NP-MRD: Showing NP-Card for (1s,3'r,4'as,6's)-3'-(acetyloxy)-10'-hydroxy-2,4'a,8',8'-tetramethyl-1',4',9'-trioxo-3',5',6',7'-tetrahydrospiro[cyclopropane-1,2'-phenanthren]-6'-yl acetate (NP0229248)

Jump To Section:

Identification Spectra BioTaxonomy ChemoTaxonomy Physical properties Links References XML

Record Information

Version

2.0

Created at

2022-09-06 09:13:21 UTC

Updated at

2022-09-06 09:13:21 UTC

NP-MRD ID

NP0229248

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(1s,3'r,4'as,6's)-3'-(acetyloxy)-10'-hydroxy-2,4'a,8',8'-tetramethyl-1',4',9'-trioxo-3',5',6',7'-tetrahydrospiro[cyclopropane-1,2'-phenanthren]-6'-yl acetate

Description

Xanthanthusin J belongs to the class of organic compounds known as diterpenoids. These are terpene compounds formed by four isoprene units. (1s,3'r,4'as,6's)-3'-(acetyloxy)-10'-hydroxy-2,4'a,8',8'-tetramethyl-1',4',9'-trioxo-3',5',6',7'-tetrahydrospiro[cyclopropane-1,2'-phenanthren]-6'-yl acetate is found in Coleus xanthanthus. Based on a literature review very few articles have been published on Xanthanthusin J.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309062211132D          

 32 35  0  0  1  0            999 V2000
    3.2704   -2.9684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -2.9684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -3.6829    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -2.2539    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -1.5395    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.2704   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704    1.3184    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204    1.3184    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1579    0.6039    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1579   -0.8250    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    6.8724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2849   -1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -1.5395    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    6.1579   -2.2539    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -2.9684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1579   -3.6829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -2.9684    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079   -2.2539    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079   -0.8250    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.0954   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5886    0.7019    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6701    0.1716    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  5  4  1  1  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  6  0  0  0
 17 18  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 16 20  1  0  0  0  0
 20 21  1  1  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  2  0  0  0  0
 20 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
  7 27  1  0  0  0  0
 13 27  1  0  0  0  0
 27 28  1  6  0  0  0
  8 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  1  0  0  0  0
 29 32  1  0  0  0  0
  5 32  1  0  0  0  0
M  END

     RDKit          3D

 60 63  0  0  0  0  0  0  0  0999 V2000
   -5.1931    3.8085    1.4214 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5019    2.5012    1.2825 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5844    1.6757    2.2259 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7726    2.1397    0.1752 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1049    0.9356   -0.0145 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.6093    1.0814   -0.1662 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0369   -0.2962   -0.1362 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7184   -1.3545   -0.5310 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1285   -2.6875   -0.5384 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7485   -3.7160   -0.9128 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2395   -2.8430   -0.0939 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8585   -4.1131   -0.0927 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9024   -1.7920    0.3104 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3078   -1.9505    0.6995 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6762   -2.9940    1.2966 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3123   -0.8989    0.4001 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.6863   -1.0840    0.9373 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4182   -1.2549   -0.5268 C   0  0  2  0  0  0  0  0  0  0  0  0
    5.0044   -0.2179   -1.4493 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6737    0.4419    0.3749 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.5382    1.4099   -0.1912 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9679    2.4826    0.5609 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8766    3.5419    0.0387 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5874    2.6013    1.7617 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3412    0.4448   -0.3043 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1635    1.1143   -1.2739 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3286   -0.4460    0.3525 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.2840    0.0623    1.8215 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1410   -1.2754   -0.9998 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2710   -2.1016   -2.2603 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9993   -1.8947    0.0850 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6003    0.1408   -1.1926 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5257    4.6370    1.6698 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0235    3.7821    2.1275 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6537    4.0125    0.4106 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2662    0.3059    0.9000 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4254    1.4940   -1.2014 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2079    1.7367    0.6057 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.3022   -4.9600   -0.0664 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.3008   -0.2062    1.2305 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.9002   -2.0064    1.5010 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.3894   -2.2896   -0.9326 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.7465   -0.7402   -2.1126 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.2234    0.2337   -2.0894 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.5919    0.5451   -0.8915 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4461    0.7157    1.4478 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.6552    4.5266    0.4968 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.7355    3.5551   -1.0719 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.9127    3.2212    0.2325 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.0692   -0.4443    2.4042 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6949   -0.2192    2.2409 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.3563    1.1559    1.8008 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9514   -1.6285   -2.9963 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2695   -2.2940   -2.6937 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7124   -3.0897   -2.0151 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4083   -2.8884   -0.2343 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4442   -2.0218    1.0365 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8854   -1.2730    0.3193 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2063    0.5609   -2.1639 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7113    0.1175   -1.2575 H   0  0  0  0  0  0  0  0  0  0  0  0
 19 18  1  0
 18 17  1  0
 17 16  1  0
 16 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 22 24  2  0
 20 25  1  0
 25 26  2  0
 25 27  1  0
 27 28  1  1
 27  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
  9 11  1  0
 11 12  1  0
 11 13  2  0
 13 14  1  0
 14 15  2  0
  8 29  1  0
 29 30  1  0
 29 31  1  0
 29 32  1  0
 32  5  1  0
  5  6  1  0
  5  4  1  0
  4  2  1  0
  2  1  1  0
  2  3  2  0
 16 18  1  0
 16 14  1  1
 13 27  1  0
  6  7  1  0
 19 43  1  0
 19 44  1  0
 19 45  1  0
 18 42  1  6
 17 40  1  0
 17 41  1  0
 20 46  1  1
 23 47  1  0
 23 48  1  0
 23 49  1  0
 28 50  1  0
 28 51  1  0
 28 52  1  0
 12 39  1  0
 30 53  1  0
 30 54  1  0
 30 55  1  0
 31 56  1  0
 31 57  1  0
 31 58  1  0
 32 59  1  0
 32 60  1  0
  5 36  1  1
  6 37  1  0
  6 38  1  0
  1 33  1  0
  1 34  1  0
  1 35  1  0
M  END


