NP-MRD: Showing NP-Card for 1,3-bis(acetyloxy)-7-(2-hydroperoxy-3-methylidenepent-4-en-1-yl)-9,10-dihydroxy-7,8-dimethyl-1h,3h,5h,6h,6ah,8h,9h,10h-naphtho[1,8a-c]furan-5-yl deca-2,4-dienoate (NP0237642)

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Record Information

Version

2.0

Created at

2022-09-06 20:50:55 UTC

Updated at

2022-09-06 20:50:55 UTC

NP-MRD ID

NP0237642

Secondary Accession Numbers

None

Natural Product Identification

Common Name

1,3-bis(acetyloxy)-7-(2-hydroperoxy-3-methylidenepent-4-en-1-yl)-9,10-dihydroxy-7,8-dimethyl-1h,3h,5h,6h,6ah,8h,9h,10h-naphtho[1,8a-c]furan-5-yl deca-2,4-dienoate

Description

1,3-Bis(acetyloxy)-7-(2-hydroperoxy-3-methylidenepent-4-en-1-yl)-9,10-dihydroxy-7,8-dimethyl-1H,3H,5H,6H,6aH,7H,8H,9H,10H-naphtho[4,4a-c]furan-5-yl deca-2,4-dienoate belongs to the class of organic compounds known as colensane and clerodane diterpenoids. These are diterpenoids with a structure based on the clerodane or the colensane skeleton. Clerodanes arise from labdanes by two methyl migrations. 1,3-bis(acetyloxy)-7-(2-hydroperoxy-3-methylidenepent-4-en-1-yl)-9,10-dihydroxy-7,8-dimethyl-1h,3h,5h,6h,6ah,8h,9h,10h-naphtho[1,8a-c]furan-5-yl deca-2,4-dienoate is found in Casearia arguta. 1,3-Bis(acetyloxy)-7-(2-hydroperoxy-3-methylidenepent-4-en-1-yl)-9,10-dihydroxy-7,8-dimethyl-1H,3H,5H,6H,6aH,7H,8H,9H,10H-naphtho[4,4a-c]furan-5-yl deca-2,4-dienoate is an extremely weak basic (essentially neutral) compound (based on its pKa).

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1533004241506082D          

 45 47  0  0  0  0            999 V2000
    4.4833    4.7861    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7183    4.4772    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0683    4.9853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3033    4.6764    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6533    5.1844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8883    4.8756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2383    5.3836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5267    5.0748    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1767    5.5828    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9417    5.2740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.0587    4.4425    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.8273    3.1831    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5528    2.7903    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5754    1.9656    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -6.1324    6.3229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2332    4.0469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5077    4.4397    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  6  5  1  4  0  0  0
  6  7  2  0  0  0  0
  8  7  1  4  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
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 13 45  1  0  0  0  0
M  END

     RDKit          3D

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  2 48  1  0
  1 46  1  0
  1 47  1  0
M  END


  Mrv1533004241506082D          

 45 47  0  0  0  0            999 V2000
    4.4833    4.7861    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7183    4.4772    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0683    4.9853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3033    4.6764    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6533    5.1844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8883    4.8756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2383    5.3836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5267    5.0748    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1767    5.5828    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9417    5.2740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5917    5.7820    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0587    4.4425    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8048    4.0078    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8273    3.1831    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5528    2.7903    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5754    1.9656    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7162    1.8727    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1081    1.1803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3618    0.7494    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3618   -0.0756    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0763   -0.4881    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6473    1.1619    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6473    1.9869    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9329    0.7494    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2184    1.1619    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3008    1.5728    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4212    0.7095    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0038    2.0047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8467    1.5079    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0478    2.6057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9156    2.9655    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2557    3.2222    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0470    2.9888    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6733    2.2352    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.5402    2.1631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.8920    1.4168    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0106    2.8409    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5135    3.6692    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0105    4.3232    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2494    5.1796    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0272    5.5046    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.6833    5.0044    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1324    6.3229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2332    4.0469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5077    4.4397    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  6  5  1  4  0  0  0
  6  7  2  0  0  0  0
  8  7  1  4  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 19 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  2  0  0  0  0
 16 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  1  0  0  0  0
 30 31  1  0  0  0  0
 30 32  1  0  0  0  0
 15 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  2  0  0  0  0
 35 37  1  0  0  0  0
 33 38  1  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
 40 41  1  0  0  0  0
 41 42  2  0  0  0  0
 41 43  1  0  0  0  0
 39 44  1  0  0  0  0
 32 44  1  0  0  0  0
 44 45  2  0  0  0  0
 13 45  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0237642

