NP-MRD: Showing NP-Card for (1s,3as,4r,6ar)-1,4-bis(4-hydroxy-3,5-dimethoxyphenyl)-tetrahydro-1h-furo[3,4-c]furan-3a-ol (NP0232241)

Jump To Section:

Identification Spectra BioTaxonomy ChemoTaxonomy Physical properties Links References XML

Record Information

Version

2.0

Created at

2022-09-06 13:24:37 UTC

Updated at

2022-09-06 13:24:37 UTC

NP-MRD ID

NP0232241

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(1s,3as,4r,6ar)-1,4-bis(4-hydroxy-3,5-dimethoxyphenyl)-tetrahydro-1h-furo[3,4-c]furan-3a-ol

Description

8-Hydroxysyringaresinol belongs to the class of organic compounds known as furanoid lignans. These are lignans with a structure that contains either a tetrahydrofuran ring, a furan ring, or a furofuan ring system, that arises from the joining of the two phenylpropanoid units. (1s,3as,4r,6ar)-1,4-bis(4-hydroxy-3,5-dimethoxyphenyl)-tetrahydro-1h-furo[3,4-c]furan-3a-ol is found in Salvia santolinifolia. 8-Hydroxysyringaresinol is an extremely weak basic (essentially neutral) compound (based on its pKa).

Structure

MOL SDF PDB SMILES InChI


  Mrv1652309272006422D          

 32 35  0  0  0  0            999 V2000
   -1.3862    1.4356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0513   -0.1336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7188    1.9205    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7188   -0.6185    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0513    1.4356    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.6631    1.8481    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6631    2.6730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3776    1.4356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3862   -0.1336    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -2.1006   -0.5461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8150   -0.1336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1006   -1.3710    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3062    0.6510    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.5188    0.6510    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1313    0.6510    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.9563    0.6510    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.3776    3.0856    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0921    2.6730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8066    3.0856    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0921    1.8481    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5296   -0.5461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5296   -1.3710    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2441   -1.7836    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8150   -1.7836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8066    1.4356    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5210    1.8481    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2441   -0.1336    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9585   -0.5461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8149   -2.6086    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5293   -3.0211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3775    3.9106    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0920    4.3231    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  3  1  1  0  0  0  0
  3  5  1  0  0  0  0
  1 15  1  0  0  0  0
 13  5  1  0  0  0  0
  2 13  1  0  0  0  0
 13 15  1  0  0  0  0
 15  9  1  0  0  0  0
  4  2  1  0  0  0  0
  4  9  1  0  0  0  0
  5  6  1  6  0  0  0
  7  6  2  0  0  0  0
  6  8  1  0  0  0  0
 17  7  1  0  0  0  0
 17 18  2  0  0  0  0
  8 20  2  0  0  0  0
 20 18  1  0  0  0  0
  9 10  1  6  0  0  0
 12 10  2  0  0  0  0
 11 10  1  0  0  0  0
 11 21  2  0  0  0  0
 21 22  1  0  0  0  0
 22 24  2  0  0  0  0
 24 12  1  0  0  0  0
 15 16  1  6  0  0  0
 18 19  1  0  0  0  0
 20 25  1  0  0  0  0
 21 27  1  0  0  0  0
 22 23  1  0  0  0  0
 25 26  1  0  0  0  0
 27 28  1  0  0  0  0
 13 14  1  6  0  0  0
 17 31  1  0  0  0  0
 31 32  1  0  0  0  0
 24 29  1  0  0  0  0
 29 30  1  0  0  0  0
M  END