  Mrv1652309062211132D          

 32 35  0  0  1  0            999 V2000
    3.2704   -2.9684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -2.9684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -3.6829    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -2.2539    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -1.5395    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.2704   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704    1.3184    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204    1.3184    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1579    0.6039    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1579   -0.8250    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    6.8724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2849   -1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -1.5395    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    6.1579   -2.2539    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -2.9684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1579   -3.6829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -2.9684    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079   -2.2539    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079   -0.8250    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.0954   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5886    0.7019    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6701    0.1716    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  5  4  1  1  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  6  0  0  0
 17 18  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 16 20  1  0  0  0  0
 20 21  1  1  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  2  0  0  0  0
 20 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
  7 27  1  0  0  0  0
 13 27  1  0  0  0  0
 27 28  1  6  0  0  0
  8 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  1  0  0  0  0
 29 32  1  0  0  0  0
  5 32  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0229248

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CC1C[C@@]11[C@@H](OC(C)=O)C(=O)[C@@]2(C)C3=C(C(=O)C(O)=C2C1=O)C(C)(C)C[C@@H](C3)OC(C)=O

> <INCHI_IDENTIFIER>
InChI=1S/C24H28O8/c1-10-8-24(10)19(29)16-18(28)17(27)15-14(7-13(31-11(2)25)9-22(15,4)5)23(16,6)20(30)21(24)32-12(3)26/h10,13,21,28H,7-9H2,1-6H3/t10?,13-,21+,23+,24-/m1/s1

> <INCHI_KEY>
XVQBITVGCMDUAS-SBQHANAMSA-N

> <FORMULA>
C24H28O8

> <MOLECULAR_WEIGHT>
444.48

> <EXACT_MASS>
444.178417862

> <JCHEM_ACCEPTOR_COUNT>
6

> <JCHEM_ATOM_COUNT>
60

> <JCHEM_AVERAGE_POLARIZABILITY>
45.575819029012294

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(1S,3'R,4'aS,6'S)-3'-(acetyloxy)-10'-hydroxy-2,4'a,8',8'-tetramethyl-1',4',9'-trioxo-3',4',4'a,5',6',7',8',9'-octahydro-1'H-spiro[cyclopropane-1,2'-phenanthrene]-6'-yl acetate

