKA>
18.717217037517344

> <JCHEM_PKA_STRONGEST_ACIDIC>
13.585722310966975

> <JCHEM_PKA_STRONGEST_BASIC>
9.438574406779248

> <JCHEM_POLAR_SURFACE_AREA>
67.87

> <JCHEM_REFRACTIVITY>
107.41569999999999

> <JCHEM_ROTATABLE_BOND_COUNT>
4

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
2.68e-01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
methyl 12-acetyl-5-methoxy-8,16-diazapentacyclo[10.6.1.0¹,⁹.0²,⁷.0¹⁶,¹⁹]nonadeca-2,4,6,9-tetraene-10-carboxylate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 20-APR-15   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   20-APR-15         0                                  
HETATM    1  C   UNK     0       3.880  10.684   0.000  0.00  0.00           C+0
HETATM    2  O   UNK     0       3.637   9.163   0.000  0.00  0.00           O+0
HETATM    3  C   UNK     0       4.833   8.193   0.000  0.00  0.00           C+0
HETATM    4  O   UNK     0       6.271   8.743   0.000  0.00  0.00           O+0
HETATM    5  C   UNK     0       4.591   6.672   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       5.786   5.702   0.000  0.00  0.00           C+0
HETATM    7  N   UNK     0       7.308   5.941   0.000  0.00  0.00           N+0
HETATM    8  C   UNK     0       8.005   4.568   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       9.493   4.168   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       9.890   2.680   0.000  0.00  0.00           C+0
HETATM   11  O   UNK     0      11.377   2.280   0.000  0.00  0.00           O+0
HETATM   12  C   UNK     0      12.467   3.367   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       8.799   1.592   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       7.312   1.992   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       6.915   3.480   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       5.544   4.181   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       6.512   2.983   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       5.672   1.692   0.000  0.00  0.00           C+0
HETATM   19  N   UNK     0       3.863   2.110   0.000  0.00  0.00           N+0
HETATM   20  C   UNK     0       2.425   1.559   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       1.229   2.530   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       1.472   4.050   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       2.910   4.601   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0       3.152   6.122   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0       4.106   3.630   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0       1.714   5.571   0.000  0.00  0.00           C+0
HETATM   27  O   UNK     0       1.957   7.092   0.000  0.00  0.00           O+0
HETATM   28  C   UNK     0       0.276   5.021   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4    5                                                  
CONECT    4    3                                                            
CONECT    5    3    6   24                                                  
CONECT    6    5    7   16                                                  
CONECT    7    6    8                                                       
CONECT    8    7    9   15                                                  
CONECT    9    8   10                                                       
CONECT   10    9   11   13                                                  
CONECT   11   10   12                                                       
CONECT   12   11                                                            
CONECT   13   10   14                                                       
CONECT   14   13   15                                                       
CONECT   15   14    8   16                                                  
CONECT   16   15    6   17   25                                             
CONECT   17   16   18                                                       
CONECT   18   17   19                                                       
CONECT   19   18   20   25                                                  
CONECT   20   19   21                                                       
CONECT   21   20   22                                                       
CONECT   22   21   23                                                       
CONECT   23   22   24   25   26                                             
CONECT   24   23    5                                                       
CONECT   25   23   16   19                                                  
CONECT   26   23   27   28                                                  
CONECT   27   26                                                            
CONECT   28   26                                                            
MASTER        0    0    0    0    0    0    0    0   28    0   64    0
END

View in JSmol

Synonyms

Value	Source
Methyl 12-acetyl-5-methoxy-8,16-diazapentacyclo[10.6.1.0,.0,.0,]nonadeca-2(7),3,5,9-tetraene-10-carboxylic acid	Generator

Chemical Formula

C₂₂H₂₆N₂O₄

Average Mass

382.4600 Da

Monoisotopic Mass

382.18926 Da

IUPAC Name

methyl 12-acetyl-5-methoxy-8,16-diazapentacyclo[10.6.1.0¹,⁹.0²,⁷.0¹⁶,¹⁹]nonadeca-2,4,6,9-tetraene-10-carboxylate

Traditional Name

methyl 12-acetyl-5-methoxy-8,16-diazapentacyclo[10.6.1.0¹,⁹.0²,⁷.0¹⁶,¹⁹]nonadeca-2,4,6,9-tetraene-10-carboxylate

CAS Registry Number

Not Available

SMILES

COC(=O)C1=C2NC3=CC(OC)=CC=C3C22CCN3CCCC(C1)(C23)C(C)=O

InChI Identifier

InChI=1S/C22H26N2O4/c1-13(25)21-7-4-9-24-10-8-22(20(21)24)16-6-5-14(27-2)11-17(16)23-18(22)15(12-21)19(26)28-3/h5-6,11,20,23H,4,7-10,12H2,1-3H3

InChI Key

UPEIYBJSTNGANI-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Catharanthus trichophyllus	LOTUS Database	35616633
Vinca minor	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as phenolic glycosides. These are organic compounds containing a phenolic structure attached to a glycosyl moiety. Some examples of phenolic structures include lignans, and flavonoids. Among the sugar units found in natural glycosides are D-glucose, L-Fructose, and L rhamnose.

Kingdom

Organic compounds

Super Class

Organic oxygen compounds

Class

Organooxygen compounds

Sub Class

Carbohydrates and carbohydrate conjugates

Direct Parent

Phenolic glycosides

Alternative Parents

Substituents

Phenolic glycoside
Cinnamic acid or derivatives
Coumaric acid or derivatives
Hydroxycinnamic acid or derivatives
Cinnamic acid ester
O-glycosyl compound
3-phenylpropanoic-acid
Phenoxy compound
Catechol
Phenol ether
Styrene
1-hydroxy-4-unsubstituted benzenoid
1-hydroxy-2-unsubstituted benzenoid
Fatty acid ester
Phenol
Monocyclic benzene moiety
Fatty acyl
Oxane
Benzenoid
Monosaccharide
Dicarboxylic acid or derivatives
Enoate ester
Alpha,beta-unsaturated carboxylic ester
Secondary alcohol
Carboxylic acid ester
Polyol
Organoheterocyclic compound
Oxacycle
Carboxylic acid derivative
Carboxylic acid
Acetal
Carbonyl group
Hydrocarbon derivative
Alcohol
Organic oxide
Aromatic heteromonocyclic compound

Molecular Framework

Aromatic heteromonocyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	2.41	ALOGPS
logP	1.71	ChemAxon
logS	-3.2	ALOGPS
pKa (Strongest Acidic)	13.59	ChemAxon
pKa (Strongest Basic)	9.44	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	67.87 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	107.42 m³·mol⁻¹	ChemAxon
Polarizability	41.62 Å³	ChemAxon
Number of Rings	5	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

586568

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for minovincine (NP0245131)

MOL for NP0245131 (minovincine)

3D MOL for NP0245131 (minovincine)

3D SDF for NP0245131 (minovincine)

3D-SDF for NP0245131 (minovincine)

PDB for NP0245131 (minovincine)

3D PDB for NP0245131 (minovincine)

SMILES for NP0245131 (minovincine)

INCHI for NP0245131 (minovincine)

Structure for NP0245131 (minovincine)

3D Structure for NP0245131 (minovincine)