  Mrv1652309272006422D          

 32 35  0  0  0  0            999 V2000
   -1.3862    1.4356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0513   -0.1336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7188    1.9205    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7188   -0.6185    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0513    1.4356    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.6631    1.8481    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6631    2.6730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3776    1.4356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3862   -0.1336    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -2.1006   -0.5461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8150   -0.1336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1006   -1.3710    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3062    0.6510    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.5188    0.6510    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1313    0.6510    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.9563    0.6510    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.3776    3.0856    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0921    2.6730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8066    3.0856    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0921    1.8481    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5296   -0.5461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5296   -1.3710    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2441   -1.7836    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8150   -1.7836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8066    1.4356    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5210    1.8481    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2441   -0.1336    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9585   -0.5461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8149   -2.6086    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5293   -3.0211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3775    3.9106    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0920    4.3231    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  3  1  1  0  0  0  0
  3  5  1  0  0  0  0
  1 15  1  0  0  0  0
 13  5  1  0  0  0  0
  2 13  1  0  0  0  0
 13 15  1  0  0  0  0
 15  9  1  0  0  0  0
  4  2  1  0  0  0  0
  4  9  1  0  0  0  0
  5  6  1  6  0  0  0
  7  6  2  0  0  0  0
  6  8  1  0  0  0  0
 17  7  1  0  0  0  0
 17 18  2  0  0  0  0
  8 20  2  0  0  0  0
 20 18  1  0  0  0  0
  9 10  1  6  0  0  0
 12 10  2  0  0  0  0
 11 10  1  0  0  0  0
 11 21  2  0  0  0  0
 21 22  1  0  0  0  0
 22 24  2  0  0  0  0
 24 12  1  0  0  0  0
 15 16  1  6  0  0  0
 18 19  1  0  0  0  0
 20 25  1  0  0  0  0
 21 27  1  0  0  0  0
 22 23  1  0  0  0  0
 25 26  1  0  0  0  0
 27 28  1  0  0  0  0
 13 14  1  6  0  0  0
 17 31  1  0  0  0  0
 31 32  1  0  0  0  0
 24 29  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0232241

> <DATABASE_NAME>
NP-MRD

> <SMILES>
[H][C@]12CO[C@H](C3=CC(OC)=C(O)C(OC)=C3)[C@@]1(O)CO[C@@H]2C1=CC(OC)=C(O)C(OC)=C1

> <INCHI_IDENTIFIER>
InChI=1S/C22H26O9/c1-26-14-5-11(6-15(27-2)18(14)23)20-13-9-30-21(22(13,25)10-31-20)12-7-16(28-3)19(24)17(8-12)29-4/h5-8,13,20-21,23-25H,9-10H2,1-4H3/t13-,20-,21-,22-/m1/s1

> <INCHI_KEY>
NUUIAGCSVIKGMC-FHIZRCNDSA-N

> <FORMULA>
C22H26O9

> <MOLECULAR_WEIGHT>
434.441

> <EXACT_MASS>
434.157682417

> <JCHEM_ACCEPTOR_COUNT>
9

> <JCHEM_ATOM_COUNT>
57

> <JCHEM_AVERAGE_POLARIZABILITY>
42.52624455081521

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(1S,3aS,4R,6aR)-1,4-bis(4-hydroxy-3,5-dimethoxyphenyl)-hexahydrofuro[3,4-c]furan-3a-ol

> <ALOGPS_LOGP>
1.74

> <JCHEM_LOGP>
1.4124083249999995

> <ALOGPS_LOGS>
-3.18

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
9.602390814442648

> <JCHEM_PKA_STRONGEST_ACIDIC>
9.000531848275605

> <JCHEM_PKA_STRONGEST_BASIC>
-3.786975955908129

> <JCHEM_POLAR_SURFACE_AREA>
116.07000000000002

> <JCHEM_REFRACTIVITY>
108.90769999999998

> <JCHEM_ROTATABLE_BOND_COUNT>
6

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
2.85e-01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(1S,3aS,4R,6aR)-1,4-bis(4-hydroxy-3,5-dimethoxyphenyl)-tetrahydro-1H-furo[3,4-c]furan-3a-ol

