NP-MRD: Showing NP-Card for 2'-(acetyloxy)-5'-{5-hydroxy-hexahydrofuro[2,3-b]furan-2-yl}-4',5'-dimethyl-12'-oxaspiro[oxirane-2,10'-tricyclo[6.2.2.0¹,⁶]dodecan]-11'-yl 2-methylpropanoate (NP0228598)

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Record Information

Version

2.0

Created at

2022-09-06 08:18:59 UTC

Updated at

2022-09-06 08:19:00 UTC

NP-MRD ID

NP0228598

Secondary Accession Numbers

None

Natural Product Identification

Common Name

2'-(acetyloxy)-5'-{5-hydroxy-hexahydrofuro[2,3-b]furan-2-yl}-4',5'-dimethyl-12'-oxaspiro[oxirane-2,10'-tricyclo[6.2.2.0¹,⁶]dodecan]-11'-yl 2-methylpropanoate

Description

2'-(Acetyloxy)-5'-{5-hydroxy-hexahydrofuro[2,3-b]furan-2-yl}-4',5'-dimethyl-12'-oxaspiro[oxirane-2,10'-tricyclo[6.2.2.0¹,⁶]Dodecane]-11'-yl 2-methylpropanoate belongs to the class of organic compounds known as furofurans. These are organic compounds containing a two furan rings fused to each other. Furan is a five-membered aromatic ring with four carbon atoms and one oxygen atom. 2'-(acetyloxy)-5'-{5-hydroxy-hexahydrofuro[2,3-b]furan-2-yl}-4',5'-dimethyl-12'-oxaspiro[oxirane-2,10'-tricyclo[6.2.2.0¹,⁶]dodecan]-11'-yl 2-methylpropanoate is found in Scutellaria altissima. Based on a literature review very few articles have been published on 2'-(acetyloxy)-5'-{5-hydroxy-hexahydrofuro[2,3-b]furan-2-yl}-4',5'-dimethyl-12'-oxaspiro[oxirane-2,10'-tricyclo[6.2.2.0¹,⁶]Dodecane]-11'-yl 2-methylpropanoate.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309062210192D          

 35 40  0  0  0  0            999 V2000
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M  END

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M  END


  Mrv1652309062210192D          

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  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
 18 19  1  0  0  0  0
 11 19  1  0  0  0  0
  9 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 24 26  1  0  0  0  0
 24 27  1  0  0  0  0
  5 27  1  0  0  0  0
 20 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
 32 34  1  0  0  0  0
 28 35  1  0  0  0  0
 22 35  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0228598

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CC(C)C(=O)OC1OC2CC3C(C)(C4CC5CC(O)OC5O4)C(C)CC(OC(C)=O)C13C1(CO1)C2

> <INCHI_IDENTIFIER>
InChI=1S/C26H38O9/c1-12(2)21(29)35-23-26-17(9-16(32-23)10-25(26)11-30-25)24(5,13(3)6-19(26)31-14(4)27)18-7-15-8-20(28)34-22(15)33-18/h12-13,15-20,22-23,28H,6-11H2,1-5H3

> <INCHI_KEY>
BKNXMAVBDJZREO-UHFFFAOYSA-N

> <FORMULA>
C26H38O9

> <MOLECULAR_WEIGHT>
494.581

> <EXACT_MASS>
494.251582804

> <JCHEM_ACCEPTOR_COUNT>
7

> <JCHEM_ATOM_COUNT>
73

> <JCHEM_AVERAGE_POLARIZABILITY>
51.56055959908603

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
2'-(acetyloxy)-5'-{5-hydroxy-hexahydrofuro[2,3-b]furan-2-yl}-4',5'-dimethyl-12'-oxaspiro[oxirane-2,10'-tricyclo[6.2.2.0^{1,6}]dodecane]-11'-yl 2-methylpropanoate

