NP-MRD: Showing NP-Card for 8,9-dihydroxy-10-(hydroxymethyl)-6,10,14,15,21,21-hexamethyl-3,24-dioxaheptacyclo[16.5.2.0¹,¹⁵.0²,⁴.0⁵,¹⁴.0⁶,¹¹.0¹⁸,²³]pentacosan-25-one (NP0229504)

Jump To Section:

Identification Spectra BioTaxonomy ChemoTaxonomy Physical properties Links References XML

Record Information

Version

2.0

Created at

2022-09-06 09:35:27 UTC

Updated at

2022-09-06 09:35:27 UTC

NP-MRD ID

NP0229504

Secondary Accession Numbers

None

Natural Product Identification

Common Name

8,9-dihydroxy-10-(hydroxymethyl)-6,10,14,15,21,21-hexamethyl-3,24-dioxaheptacyclo[16.5.2.0¹,¹⁵.0²,⁴.0⁵,¹⁴.0⁶,¹¹.0¹⁸,²³]pentacosan-25-one

Description

8,9-Dihydroxy-10-(hydroxymethyl)-6,10,14,15,21,21-hexamethyl-3,24-dioxaheptacyclo[16.5.2.0¹,¹⁵.0²,⁴.0⁵,¹⁴.0⁶,¹¹.0¹⁸,²³]Pentacosan-25-one belongs to the class of organic compounds known as triterpenoids. These are terpene molecules containing six isoprene units. 8,9-dihydroxy-10-(hydroxymethyl)-6,10,14,15,21,21-hexamethyl-3,24-dioxaheptacyclo[16.5.2.0¹,¹⁵.0²,⁴.0⁵,¹⁴.0⁶,¹¹.0¹⁸,²³]pentacosan-25-one is found in Anamirta cocculus. 8,9-Dihydroxy-10-(hydroxymethyl)-6,10,14,15,21,21-hexamethyl-3,24-dioxaheptacyclo[16.5.2.0¹,¹⁵.0²,⁴.0⁵,¹⁴.0⁶,¹¹.0¹⁸,²³]Pentacosan-25-one is an extremely weak basic (essentially neutral) compound (based on its pKa).

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1533004171520542D          

 36 42  0  0  0  0            999 V2000
    2.2533   -1.8770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7481   -1.2248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1935   -1.8356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0502   -0.7847    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0825    0.0396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8125    0.4239    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2850    1.1515    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1395    1.1154    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4871    0.3187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9391    1.0088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3211    0.3183    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4084    1.1387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7351    1.0319    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5601    1.0302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9711    0.3149    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7961    0.3132    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6546    1.1259    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5720    0.5937    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7169    1.4059    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.2071   -0.4022    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0321   -0.4039    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.7931   -1.1158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2042   -1.8311    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9682   -1.1141    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5571   -0.3987    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1432   -1.1123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7321   -0.3970    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3247   -1.1211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9147   -1.8371    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4997   -1.1240    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0072   -0.4213    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1660   -0.9889    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5456   -0.3994    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7613   -0.6553    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5103   -0.0162    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4781   -0.8405    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 16 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 15 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 11 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 28 30  1  0  0  0  0
 30 31  1  0  0  0  0
  9 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
  6 33  1  0  0  0  0
 33 34  2  0  0  0  0
 31 35  1  0  0  0  0
  6 35  1  0  0  0  0
 35 36  1  0  0  0  0
  2 36  1  0  0  0  0
M  END

