NP-MRD: Showing NP-Card for (2r,4s,4as,5r,6r,8ar)-8a-hydroxy-5-{5-hydroxy-4-[(3r)-oct-1-en-3-yl]-2-oxopyrrole-3-carbonyl}-4,6-dimethyl-2,3,4,4a,5,6-hexahydro-1h-naphthalene-2-carboxylic acid (NP0241731)

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Record Information

Version

2.0

Created at

2022-09-07 01:53:05 UTC

Updated at

2022-09-07 01:53:06 UTC

NP-MRD ID

NP0241731

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(2r,4s,4as,5r,6r,8ar)-8a-hydroxy-5-{5-hydroxy-4-[(3r)-oct-1-en-3-yl]-2-oxopyrrole-3-carbonyl}-4,6-dimethyl-2,3,4,4a,5,6-hexahydro-1h-naphthalene-2-carboxylic acid

Description

(2R,4S,4aS,5R,6R,8aR)-8a-hydroxy-5-{5-hydroxy-4-[(3R)-oct-1-en-3-yl]-2-oxo-2H-pyrrole-3-carbonyl}-4,6-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene-2-carboxylic acid belongs to the class of organic compounds known as tertiary alcohols. Tertiary alcohols are compounds in which a hydroxy group, -OH, is attached to a saturated carbon atom R3COH (R not H ). Based on a literature review very few articles have been published on (2R,4S,4aS,5R,6R,8aR)-8a-hydroxy-5-{5-hydroxy-4-[(3R)-oct-1-en-3-yl]-2-oxo-2H-pyrrole-3-carbonyl}-4,6-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene-2-carboxylic acid.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309072203532D          

 33 35  0  0  1  0            999 V2000
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   -1.4521   -3.5300    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4521   -2.7050    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.7376   -2.2925    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0231   -2.7050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6914   -2.2925    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4058   -2.7050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END

     RDKit          3D

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M  END


  Mrv1652309072203532D          

 33 35  0  0  1  0            999 V2000
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M  END
> <DATABASE_ID>
NP0241731

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CCCCC[C@H](C=C)C1=C(C(=O)[C@@H]2[C@H](C)C=C[C@]3(O)C[C@@H](C[C@H](C)[C@@H]23)C(O)=O)C(=O)N=C1O

> <INCHI_IDENTIFIER>
InChI=1S/C26H35NO6/c1-5-7-8-9-16(6-2)19-20(24(30)27-23(19)29)22(28)18-14(3)10-11-26(33)13-17(25(31)32)12-15(4)21(18)26/h6,10-11,14-18,21,33H,2,5,7-9,12-13H2,1,3-4H3,(H,31,32)(H,27,29,30)/t14-,15+,16+,17-,18-,21+,26+/m1/s1

> <INCHI_KEY>
DLAQLPWTEPAWGC-HMNAPRTISA-N

> <FORMULA>
C26H35NO6

> <MOLECULAR_WEIGHT>
457.567

> <EXACT_MASS>
457.246437851

> <JCHEM_ACCEPTOR_COUNT>
7

> <JCHEM_ATOM_COUNT>
68

> <JCHEM_AVERAGE_POLARIZABILITY>
50.08154037488331

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(2R,4S,4aS,5R,6R,8aR)-8a-hydroxy-5-{5-hydroxy-4-[(3R)-oct-1-en-3-yl]-2-oxo-2H-pyrrole-3-carbonyl}-4,6-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene-2-carboxylic acid

> <JCHEM_LOGP>
4.160926931666666

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-1

> <JCHEM_PKA>
5.067969526000808

> <JCHEM_PKA_STRONGEST_ACIDIC>
4.050856423174361

> <JCHEM_PKA_STRONGEST_BASIC>
-3.0811438339152026

> <JCHEM_POLAR_SURFACE_AREA>
124.26000000000002

> <JCHEM_REFRACTIVITY>
125.45829999999997

> <JCHEM_ROTATABLE_BOND_COUNT>
9

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
(2R,4S,4aS,5R,6R,8aR)-8a-hydroxy-5-{5-hydroxy-4-[(3R)-oct-1-en-3-yl]-2-oxopyrrole-3-carbonyl}-4,6-dimethyl-2,3,4,4a,5,6-hexahydro-1H-naphthalene-2-carboxylic acid