> <JCHEM_LOGP>
2.240512767000001

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
16.996638333926605

> <JCHEM_PKA_STRONGEST_ACIDIC>
11.498846151335036

> <JCHEM_PKA_STRONGEST_BASIC>
-2.6982765906172164

> <JCHEM_POLAR_SURFACE_AREA>
124.04000000000002

> <JCHEM_REFRACTIVITY>
112.68849999999998

> <JCHEM_ROTATABLE_BOND_COUNT>
4

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
(1S,3'R,4'aS,6'S)-3'-(acetyloxy)-10'-hydroxy-2,4'a,8',8'-tetramethyl-1',4',9'-trioxo-3',5',6',7'-tetrahydrospiro[cyclopropane-1,2'-phenanthrene]-6'-yl acetate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 06-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   06-SEP-22         0                                  
HETATM    1  C   UNK     0       6.105  -5.541   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       4.565  -5.541   0.000  0.00  0.00           C+0
HETATM    3  O   UNK     0       3.795  -6.875   0.000  0.00  0.00           O+0
HETATM    4  O   UNK     0       3.795  -4.207   0.000  0.00  0.00           O+0
HETATM    5  C   UNK     0       4.565  -2.874   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       6.105  -2.874   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       6.875  -1.540   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       6.105  -0.206   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       6.875   1.127   0.000  0.00  0.00           C+0
HETATM   10  O   UNK     0       6.105   2.461   0.000  0.00  0.00           O+0
HETATM   11  C   UNK     0       8.415   1.127   0.000  0.00  0.00           C+0
HETATM   12  O   UNK     0       9.185   2.461   0.000  0.00  0.00           O+0
HETATM   13  C   UNK     0       9.185  -0.206   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      10.725  -0.206   0.000  0.00  0.00           C+0
HETATM   15  O   UNK     0      11.495   1.127   0.000  0.00  0.00           O+0
HETATM   16  C   UNK     0      11.495  -1.540   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      12.828  -0.770   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      12.828  -2.310   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0      13.598  -3.644   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0      10.725  -2.874   0.000  0.00  0.00           C+0
HETATM   21  O   UNK     0      11.495  -4.207   0.000  0.00  0.00           O+0
HETATM   22  C   UNK     0      10.725  -5.541   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0      11.495  -6.875   0.000  0.00  0.00           C+0
HETATM   24  O   UNK     0       9.185  -5.541   0.000  0.00  0.00           O+0
HETATM   25  C   UNK     0       9.185  -2.874   0.000  0.00  0.00           C+0
HETATM   26  O   UNK     0       8.415  -4.207   0.000  0.00  0.00           O+0
HETATM   27  C   UNK     0       8.415  -1.540   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0       7.645  -2.874   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0       4.565  -0.206   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0       4.832   1.310   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0       3.118   0.320   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0       3.795  -1.540   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3    4                                                  
CONECT    3    2                                                            
CONECT    4    2    5                                                       
CONECT    5    4    6   32                                                  
CONECT    6    5    7                                                       
CONECT    7    6    8   27                                                  
CONECT    8    7    9   29                                                  
CONECT    9    8   10   11                                                  
CONECT   10    9                                                            
CONECT   11    9   12   13                                                  
CONECT   12   11                                                            
CONECT   13   11   14   27                                                  
CONECT   14   13   15   16                                                  
CONECT   15   14                                                            
CONECT   16   14   17   18   20                                             
CONECT   17   16   18                                                       
CONECT   18   17   16   19                                                  
CONECT   19   18                                                            
CONECT   20   16   21   25                                                  
CONECT   21   20   22                                                       
CONECT   22   21   23   24                                                  
CONECT   23   22                                                            
CONECT   24   22                                                            
CONECT   25   20   26   27                                                  
CONECT   26   25                                                            
CONECT   27   25    7   13   28                                             
CONECT   28   27                                                            
CONECT   29    8   30   31   32                                             
CONECT   30   29                                                            
CONECT   31   29                                                            
CONECT   32   29    5                                                       
MASTER        0    0    0    0    0    0    0    0   32    0   70    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₄H₂₈O₈

Average Mass

444.4800 Da

Monoisotopic Mass

444.17842 Da

IUPAC Name

(1S,3'R,4'aS,6'S)-3'-(acetyloxy)-10'-hydroxy-2,4'a,8',8'-tetramethyl-1',4',9'-trioxo-3',4',4'a,5',6',7',8',9'-octahydro-1'H-spiro[cyclopropane-1,2'-phenanthrene]-6'-yl acetate

Traditional Name

(1S,3'R,4'aS,6'S)-3'-(acetyloxy)-10'-hydroxy-2,4'a,8',8'-tetramethyl-1',4',9'-trioxo-3',5',6',7'-tetrahydrospiro[cyclopropane-1,2'-phenanthrene]-6'-yl acetate

CAS Registry Number

Not Available

SMILES

CC1C[C@@]11[C@@H](OC(C)=O)C(=O)[C@@]2(C)C3=C(C(=O)C(O)=C2C1=O)C(C)(C)C[C@@H](C3)OC(C)=O

InChI Identifier

InChI=1S/C24H28O8/c1-10-8-24(10)19(29)16-18(28)17(27)15-14(7-13(31-11(2)25)9-22(15,4)5)23(16,6)20(30)21(24)32-12(3)26/h10,13,21,28H,7-9H2,1-6H3/t10?,13-,21+,23+,24-/m1/s1

