NP-MRD: Showing NP-Card for 5-[2-(3,4-dihydroxyphenyl)-4-[(1e)-2-(3,4-dihydroxyphenyl)ethenyl]-6-hydroxy-2,3-dihydro-1-benzofuran-3-yl]benzene-1,3-diol (NP0242205)

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Record Information

Version

2.0

Created at

2022-09-07 02:28:07 UTC

Updated at

2022-09-07 02:28:07 UTC

NP-MRD ID

NP0242205

Secondary Accession Numbers

None

Natural Product Identification

Common Name

5-[2-(3,4-dihydroxyphenyl)-4-[(1e)-2-(3,4-dihydroxyphenyl)ethenyl]-6-hydroxy-2,3-dihydro-1-benzofuran-3-yl]benzene-1,3-diol

Description

Scirpusin B belongs to the class of organic compounds known as 2-arylbenzofuran flavonoids. These are phenylpropanoids containing the 2-phenylbenzofuran moiety. 5-[2-(3,4-dihydroxyphenyl)-4-[(1e)-2-(3,4-dihydroxyphenyl)ethenyl]-6-hydroxy-2,3-dihydro-1-benzofuran-3-yl]benzene-1,3-diol is found in Bolboschoenus fluviatilis, Caragana tibetica, Cyperus rotundus, Maackia amurensis, Melaleuca leucadendra, Schoenoplectus californicus and Senna garrettiana. 5-[2-(3,4-dihydroxyphenyl)-4-[(1e)-2-(3,4-dihydroxyphenyl)ethenyl]-6-hydroxy-2,3-dihydro-1-benzofuran-3-yl]benzene-1,3-diol was first documented in 2020 (PMID: 31986026). Based on a literature review a small amount of articles have been published on Scirpusin B (PMID: 35597313) (PMID: 35177914) (PMID: 34498252).

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309072204282D          

 36 40  0  0  0  0            999 V2000
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M  END

     RDKit          3D

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M  END


  Mrv1652309072204282D          

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M  END
> <DATABASE_ID>
NP0242205

> <DATABASE_NAME>
NP-MRD

> <SMILES>
OC1=CC(\C=C\C2=CC=C(O)C(O)=C2)=C2C(C(OC2=C1)C1=CC=C(O)C(O)=C1)C1=CC(O)=CC(O)=C1

> <INCHI_IDENTIFIER>
InChI=1S/C28H22O8/c29-18-9-17(10-19(30)12-18)27-26-15(3-1-14-2-5-21(32)23(34)7-14)8-20(31)13-25(26)36-28(27)16-4-6-22(33)24(35)11-16/h1-13,27-35H/b3-1+

> <INCHI_KEY>
MTYSFTYBAMMIGE-HNQUOIGGSA-N

> <FORMULA>
C28H22O8

> <MOLECULAR_WEIGHT>
486.476

> <EXACT_MASS>
486.131467668

> <JCHEM_ACCEPTOR_COUNT>
8

> <JCHEM_ATOM_COUNT>
58

> <JCHEM_AVERAGE_POLARIZABILITY>
49.49866947924907

> <JCHEM_BIOAVAILABILITY>
0

> <JCHEM_DONOR_COUNT>
7

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
4-[3-(3,5-dihydroxyphenyl)-4-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-6-hydroxy-2,3-dihydro-1-benzofuran-2-yl]benzene-1,2-diol

> <JCHEM_LOGP>
5.3533638266666665

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
5

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
8.841373026255022

> <JCHEM_PKA_STRONGEST_ACIDIC>
8.386799043733703

> <JCHEM_PKA_STRONGEST_BASIC>
-4.905967902153753

> <JCHEM_POLAR_SURFACE_AREA>
150.84

> <JCHEM_REFRACTIVITY>
134.00130000000001

> <JCHEM_ROTATABLE_BOND_COUNT>
4

> <JCHEM_RULE_OF_FIVE>
0

> <JCHEM_TRADITIONAL_IUPAC>
4-[3-(3,5-dihydroxyphenyl)-4-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-6-hydroxy-2,3-dihydro-1-benzofuran-2-yl]benzene-1,2-diol