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 07-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   07-SEP-22         0                                  
HETATM    1  C   UNK     0      -1.377  -7.359   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -2.711  -6.589   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      -2.711  -5.049   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      -1.377  -4.279   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      -0.043  -5.049   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       1.291  -4.279   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       2.624  -5.049   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       3.958  -4.279   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      -4.044  -4.279   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      -5.451  -4.906   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0      -5.771  -6.412   0.000  0.00  0.00           C+0
HETATM   12  O   UNK     0      -4.627  -7.442   0.000  0.00  0.00           O+0
HETATM   13  C   UNK     0      -7.236  -6.888   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      -7.556  -8.394   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      -6.412  -9.425   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      -4.947  -8.949   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      -6.732 -10.931   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      -8.196 -11.407   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0      -8.517 -12.913   0.000  0.00  0.00           C+0
HETATM   20  O   UNK     0      -9.981 -13.389   0.000  0.00  0.00           O+0
HETATM   21  O   UNK     0      -7.372 -13.944   0.000  0.00  0.00           O+0
HETATM   22  C   UNK     0      -9.341 -10.376   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0      -9.021  -8.870   0.000  0.00  0.00           C+0
HETATM   24  O   UNK     0     -10.485  -9.346   0.000  0.00  0.00           O+0
HETATM   25  C   UNK     0     -10.165  -7.840   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0      -9.845  -6.333   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0      -8.380  -5.857   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0      -8.060  -4.351   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0      -6.482  -3.761   0.000  0.00  0.00           C+0
HETATM   30  O   UNK     0      -7.988  -3.441   0.000  0.00  0.00           O+0
HETATM   31  N   UNK     0      -5.712  -2.428   0.000  0.00  0.00           N+0
HETATM   32  C   UNK     0      -4.205  -2.748   0.000  0.00  0.00           C+0
HETATM   33  O   UNK     0      -3.061  -1.717   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4    9                                                  
CONECT    4    3    5                                                       
CONECT    5    4    6                                                       
CONECT    6    5    7                                                       
CONECT    7    6    8                                                       
CONECT    8    7                                                            
CONECT    9    3   10   32                                                  
CONECT   10    9   11   29                                                  
CONECT   11   10   12   13                                                  
CONECT   12   11                                                            
CONECT   13   11   14   27                                                  
CONECT   14   13   15   23                                                  
CONECT   15   14   16   17                                                  
CONECT   16   15                                                            
CONECT   17   15   18                                                       
CONECT   18   17   19   22                                                  
CONECT   19   18   20   21                                                  
CONECT   20   19                                                            
CONECT   21   19                                                            
CONECT   22   18   23                                                       
CONECT   23   22   14   24   25                                             
CONECT   24   23                                                            
CONECT   25   23   26                                                       
CONECT   26   25   27                                                       
CONECT   27   26   13   28                                                  
CONECT   28   27                                                            
CONECT   29   10   30   31                                                  
CONECT   30   29                                                            
CONECT   31   29   32                                                       
CONECT   32   31    9   33                                                  
CONECT   33   32                                                            
MASTER        0    0    0    0    0    0    0    0   33    0   70    0
END

View in JSmol

Synonyms

Value	Source
(2R,4S,4AS,5R,6R,8ar)-8a-hydroxy-5-{5-hydroxy-4-[(3R)-oct-1-en-3-yl]-2-oxo-2H-pyrrole-3-carbonyl}-4,6-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene-2-carboxylate	Generator

Chemical Formula

C₂₆H₃₅NO₆

Average Mass

457.5670 Da

Monoisotopic Mass

457.24644 Da

IUPAC Name

Not Available

Traditional Name

Not Available

CAS Registry Number

Not Available

SMILES

CCCCC[C@H](C=C)C1=C(C(=O)[C@@H]2[C@H](C)C=C[C@]3(O)C[C@@H](C[C@H](C)[C@@H]23)C(O)=O)C(=O)N=C1O

InChI Identifier

InChI=1S/C26H35NO6/c1-5-7-8-9-16(6-2)19-20(24(30)27-23(19)29)22(28)18-14(3)10-11-26(33)13-17(25(31)32)12-15(4)21(18)26/h6,10-11,14-18,21,33H,2,5,7-9,12-13H2,1,3-4H3,(H,31,32)(H,27,29,30)/t14-,15+,16+,17-,18-,21+,26+/m1/s1

InChI Key

DLAQLPWTEPAWGC-HMNAPRTISA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Not Available

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as tertiary alcohols. Tertiary alcohols are compounds in which a hydroxy group, -OH, is attached to a saturated carbon atom R3COH (R not H ).