> <JCHEM_LOGP>
2.248697317999998

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
6

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_ACIDIC>
12.39171063174857

> <JCHEM_PKA_STRONGEST_BASIC>
-3.7386005606606676

> <JCHEM_POLAR_SURFACE_AREA>
113.05000000000003

> <JCHEM_REFRACTIVITY>
119.73169999999998

> <JCHEM_ROTATABLE_BOND_COUNT>
6

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
2'-(acetyloxy)-5'-{5-hydroxy-hexahydrofuro[2,3-b]furan-2-yl}-4',5'-dimethyl-12'-oxaspiro[oxirane-2,10'-tricyclo[6.2.2.0^{1,6}]dodecane]-11'-yl 2-methylpropanoate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 06-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   06-SEP-22         0                                  
HETATM    1  C   UNK     0       2.733  -4.192   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       1.606  -3.029   0.000  0.00  0.00           C+0
HETATM    3  O   UNK     0       0.286  -3.930   0.000  0.00  0.00           O+0
HETATM    4  O   UNK     0       1.866  -1.354   0.000  0.00  0.00           O+0
HETATM    5  C   UNK     0       1.824   0.392   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       0.294   0.157   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      -0.636   1.439   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      -2.028   0.435   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       0.118   2.836   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      -0.303   4.471   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0      -1.361   3.263   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      -1.886   4.711   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      -3.425   4.660   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      -4.700   5.524   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      -5.915   4.578   0.000  0.00  0.00           C+0
HETATM   16  O   UNK     0      -7.443   5.022   0.000  0.00  0.00           O+0
HETATM   17  O   UNK     0      -5.391   3.130   0.000  0.00  0.00           O+0
HETATM   18  C   UNK     0      -3.852   3.180   0.000  0.00  0.00           C+0
HETATM   19  O   UNK     0      -2.577   2.317   0.000  0.00  0.00           O+0
HETATM   20  C   UNK     0       1.508   2.954   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       2.152   4.734   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       3.839   5.212   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       4.860   3.806   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0       4.489   2.123   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0       5.991   1.782   0.000  0.00  0.00           C+0
HETATM   26  O   UNK     0       4.944   0.652   0.000  0.00  0.00           O+0
HETATM   27  C   UNK     0       2.985   1.336   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0       3.640   2.810   0.000  0.00  0.00           C+0
HETATM   29  O   UNK     0       2.252   3.616   0.000  0.00  0.00           O+0
HETATM   30  C   UNK     0       2.263   1.967   0.000  0.00  0.00           C+0
HETATM   31  O   UNK     0       0.742   1.279   0.000  0.00  0.00           O+0
HETATM   32  C   UNK     0       3.997   1.282   0.000  0.00  0.00           C+0
HETATM   33  C   UNK     0       5.386   2.625   0.000  0.00  0.00           C+0
HETATM   34  C   UNK     0       4.134  -0.445   0.000  0.00  0.00           C+0
HETATM   35  O   UNK     0       3.160   4.073   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3    4                                                  
CONECT    3    2                                                            
CONECT    4    2    5                                                       
CONECT    5    4    6   27                                                  
CONECT    6    5    7                                                       
CONECT    7    6    8    9                                                  
CONECT    8    7                                                            
CONECT    9    7   10   11   20                                             
CONECT   10    9                                                            
CONECT   11    9   12   19                                                  
CONECT   12   11   13                                                       
CONECT   13   12   14   18                                                  
CONECT   14   13   15                                                       
CONECT   15   14   16   17                                                  
CONECT   16   15                                                            
CONECT   17   15   18                                                       
CONECT   18   17   13   19                                                  
CONECT   19   18   11                                                       
CONECT   20    9   21   27                                                  
CONECT   21   20   22                                                       
CONECT   22   21   23   35                                                  
CONECT   23   22   24                                                       
CONECT   24   23   25   26   27                                             
CONECT   25   24   26                                                       
CONECT   26   25   24                                                       
CONECT   27   24    5   20   28                                             
CONECT   28   27   29   35                                                  
CONECT   29   28   30                                                       
CONECT   30   29   31   32                                                  
CONECT   31   30                                                            
CONECT   32   30   33   34                                                  
CONECT   33   32                                                            
CONECT   34   32                                                            
CONECT   35   28   22                                                       
MASTER        0    0    0    0    0    0    0    0   35    0   80    0
END

View in JSmol

Synonyms

Value	Source
2'-(Acetyloxy)-5'-{5-hydroxy-hexahydrofuro[2,3-b]furan-2-yl}-4',5'-dimethyl-12'-oxaspiro[oxirane-2,10'-tricyclo[6.2.2.0,]dodecane]-11'-yl 2-methylpropanoic acid	Generator

Chemical Formula

C₂₆H₃₈O₉

Average Mass

494.5810 Da

Monoisotopic Mass

494.25158 Da

IUPAC Name

2'-(acetyloxy)-5'-{5-hydroxy-hexahydrofuro[2,3-b]furan-2-yl}-4',5'-dimethyl-12'-oxaspiro[oxirane-2,10'-tricyclo[6.2.2.0^{1,6}]dodecane]-11'-yl 2-methylpropanoate

Traditional Name

2'-(acetyloxy)-5'-{5-hydroxy-hexahydrofuro[2,3-b]furan-2-yl}-4',5'-dimethyl-12'-oxaspiro[oxirane-2,10'-tricyclo[6.2.2.0^{1,6}]dodecane]-11'-yl 2-methylpropanoate

CAS Registry Number

Not Available

SMILES

CC(C)C(=O)OC1OC2CC3C(C)(C4CC5CC(O)OC5O4)C(C)CC(OC(C)=O)C13C1(CO1)C2

InChI Identifier

InChI=1S/C26H38O9/c1-12(2)21(29)35-23-26-17(9-16(32-23)10-25(26)11-30-25)24(5,13(3)6-19(26)31-14(4)27)18-7-15-8-20(28)34-22(15)33-18/h12-13,15-20,22-23,28H,6-11H2,1-5H3

