NP-MRD: Showing NP-Card for (1r,2s,4r,6r,9r,10r,11r,12s,14r,15r,18r)-6-(furan-3-yl)-14-hydroxy-10-(2-methoxy-2-oxoethyl)-7,9,11,15-tetramethyl-3,17-dioxapentacyclo[9.6.1.0²,⁹.0⁴,⁸.0¹⁵,¹⁸]octadec-7-en-12-yl 2,3-dimethylbut-2-enoate (NP0216357)

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Record Information

Version

2.0

Created at

2022-09-05 16:17:01 UTC

Updated at

2022-09-05 16:17:01 UTC

NP-MRD ID

NP0216357

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(1r,2s,4r,6r,9r,10r,11r,12s,14r,15r,18r)-6-(furan-3-yl)-14-hydroxy-10-(2-methoxy-2-oxoethyl)-7,9,11,15-tetramethyl-3,17-dioxapentacyclo[9.6.1.0²,⁹.0⁴,⁸.0¹⁵,¹⁸]octadec-7-en-12-yl 2,3-dimethylbut-2-enoate

Description

(1R,2S,4R,6R,9R,10R,11R,12S,14R,15R,18R)-6-(furan-3-yl)-14-hydroxy-10-(2-methoxy-2-oxoethyl)-7,9,11,15-tetramethyl-3,17-dioxapentacyclo[9.6.1.0²,⁹.0⁴,⁸.0¹⁵,¹⁸]Octadec-7-en-12-yl 2,3-dimethylbut-2-enoate belongs to the class of organic compounds known as limonoids. These are highly oxygenated, modified terpenoids with a prototypical structure either containing or derived from a precursor with a 4,4,8-trimethyl-17-furanylsteroid skeleton. All naturally occurring citrus limonoids contain a furan ring attached to the D-ring, at C-17, as well as oxygen containing functional groups at C-3, C-4, C-7, C-16 and C-17. (1r,2s,4r,6r,9r,10r,11r,12s,14r,15r,18r)-6-(furan-3-yl)-14-hydroxy-10-(2-methoxy-2-oxoethyl)-7,9,11,15-tetramethyl-3,17-dioxapentacyclo[9.6.1.0²,⁹.0⁴,⁸.0¹⁵,¹⁸]octadec-7-en-12-yl 2,3-dimethylbut-2-enoate is found in Azadirachta indica. Based on a literature review very few articles have been published on (1R,2S,4R,6R,9R,10R,11R,12S,14R,15R,18R)-6-(furan-3-yl)-14-hydroxy-10-(2-methoxy-2-oxoethyl)-7,9,11,15-tetramethyl-3,17-dioxapentacyclo[9.6.1.0²,⁹.0⁴,⁸.0¹⁵,¹⁸]Octadec-7-en-12-yl 2,3-dimethylbut-2-enoate.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309052218172D          

 41 46  0  0  1  0            999 V2000
    3.7948    4.1872    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4019    3.6286    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4343    2.5771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2541    1.7720    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.8612    1.2134    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.1246    1.9952    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6825    1.2908    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3016    1.8361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2242    2.6575    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0115    1.4159    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    6.7688    1.7433    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9491    2.5484    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7704    2.6257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0978    1.8685    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.4788    1.3231    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  6  5  1  1  0  0  0
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 30 39  1  0  0  0  0
  6 39  1  0  0  0  0
 39 40  1  1  0  0  0
 39 41  1  0  0  0  0
 41 22  1  1  0  0  0
 25 41  1  0  0  0  0
M  END

