NP-MRD: Showing NP-Card for 11,22-dihydroxy-7,7,19-trimethyl-19-(4-methylpent-3-en-1-yl)-2,8,20-trioxapentacyclo[12.8.0.0³,¹².0⁴,⁹.0¹⁶,²¹]docosa-1(22),3,5,9,11,14,16(21),17-octaen-13-one (NP0226114)

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Record Information

Version

2.0

Created at

2022-09-06 05:02:58 UTC

Updated at

2022-09-06 05:02:58 UTC

NP-MRD ID

NP0226114

Secondary Accession Numbers

None

Natural Product Identification

Common Name

11,22-dihydroxy-7,7,19-trimethyl-19-(4-methylpent-3-en-1-yl)-2,8,20-trioxapentacyclo[12.8.0.0³,¹².0⁴,⁹.0¹⁶,²¹]docosa-1(22),3,5,9,11,14,16(21),17-octaen-13-one

Description

11,22-Dihydroxy-7,7,19-trimethyl-19-(4-methylpent-3-en-1-yl)-2,8,20-trioxapentacyclo[12.8.0.0³,¹².0⁴,⁹.0¹⁶,²¹]Docosa-1(14),3(12),4(9),5,10,15,17,21-octaen-13-one belongs to the class of organic compounds known as pyranoxanthones. These are organic aromatic compounds containing a pyran or a hydrogenated derivative fused to a xanthone ring system. 11,22-Dihydroxy-7,7,19-trimethyl-19-(4-methylpent-3-en-1-yl)-2,8,20-trioxapentacyclo[12.8.0.0³,¹².0⁴,⁹.0¹⁶,²¹]Docosa-1(14),3(12),4(9),5,10,15,17,21-octaen-13-one is an extremely weak basic (essentially neutral) compound (based on its pKa).

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1533004231515262D          

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M  END

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M  END


  Mrv1533004231515262D          

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M  END
> <DATABASE_ID>
NP0226114

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CC(C)=CCCC1(C)OC2=C(O)C3=C(C=C2C=C1)C(=O)C1=C(O)C=C2OC(C)(C)C=CC2=C1O3

> <INCHI_IDENTIFIER>
InChI=1S/C28H28O6/c1-15(2)7-6-10-28(5)12-8-16-13-18-22(30)21-19(29)14-20-17(9-11-27(3,4)33-20)25(21)32-26(18)23(31)24(16)34-28/h7-9,11-14,29,31H,6,10H2,1-5H3

> <INCHI_KEY>
RXLXNBUNYYKWKN-UHFFFAOYSA-N

> <FORMULA>
C28H28O6

> <MOLECULAR_WEIGHT>
460.526

> <EXACT_MASS>
460.188588622

> <JCHEM_ACCEPTOR_COUNT>
5

> <JCHEM_ATOM_COUNT>
62

> <JCHEM_AVERAGE_POLARIZABILITY>
51.44880651212807

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
11,22-dihydroxy-7,7,19-trimethyl-19-(4-methylpent-3-en-1-yl)-2,8,20-trioxapentacyclo[12.8.0.0³,¹².0⁴,⁹.0¹⁶,²¹]docosa-1(14),3,5,9,11,15,17,21-octaen-13-one

> <ALOGPS_LOGP>
5.85

> <JCHEM_LOGP>
6.541424385999999

> <ALOGPS_LOGS>
-5.21

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
5

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
8.786663588594928

> <JCHEM_PKA_STRONGEST_ACIDIC>
8.15254223323942

> <JCHEM_PKA_STRONGEST_BASIC>
-3.7637433420450983

> <JCHEM_POLAR_SURFACE_AREA>
85.22

> <JCHEM_REFRACTIVITY>
133.29049999999998

> <JCHEM_ROTATABLE_BOND_COUNT>
3

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
2.85e-03 g/l

> <JCHEM_TRADITIONAL_IUPAC>
11,22-dihydroxy-7,7,19-trimethyl-19-(4-methylpent-3-en-1-yl)-2,8,20-trioxapentacyclo[12.8.0.0³,¹².0⁴,⁹.0¹⁶,²¹]docosa-1(14),3,5,9,11,15,17,21-octaen-13-one