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CCCCCC=CC=CC(=O)OC1CC2C3(C(OC(C)=O)OC(OC(C)=O)C3=C1)C(O)C(O)C(C)C2(C)CC(OO)C(=C)C=C

> <INCHI_IDENTIFIER>
InChI=1S/C34H48O11/c1-8-10-11-12-13-14-15-16-28(37)43-24-17-25-31(41-22(5)35)44-32(42-23(6)36)34(25)27(18-24)33(7,21(4)29(38)30(34)39)19-26(45-40)20(3)9-2/h9,13-17,21,24,26-27,29-32,38-40H,2-3,8,10-12,18-19H2,1,4-7H3

> <INCHI_KEY>
SHPSAYQITLDCQK-UHFFFAOYSA-N

> <FORMULA>
C34H48O11

> <MOLECULAR_WEIGHT>
632.747

> <EXACT_MASS>
632.319662366

> <JCHEM_ACCEPTOR_COUNT>
8

> <JCHEM_ATOM_COUNT>
93

> <JCHEM_AVERAGE_POLARIZABILITY>
68.49248718199404

> <JCHEM_BIOAVAILABILITY>
0

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
1,3-bis(acetyloxy)-7-(2-hydroperoxy-3-methylidenepent-4-en-1-yl)-9,10-dihydroxy-7,8-dimethyl-1H,3H,5H,6H,6aH,7H,8H,9H,10H-naphtho[4,4a-c]furan-5-yl deca-2,4-dienoate

> <ALOGPS_LOGP>
4.30

> <JCHEM_LOGP>
4.772887191

> <ALOGPS_LOGS>
-4.90

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
13.380174132152934

> <JCHEM_PKA_STRONGEST_ACIDIC>
11.700537952674775

> <JCHEM_PKA_STRONGEST_BASIC>
-3.2721532808913185

> <JCHEM_POLAR_SURFACE_AREA>
158.04999999999998

> <JCHEM_REFRACTIVITY>
166.10180000000005

> <JCHEM_ROTATABLE_BOND_COUNT>
17

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
7.99e-03 g/l

> <JCHEM_TRADITIONAL_IUPAC>
1,3-bis(acetyloxy)-7-(2-hydroperoxy-3-methylidenepent-4-en-1-yl)-9,10-dihydroxy-7,8-dimethyl-1H,3H,5H,6H,6aH,8H,9H,10H-naphtho[4,4a-c]furan-5-yl deca-2,4-dienoate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 24-APR-15   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   24-APR-15         0                                  
HETATM    1  C   UNK     0       8.369   8.934   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       6.941   8.357   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       5.727   9.306   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       4.299   8.729   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       3.086   9.678   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       1.658   9.101   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       0.445  10.049   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      -0.983   9.473   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      -2.197  10.421   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      -3.625   9.845   0.000  0.00  0.00           C+0
HETATM   11  O   UNK     0      -4.838  10.793   0.000  0.00  0.00           O+0
HETATM   12  O   UNK     0      -3.843   8.293   0.000  0.00  0.00           O+0
HETATM   13  C   UNK     0      -5.236   7.481   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      -5.278   5.942   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      -6.632   5.209   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      -6.674   3.669   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      -5.070   3.496   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      -5.802   2.203   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0      -4.409   1.399   0.000  0.00  0.00           C+0
HETATM   20  O   UNK     0      -4.409  -0.141   0.000  0.00  0.00           O+0
HETATM   21  O   UNK     0      -5.742  -0.911   0.000  0.00  0.00           O+0
HETATM   22  C   UNK     0      -3.075   2.169   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0      -3.075   3.709   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0      -1.741   1.399   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0      -0.408   2.169   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0      -8.028   2.936   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0      -8.253   1.324   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0      -9.340   3.742   0.000  0.00  0.00           C+0
HETATM   29  O   UNK     0     -10.914   2.815   0.000  0.00  0.00           O+0
HETATM   30  C   UNK     0      -9.422   4.864   0.000  0.00  0.00           C+0
HETATM   31  O   UNK     0     -11.042   5.536   0.000  0.00  0.00           O+0
HETATM   32  C   UNK     0      -7.944   6.015   0.000  0.00  0.00           C+0
HETATM   33  C   UNK     0      -9.421   5.579   0.000  0.00  0.00           C+0
HETATM   34  O   UNK     0     -10.590   4.172   0.000  0.00  0.00           O+0
HETATM   35  C   UNK     0     -12.208   4.038   0.000  0.00  0.00           C+0
HETATM   36  O   UNK     0     -12.865   2.645   0.000  0.00  0.00           O+0
HETATM   37  C   UNK     0     -13.086   5.303   0.000  0.00  0.00           C+0
HETATM   38  O   UNK     0     -10.292   6.849   0.000  0.00  0.00           O+0
HETATM   39  C   UNK     0      -9.353   8.070   0.000  0.00  0.00           C+0
HETATM   40  O   UNK     0      -9.799   9.669   0.000  0.00  0.00           O+0
HETATM   41  C   UNK     0     -11.251  10.275   0.000  0.00  0.00           C+0
HETATM   42  O   UNK     0     -12.475   9.342   0.000  0.00  0.00           O+0
HETATM   43  C   UNK     0     -11.447  11.803   0.000  0.00  0.00           C+0
HETATM   44  C   UNK     0      -7.902   7.554   0.000  0.00  0.00           C+0
HETATM   45  C   UNK     0      -6.548   8.287   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4                                                       
CONECT    4    3    5                                                       
CONECT    5    4    6                                                       
CONECT    6    5    7                                                       
CONECT    7    6    8                                                       
CONECT    8    7    9                                                       
CONECT    9    8   10                                                       
CONECT   10    9   11   12                                                  
CONECT   11   10                                                            
CONECT   12   10   13                                                       
CONECT   13   12   14   45                                                  
CONECT   14   13   15                                                       
CONECT   15   14   16   32                                                  
CONECT   16   15   17   18   26                                             
CONECT   17   16                                                            
CONECT   18   16   19                                                       
CONECT   19   18   20   22                                                  
CONECT   20   19   21                                                       
CONECT   21   20                                                            
CONECT   22   19   23   24                                                  
CONECT   23   22                                                            
CONECT   24   22   25                                                       
CONECT   25   24                                                            
CONECT   26   16   27   28                                                  
CONECT   27   26                                                            
CONECT   28   26   29   30                                                  
CONECT   29   28                                                            
CONECT   30   28   31   32                                                  
CONECT   31   30                                                            
CONECT   32   30   15   33   44                                             
CONECT   33   32   34   38                                                  
CONECT   34   33   35                                                       
CONECT   35   34   36   37                                                  
CONECT   36   35                                                            
CONECT   37   35                                                            
CONECT   38   33   39                                                       
CONECT   39   38   40   44                                                  
CONECT   40   39   41                                                       
CONECT   41   40   42   43                                                  
CONECT   42   41                                                            
CONECT   43   41                                                            
CONECT   44   39   32   45                                                  
CONECT   45   44   13                                                       
MASTER        0    0    0    0    0    0    0    0   45    0   94    0
END