     RDKit          3D

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M  END


  Mrv1652309052218172D          

 41 46  0  0  1  0            999 V2000
    3.7948    4.1872    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4019    3.6286    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8612    1.2134    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.1246    1.9952    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6825    1.2908    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3016    1.8361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2242    2.6575    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0115    1.4159    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    6.7688    1.7433    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9491    2.5484    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7704    2.6257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0978    1.8685    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.4788    1.3231    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8313    0.6108    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0099    0.5335    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.3909   -0.0119    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6809    0.4083    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.8936    0.1619    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.5499   -0.5881    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7304   -0.4930    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5676    0.3158    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.8950   -0.1619    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8577    0.7360    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.1388    0.3313    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8666    1.5610    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5855    1.9657    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.5650    2.7904    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2690    3.2205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9935    2.8259    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2485    4.0453    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9526    4.4754    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5241    4.4399    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8200    4.0098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5036    5.2647    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4668    1.5256    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.5326    2.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2865    0.7205    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  6  5  1  1  0  0  0
  6  7  1  0  0  0  0
  7  8  1  1  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  6  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 13 17  2  0  0  0  0
 12 18  1  0  0  0  0
 18 19  1  0  0  0  0
  9 19  1  0  0  0  0
 19 20  1  1  0  0  0
 21 20  1  6  0  0  0
  7 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  6  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  1  0  0  0
 25 27  1  0  0  0  0
 27 28  1  6  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  6  0  0  0
 31 32  1  0  0  0  0
 32 33  2  0  0  0  0
 32 34  1  0  0  0  0
 34 35  1  0  0  0  0
 34 36  2  0  0  0  0
 36 37  1  0  0  0  0
 36 38  1  0  0  0  0
 30 39  1  0  0  0  0
  6 39  1  0  0  0  0
 39 40  1  1  0  0  0
 39 41  1  0  0  0  0
 41 22  1  1  0  0  0
 25 41  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0216357

> <DATABASE_NAME>
NP-MRD

> <SMILES>
COC(=O)C[C@H]1[C@@]2(C)[C@H](O[C@@H]3C[C@H](C(C)=C23)C2=COC=C2)[C@@H]2OC[C@@]3(C)[C@H]2[C@]1(C)[C@H](C[C@H]3O)OC(=O)C(C)=C(C)C

> <INCHI_IDENTIFIER>
InChI=1S/C33H44O8/c1-16(2)17(3)30(36)41-24-13-23(34)31(5)15-39-27-28(31)32(24,6)22(12-25(35)37-8)33(7)26-18(4)20(19-9-10-38-14-19)11-21(26)40-29(27)33/h9-10,14,20-24,27-29,34H,11-13,15H2,1-8H3/t20-,21-,22-,23-,24+,27-,28+,29-,31-,32+,33-/m1/s1

> <INCHI_KEY>
HDWJWGSHTLTMDA-SWSOGBNYSA-N

> <FORMULA>
C33H44O8

> <MOLECULAR_WEIGHT>
568.707

> <EXACT_MASS>
568.303618377

> <JCHEM_ACCEPTOR_COUNT>
5

> <JCHEM_ATOM_COUNT>
85

> <JCHEM_AVERAGE_POLARIZABILITY>
61.138341688507275

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(1R,2S,4R,6R,9R,10R,11R,12S,14R,15R,18R)-6-(furan-3-yl)-14-hydroxy-10-(2-methoxy-2-oxoethyl)-7,9,11,15-tetramethyl-3,17-dioxapentacyclo[9.6.1.0^{2,9}.0^{4,8}.0^{15,18}]octadec-7-en-12-yl 2,3-dimethylbut-2-enoate