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 07-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   07-SEP-22         0                                  
HETATM    1  O   UNK     0      -1.839   3.513   0.000  0.00  0.00           O+0
HETATM    2  C   UNK     0      -0.333   3.192   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       0.698   4.337   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       2.204   4.017   0.000  0.00  0.00           C+0
HETATM    5  O   UNK     0       3.235   5.161   0.000  0.00  0.00           O+0
HETATM    6  C   UNK     0       2.680   2.552   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       1.650   1.408   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       2.126  -0.057   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       3.590  -0.533   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       4.924   0.237   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       4.924   1.777   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       6.258   2.547   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       6.258   4.087   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       7.591   4.857   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       7.591   6.397   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       6.258   7.167   0.000  0.00  0.00           C+0
HETATM   17  O   UNK     0       6.258   8.707   0.000  0.00  0.00           O+0
HETATM   18  C   UNK     0       4.924   6.397   0.000  0.00  0.00           C+0
HETATM   19  O   UNK     0       3.590   7.167   0.000  0.00  0.00           O+0
HETATM   20  C   UNK     0       4.924   4.857   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       6.258  -0.533   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       6.258  -2.073   0.000  0.00  0.00           C+0
HETATM   23  O   UNK     0       7.591  -2.843   0.000  0.00  0.00           O+0
HETATM   24  C   UNK     0       4.924  -2.843   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0       3.590  -2.073   0.000  0.00  0.00           C+0
HETATM   26  O   UNK     0       2.126  -2.549   0.000  0.00  0.00           O+0
HETATM   27  C   UNK     0       1.220  -1.303   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0      -0.320  -1.303   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0      -1.090  -2.637   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0      -2.630  -2.637   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0      -3.400  -1.303   0.000  0.00  0.00           C+0
HETATM   32  O   UNK     0      -4.940  -1.303   0.000  0.00  0.00           O+0
HETATM   33  C   UNK     0      -2.630   0.031   0.000  0.00  0.00           C+0
HETATM   34  O   UNK     0      -3.400   1.365   0.000  0.00  0.00           O+0
HETATM   35  C   UNK     0      -1.090   0.031   0.000  0.00  0.00           C+0
HETATM   36  C   UNK     0       0.143   1.728   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3   36                                                  
CONECT    3    2    4                                                       
CONECT    4    3    5    6                                                  
CONECT    5    4                                                            
CONECT    6    4    7                                                       
CONECT    7    6    8   36                                                  
CONECT    8    7    9   27                                                  
CONECT    9    8   10   25                                                  
CONECT   10    9   11   21                                                  
CONECT   11   10   12                                                       
CONECT   12   11   13                                                       
CONECT   13   12   14   20                                                  
CONECT   14   13   15                                                       
CONECT   15   14   16                                                       
CONECT   16   15   17   18                                                  
CONECT   17   16                                                            
CONECT   18   16   19   20                                                  
CONECT   19   18                                                            
CONECT   20   18   13                                                       
CONECT   21   10   22                                                       
CONECT   22   21   23   24                                                  
CONECT   23   22                                                            
CONECT   24   22   25                                                       
CONECT   25   24    9   26                                                  
CONECT   26   25   27                                                       
CONECT   27   26    8   28                                                  
CONECT   28   27   29   35                                                  
CONECT   29   28   30                                                       
CONECT   30   29   31                                                       
CONECT   31   30   32   33                                                  
CONECT   32   31                                                            
CONECT   33   31   34   35                                                  
CONECT   34   33                                                            
CONECT   35   33   28                                                       
CONECT   36    7    2                                                       
MASTER        0    0    0    0    0    0    0    0   36    0   80    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₈H₂₂O₈

Average Mass

486.4760 Da

Monoisotopic Mass

486.13147 Da

IUPAC Name

Not Available

Traditional Name

Not Available

CAS Registry Number

Not Available

SMILES

OC1=CC(\C=C\C2=CC=C(O)C(O)=C2)=C2C(C(OC2=C1)C1=CC=C(O)C(O)=C1)C1=CC(O)=CC(O)=C1

InChI Identifier

InChI=1S/C28H22O8/c29-18-9-17(10-19(30)12-18)27-26-15(3-1-14-2-5-21(32)23(34)7-14)8-20(31)13-25(26)36-28(27)16-4-6-22(33)24(35)11-16/h1-13,27-35H/b3-1+

InChI Key

MTYSFTYBAMMIGE-HNQUOIGGSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Bolboschoenus fluviatilis	LOTUS Database	35616633
Caragana tibetica	LOTUS Database	35616633
Cyperus rotundus	LOTUS Database	35616633
Maackia amurensis	LOTUS Database	35616633
Melaleuca leucadendra	LOTUS Database	35616633
Schoenoplectus californicus	LOTUS Database	35616633
Senna garrettiana	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as 2-arylbenzofuran flavonoids. These are phenylpropanoids containing the 2-phenylbenzofuran moiety.

