NP-MRD: Showing NP-Card for (1r,2s,5s,6s)-5-[(benzoyloxy)methyl]-2,5,6-trihydroxycyclohex-3-en-1-yl benzoate (NP0221404)

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Record Information

Version

2.0

Created at

2022-09-05 22:58:32 UTC

Updated at

2022-09-05 22:58:32 UTC

NP-MRD ID

NP0221404

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(1r,2s,5s,6s)-5-[(benzoyloxy)methyl]-2,5,6-trihydroxycyclohex-3-en-1-yl benzoate

Description

(1r,2s,5s,6s)-5-[(benzoyloxy)methyl]-2,5,6-trihydroxycyclohex-3-en-1-yl benzoate is found in Monanthotaxis buchananii.

Structure

MOL SDF PDB SMILES InChI


  Mrv1652309062200582D          

 28 30  0  0  1  0            999 V2000
    4.5468   -0.0233    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8289   -0.7985    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2986   -1.4305    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4862   -1.2873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9559   -1.9192    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.4256   -1.2873    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6704   -2.3317    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6704   -3.1567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9559   -3.5692    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.9559   -4.3942    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2414   -3.1567    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.5269   -3.5692    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5269   -4.3942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2414   -4.8067    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8125   -4.8067    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8125   -5.6317    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0980   -6.0442    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6165   -5.6317    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6165   -4.8067    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0980   -4.3942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2414   -2.3317    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.5269   -1.9192    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6414   -0.9418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1717   -0.3098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9842   -0.4531    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2663   -1.2283    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7360   -1.8603    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9236   -1.7170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  5  4  1  1  0  0  0
  5  6  1  6  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  6  0  0  0
  9 11  1  0  0  0  0
 11 12  1  1  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 15 20  1  0  0  0  0
 11 21  1  0  0  0  0
  5 21  1  0  0  0  0
 21 22  1  6  0  0  0
  2 23  1  0  0  0  0
 23 24  2  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 23 28  1  0  0  0  0
M  END


  Mrv1652309062200582D          

 28 30  0  0  1  0            999 V2000
    4.5468   -0.0233    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8289   -0.7985    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2986   -1.4305    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4862   -1.2873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9559   -1.9192    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.4256   -1.2873    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6704   -2.3317    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6704   -3.1567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9559   -3.5692    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.9559   -4.3942    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2414   -3.1567    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.5269   -3.5692    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5269   -4.3942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2414   -4.8067    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8125   -4.8067    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8125   -5.6317    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0980   -6.0442    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6165   -5.6317    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6165   -4.8067    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0980   -4.3942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2414   -2.3317    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.5269   -1.9192    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6414   -0.9418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1717   -0.3098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9842   -0.4531    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2663   -1.2283    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7360   -1.8603    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9236   -1.7170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  5  4  1  1  0  0  0
  5  6  1  6  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  6  0  0  0
  9 11  1  0  0  0  0
 11 12  1  1  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 15 20  1  0  0  0  0
 11 21  1  0  0  0  0
  5 21  1  0  0  0  0
 21 22  1  6  0  0  0
  2 23  1  0  0  0  0
 23 24  2  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 23 28  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0221404

> <DATABASE_NAME>
NP-MRD

> <SMILES>
O[C@H]1C=C[C@](O)(COC(=O)C2=CC=CC=C2)[C@@H](O)[C@@H]1OC(=O)C1=CC=CC=C1

> <INCHI_IDENTIFIER>
InChI=1S/C21H20O7/c22-16-11-12-21(26,13-27-19(24)14-7-3-1-4-8-14)18(23)17(16)28-20(25)15-9-5-2-6-10-15/h1-12,16-18,22-23,26H,13H2/t16-,17+,18-,21-/m0/s1

> <INCHI_KEY>
PFCBOFJOXAUYRA-NYUBLWNDSA-N

> <FORMULA>
C21H20O7

> <MOLECULAR_WEIGHT>
384.384

> <EXACT_MASS>
384.120902984

> <JCHEM_ACCEPTOR_COUNT>
5

> <JCHEM_ATOM_COUNT>
48

> <JCHEM_AVERAGE_POLARIZABILITY>
37.78261137746807

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(1R,2S,5S,6S)-5-[(benzoyloxy)methyl]-2,5,6-trihydroxycyclohex-3-en-1-yl benzoate