> <JCHEM_LOGP>
3.760077126666668

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
6

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_ACIDIC>
14.540990011369153

> <JCHEM_PKA_STRONGEST_BASIC>
-2.8387663843821014

> <JCHEM_POLAR_SURFACE_AREA>
104.43

> <JCHEM_REFRACTIVITY>
151.21720000000002

> <JCHEM_ROTATABLE_BOND_COUNT>
7

> <JCHEM_RULE_OF_FIVE>
0

> <JCHEM_TRADITIONAL_IUPAC>
(1R,2S,4R,6R,9R,10R,11R,12S,14R,15R,18R)-6-(furan-3-yl)-14-hydroxy-10-(2-methoxy-2-oxoethyl)-7,9,11,15-tetramethyl-3,17-dioxapentacyclo[9.6.1.0^{2,9}.0^{4,8}.0^{15,18}]octadec-7-en-12-yl 2,3-dimethylbut-2-enoate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 05-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   05-SEP-22         0                                  
HETATM    1  C   UNK     0       7.084   7.816   0.000  0.00  0.00           C+0
HETATM    2  O   UNK     0       8.217   6.773   0.000  0.00  0.00           O+0
HETATM    3  C   UNK     0       7.880   5.271   0.000  0.00  0.00           C+0
HETATM    4  O   UNK     0       9.014   4.228   0.000  0.00  0.00           O+0
HETATM    5  C   UNK     0       6.411   4.811   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       6.074   3.308   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       7.208   2.265   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       7.699   3.724   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       8.741   2.409   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       9.896   3.427   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       9.752   4.961   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      11.222   2.643   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      12.635   3.254   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      12.972   4.757   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      14.505   4.901   0.000  0.00  0.00           C+0
HETATM   16  O   UNK     0      15.116   3.488   0.000  0.00  0.00           O+0
HETATM   17  C   UNK     0      13.960   2.470   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      10.885   1.140   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       9.352   0.996   0.000  0.00  0.00           C+0
HETATM   20  O   UNK     0       8.196  -0.022   0.000  0.00  0.00           O+0
HETATM   21  C   UNK     0       6.871   0.762   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       5.401   0.302   0.000  0.00  0.00           C+0
HETATM   23  O   UNK     0       4.760  -1.098   0.000  0.00  0.00           O+0
HETATM   24  C   UNK     0       3.230  -0.920   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0       2.926   0.589   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0       1.671  -0.302   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0       1.601   1.374   0.000  0.00  0.00           C+0
HETATM   28  O   UNK     0       0.259   0.618   0.000  0.00  0.00           O+0
HETATM   29  C   UNK     0       1.618   2.914   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0       2.960   3.669   0.000  0.00  0.00           C+0
HETATM   31  O   UNK     0       2.921   5.209   0.000  0.00  0.00           O+0
HETATM   32  C   UNK     0       4.236   6.012   0.000  0.00  0.00           C+0
HETATM   33  O   UNK     0       5.588   5.275   0.000  0.00  0.00           O+0
HETATM   34  C   UNK     0       4.197   7.551   0.000  0.00  0.00           C+0
HETATM   35  C   UNK     0       5.511   8.354   0.000  0.00  0.00           C+0
HETATM   36  C   UNK     0       2.845   8.288   0.000  0.00  0.00           C+0
HETATM   37  C   UNK     0       1.531   7.485   0.000  0.00  0.00           C+0
HETATM   38  C   UNK     0       2.807   9.827   0.000  0.00  0.00           C+0
HETATM   39  C   UNK     0       4.605   2.848   0.000  0.00  0.00           C+0
HETATM   40  C   UNK     0       4.728   4.383   0.000  0.00  0.00           C+0
HETATM   41  C   UNK     0       4.268   1.345   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4    5                                                  
CONECT    4    3                                                            
CONECT    5    3    6                                                       
CONECT    6    5    7   39                                                  
CONECT    7    6    8    9   21                                             
CONECT    8    7                                                            
CONECT    9    7   10   19                                                  
CONECT   10    9   11   12                                                  
CONECT   11   10                                                            
CONECT   12   10   13   18                                                  
CONECT   13   12   14   17                                                  
CONECT   14   13   15                                                       
CONECT   15   14   16                                                       
CONECT   16   15   17                                                       
CONECT   17   16   13                                                       
CONECT   18   12   19                                                       
CONECT   19   18    9   20                                                  
CONECT   20   19   21                                                       
CONECT   21   20    7   22                                                  
CONECT   22   21   23   41                                                  
CONECT   23   22   24                                                       
CONECT   24   23   25                                                       
CONECT   25   24   26   27   41                                             
CONECT   26   25                                                            
CONECT   27   25   28   29                                                  
CONECT   28   27                                                            
CONECT   29   27   30                                                       
CONECT   30   29   31   39                                                  
CONECT   31   30   32                                                       
CONECT   32   31   33   34                                                  
CONECT   33   32                                                            
CONECT   34   32   35   36                                                  
CONECT   35   34                                                            
CONECT   36   34   37   38                                                  
CONECT   37   36                                                            
CONECT   38   36                                                            
CONECT   39   30    6   40   41                                             
CONECT   40   39                                                            
CONECT   41   39   22   25                                                  
MASTER        0    0    0    0    0    0    0    0   41    0   92    0
END