View in JSmol

Synonyms

Value	Source
1,3-Bis(acetyloxy)-7-(2-hydroperoxy-3-methylidenepent-4-en-1-yl)-9,10-dihydroxy-7,8-dimethyl-1H,3H,5H,6H,6ah,7H,8H,9H,10H-naphtho[4,4a-c]furan-5-yl deca-2,4-dienoic acid	Generator

Chemical Formula

C₃₄H₄₈O₁₁

Average Mass

632.7470 Da

Monoisotopic Mass

632.31966 Da

IUPAC Name

1,3-bis(acetyloxy)-7-(2-hydroperoxy-3-methylidenepent-4-en-1-yl)-9,10-dihydroxy-7,8-dimethyl-1H,3H,5H,6H,6aH,7H,8H,9H,10H-naphtho[4,4a-c]furan-5-yl deca-2,4-dienoate

Traditional Name

1,3-bis(acetyloxy)-7-(2-hydroperoxy-3-methylidenepent-4-en-1-yl)-9,10-dihydroxy-7,8-dimethyl-1H,3H,5H,6H,6aH,8H,9H,10H-naphtho[4,4a-c]furan-5-yl deca-2,4-dienoate

CAS Registry Number

Not Available

SMILES

CCCCCC=CC=CC(=O)OC1CC2C3(C(OC(C)=O)OC(OC(C)=O)C3=C1)C(O)C(O)C(C)C2(C)CC(OO)C(=C)C=C

InChI Identifier

InChI=1S/C34H48O11/c1-8-10-11-12-13-14-15-16-28(37)43-24-17-25-31(41-22(5)35)44-32(42-23(6)36)34(25)27(18-24)33(7,21(4)29(38)30(34)39)19-26(45-40)20(3)9-2/h9,13-17,21,24,26-27,29-32,38-40H,2-3,8,10-12,18-19H2,1,4-7H3

InChI Key

SHPSAYQITLDCQK-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Casearia arguta	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as colensane and clerodane diterpenoids. These are diterpenoids with a structure based on the clerodane or the colensane skeleton. Clerodanes arise from labdanes by two methyl migrations.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Diterpenoids