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 27-SEP-20   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   27-SEP-20         0                                  
HETATM    1  C   UNK     0      -2.588   2.680   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -0.096  -0.249   0.000  0.00  0.00           C+0
HETATM    3  O   UNK     0      -1.342   3.585   0.000  0.00  0.00           O+0
HETATM    4  O   UNK     0      -1.342  -1.155   0.000  0.00  0.00           O+0
HETATM    5  C   UNK     0      -0.096   2.680   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       1.238   3.450   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       1.238   4.990   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       2.572   2.680   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      -2.588  -0.249   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      -3.921  -1.019   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0      -5.255  -0.249   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      -3.921  -2.559   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      -0.572   1.215   0.000  0.00  0.00           C+0
HETATM   14  O   UNK     0       0.968   1.215   0.000  0.00  0.00           O+0
HETATM   15  C   UNK     0      -2.112   1.215   0.000  0.00  0.00           C+0
HETATM   16  H   UNK     0      -3.652   1.215   0.000  0.00  0.00           H+0
HETATM   17  C   UNK     0       2.572   5.760   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       3.905   4.990   0.000  0.00  0.00           C+0
HETATM   19  O   UNK     0       5.239   5.760   0.000  0.00  0.00           O+0
HETATM   20  C   UNK     0       3.905   3.450   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0      -6.589  -1.019   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0      -6.589  -2.559   0.000  0.00  0.00           C+0
HETATM   23  O   UNK     0      -7.922  -3.329   0.000  0.00  0.00           O+0
HETATM   24  C   UNK     0      -5.255  -3.329   0.000  0.00  0.00           C+0
HETATM   25  O   UNK     0       5.239   2.680   0.000  0.00  0.00           O+0
HETATM   26  C   UNK     0       6.573   3.450   0.000  0.00  0.00           C+0
HETATM   27  O   UNK     0      -7.922  -0.249   0.000  0.00  0.00           O+0
HETATM   28  C   UNK     0      -9.256  -1.019   0.000  0.00  0.00           C+0
HETATM   29  O   UNK     0      -5.254  -4.869   0.000  0.00  0.00           O+0
HETATM   30  C   UNK     0      -6.588  -5.639   0.000  0.00  0.00           C+0
HETATM   31  O   UNK     0       2.571   7.300   0.000  0.00  0.00           O+0
HETATM   32  C   UNK     0       3.905   8.070   0.000  0.00  0.00           C+0
CONECT    1    3   15                                                       
CONECT    2   13    4                                                       
CONECT    3    1    5                                                       
CONECT    4    2    9                                                       
CONECT    5    3   13    6                                                  
CONECT    6    5    7    8                                                  
CONECT    7    6   17                                                       
CONECT    8    6   20                                                       
CONECT    9   15    4   10                                                  
CONECT   10    9   12   11                                                  
CONECT   11   10   21                                                       
CONECT   12   10   24                                                       
CONECT   13    5    2   15   14                                             
CONECT   14   13                                                            
CONECT   15    1   13    9   16                                             
CONECT   16   15                                                            
CONECT   17    7   18   31                                                  
CONECT   18   17   20   19                                                  
CONECT   19   18                                                            
CONECT   20    8   18   25                                                  
CONECT   21   11   22   27                                                  
CONECT   22   21   24   23                                                  
CONECT   23   22                                                            
CONECT   24   22   12   29                                                  
CONECT   25   20   26                                                       
CONECT   26   25                                                            
CONECT   27   21   28                                                       
CONECT   28   27                                                            
CONECT   29   24   30                                                       
CONECT   30   29                                                            
CONECT   31   17   32                                                       
CONECT   32   31                                                            
MASTER        0    0    0    0    0    0    0    0   32    0   70    0
END

View in JSmol

Synonyms

Value	Source
(+)-1-Hydroxysyringaresinol	PhytoBank
8-Hydroxysyringaresinol	PhytoBank

Chemical Formula

C₂₂H₂₆O₉

Average Mass

434.4410 Da

Monoisotopic Mass

434.15768 Da

IUPAC Name

(1S,3aS,4R,6aR)-1,4-bis(4-hydroxy-3,5-dimethoxyphenyl)-hexahydrofuro[3,4-c]furan-3a-ol

Traditional Name

(1S,3aS,4R,6aR)-1,4-bis(4-hydroxy-3,5-dimethoxyphenyl)-tetrahydro-1H-furo[3,4-c]furan-3a-ol

CAS Registry Number

Not Available

SMILES

[H][C@]12CO[C@H](C3=CC(OC)=C(O)C(OC)=C3)[C@@]1(O)CO[C@@H]2C1=CC(OC)=C(O)C(OC)=C1

InChI Identifier

InChI=1S/C22H26O9/c1-26-14-5-11(6-15(27-2)18(14)23)20-13-9-30-21(22(13,25)10-31-20)12-7-16(28-3)19(24)17(8-12)29-4/h5-8,13,20-21,23-25H,9-10H2,1-4H3/t13-,20-,21-,22-/m1/s1

InChI Key

NUUIAGCSVIKGMC-FHIZRCNDSA-N

Experimental Spectra

Not Available

Predicted Spectra

Not Available

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Salvia santolinifolia	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as furanoid lignans. These are lignans with a structure that contains either a tetrahydrofuran ring, a furan ring, or a furofuan ring system, that arises from the joining of the two phenylpropanoid units.