View in JSmol

Synonyms

Value	Source
(1R,2S,4R,6R,9R,10R,11R,12S,14R,15R,18R)-6-(Furan-3-yl)-14-hydroxy-10-(2-methoxy-2-oxoethyl)-7,9,11,15-tetramethyl-3,17-dioxapentacyclo[9.6.1.0,.0,.0,]octadec-7-en-12-yl 2,3-dimethylbut-2-enoic acid	Generator

Chemical Formula

C₃₃H₄₄O₈

Average Mass

568.7070 Da

Monoisotopic Mass

568.30362 Da

IUPAC Name

(1R,2S,4R,6R,9R,10R,11R,12S,14R,15R,18R)-6-(furan-3-yl)-14-hydroxy-10-(2-methoxy-2-oxoethyl)-7,9,11,15-tetramethyl-3,17-dioxapentacyclo[9.6.1.0^{2,9}.0^{4,8}.0^{15,18}]octadec-7-en-12-yl 2,3-dimethylbut-2-enoate

Traditional Name

CAS Registry Number

Not Available

SMILES

COC(=O)C[C@H]1[C@@]2(C)[C@H](O[C@@H]3C[C@H](C(C)=C23)C2=COC=C2)[C@@H]2OC[C@@]3(C)[C@H]2[C@]1(C)[C@H](C[C@H]3O)OC(=O)C(C)=C(C)C

InChI Identifier

InChI=1S/C33H44O8/c1-16(2)17(3)30(36)41-24-13-23(34)31(5)15-39-27-28(31)32(24,6)22(12-25(35)37-8)33(7)26-18(4)20(19-9-10-38-14-19)11-21(26)40-29(27)33/h9-10,14,20-24,27-29,34H,11-13,15H2,1-8H3/t20-,21-,22-,23-,24+,27-,28+,29-,31-,32+,33-/m1/s1

InChI Key

HDWJWGSHTLTMDA-SWSOGBNYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Azadirachta indica	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as limonoids. These are highly oxygenated, modified terpenoids with a prototypical structure either containing or derived from a precursor with a 4,4,8-trimethyl-17-furanylsteroid skeleton. All naturally occurring citrus limonoids contain a furan ring attached to the D-ring, at C-17, as well as oxygen containing functional groups at C-3, C-4, C-7, C-16 and C-17.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Triterpenoids

Direct Parent

Limonoids

Alternative Parents

Substituents

Limonoid skeleton
Naphthofuran
Fatty acid ester
Dicarboxylic acid or derivatives
Fatty acyl
Cyclic alcohol
Heteroaromatic compound
Furan
Alpha,beta-unsaturated carboxylic ester
Enoate ester
Methyl ester
Tetrahydrofuran
Carboxylic acid ester
Secondary alcohol
Carboxylic acid derivative
Dialkyl ether
Ether
Oxacycle
Organoheterocyclic compound
Organic oxide
Hydrocarbon derivative
Carbonyl group
Alcohol
Organic oxygen compound
Organooxygen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	3.76	ChemAxon
pKa (Strongest Acidic)	14.54	ChemAxon
pKa (Strongest Basic)	-2.8	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	104.43 Å²	ChemAxon
Rotatable Bond Count	7	ChemAxon
Refractivity	151.22 m³·mol⁻¹	ChemAxon
Polarizability	61.14 Å³	ChemAxon
Number of Rings	6	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

163046290

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for (1r,2s,4r,6r,9r,10r,11r,12s,14r,15r,18r)-6-(furan-3-yl)-14-hydroxy-10-(2-methoxy-2-oxoethyl)-7,9,11,15-tetramethyl-3,17-dioxapentacyclo[9.6.1.0²,⁹.0⁴,⁸.0¹⁵,¹⁸]octadec-7-en-12-yl 2,3-dimethylbut-2-enoate (NP0216357)

