NP-MRD: Showing NP-Card for ethyl (1s,2r,4s,9s,10s,13r,14r)-4-hydroxy-2,14-dimethyl-13-[(2r,3e)-6-methylhept-3-en-2-yl]-5-oxotetracyclo[7.7.0.0²,⁶.0¹⁰,¹⁴]hexadec-6-ene-4-carboxylate (NP0226459)

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Record Information

Version

2.0

Created at

2022-09-06 05:30:19 UTC

Updated at

2022-09-06 05:30:19 UTC

NP-MRD ID

NP0226459

Secondary Accession Numbers

None

Natural Product Identification

Common Name

ethyl (1s,2r,4s,9s,10s,13r,14r)-4-hydroxy-2,14-dimethyl-13-[(2r,3e)-6-methylhept-3-en-2-yl]-5-oxotetracyclo[7.7.0.0²,⁶.0¹⁰,¹⁴]hexadec-6-ene-4-carboxylate

Description

(22E)-2beta-Hydroxy-3-oxo-A-norcholesta-5,22-diene-2-carboxylic acid ethyl ester belongs to the class of organic compounds known as androstane steroids. These are steroids with a structure based on the 19-carbon androstane skeleton. ethyl (1s,2r,4s,9s,10s,13r,14r)-4-hydroxy-2,14-dimethyl-13-[(2r,3e)-6-methylhept-3-en-2-yl]-5-oxotetracyclo[7.7.0.0²,⁶.0¹⁰,¹⁴]hexadec-6-ene-4-carboxylate is found in Haliclona oculata. Based on a literature review very few articles have been published on (22E)-2beta-Hydroxy-3-oxo-A-norcholesta-5,22-diene-2-carboxylic acid ethyl ester.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309062207302D          

 33 36  0  0  1  0            999 V2000
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M  END

     RDKit          3D

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M  END


  Mrv1652309062207302D          

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  9 15  1  0  0  0  0
 15 16  1  1  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  1  0  0  0
 18 20  1  0  0  0  0
 14 20  1  0  0  0  0
 20 21  1  1  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 18 23  1  0  0  0  0
 23 24  1  1  0  0  0
 24 25  1  1  0  0  0
 24 26  1  0  0  0  0
 26 27  2  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  1  0  0  0  0
 11 32  1  0  0  0  0
  6 32  1  0  0  0  0
 32 33  2  0  0  0  0
M  END
> <DATABASE_ID>
NP0226459

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CCOC(=O)[C@]1(O)C[C@]2(C)[C@H]3CC[C@]4(C)[C@H](CC[C@H]4[C@@H]3CC=C2C1=O)[C@H](C)\C=C\CC(C)C

> <INCHI_IDENTIFIER>
InChI=1S/C29H44O4/c1-7-33-26(31)29(32)17-28(6)23-15-16-27(5)21(19(4)10-8-9-18(2)3)13-14-22(27)20(23)11-12-24(28)25(29)30/h8,10,12,18-23,32H,7,9,11,13-17H2,1-6H3/b10-8+/t19-,20+,21-,22+,23+,27-,28-,29+/m1/s1

> <INCHI_KEY>
TWCNAOPINFLZPU-SAROAOBESA-N

> <FORMULA>
C29H44O4

> <MOLECULAR_WEIGHT>
456.667

> <EXACT_MASS>
456.323959897

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_ATOM_COUNT>
77

> <JCHEM_AVERAGE_POLARIZABILITY>
54.30510462315954

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
ethyl (1S,2R,4S,9S,10S,13R,14R)-4-hydroxy-2,14-dimethyl-13-[(2R,3E)-6-methylhept-3-en-2-yl]-5-oxotetracyclo[7.7.0.0^{2,6}.0^{10,14}]hexadec-6-ene-4-carboxylate