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 23-APR-15   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   23-APR-15         0                                  
HETATM    1  C   UNK     0      -0.446  -0.994   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -0.282  -2.525   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      -1.527  -3.432   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      -1.363  -4.964   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      -2.607  -5.871   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      -2.443  -7.402   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      -3.980  -7.298   0.000  0.00  0.00           C+0
HETATM    8  O   UNK     0      -0.964  -6.975   0.000  0.00  0.00           O+0
HETATM    9  C   UNK     0       0.146  -8.043   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       1.625  -7.616   0.000  0.00  0.00           C+0
HETATM   11  O   UNK     0       1.995  -6.121   0.000  0.00  0.00           O+0
HETATM   12  C   UNK     0       2.735  -8.684   0.000  0.00  0.00           C+0
HETATM   13  O   UNK     0       4.215  -8.256   0.000  0.00  0.00           O+0
HETATM   14  C   UNK     0       5.324  -9.324   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       6.804  -8.897   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       7.174  -7.402   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       8.654  -6.975   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       9.763  -8.043   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0      10.622  -6.765   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0      11.171  -8.667   0.000  0.00  0.00           C+0
HETATM   21  O   UNK     0       9.393  -9.538   0.000  0.00  0.00           O+0
HETATM   22  C   UNK     0       7.914  -9.965   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       7.544 -11.460   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0       6.064 -11.887   0.000  0.00  0.00           C+0
HETATM   25  O   UNK     0       5.694 -13.382   0.000  0.00  0.00           O+0
HETATM   26  C   UNK     0       4.955 -10.819   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0       3.475 -11.246   0.000  0.00  0.00           C+0
HETATM   28  O   UNK     0       3.105 -12.741   0.000  0.00  0.00           O+0
HETATM   29  C   UNK     0       2.365 -10.178   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0       0.886 -10.606   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0      -0.224  -9.538   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0      -1.704  -9.965   0.000  0.00  0.00           C+0
HETATM   33  C   UNK     0      -2.813  -8.897   0.000  0.00  0.00           C+0
HETATM   34  C   UNK     0       1.126  -3.149   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3   34                                                  
CONECT    3    2    4                                                       
CONECT    4    3    5                                                       
CONECT    5    4    6                                                       
CONECT    6    5    7    8   33                                             
CONECT    7    6                                                            
CONECT    8    6    9                                                       
CONECT    9    8   10   31                                                  
CONECT   10    9   11   12                                                  
CONECT   11   10                                                            
CONECT   12   10   13   29                                                  
CONECT   13   12   14                                                       
CONECT   14   13   15   26                                                  
CONECT   15   14   16   22                                                  
CONECT   16   15   17                                                       
CONECT   17   16   18                                                       
CONECT   18   17   19   20   21                                             
CONECT   19   18                                                            
CONECT   20   18                                                            
CONECT   21   18   22                                                       
CONECT   22   21   15   23                                                  
CONECT   23   22   24                                                       
CONECT   24   23   25   26                                                  
CONECT   25   24                                                            
CONECT   26   24   14   27                                                  
CONECT   27   26   28   29                                                  
CONECT   28   27                                                            
CONECT   29   27   12   30                                                  
CONECT   30   29   31                                                       
CONECT   31   30    9   32                                                  
CONECT   32   31   33                                                       
CONECT   33   32    6                                                       
CONECT   34    2                                                            
MASTER        0    0    0    0    0    0    0    0   34    0   76    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₈H₂₈O₆

Average Mass

460.5260 Da

Monoisotopic Mass

460.18859 Da

IUPAC Name

11,22-dihydroxy-7,7,19-trimethyl-19-(4-methylpent-3-en-1-yl)-2,8,20-trioxapentacyclo[12.8.0.0³,¹².0⁴,⁹.0¹⁶,²¹]docosa-1(14),3,5,9,11,15,17,21-octaen-13-one

Traditional Name

11,22-dihydroxy-7,7,19-trimethyl-19-(4-methylpent-3-en-1-yl)-2,8,20-trioxapentacyclo[12.8.0.0³,¹².0⁴,⁹.0¹⁶,²¹]docosa-1(14),3,5,9,11,15,17,21-octaen-13-one

CAS Registry Number

Not Available

SMILES

CC(C)=CCCC1(C)OC2=C(O)C3=C(C=C2C=C1)C(=O)C1=C(O)C=C2OC(C)(C)C=CC2=C1O3

InChI Identifier

InChI=1S/C28H28O6/c1-15(2)7-6-10-28(5)12-8-16-13-18-22(30)21-19(29)14-20-17(9-11-27(3,4)33-20)25(21)32-26(18)23(31)24(16)34-28/h7-9,11-14,29,31H,6,10H2,1-5H3

InChI Key

RXLXNBUNYYKWKN-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Not Available

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as pyranoxanthones. These are organic aromatic compounds containing a pyran or a hydrogenated derivative fused to a xanthone ring system.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Benzopyrans