InChI Key

XVQBITVGCMDUAS-SBQHANAMSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Coleus xanthanthus	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as diterpenoids. These are terpene compounds formed by four isoprene units.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Diterpenoids

Direct Parent

Diterpenoids

Alternative Parents

Substituents

Diterpenoid
Abietane diterpenoid
Phenanthrene
Alpha-acyloxy ketone
Dicarboxylic acid or derivatives
Vinylogous acid
Ketone
Carboxylic acid ester
Enol
Carboxylic acid derivative
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Organooxygen compound
Carbonyl group
Aliphatic homopolycyclic compound

Molecular Framework

Aliphatic homopolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	2.24	ChemAxon
pKa (Strongest Acidic)	11.5	ChemAxon
pKa (Strongest Basic)	-2.7	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	6	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	124.04 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	112.69 m³·mol⁻¹	ChemAxon
Polarizability	45.58 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

C00045454

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

101188396

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for (1s,3'r,4'as,6's)-3'-(acetyloxy)-10'-hydroxy-2,4'a,8',8'-tetramethyl-1',4',9'-trioxo-3',5',6',7'-tetrahydrospiro[cyclopropane-1,2'-phenanthren]-6'-yl acetate (NP0229248)

MOL for NP0229248 ((1s,3'r,4'as,6's)-3'-(acetyloxy)-10'-hydroxy-2,4'a,8',8'-tetramethyl-1',4',9'-trioxo-3',5',6',7'-tetrahydrospiro[cyclopropane-1,2'-phenanthren]-6'-yl acetate)

3D MOL for NP0229248 ((1s,3'r,4'as,6's)-3'-(acetyloxy)-10'-hydroxy-2,4'a,8',8'-tetramethyl-1',4',9'-trioxo-3',5',6',7'-tetrahydrospiro[cyclopropane-1,2'-phenanthren]-6'-yl acetate)

3D SDF for NP0229248 ((1s,3'r,4'as,6's)-3'-(acetyloxy)-10'-hydroxy-2,4'a,8',8'-tetramethyl-1',4',9'-trioxo-3',5',6',7'-tetrahydrospiro[cyclopropane-1,2'-phenanthren]-6'-yl acetate)

3D-SDF for NP0229248 ((1s,3'r,4'as,6's)-3'-(acetyloxy)-10'-hydroxy-2,4'a,8',8'-tetramethyl-1',4',9'-trioxo-3',5',6',7'-tetrahydrospiro[cyclopropane-1,2'-phenanthren]-6'-yl acetate)

PDB for NP0229248 ((1s,3'r,4'as,6's)-3'-(acetyloxy)-10'-hydroxy-2,4'a,8',8'-tetramethyl-1',4',9'-trioxo-3',5',6',7'-tetrahydrospiro[cyclopropane-1,2'-phenanthren]-6'-yl acetate)

3D PDB for NP0229248 ((1s,3'r,4'as,6's)-3'-(acetyloxy)-10'-hydroxy-2,4'a,8',8'-tetramethyl-1',4',9'-trioxo-3',5',6',7'-tetrahydrospiro[cyclopropane-1,2'-phenanthren]-6'-yl acetate)

SMILES for NP0229248 ((1s,3'r,4'as,6's)-3'-(acetyloxy)-10'-hydroxy-2,4'a,8',8'-tetramethyl-1',4',9'-trioxo-3',5',6',7'-tetrahydrospiro[cyclopropane-1,2'-phenanthren]-6'-yl acetate)

INCHI for NP0229248 ((1s,3'r,4'as,6's)-3'-(acetyloxy)-10'-hydroxy-2,4'a,8',8'-tetramethyl-1',4',9'-trioxo-3',5',6',7'-tetrahydrospiro[cyclopropane-1,2'-phenanthren]-6'-yl acetate)

Structure for NP0229248 ((1s,3'r,4'as,6's)-3'-(acetyloxy)-10'-hydroxy-2,4'a,8',8'-tetramethyl-1',4',9'-trioxo-3',5',6',7'-tetrahydrospiro[cyclopropane-1,2'-phenanthren]-6'-yl acetate)

3D Structure for NP0229248 ((1s,3'r,4'as,6's)-3'-(acetyloxy)-10'-hydroxy-2,4'a,8',8'-tetramethyl-1',4',9'-trioxo-3',5',6',7'-tetrahydrospiro[cyclopropane-1,2'-phenanthren]-6'-yl acetate)