InChI Key

BKNXMAVBDJZREO-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Scutellaria altissima	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as furofurans. These are organic compounds containing a two furan rings fused to each other. Furan is a five-membered aromatic ring with four carbon atoms and one oxygen atom.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Furofurans

Sub Class

Not Available

Direct Parent

Furofurans

Alternative Parents

Substituents

Furofuran
Dicarboxylic acid or derivatives
Oxane
Tetrahydrofuran
Hemiacetal
Carboxylic acid ester
Acetal
Ether
Oxirane
Dialkyl ether
Carboxylic acid derivative
Oxacycle
Hydrocarbon derivative
Organooxygen compound
Organic oxide
Organic oxygen compound
Carbonyl group
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	2.25	ChemAxon
pKa (Strongest Acidic)	12.39	ChemAxon
pKa (Strongest Basic)	-3.7	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	7	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	113.05 Å²	ChemAxon
Rotatable Bond Count	6	ChemAxon
Refractivity	119.73 m³·mol⁻¹	ChemAxon
Polarizability	51.56 Å³	ChemAxon
Number of Rings	6	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

163103525

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for 2'-(acetyloxy)-5'-{5-hydroxy-hexahydrofuro[2,3-b]furan-2-yl}-4',5'-dimethyl-12'-oxaspiro[oxirane-2,10'-tricyclo[6.2.2.0¹,⁶]dodecan]-11'-yl 2-methylpropanoate (NP0228598)

MOL for NP0228598 (2'-(acetyloxy)-5'-{5-hydroxy-hexahydrofuro[2,3-b]furan-2-yl}-4',5'-dimethyl-12'-oxaspiro[oxirane-2,10'-tricyclo[6.2.2.0¹,⁶]dodecan]-11'-yl 2-methylpropanoate)

3D MOL for NP0228598 (2'-(acetyloxy)-5'-{5-hydroxy-hexahydrofuro[2,3-b]furan-2-yl}-4',5'-dimethyl-12'-oxaspiro[oxirane-2,10'-tricyclo[6.2.2.0¹,⁶]dodecan]-11'-yl 2-methylpropanoate)

3D SDF for NP0228598 (2'-(acetyloxy)-5'-{5-hydroxy-hexahydrofuro[2,3-b]furan-2-yl}-4',5'-dimethyl-12'-oxaspiro[oxirane-2,10'-tricyclo[6.2.2.0¹,⁶]dodecan]-11'-yl 2-methylpropanoate)

3D-SDF for NP0228598 (2'-(acetyloxy)-5'-{5-hydroxy-hexahydrofuro[2,3-b]furan-2-yl}-4',5'-dimethyl-12'-oxaspiro[oxirane-2,10'-tricyclo[6.2.2.0¹,⁶]dodecan]-11'-yl 2-methylpropanoate)

PDB for NP0228598 (2'-(acetyloxy)-5'-{5-hydroxy-hexahydrofuro[2,3-b]furan-2-yl}-4',5'-dimethyl-12'-oxaspiro[oxirane-2,10'-tricyclo[6.2.2.0¹,⁶]dodecan]-11'-yl 2-methylpropanoate)

3D PDB for NP0228598 (2'-(acetyloxy)-5'-{5-hydroxy-hexahydrofuro[2,3-b]furan-2-yl}-4',5'-dimethyl-12'-oxaspiro[oxirane-2,10'-tricyclo[6.2.2.0¹,⁶]dodecan]-11'-yl 2-methylpropanoate)

SMILES for NP0228598 (2'-(acetyloxy)-5'-{5-hydroxy-hexahydrofuro[2,3-b]furan-2-yl}-4',5'-dimethyl-12'-oxaspiro[oxirane-2,10'-tricyclo[6.2.2.0¹,⁶]dodecan]-11'-yl 2-methylpropanoate)

INCHI for NP0228598 (2'-(acetyloxy)-5'-{5-hydroxy-hexahydrofuro[2,3-b]furan-2-yl}-4',5'-dimethyl-12'-oxaspiro[oxirane-2,10'-tricyclo[6.2.2.0¹,⁶]dodecan]-11'-yl 2-methylpropanoate)

Structure for NP0228598 (2'-(acetyloxy)-5'-{5-hydroxy-hexahydrofuro[2,3-b]furan-2-yl}-4',5'-dimethyl-12'-oxaspiro[oxirane-2,10'-tricyclo[6.2.2.0¹,⁶]dodecan]-11'-yl 2-methylpropanoate)

3D Structure for NP0228598 (2'-(acetyloxy)-5'-{5-hydroxy-hexahydrofuro[2,3-b]furan-2-yl}-4',5'-dimethyl-12'-oxaspiro[oxirane-2,10'-tricyclo[6.2.2.0¹,⁶]dodecan]-11'-yl 2-methylpropanoate)