Record Information |
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Version | 1.0 |
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Created at | 2022-09-05 19:12:16 UTC |
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Updated at | 2022-09-05 19:12:16 UTC |
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NP-MRD ID | NP0218513 |
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Secondary Accession Numbers | None |
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Natural Product Identification |
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Common Name | (1r,3ar,5ar,9as,11ar)-3a,6,6,9a,11a-pentamethyl-1-[(2r,5s)-5,6,7-trihydroxy-6-methylheptan-2-yl]-1h,2h,3h,5h,5ah,8h,9h,11h-cyclopenta[a]phenanthren-7-one |
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Description | Ganodermanontriol, also known as GNDT triterpene, belongs to the class of organic compounds known as triterpenoids. These are terpene molecules containing six isoprene units. It was first documented in 2017 (PMID: 28912878). Based on a literature review a significant number of articles have been published on Ganodermanontriol (PMID: 33130280) (PMID: 31836806) (PMID: 31775117) (PMID: 30539830). |
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Structure | C[C@H](CC[C@H](O)C(C)(O)CO)[C@H]1CC[C@@]2(C)C3=CC[C@H]4C(C)(C)C(=O)CC[C@]4(C)C3=CC[C@]12C InChI=1S/C30H48O4/c1-19(8-11-25(33)30(7,34)18-31)20-12-16-29(6)22-9-10-23-26(2,3)24(32)14-15-27(23,4)21(22)13-17-28(20,29)5/h9,13,19-20,23,25,31,33-34H,8,10-12,14-18H2,1-7H3/t19-,20-,23+,25+,27-,28-,29+,30?/m1/s1 |
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Synonyms | Value | Source |
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GNDT Triterpene | MeSH |
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Chemical Formula | C30H48O4 |
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Average Mass | 472.7100 Da |
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Monoisotopic Mass | 472.35526 Da |
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IUPAC Name | (2S,7R,11R,14R,15R)-2,6,6,11,15-pentamethyl-14-[(2R,5S)-5,6,7-trihydroxy-6-methylheptan-2-yl]tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-1(17),9-dien-5-one |
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Traditional Name | (2S,7R,11R,14R,15R)-2,6,6,11,15-pentamethyl-14-[(2R,5S)-5,6,7-trihydroxy-6-methylheptan-2-yl]tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-1(17),9-dien-5-one |
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CAS Registry Number | Not Available |
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SMILES | C[C@H](CC[C@H](O)C(C)(O)CO)[C@H]1CC[C@@]2(C)C3=CC[C@H]4C(C)(C)C(=O)CC[C@]4(C)C3=CC[C@]12C |
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InChI Identifier | InChI=1S/C30H48O4/c1-19(8-11-25(33)30(7,34)18-31)20-12-16-29(6)22-9-10-23-26(2,3)24(32)14-15-27(23,4)21(22)13-17-28(20,29)5/h9,13,19-20,23,25,31,33-34H,8,10-12,14-18H2,1-7H3/t19-,20-,23+,25+,27-,28-,29+,30?/m1/s1 |
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InChI Key | KASALCUNLBTNAA-VIKWRQSJSA-N |
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Experimental Spectra |
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| Not Available | Predicted Spectra |
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| Not Available | Chemical Shift Submissions |
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| Not Available | Species |
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Species of Origin | Not Available |
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Chemical Taxonomy |
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Description | Belongs to the class of organic compounds known as triterpenoids. These are terpene molecules containing six isoprene units. |
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Kingdom | Organic compounds |
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Super Class | Lipids and lipid-like molecules |
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Class | Prenol lipids |
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Sub Class | Triterpenoids |
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Direct Parent | Triterpenoids |
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Alternative Parents | |
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Substituents | - Triterpenoid
- 26-hydroxysteroid
- Trihydroxy bile acid, alcohol, or derivatives
- 25-hydroxysteroid
- 24-hydroxysteroid
- Cholane-skeleton
- Hydroxy bile acid, alcohol, or derivatives
- Bile acid, alcohol, or derivatives
- 3-oxo-delta-7-steroid
- 3-oxosteroid
- 14-alpha-methylsteroid
- 3-oxo-5-alpha-steroid
- Oxosteroid
- Delta-7-steroid
- Steroid
- Fatty alcohol
- Fatty acyl
- Tertiary alcohol
- Ketone
- Secondary alcohol
- Cyclic ketone
- Polyol
- Organooxygen compound
- Primary alcohol
- Organic oxygen compound
- Carbonyl group
- Hydrocarbon derivative
- Alcohol
- Organic oxide
- Aliphatic homopolycyclic compound
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Molecular Framework | Aliphatic homopolycyclic compounds |
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External Descriptors | Not Available |
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Physical Properties |
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State | Not Available |
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Experimental Properties | Property | Value | Reference |
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Melting Point | Not Available | Not Available | Boiling Point | Not Available | Not Available | Water Solubility | Not Available | Not Available | LogP | Not Available | Not Available |
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Predicted Properties | |
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General References | - Zheng DS, Chen LS: Triterpenoids from Ganoderma lucidum inhibit the activation of EBV antigens as telomerase inhibitors. Exp Ther Med. 2017 Oct;14(4):3273-3278. doi: 10.3892/etm.2017.4883. Epub 2017 Aug 3. [PubMed:28912878 ]
- M P, Reddy GJ, Hema K, Dodoala S, Koganti B: Unravelling high-affinity binding compounds towards transmembrane protease serine 2 enzyme in treating SARS-CoV-2 infection using molecular modelling and docking studies. Eur J Pharmacol. 2021 Jan 5;890:173688. doi: 10.1016/j.ejphar.2020.173688. Epub 2020 Oct 29. [PubMed:33130280 ]
- Bharadwaj S, Lee KE, Dwivedi VD, Yadava U, Panwar A, Lucas SJ, Pandey A, Kang SG: Discovery of Ganoderma lucidum triterpenoids as potential inhibitors against Dengue virus NS2B-NS3 protease. Sci Rep. 2019 Dec 13;9(1):19059. doi: 10.1038/s41598-019-55723-5. [PubMed:31836806 ]
- Hu Z, Du R, Xiu L, Bian Z, Ma C, Sato N, Hattori M, Zhang H, Liang Y, Yu S, Wang X: Protective effect of triterpenes of Ganoderma lucidum on lipopolysaccharide-induced inflammatory responses and acute liver injury. Cytokine. 2020 Mar;127:154917. doi: 10.1016/j.cyto.2019.154917. Epub 2019 Nov 24. [PubMed:31775117 ]
- Xu C, Guo H, Kong D, Pang D, Ding Y: Ganodermanontriol inhibits expression of special AT rich sequence binding protein 1 gene in human hepatocellular carcinoma. J Cancer Res Ther. 2018 Dec;14(Supplement):S964-S968. doi: 10.4103/0973-1482.203597. [PubMed:30539830 ]
- LOTUS database [Link]
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