> <JCHEM_LOGP>
6.51578963966667

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_ACIDIC>
10.652534904402955

> <JCHEM_PKA_STRONGEST_BASIC>
-4.700381232814146

> <JCHEM_POLAR_SURFACE_AREA>
63.6

> <JCHEM_REFRACTIVITY>
133.3652

> <JCHEM_ROTATABLE_BOND_COUNT>
7

> <JCHEM_RULE_OF_FIVE>
0

> <JCHEM_TRADITIONAL_IUPAC>
ethyl (1S,2R,4S,9S,10S,13R,14R)-4-hydroxy-2,14-dimethyl-13-[(2R,3E)-6-methylhept-3-en-2-yl]-5-oxotetracyclo[7.7.0.0^{2,6}.0^{10,14}]hexadec-6-ene-4-carboxylate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 06-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   06-SEP-22         0                                  
HETATM    1  C   UNK     0      11.246  -5.021   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      12.077  -3.725   0.000  0.00  0.00           C+0
HETATM    3  O   UNK     0      11.370  -2.357   0.000  0.00  0.00           O+0
HETATM    4  C   UNK     0      12.202  -1.061   0.000  0.00  0.00           C+0
HETATM    5  O   UNK     0      13.740  -1.133   0.000  0.00  0.00           O+0
HETATM    6  C   UNK     0      11.495   0.307   0.000  0.00  0.00           C+0
HETATM    7  O   UNK     0      12.929   0.867   0.000  0.00  0.00           O+0
HETATM    8  C   UNK     0      10.208  -0.539   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       9.006   0.424   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       8.616  -1.066   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       9.550   1.865   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       8.574   3.056   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       7.054   2.806   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       6.510   1.366   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       7.486   0.174   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       6.942  -1.266   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       5.423  -1.516   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       4.447  -0.325   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       3.755  -1.701   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       4.991   1.116   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       3.788   2.079   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       2.502   1.233   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       2.909  -0.253   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0       1.946  -1.455   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0       0.424  -1.223   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0       2.506  -2.890   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0       1.544  -4.092   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0       2.104  -5.526   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0       1.141  -6.729   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0      -0.381  -6.496   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0       1.701  -8.163   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0      11.088   1.793   0.000  0.00  0.00           C+0
HETATM   33  O   UNK     0      12.050   2.995   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4                                                       
CONECT    4    3    5    6                                                  
CONECT    5    4                                                            
CONECT    6    4    7    8   32                                             
CONECT    7    6                                                            
CONECT    8    6    9                                                       
CONECT    9    8   10   11   15                                             
CONECT   10    9                                                            
CONECT   11    9   12   32                                                  
CONECT   12   11   13                                                       
CONECT   13   12   14                                                       
CONECT   14   13   15   20                                                  
CONECT   15   14    9   16                                                  
CONECT   16   15   17                                                       
CONECT   17   16   18                                                       
CONECT   18   17   19   20   23                                             
CONECT   19   18                                                            
CONECT   20   18   14   21                                                  
CONECT   21   20   22                                                       
CONECT   22   21   23                                                       
CONECT   23   22   18   24                                                  
CONECT   24   23   25   26                                                  
CONECT   25   24                                                            
CONECT   26   24   27                                                       
CONECT   27   26   28                                                       
CONECT   28   27   29                                                       
CONECT   29   28   30   31                                                  
CONECT   30   29                                                            
CONECT   31   29                                                            
CONECT   32   11    6   33                                                  
CONECT   33   32                                                            
MASTER        0    0    0    0    0    0    0    0   33    0   72    0
END

View in JSmol

Synonyms

Value	Source
(22E)-2b-Hydroxy-3-oxo-a-norcholesta-5,22-diene-2-carboxylate ethyl ester	Generator
(22E)-2b-Hydroxy-3-oxo-a-norcholesta-5,22-diene-2-carboxylic acid ethyl ester	Generator
(22E)-2beta-Hydroxy-3-oxo-a-norcholesta-5,22-diene-2-carboxylate ethyl ester	Generator
(22E)-2Β-hydroxy-3-oxo-a-norcholesta-5,22-diene-2-carboxylate ethyl ester	Generator
(22E)-2Β-hydroxy-3-oxo-a-norcholesta-5,22-diene-2-carboxylic acid ethyl ester	Generator

Chemical Formula

C₂₉H₄₄O₄

Average Mass

456.6670 Da

Monoisotopic Mass

456.32396 Da

IUPAC Name

ethyl (1S,2R,4S,9S,10S,13R,14R)-4-hydroxy-2,14-dimethyl-13-[(2R,3E)-6-methylhept-3-en-2-yl]-5-oxotetracyclo[7.7.0.0^{2,6}.0^{10,14}]hexadec-6-ene-4-carboxylate

Traditional Name

ethyl (1S,2R,4S,9S,10S,13R,14R)-4-hydroxy-2,14-dimethyl-13-[(2R,3E)-6-methylhept-3-en-2-yl]-5-oxotetracyclo[7.7.0.0^{2,6}.0^{10,14}]hexadec-6-ene-4-carboxylate

CAS Registry Number

Not Available

SMILES

CCOC(=O)[C@]1(O)C[C@]2(C)[C@H]3CC[C@]4(C)[C@H](CC[C@H]4[C@@H]3CC=C2C1=O)[C@H](C)\C=C\CC(C)C

InChI Identifier

InChI=1S/C29H44O4/c1-7-33-26(31)29(32)17-28(6)23-15-16-27(5)21(19(4)10-8-9-18(2)3)13-14-22(27)20(23)11-12-24(28)25(29)30/h8,10,12,18-23,32H,7,9,11,13-17H2,1-6H3/b10-8+/t19-,20+,21-,22+,23+,27-,28-,29+/m1/s1