Kingdom

Organic compounds

Super Class

Phenylpropanoids and polyketides

Class

2-arylbenzofuran flavonoids

Sub Class

Not Available

Direct Parent

2-arylbenzofuran flavonoids

Alternative Parents

Substituents

2-arylbenzofuran flavonoid
1-phenylcoumaran
Stilbene
Coumaran
Styrene
Resorcinol
Catechol
Alkyl aryl ether
1-hydroxy-2-unsubstituted benzenoid
1-hydroxy-4-unsubstituted benzenoid
Phenol
Benzenoid
Monocyclic benzene moiety
Oxacycle
Organoheterocyclic compound
Ether
Hydrocarbon derivative
Organooxygen compound
Organic oxygen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

C00015870

Chemspider ID

4572842

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

5458999

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Mittas D, Spitaler U, Bertagnoll M, Oettl S, Gille E, Schwaiger S, Stuppner H: Identification and structural elucidation of bioactive compounds from Scirpoides holoschoenus. Phytochemistry. 2022 Aug;200:113241. doi: 10.1016/j.phytochem.2022.113241. Epub 2022 May 18. [PubMed:35597313 ]
Majeed M, Nagabhushanam K, Bhat B, Ansari M, Pandey A, Bani S, Mundkur L: The Anti-Obesity Potential of Cyperus rotundus Extract Containing Piceatannol, Scirpusin A and Scirpusin B from Rhizomes: Preclinical and Clinical Evaluations. Diabetes Metab Syndr Obes. 2022 Feb 9;15:369-382. doi: 10.2147/DMSO.S348412. eCollection 2022. [PubMed:35177914 ]
Matsumoto Y, Katano Y: Cardiovascular Protective Effects of Polyphenols Contained in Passion Fruit Seeds Namely Piceatannol and Scirpusin B: A Review. Tokai J Exp Clin Med. 2021 Sep 20;46(3):151-161. [PubMed:34498252 ]
Pan ZH, Ning DS, Fu YX, Li DP, Zou ZQ, Xie YC, Yu LL, Li LC: Preparative Isolation of Piceatannol Derivatives from Passion Fruit (Passiflora edulis) Seeds by High-Speed Countercurrent Chromatography Combined with High-Performance Liquid Chromatography and Screening for alpha-Glucosidase Inhibitory Activities. J Agric Food Chem. 2020 Feb 12;68(6):1555-1562. doi: 10.1021/acs.jafc.9b04871. Epub 2020 Feb 4. [PubMed:31986026 ]
LOTUS database [Link]

Showing NP-Card for 5-[2-(3,4-dihydroxyphenyl)-4-[(1e)-2-(3,4-dihydroxyphenyl)ethenyl]-6-hydroxy-2,3-dihydro-1-benzofuran-3-yl]benzene-1,3-diol (NP0242205)

MOL for NP0242205 (5-[2-(3,4-dihydroxyphenyl)-4-[(1e)-2-(3,4-dihydroxyphenyl)ethenyl]-6-hydroxy-2,3-dihydro-1-benzofuran-3-yl]benzene-1,3-diol)

3D MOL for NP0242205 (5-[2-(3,4-dihydroxyphenyl)-4-[(1e)-2-(3,4-dihydroxyphenyl)ethenyl]-6-hydroxy-2,3-dihydro-1-benzofuran-3-yl]benzene-1,3-diol)

3D SDF for NP0242205 (5-[2-(3,4-dihydroxyphenyl)-4-[(1e)-2-(3,4-dihydroxyphenyl)ethenyl]-6-hydroxy-2,3-dihydro-1-benzofuran-3-yl]benzene-1,3-diol)

3D-SDF for NP0242205 (5-[2-(3,4-dihydroxyphenyl)-4-[(1e)-2-(3,4-dihydroxyphenyl)ethenyl]-6-hydroxy-2,3-dihydro-1-benzofuran-3-yl]benzene-1,3-diol)

PDB for NP0242205 (5-[2-(3,4-dihydroxyphenyl)-4-[(1e)-2-(3,4-dihydroxyphenyl)ethenyl]-6-hydroxy-2,3-dihydro-1-benzofuran-3-yl]benzene-1,3-diol)

3D PDB for NP0242205 (5-[2-(3,4-dihydroxyphenyl)-4-[(1e)-2-(3,4-dihydroxyphenyl)ethenyl]-6-hydroxy-2,3-dihydro-1-benzofuran-3-yl]benzene-1,3-diol)

SMILES for NP0242205 (5-[2-(3,4-dihydroxyphenyl)-4-[(1e)-2-(3,4-dihydroxyphenyl)ethenyl]-6-hydroxy-2,3-dihydro-1-benzofuran-3-yl]benzene-1,3-diol)

INCHI for NP0242205 (5-[2-(3,4-dihydroxyphenyl)-4-[(1e)-2-(3,4-dihydroxyphenyl)ethenyl]-6-hydroxy-2,3-dihydro-1-benzofuran-3-yl]benzene-1,3-diol)

Structure for NP0242205 (5-[2-(3,4-dihydroxyphenyl)-4-[(1e)-2-(3,4-dihydroxyphenyl)ethenyl]-6-hydroxy-2,3-dihydro-1-benzofuran-3-yl]benzene-1,3-diol)

3D Structure for NP0242205 (5-[2-(3,4-dihydroxyphenyl)-4-[(1e)-2-(3,4-dihydroxyphenyl)ethenyl]-6-hydroxy-2,3-dihydro-1-benzofuran-3-yl]benzene-1,3-diol)