     RDKit          3D

 82 88  0  0  0  0  0  0  0  0999 V2000
   -5.9352   -0.1345    2.3842 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0585    0.4774    1.2864 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1678    1.9801    1.4477 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6971    0.0373   -0.0307 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9440    0.6040   -1.1905 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4984    0.2840   -1.0756 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.9794   -0.1567   -2.3986 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4779   -0.2437   -2.3326 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9910   -1.0569   -1.1336 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.5116   -2.4544   -1.4266 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4991   -0.9854   -1.0554 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.0516   -2.2665   -1.5863 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0548    0.0925   -2.0034 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5489    0.0492   -2.0515 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2708   -0.1368   -0.7783 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.4904   -0.4826    0.4279 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.9062   -1.8215    1.0609 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7776    0.5513    1.5320 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2433    0.6859    1.8192 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.7435   -0.3423    2.6015 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1023    0.8678    0.6373 C   0  0  2  0  0  0  0  0  0  0  0  0
    5.9143    1.9786    0.7214 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2694    1.0044   -0.6163 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.6887    2.3526   -0.7218 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2700    0.8330   -1.7542 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2667    1.8290   -1.6768 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0056   -0.5443    0.2846 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.3485   -1.2339    1.4276 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.5564   -2.2386    1.3123 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1179   -0.9654    1.3744 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.6330   -0.4536    0.0784 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.5511    0.9647   -0.0506 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6696    1.4848   -0.6852 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9798    2.6816   -0.9142 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1462   -0.6238    0.0717 C   0  0  1  0  0  0  0  0  0  0  0  0
   -3.6513   -0.0118    1.3554 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3927   -1.0124    2.7630 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.9514   -0.3410    2.0224 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0396    0.5805    3.2394 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4128    2.4951    0.4979 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9563    2.2755    2.1700 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2212    2.4288    1.8077 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5974   -1.0665   -0.0667 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7619    0.3252    0.0009 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0702    1.6822   -1.3415 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3674    0.1177   -2.1183 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2030    0.6945   -3.1118 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4788   -1.0193   -2.8494 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1737   -0.8499   -3.2266 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0997    0.7745   -2.3426 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6019   -2.3810   -1.6390 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0776   -2.7723   -2.4087 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4074   -3.1768   -0.6326 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.8578   -2.2447   -2.7041 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.5293   -3.1757   -1.2293 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.1503   -2.3744   -1.5339 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.7717    1.1013   -1.6474 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.6747   -0.0253   -3.0350 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.8260    1.0288   -2.5531 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.8186   -0.7090   -2.8477 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.9783   -1.0158   -0.9403 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.9259   -2.1120    0.7377 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.9441   -1.7651    2.1689 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.1469   -2.6104    0.8480 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.3479    0.1695    2.4841 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.2766    1.5035    1.3276 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.3358    1.6172    2.4534 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.4924   -0.8157    2.1309 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.7760   -0.0168    0.4726 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.8666    2.3079    1.6612 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.9078    2.9313    0.2245 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.6194    2.4276   -0.8824 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.1745    2.9812   -1.5263 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.7986   -0.1278   -1.6979 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.8206    0.9627   -2.7551 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.1410    1.4731   -1.4517 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.6803    0.5428    0.3618 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.8038   -1.1405    2.4227 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6178   -0.6060    2.2692 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4998   -1.6385    0.0168 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9830    0.8136    1.6513 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6366   -0.8429    2.1212 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  6
  9 31  1  0
 31 32  1  1
 32 33  1  0
 33 34  2  0
 31 30  1  0
 30 29  1  0
 29 28  1  0
 28 27  1  0
 27 16  1  0
 16 17  1  1
 16 18  1  0
 18 19  1  0
 19 20  1  0
 19 21  1  0
 21 22  1  0
 21 23  1  0
 23 24  1  6
 23 25  1  0
 25 26  1  0
 23 15  1  0
 15 14  1  0
 14 13  1  0
 13 11  1  0
 11 12  1  6
 31 35  1  0
 35 36  1  0
 36  2  1  0
  6 33  1  1
 28 30  1  0
 11 27  1  0
 35  6  1  0
 11  9  1  0
 15 16  1  0
  1 37  1  0
  1 38  1  0
  1 39  1  0
  3 40  1  0
  3 41  1  0
  3 42  1  0
  4 43  1  0
  4 44  1  0
  5 45  1  0
  5 46  1  0
  7 47  1  0
  7 48  1  0
  8 49  1  0
  8 50  1  0
 10 51  1  0
 10 52  1  0
 10 53  1  0
 30 79  1  1
 28 78  1  1
 27 77  1  1
 17 62  1  0
 17 63  1  0
 17 64  1  0
 18 65  1  0
 18 66  1  0
 19 67  1  1
 20 68  1  0
 21 69  1  6
 22 70  1  0
 24 71  1  0
 24 72  1  0
 24 73  1  0
 25 74  1  0
 25 75  1  0
 26 76  1  0
 15 61  1  6
 14 59  1  0
 14 60  1  0
 13 57  1  0
 13 58  1  0
 12 54  1  0
 12 55  1  0
 12 56  1  0
 35 80  1  6
 36 81  1  0
 36 82  1  0
M  END