Kingdom

Organic compounds

Super Class

Organic oxygen compounds

Class

Organooxygen compounds

Sub Class

Alcohols and polyols

Direct Parent

Tertiary alcohols

Alternative Parents

Substituents

Tertiary alcohol
Cyclic alcohol
N-acylimine
Ketone
Azacycle
Organoheterocyclic compound
Organic 1,3-dipolar compound
Propargyl-type 1,3-dipolar organic compound
Monocarboxylic acid or derivatives
Carboxylic acid
Carboxylic acid derivative
Organic nitrogen compound
Organopnictogen compound
Organic oxide
Hydrocarbon derivative
Organonitrogen compound
Carbonyl group
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

163044875

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for (2r,4s,4as,5r,6r,8ar)-8a-hydroxy-5-{5-hydroxy-4-[(3r)-oct-1-en-3-yl]-2-oxopyrrole-3-carbonyl}-4,6-dimethyl-2,3,4,4a,5,6-hexahydro-1h-naphthalene-2-carboxylic acid (NP0241731)

MOL for NP0241731 ((2r,4s,4as,5r,6r,8ar)-8a-hydroxy-5-{5-hydroxy-4-[(3r)-oct-1-en-3-yl]-2-oxopyrrole-3-carbonyl}-4,6-dimethyl-2,3,4,4a,5,6-hexahydro-1h-naphthalene-2-carboxylic acid)

3D MOL for NP0241731 ((2r,4s,4as,5r,6r,8ar)-8a-hydroxy-5-{5-hydroxy-4-[(3r)-oct-1-en-3-yl]-2-oxopyrrole-3-carbonyl}-4,6-dimethyl-2,3,4,4a,5,6-hexahydro-1h-naphthalene-2-carboxylic acid)

3D SDF for NP0241731 ((2r,4s,4as,5r,6r,8ar)-8a-hydroxy-5-{5-hydroxy-4-[(3r)-oct-1-en-3-yl]-2-oxopyrrole-3-carbonyl}-4,6-dimethyl-2,3,4,4a,5,6-hexahydro-1h-naphthalene-2-carboxylic acid)

3D-SDF for NP0241731 ((2r,4s,4as,5r,6r,8ar)-8a-hydroxy-5-{5-hydroxy-4-[(3r)-oct-1-en-3-yl]-2-oxopyrrole-3-carbonyl}-4,6-dimethyl-2,3,4,4a,5,6-hexahydro-1h-naphthalene-2-carboxylic acid)

PDB for NP0241731 ((2r,4s,4as,5r,6r,8ar)-8a-hydroxy-5-{5-hydroxy-4-[(3r)-oct-1-en-3-yl]-2-oxopyrrole-3-carbonyl}-4,6-dimethyl-2,3,4,4a,5,6-hexahydro-1h-naphthalene-2-carboxylic acid)

3D PDB for NP0241731 ((2r,4s,4as,5r,6r,8ar)-8a-hydroxy-5-{5-hydroxy-4-[(3r)-oct-1-en-3-yl]-2-oxopyrrole-3-carbonyl}-4,6-dimethyl-2,3,4,4a,5,6-hexahydro-1h-naphthalene-2-carboxylic acid)

SMILES for NP0241731 ((2r,4s,4as,5r,6r,8ar)-8a-hydroxy-5-{5-hydroxy-4-[(3r)-oct-1-en-3-yl]-2-oxopyrrole-3-carbonyl}-4,6-dimethyl-2,3,4,4a,5,6-hexahydro-1h-naphthalene-2-carboxylic acid)

INCHI for NP0241731 ((2r,4s,4as,5r,6r,8ar)-8a-hydroxy-5-{5-hydroxy-4-[(3r)-oct-1-en-3-yl]-2-oxopyrrole-3-carbonyl}-4,6-dimethyl-2,3,4,4a,5,6-hexahydro-1h-naphthalene-2-carboxylic acid)

Structure for NP0241731 ((2r,4s,4as,5r,6r,8ar)-8a-hydroxy-5-{5-hydroxy-4-[(3r)-oct-1-en-3-yl]-2-oxopyrrole-3-carbonyl}-4,6-dimethyl-2,3,4,4a,5,6-hexahydro-1h-naphthalene-2-carboxylic acid)

3D Structure for NP0241731 ((2r,4s,4as,5r,6r,8ar)-8a-hydroxy-5-{5-hydroxy-4-[(3r)-oct-1-en-3-yl]-2-oxopyrrole-3-carbonyl}-4,6-dimethyl-2,3,4,4a,5,6-hexahydro-1h-naphthalene-2-carboxylic acid)