Direct Parent

Colensane and clerodane diterpenoids

Alternative Parents

Substituents

Clerodane diterpenoid
Naphthofuran
Tricarboxylic acid or derivatives
Fatty acid ester
Fatty acyl
Cyclic alcohol
Tetrahydrofuran
Alpha,beta-unsaturated carboxylic ester
Enoate ester
1,2-diol
Carboxylic acid ester
Hydroperoxide
Secondary alcohol
Peroxol
Alkyl hydroperoxide
Acetal
Carboxylic acid derivative
Oxacycle
Organoheterocyclic compound
Organooxygen compound
Alcohol
Organic oxide
Organic oxygen compound
Carbonyl group
Hydrocarbon derivative
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	4.3	ALOGPS
logP	4.77	ChemAxon
logS	-4.9	ALOGPS
pKa (Strongest Acidic)	11.7	ChemAxon
pKa (Strongest Basic)	-3.3	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	8	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	158.05 Å²	ChemAxon
Rotatable Bond Count	17	ChemAxon
Refractivity	166.1 m³·mol⁻¹	ChemAxon
Polarizability	68.49 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

Not Available

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for 1,3-bis(acetyloxy)-7-(2-hydroperoxy-3-methylidenepent-4-en-1-yl)-9,10-dihydroxy-7,8-dimethyl-1h,3h,5h,6h,6ah,8h,9h,10h-naphtho[1,8a-c]furan-5-yl deca-2,4-dienoate (NP0237642)

MOL for NP0237642 (1,3-bis(acetyloxy)-7-(2-hydroperoxy-3-methylidenepent-4-en-1-yl)-9,10-dihydroxy-7,8-dimethyl-1h,3h,5h,6h,6ah,8h,9h,10h-naphtho[1,8a-c]furan-5-yl deca-2,4-dienoate)

3D MOL for NP0237642 (1,3-bis(acetyloxy)-7-(2-hydroperoxy-3-methylidenepent-4-en-1-yl)-9,10-dihydroxy-7,8-dimethyl-1h,3h,5h,6h,6ah,8h,9h,10h-naphtho[1,8a-c]furan-5-yl deca-2,4-dienoate)

3D SDF for NP0237642 (1,3-bis(acetyloxy)-7-(2-hydroperoxy-3-methylidenepent-4-en-1-yl)-9,10-dihydroxy-7,8-dimethyl-1h,3h,5h,6h,6ah,8h,9h,10h-naphtho[1,8a-c]furan-5-yl deca-2,4-dienoate)

3D-SDF for NP0237642 (1,3-bis(acetyloxy)-7-(2-hydroperoxy-3-methylidenepent-4-en-1-yl)-9,10-dihydroxy-7,8-dimethyl-1h,3h,5h,6h,6ah,8h,9h,10h-naphtho[1,8a-c]furan-5-yl deca-2,4-dienoate)

PDB for NP0237642 (1,3-bis(acetyloxy)-7-(2-hydroperoxy-3-methylidenepent-4-en-1-yl)-9,10-dihydroxy-7,8-dimethyl-1h,3h,5h,6h,6ah,8h,9h,10h-naphtho[1,8a-c]furan-5-yl deca-2,4-dienoate)

3D PDB for NP0237642 (1,3-bis(acetyloxy)-7-(2-hydroperoxy-3-methylidenepent-4-en-1-yl)-9,10-dihydroxy-7,8-dimethyl-1h,3h,5h,6h,6ah,8h,9h,10h-naphtho[1,8a-c]furan-5-yl deca-2,4-dienoate)

SMILES for NP0237642 (1,3-bis(acetyloxy)-7-(2-hydroperoxy-3-methylidenepent-4-en-1-yl)-9,10-dihydroxy-7,8-dimethyl-1h,3h,5h,6h,6ah,8h,9h,10h-naphtho[1,8a-c]furan-5-yl deca-2,4-dienoate)

INCHI for NP0237642 (1,3-bis(acetyloxy)-7-(2-hydroperoxy-3-methylidenepent-4-en-1-yl)-9,10-dihydroxy-7,8-dimethyl-1h,3h,5h,6h,6ah,8h,9h,10h-naphtho[1,8a-c]furan-5-yl deca-2,4-dienoate)

Structure for NP0237642 (1,3-bis(acetyloxy)-7-(2-hydroperoxy-3-methylidenepent-4-en-1-yl)-9,10-dihydroxy-7,8-dimethyl-1h,3h,5h,6h,6ah,8h,9h,10h-naphtho[1,8a-c]furan-5-yl deca-2,4-dienoate)

3D Structure for NP0237642 (1,3-bis(acetyloxy)-7-(2-hydroperoxy-3-methylidenepent-4-en-1-yl)-9,10-dihydroxy-7,8-dimethyl-1h,3h,5h,6h,6ah,8h,9h,10h-naphtho[1,8a-c]furan-5-yl deca-2,4-dienoate)