  Mrv1533004171520542D          

 36 42  0  0  0  0            999 V2000
    2.2533   -1.8770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7481   -1.2248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1935   -1.8356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0502   -0.7847    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0825    0.0396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8125    0.4239    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2850    1.1515    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1395    1.1154    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4871    0.3187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9391    1.0088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3211    0.3183    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4084    1.1387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7351    1.0319    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5601    1.0302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9711    0.3149    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7961    0.3132    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6546    1.1259    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5720    0.5937    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7169    1.4059    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.2071   -0.4022    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0321   -0.4039    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.7931   -1.1158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2042   -1.8311    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9682   -1.1141    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5571   -0.3987    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1432   -1.1123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7321   -0.3970    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3247   -1.1211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9147   -1.8371    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4997   -1.1240    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0072   -0.4213    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1660   -0.9889    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5456   -0.3994    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7613   -0.6553    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5103   -0.0162    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4781   -0.8405    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 16 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 15 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 11 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 28 30  1  0  0  0  0
 30 31  1  0  0  0  0
  9 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
  6 33  1  0  0  0  0
 33 34  2  0  0  0  0
 31 35  1  0  0  0  0
  6 35  1  0  0  0  0
 35 36  1  0  0  0  0
  2 36  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0229504

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CC1(C)CCC23CCC4(C)C(OC2=O)(C2OC2C2C5(C)CC(O)C(O)C(C)(CO)C5CCC42C)C3C1

> <INCHI_IDENTIFIER>
InChI=1S/C30H46O6/c1-24(2)9-11-29-12-10-28(6)27(5)8-7-17-25(3,13-16(32)21(33)26(17,4)15-31)20(27)19-22(35-19)30(28,18(29)14-24)36-23(29)34/h16-22,31-33H,7-15H2,1-6H3

> <INCHI_KEY>
ZBHMCGDZOXUNFU-UHFFFAOYSA-N

> <FORMULA>
C30H46O6

> <MOLECULAR_WEIGHT>
502.692

> <EXACT_MASS>
502.329439201

> <JCHEM_ACCEPTOR_COUNT>
5

> <JCHEM_ATOM_COUNT>
82

> <JCHEM_AVERAGE_POLARIZABILITY>
56.89995476779042

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
8,9-dihydroxy-10-(hydroxymethyl)-6,10,14,15,21,21-hexamethyl-3,24-dioxaheptacyclo[16.5.2.0¹,¹⁵.0²,⁴.0⁵,¹⁴.0⁶,¹¹.0¹⁸,²³]pentacosan-25-one

> <ALOGPS_LOGP>
3.42

> <JCHEM_LOGP>
3.3177133290000005

> <ALOGPS_LOGS>
-4.93

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
7

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
14.82733776237886

> <JCHEM_PKA_STRONGEST_ACIDIC>
13.553762351399104

> <JCHEM_PKA_STRONGEST_BASIC>
-2.78748335952808

> <JCHEM_POLAR_SURFACE_AREA>
99.52000000000001

> <JCHEM_REFRACTIVITY>
133.00549999999998

> <JCHEM_ROTATABLE_BOND_COUNT>
1

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
5.97e-03 g/l

> <JCHEM_TRADITIONAL_IUPAC>
8,9-dihydroxy-10-(hydroxymethyl)-6,10,14,15,21,21-hexamethyl-3,24-dioxaheptacyclo[16.5.2.0¹,¹⁵.0²,⁴.0⁵,¹⁴.0⁶,¹¹.0¹⁸,²³]pentacosan-25-one