Kingdom

Organic compounds

Super Class

Lignans, neolignans and related compounds

Class

Furanoid lignans

Sub Class

Not Available

Direct Parent

Furanoid lignans

Alternative Parents

Substituents

Furanoid lignan
Furofuran lignan skeleton
M-dimethoxybenzene
Dimethoxybenzene
Methoxyphenol
Phenoxy compound
Anisole
Furofuran
Methoxybenzene
Phenol ether
Alkyl aryl ether
Phenol
Benzenoid
Monocyclic benzene moiety
Tertiary alcohol
Tetrahydrofuran
Organoheterocyclic compound
Oxacycle
Ether
Dialkyl ether
Alcohol
Organooxygen compound
Hydrocarbon derivative
Organic oxygen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	1.74	ALOGPS
logP	1.41	ChemAxon
logS	-3.2	ALOGPS
pKa (Strongest Acidic)	9	ChemAxon
pKa (Strongest Basic)	-3.8	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	9	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	116.07 Å²	ChemAxon
Rotatable Bond Count	6	ChemAxon
Refractivity	108.91 m³·mol⁻¹	ChemAxon
Polarizability	42.53 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

145709470

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for (1s,3as,4r,6ar)-1,4-bis(4-hydroxy-3,5-dimethoxyphenyl)-tetrahydro-1h-furo[3,4-c]furan-3a-ol (NP0232241)

MOL for NP0232241 ((1s,3as,4r,6ar)-1,4-bis(4-hydroxy-3,5-dimethoxyphenyl)-tetrahydro-1h-furo[3,4-c]furan-3a-ol)

3D MOL for NP0232241 ((1s,3as,4r,6ar)-1,4-bis(4-hydroxy-3,5-dimethoxyphenyl)-tetrahydro-1h-furo[3,4-c]furan-3a-ol)

3D SDF for NP0232241 ((1s,3as,4r,6ar)-1,4-bis(4-hydroxy-3,5-dimethoxyphenyl)-tetrahydro-1h-furo[3,4-c]furan-3a-ol)

3D-SDF for NP0232241 ((1s,3as,4r,6ar)-1,4-bis(4-hydroxy-3,5-dimethoxyphenyl)-tetrahydro-1h-furo[3,4-c]furan-3a-ol)

PDB for NP0232241 ((1s,3as,4r,6ar)-1,4-bis(4-hydroxy-3,5-dimethoxyphenyl)-tetrahydro-1h-furo[3,4-c]furan-3a-ol)

3D PDB for NP0232241 ((1s,3as,4r,6ar)-1,4-bis(4-hydroxy-3,5-dimethoxyphenyl)-tetrahydro-1h-furo[3,4-c]furan-3a-ol)

SMILES for NP0232241 ((1s,3as,4r,6ar)-1,4-bis(4-hydroxy-3,5-dimethoxyphenyl)-tetrahydro-1h-furo[3,4-c]furan-3a-ol)

INCHI for NP0232241 ((1s,3as,4r,6ar)-1,4-bis(4-hydroxy-3,5-dimethoxyphenyl)-tetrahydro-1h-furo[3,4-c]furan-3a-ol)

Structure for NP0232241 ((1s,3as,4r,6ar)-1,4-bis(4-hydroxy-3,5-dimethoxyphenyl)-tetrahydro-1h-furo[3,4-c]furan-3a-ol)

3D Structure for NP0232241 ((1s,3as,4r,6ar)-1,4-bis(4-hydroxy-3,5-dimethoxyphenyl)-tetrahydro-1h-furo[3,4-c]furan-3a-ol)