> <JCHEM_LOGP>
2.230142304333333

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
13.490097355722192

> <JCHEM_PKA_STRONGEST_ACIDIC>
12.359808337561567

> <JCHEM_PKA_STRONGEST_BASIC>
-3.365935543759157

> <JCHEM_POLAR_SURFACE_AREA>
113.29

> <JCHEM_REFRACTIVITY>
99.99450000000003

> <JCHEM_ROTATABLE_BOND_COUNT>
7

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
(1R,2S,5S,6S)-5-[(benzoyloxy)methyl]-2,5,6-trihydroxycyclohex-3-en-1-yl benzoate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 06-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   06-SEP-22         0                                  
HETATM    1  O   UNK     0       8.487  -0.043   0.000  0.00  0.00           O+0
HETATM    2  C   UNK     0       9.014  -1.491   0.000  0.00  0.00           C+0
HETATM    3  O   UNK     0       8.024  -2.670   0.000  0.00  0.00           O+0
HETATM    4  C   UNK     0       6.508  -2.403   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       5.518  -3.583   0.000  0.00  0.00           C+0
HETATM    6  O   UNK     0       4.528  -2.403   0.000  0.00  0.00           O+0
HETATM    7  C   UNK     0       6.851  -4.353   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       6.851  -5.893   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       5.518  -6.663   0.000  0.00  0.00           C+0
HETATM   10  O   UNK     0       5.518  -8.203   0.000  0.00  0.00           O+0
HETATM   11  C   UNK     0       4.184  -5.893   0.000  0.00  0.00           C+0
HETATM   12  O   UNK     0       2.850  -6.663   0.000  0.00  0.00           O+0
HETATM   13  C   UNK     0       2.850  -8.203   0.000  0.00  0.00           C+0
HETATM   14  O   UNK     0       4.184  -8.973   0.000  0.00  0.00           O+0
HETATM   15  C   UNK     0       1.517  -8.973   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       1.517 -10.513   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       0.183 -11.283   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      -1.151 -10.513   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0      -1.151  -8.973   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       0.183  -8.203   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       4.184  -4.353   0.000  0.00  0.00           C+0
HETATM   22  O   UNK     0       2.850  -3.583   0.000  0.00  0.00           O+0
HETATM   23  C   UNK     0      10.531  -1.758   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0      11.521  -0.578   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0      13.037  -0.846   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0      13.564  -2.293   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0      12.574  -3.473   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0      11.057  -3.205   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3   23                                                  
CONECT    3    2    4                                                       
CONECT    4    3    5                                                       
CONECT    5    4    6    7   21                                             
CONECT    6    5                                                            
CONECT    7    5    8                                                       
CONECT    8    7    9                                                       
CONECT    9    8   10   11                                                  
CONECT   10    9                                                            
CONECT   11    9   12   21                                                  
CONECT   12   11   13                                                       
CONECT   13   12   14   15                                                  
CONECT   14   13                                                            
CONECT   15   13   16   20                                                  
CONECT   16   15   17                                                       
CONECT   17   16   18                                                       
CONECT   18   17   19                                                       
CONECT   19   18   20                                                       
CONECT   20   19   15                                                       
CONECT   21   11    5   22                                                  
CONECT   22   21                                                            
CONECT   23    2   24   28                                                  
CONECT   24   23   25                                                       
CONECT   25   24   26                                                       
CONECT   26   25   27                                                       
CONECT   27   26   28                                                       
CONECT   28   27   23                                                       
MASTER        0    0    0    0    0    0    0    0   28    0   60    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₁H₂₀O₇

Average Mass

384.3840 Da

Monoisotopic Mass

384.12090 Da

IUPAC Name

(1R,2S,5S,6S)-5-[(benzoyloxy)methyl]-2,5,6-trihydroxycyclohex-3-en-1-yl benzoate

Traditional Name

(1R,2S,5S,6S)-5-[(benzoyloxy)methyl]-2,5,6-trihydroxycyclohex-3-en-1-yl benzoate

CAS Registry Number

Not Available

SMILES

O[C@H]1C=C[C@](O)(COC(=O)C2=CC=CC=C2)[C@@H](O)[C@@H]1OC(=O)C1=CC=CC=C1

InChI Identifier

InChI=1S/C21H20O7/c22-16-11-12-21(26,13-27-19(24)14-7-3-1-4-8-14)18(23)17(16)28-20(25)15-9-5-2-6-10-15/h1-12,16-18,22-23,26H,13H2/t16-,17+,18-,21-/m0/s1

InChI Key

PFCBOFJOXAUYRA-NYUBLWNDSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Monanthotaxis buchananii	LOTUS Database	35616633

Chemical Taxonomy

Classification

Not classified

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	2.23	ChemAxon
pKa (Strongest Acidic)	12.36	ChemAxon
pKa (Strongest Basic)	-3.4	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	113.29 Å²	ChemAxon
Rotatable Bond Count	7	ChemAxon
Refractivity	99.99 m³·mol⁻¹	ChemAxon
Polarizability	37.78 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

External Links

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for (1r,2s,5s,6s)-5-[(benzoyloxy)methyl]-2,5,6-trihydroxycyclohex-3-en-1-yl benzoate (NP0221404)

MOL for NP0221404 ((1r,2s,5s,6s)-5-[(benzoyloxy)methyl]-2,5,6-trihydroxycyclohex-3-en-1-yl benzoate)

3D MOL for NP0221404 ((1r,2s,5s,6s)-5-[(benzoyloxy)methyl]-2,5,6-trihydroxycyclohex-3-en-1-yl benzoate)

3D SDF for NP0221404 ((1r,2s,5s,6s)-5-[(benzoyloxy)methyl]-2,5,6-trihydroxycyclohex-3-en-1-yl benzoate)

3D-SDF for NP0221404 ((1r,2s,5s,6s)-5-[(benzoyloxy)methyl]-2,5,6-trihydroxycyclohex-3-en-1-yl benzoate)

PDB for NP0221404 ((1r,2s,5s,6s)-5-[(benzoyloxy)methyl]-2,5,6-trihydroxycyclohex-3-en-1-yl benzoate)

3D PDB for NP0221404 ((1r,2s,5s,6s)-5-[(benzoyloxy)methyl]-2,5,6-trihydroxycyclohex-3-en-1-yl benzoate)

SMILES for NP0221404 ((1r,2s,5s,6s)-5-[(benzoyloxy)methyl]-2,5,6-trihydroxycyclohex-3-en-1-yl benzoate)

INCHI for NP0221404 ((1r,2s,5s,6s)-5-[(benzoyloxy)methyl]-2,5,6-trihydroxycyclohex-3-en-1-yl benzoate)

Structure for NP0221404 ((1r,2s,5s,6s)-5-[(benzoyloxy)methyl]-2,5,6-trihydroxycyclohex-3-en-1-yl benzoate)

3D Structure for NP0221404 ((1r,2s,5s,6s)-5-[(benzoyloxy)methyl]-2,5,6-trihydroxycyclohex-3-en-1-yl benzoate)