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 17-APR-15   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   17-APR-15         0                                  
HETATM    1  C   UNK     0       4.206  -3.504   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       3.263  -2.286   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       2.228  -3.426   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       1.960  -1.465   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       2.021   0.074   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       3.383   0.791   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       4.265   2.149   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       5.860   2.082   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       6.509   0.595   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       7.353   1.883   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       8.066   0.594   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       8.229   2.126   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       8.839   1.926   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      10.379   1.923   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      11.146   0.588   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      12.686   0.585   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      12.422   2.102   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      14.134   1.108   0.000  0.00  0.00           C+0
HETATM   19  O   UNK     0      14.405   2.624   0.000  0.00  0.00           O+0
HETATM   20  C   UNK     0      13.453  -0.751   0.000  0.00  0.00           C+0
HETATM   21  O   UNK     0      14.993  -0.754   0.000  0.00  0.00           O+0
HETATM   22  C   UNK     0      12.681  -2.083   0.000  0.00  0.00           C+0
HETATM   23  O   UNK     0      13.448  -3.418   0.000  0.00  0.00           O+0
HETATM   24  C   UNK     0      11.141  -2.080   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0      10.373  -0.744   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0       9.601  -2.076   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0       8.833  -0.741   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0       8.073  -2.093   0.000  0.00  0.00           C+0
HETATM   29  O   UNK     0       7.308  -3.429   0.000  0.00  0.00           O+0
HETATM   30  C   UNK     0       6.533  -2.098   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0       5.613  -0.786   0.000  0.00  0.00           C+0
HETATM   32  O   UNK     0       4.043  -1.846   0.000  0.00  0.00           O+0
HETATM   33  C   UNK     0       2.885  -0.746   0.000  0.00  0.00           C+0
HETATM   34  O   UNK     0       1.421  -1.223   0.000  0.00  0.00           O+0
HETATM   35  C   UNK     0       4.686  -0.030   0.000  0.00  0.00           C+0
HETATM   36  C   UNK     0       4.626  -1.569   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3    4   36                                             
CONECT    3    2                                                            
CONECT    4    2    5                                                       
CONECT    5    4    6                                                       
CONECT    6    5    7   33   35                                             
CONECT    7    6    8                                                       
CONECT    8    7    9                                                       
CONECT    9    8   10   11   31                                             
CONECT   10    9                                                            
CONECT   11    9   12   13   27                                             
CONECT   12   11                                                            
CONECT   13   11   14                                                       
CONECT   14   13   15                                                       
CONECT   15   14   16   25                                                  
CONECT   16   15   17   18   20                                             
CONECT   17   16                                                            
CONECT   18   16   19                                                       
CONECT   19   18                                                            
CONECT   20   16   21   22                                                  
CONECT   21   20                                                            
CONECT   22   20   23   24                                                  
CONECT   23   22                                                            
CONECT   24   22   25                                                       
CONECT   25   24   15   26   27                                             
CONECT   26   25                                                            
CONECT   27   25   11   28                                                  
CONECT   28   27   29   30                                                  
CONECT   29   28   30                                                       
CONECT   30   29   28   31                                                  
CONECT   31   30    9   32   35                                             
CONECT   32   31   33                                                       
CONECT   33   32    6   34                                                  
CONECT   34   33                                                            
CONECT   35   31    6   36                                                  
CONECT   36   35    2                                                       
MASTER        0    0    0    0    0    0    0    0   36    0   84    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₃₀H₄₆O₆

Average Mass

502.6920 Da

Monoisotopic Mass

502.32944 Da

IUPAC Name

8,9-dihydroxy-10-(hydroxymethyl)-6,10,14,15,21,21-hexamethyl-3,24-dioxaheptacyclo[16.5.2.0¹,¹⁵.0²,⁴.0⁵,¹⁴.0⁶,¹¹.0¹⁸,²³]pentacosan-25-one

Traditional Name

8,9-dihydroxy-10-(hydroxymethyl)-6,10,14,15,21,21-hexamethyl-3,24-dioxaheptacyclo[16.5.2.0¹,¹⁵.0²,⁴.0⁵,¹⁴.0⁶,¹¹.0¹⁸,²³]pentacosan-25-one

CAS Registry Number

Not Available

SMILES

CC1(C)CCC23CCC4(C)C(OC2=O)(C2OC2C2C5(C)CC(O)C(O)C(C)(CO)C5CCC42C)C3C1

InChI Identifier

InChI=1S/C30H46O6/c1-24(2)9-11-29-12-10-28(6)27(5)8-7-17-25(3,13-16(32)21(33)26(17,4)15-31)20(27)19-22(35-19)30(28,18(29)14-24)36-23(29)34/h16-22,31-33H,7-15H2,1-6H3

InChI Key

ZBHMCGDZOXUNFU-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Anamirta cocculus	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as triterpenoids. These are terpene molecules containing six isoprene units.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Triterpenoids