InChI Key

TWCNAOPINFLZPU-SAROAOBESA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Haliclona oculata	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as androstane steroids. These are steroids with a structure based on the 19-carbon androstane skeleton.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Steroids and steroid derivatives

Sub Class

Androstane steroids

Direct Parent

Androstane steroids

Alternative Parents

Substituents

Androstane-skeleton
Acyloin
Tertiary alcohol
Cyclic alcohol
Ketone
Carboxylic acid ester
Monocarboxylic acid or derivatives
Carboxylic acid derivative
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Organooxygen compound
Carbonyl group
Alcohol
Aliphatic homopolycyclic compound

Molecular Framework

Aliphatic homopolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	6.52	ChemAxon
pKa (Strongest Acidic)	10.65	ChemAxon
pKa (Strongest Basic)	-4.7	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	63.6 Å²	ChemAxon
Rotatable Bond Count	7	ChemAxon
Refractivity	133.37 m³·mol⁻¹	ChemAxon
Polarizability	54.31 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

10181425

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

21573859

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for ethyl (1s,2r,4s,9s,10s,13r,14r)-4-hydroxy-2,14-dimethyl-13-[(2r,3e)-6-methylhept-3-en-2-yl]-5-oxotetracyclo[7.7.0.0²,⁶.0¹⁰,¹⁴]hexadec-6-ene-4-carboxylate (NP0226459)

MOL for NP0226459 (ethyl (1s,2r,4s,9s,10s,13r,14r)-4-hydroxy-2,14-dimethyl-13-[(2r,3e)-6-methylhept-3-en-2-yl]-5-oxotetracyclo[7.7.0.0²,⁶.0¹⁰,¹⁴]hexadec-6-ene-4-carboxylate)

3D MOL for NP0226459 (ethyl (1s,2r,4s,9s,10s,13r,14r)-4-hydroxy-2,14-dimethyl-13-[(2r,3e)-6-methylhept-3-en-2-yl]-5-oxotetracyclo[7.7.0.0²,⁶.0¹⁰,¹⁴]hexadec-6-ene-4-carboxylate)

3D SDF for NP0226459 (ethyl (1s,2r,4s,9s,10s,13r,14r)-4-hydroxy-2,14-dimethyl-13-[(2r,3e)-6-methylhept-3-en-2-yl]-5-oxotetracyclo[7.7.0.0²,⁶.0¹⁰,¹⁴]hexadec-6-ene-4-carboxylate)

3D-SDF for NP0226459 (ethyl (1s,2r,4s,9s,10s,13r,14r)-4-hydroxy-2,14-dimethyl-13-[(2r,3e)-6-methylhept-3-en-2-yl]-5-oxotetracyclo[7.7.0.0²,⁶.0¹⁰,¹⁴]hexadec-6-ene-4-carboxylate)

PDB for NP0226459 (ethyl (1s,2r,4s,9s,10s,13r,14r)-4-hydroxy-2,14-dimethyl-13-[(2r,3e)-6-methylhept-3-en-2-yl]-5-oxotetracyclo[7.7.0.0²,⁶.0¹⁰,¹⁴]hexadec-6-ene-4-carboxylate)

3D PDB for NP0226459 (ethyl (1s,2r,4s,9s,10s,13r,14r)-4-hydroxy-2,14-dimethyl-13-[(2r,3e)-6-methylhept-3-en-2-yl]-5-oxotetracyclo[7.7.0.0²,⁶.0¹⁰,¹⁴]hexadec-6-ene-4-carboxylate)

SMILES for NP0226459 (ethyl (1s,2r,4s,9s,10s,13r,14r)-4-hydroxy-2,14-dimethyl-13-[(2r,3e)-6-methylhept-3-en-2-yl]-5-oxotetracyclo[7.7.0.0²,⁶.0¹⁰,¹⁴]hexadec-6-ene-4-carboxylate)

INCHI for NP0226459 (ethyl (1s,2r,4s,9s,10s,13r,14r)-4-hydroxy-2,14-dimethyl-13-[(2r,3e)-6-methylhept-3-en-2-yl]-5-oxotetracyclo[7.7.0.0²,⁶.0¹⁰,¹⁴]hexadec-6-ene-4-carboxylate)

Structure for NP0226459 (ethyl (1s,2r,4s,9s,10s,13r,14r)-4-hydroxy-2,14-dimethyl-13-[(2r,3e)-6-methylhept-3-en-2-yl]-5-oxotetracyclo[7.7.0.0²,⁶.0¹⁰,¹⁴]hexadec-6-ene-4-carboxylate)

3D Structure for NP0226459 (ethyl (1s,2r,4s,9s,10s,13r,14r)-4-hydroxy-2,14-dimethyl-13-[(2r,3e)-6-methylhept-3-en-2-yl]-5-oxotetracyclo[7.7.0.0²,⁶.0¹⁰,¹⁴]hexadec-6-ene-4-carboxylate)