Sub Class

1-benzopyrans

Direct Parent

Pyranoxanthones

Alternative Parents

Substituents

Pyranoxanthone
Pyranochromene
2,2-dimethyl-1-benzopyran
Chromone
1-hydroxy-4-unsubstituted benzenoid
1-hydroxy-2-unsubstituted benzenoid
Alkyl aryl ether
Pyranone
Pyran
Benzenoid
Heteroaromatic compound
Vinylogous acid
Ether
Oxacycle
Organic oxygen compound
Hydrocarbon derivative
Organooxygen compound
Organic oxide
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	5.85	ALOGPS
logP	6.54	ChemAxon
logS	-5.2	ALOGPS
pKa (Strongest Acidic)	8.15	ChemAxon
pKa (Strongest Basic)	-3.8	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	85.22 Å²	ChemAxon
Rotatable Bond Count	3	ChemAxon
Refractivity	133.29 m³·mol⁻¹	ChemAxon
Polarizability	51.45 Å³	ChemAxon
Number of Rings	5	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

Not Available

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for 11,22-dihydroxy-7,7,19-trimethyl-19-(4-methylpent-3-en-1-yl)-2,8,20-trioxapentacyclo[12.8.0.0³,¹².0⁴,⁹.0¹⁶,²¹]docosa-1(22),3,5,9,11,14,16(21),17-octaen-13-one (NP0226114)

MOL for NP0226114 (11,22-dihydroxy-7,7,19-trimethyl-19-(4-methylpent-3-en-1-yl)-2,8,20-trioxapentacyclo[12.8.0.0³,¹².0⁴,⁹.0¹⁶,²¹]docosa-1(22),3,5,9,11,14,16(21),17-octaen-13-one)

3D MOL for NP0226114 (11,22-dihydroxy-7,7,19-trimethyl-19-(4-methylpent-3-en-1-yl)-2,8,20-trioxapentacyclo[12.8.0.0³,¹².0⁴,⁹.0¹⁶,²¹]docosa-1(22),3,5,9,11,14,16(21),17-octaen-13-one)

3D SDF for NP0226114 (11,22-dihydroxy-7,7,19-trimethyl-19-(4-methylpent-3-en-1-yl)-2,8,20-trioxapentacyclo[12.8.0.0³,¹².0⁴,⁹.0¹⁶,²¹]docosa-1(22),3,5,9,11,14,16(21),17-octaen-13-one)

3D-SDF for NP0226114 (11,22-dihydroxy-7,7,19-trimethyl-19-(4-methylpent-3-en-1-yl)-2,8,20-trioxapentacyclo[12.8.0.0³,¹².0⁴,⁹.0¹⁶,²¹]docosa-1(22),3,5,9,11,14,16(21),17-octaen-13-one)

PDB for NP0226114 (11,22-dihydroxy-7,7,19-trimethyl-19-(4-methylpent-3-en-1-yl)-2,8,20-trioxapentacyclo[12.8.0.0³,¹².0⁴,⁹.0¹⁶,²¹]docosa-1(22),3,5,9,11,14,16(21),17-octaen-13-one)

3D PDB for NP0226114 (11,22-dihydroxy-7,7,19-trimethyl-19-(4-methylpent-3-en-1-yl)-2,8,20-trioxapentacyclo[12.8.0.0³,¹².0⁴,⁹.0¹⁶,²¹]docosa-1(22),3,5,9,11,14,16(21),17-octaen-13-one)

SMILES for NP0226114 (11,22-dihydroxy-7,7,19-trimethyl-19-(4-methylpent-3-en-1-yl)-2,8,20-trioxapentacyclo[12.8.0.0³,¹².0⁴,⁹.0¹⁶,²¹]docosa-1(22),3,5,9,11,14,16(21),17-octaen-13-one)

INCHI for NP0226114 (11,22-dihydroxy-7,7,19-trimethyl-19-(4-methylpent-3-en-1-yl)-2,8,20-trioxapentacyclo[12.8.0.0³,¹².0⁴,⁹.0¹⁶,²¹]docosa-1(22),3,5,9,11,14,16(21),17-octaen-13-one)

Structure for NP0226114 (11,22-dihydroxy-7,7,19-trimethyl-19-(4-methylpent-3-en-1-yl)-2,8,20-trioxapentacyclo[12.8.0.0³,¹².0⁴,⁹.0¹⁶,²¹]docosa-1(22),3,5,9,11,14,16(21),17-octaen-13-one)

3D Structure for NP0226114 (11,22-dihydroxy-7,7,19-trimethyl-19-(4-methylpent-3-en-1-yl)-2,8,20-trioxapentacyclo[12.8.0.0³,¹².0⁴,⁹.0¹⁶,²¹]docosa-1(22),3,5,9,11,14,16(21),17-octaen-13-one)