Direct Parent

Triterpenoids

Alternative Parents

Substituents

Triterpenoid
Steroid lactone
12-hydroxysteroid
Hydroxysteroid
Steroid
Caprolactone
Oxepane
Gamma butyrolactone
Cyclic alcohol
Tetrahydrofuran
Carboxylic acid ester
Secondary alcohol
Lactone
Carboxylic acid derivative
Dialkyl ether
Oxirane
Ether
Oxacycle
Organoheterocyclic compound
Monocarboxylic acid or derivatives
Organic oxygen compound
Carbonyl group
Alcohol
Organic oxide
Primary alcohol
Organooxygen compound
Hydrocarbon derivative
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	3.42	ALOGPS
logP	3.32	ChemAxon
logS	-4.9	ALOGPS
pKa (Strongest Acidic)	13.55	ChemAxon
pKa (Strongest Basic)	-2.8	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	99.52 Å²	ChemAxon
Rotatable Bond Count	1	ChemAxon
Refractivity	133.01 m³·mol⁻¹	ChemAxon
Polarizability	56.9 Å³	ChemAxon
Number of Rings	7	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

Not Available

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for 8,9-dihydroxy-10-(hydroxymethyl)-6,10,14,15,21,21-hexamethyl-3,24-dioxaheptacyclo[16.5.2.0¹,¹⁵.0²,⁴.0⁵,¹⁴.0⁶,¹¹.0¹⁸,²³]pentacosan-25-one (NP0229504)

MOL for NP0229504 (8,9-dihydroxy-10-(hydroxymethyl)-6,10,14,15,21,21-hexamethyl-3,24-dioxaheptacyclo[16.5.2.0¹,¹⁵.0²,⁴.0⁵,¹⁴.0⁶,¹¹.0¹⁸,²³]pentacosan-25-one)

3D MOL for NP0229504 (8,9-dihydroxy-10-(hydroxymethyl)-6,10,14,15,21,21-hexamethyl-3,24-dioxaheptacyclo[16.5.2.0¹,¹⁵.0²,⁴.0⁵,¹⁴.0⁶,¹¹.0¹⁸,²³]pentacosan-25-one)

3D SDF for NP0229504 (8,9-dihydroxy-10-(hydroxymethyl)-6,10,14,15,21,21-hexamethyl-3,24-dioxaheptacyclo[16.5.2.0¹,¹⁵.0²,⁴.0⁵,¹⁴.0⁶,¹¹.0¹⁸,²³]pentacosan-25-one)

3D-SDF for NP0229504 (8,9-dihydroxy-10-(hydroxymethyl)-6,10,14,15,21,21-hexamethyl-3,24-dioxaheptacyclo[16.5.2.0¹,¹⁵.0²,⁴.0⁵,¹⁴.0⁶,¹¹.0¹⁸,²³]pentacosan-25-one)

PDB for NP0229504 (8,9-dihydroxy-10-(hydroxymethyl)-6,10,14,15,21,21-hexamethyl-3,24-dioxaheptacyclo[16.5.2.0¹,¹⁵.0²,⁴.0⁵,¹⁴.0⁶,¹¹.0¹⁸,²³]pentacosan-25-one)

3D PDB for NP0229504 (8,9-dihydroxy-10-(hydroxymethyl)-6,10,14,15,21,21-hexamethyl-3,24-dioxaheptacyclo[16.5.2.0¹,¹⁵.0²,⁴.0⁵,¹⁴.0⁶,¹¹.0¹⁸,²³]pentacosan-25-one)

SMILES for NP0229504 (8,9-dihydroxy-10-(hydroxymethyl)-6,10,14,15,21,21-hexamethyl-3,24-dioxaheptacyclo[16.5.2.0¹,¹⁵.0²,⁴.0⁵,¹⁴.0⁶,¹¹.0¹⁸,²³]pentacosan-25-one)

INCHI for NP0229504 (8,9-dihydroxy-10-(hydroxymethyl)-6,10,14,15,21,21-hexamethyl-3,24-dioxaheptacyclo[16.5.2.0¹,¹⁵.0²,⁴.0⁵,¹⁴.0⁶,¹¹.0¹⁸,²³]pentacosan-25-one)

Structure for NP0229504 (8,9-dihydroxy-10-(hydroxymethyl)-6,10,14,15,21,21-hexamethyl-3,24-dioxaheptacyclo[16.5.2.0¹,¹⁵.0²,⁴.0⁵,¹⁴.0⁶,¹¹.0¹⁸,²³]pentacosan-25-one)

3D Structure for NP0229504 (8,9-dihydroxy-10-(hydroxymethyl)-6,10,14,15,21,21-hexamethyl-3,24-dioxaheptacyclo[16.5.2.0¹,¹⁵.0²,⁴.0⁵,¹⁴.0⁶,¹¹.0¹⁸,²³]pentacosan-25-one)