MOL for NP0216357 ((1r,2s,4r,6r,9r,10r,11r,12s,14r,15r,18r)-6-(furan-3-yl)-14-hydroxy-10-(2-methoxy-2-oxoethyl)-7,9,11,15-tetramethyl-3,17-dioxapentacyclo[9.6.1.0²,⁹.0⁴,⁸.0¹⁵,¹⁸]octadec-7-en-12-yl 2,3-dimethylbut-2-enoate)

3D MOL for NP0216357 ((1r,2s,4r,6r,9r,10r,11r,12s,14r,15r,18r)-6-(furan-3-yl)-14-hydroxy-10-(2-methoxy-2-oxoethyl)-7,9,11,15-tetramethyl-3,17-dioxapentacyclo[9.6.1.0²,⁹.0⁴,⁸.0¹⁵,¹⁸]octadec-7-en-12-yl 2,3-dimethylbut-2-enoate)

3D SDF for NP0216357 ((1r,2s,4r,6r,9r,10r,11r,12s,14r,15r,18r)-6-(furan-3-yl)-14-hydroxy-10-(2-methoxy-2-oxoethyl)-7,9,11,15-tetramethyl-3,17-dioxapentacyclo[9.6.1.0²,⁹.0⁴,⁸.0¹⁵,¹⁸]octadec-7-en-12-yl 2,3-dimethylbut-2-enoate)

3D-SDF for NP0216357 ((1r,2s,4r,6r,9r,10r,11r,12s,14r,15r,18r)-6-(furan-3-yl)-14-hydroxy-10-(2-methoxy-2-oxoethyl)-7,9,11,15-tetramethyl-3,17-dioxapentacyclo[9.6.1.0²,⁹.0⁴,⁸.0¹⁵,¹⁸]octadec-7-en-12-yl 2,3-dimethylbut-2-enoate)

PDB for NP0216357 ((1r,2s,4r,6r,9r,10r,11r,12s,14r,15r,18r)-6-(furan-3-yl)-14-hydroxy-10-(2-methoxy-2-oxoethyl)-7,9,11,15-tetramethyl-3,17-dioxapentacyclo[9.6.1.0²,⁹.0⁴,⁸.0¹⁵,¹⁸]octadec-7-en-12-yl 2,3-dimethylbut-2-enoate)

3D PDB for NP0216357 ((1r,2s,4r,6r,9r,10r,11r,12s,14r,15r,18r)-6-(furan-3-yl)-14-hydroxy-10-(2-methoxy-2-oxoethyl)-7,9,11,15-tetramethyl-3,17-dioxapentacyclo[9.6.1.0²,⁹.0⁴,⁸.0¹⁵,¹⁸]octadec-7-en-12-yl 2,3-dimethylbut-2-enoate)

SMILES for NP0216357 ((1r,2s,4r,6r,9r,10r,11r,12s,14r,15r,18r)-6-(furan-3-yl)-14-hydroxy-10-(2-methoxy-2-oxoethyl)-7,9,11,15-tetramethyl-3,17-dioxapentacyclo[9.6.1.0²,⁹.0⁴,⁸.0¹⁵,¹⁸]octadec-7-en-12-yl 2,3-dimethylbut-2-enoate)

INCHI for NP0216357 ((1r,2s,4r,6r,9r,10r,11r,12s,14r,15r,18r)-6-(furan-3-yl)-14-hydroxy-10-(2-methoxy-2-oxoethyl)-7,9,11,15-tetramethyl-3,17-dioxapentacyclo[9.6.1.0²,⁹.0⁴,⁸.0¹⁵,¹⁸]octadec-7-en-12-yl 2,3-dimethylbut-2-enoate)

Structure for NP0216357 ((1r,2s,4r,6r,9r,10r,11r,12s,14r,15r,18r)-6-(furan-3-yl)-14-hydroxy-10-(2-methoxy-2-oxoethyl)-7,9,11,15-tetramethyl-3,17-dioxapentacyclo[9.6.1.0²,⁹.0⁴,⁸.0¹⁵,¹⁸]octadec-7-en-12-yl 2,3-dimethylbut-2-enoate)

3D Structure for NP0216357 ((1r,2s,4r,6r,9r,10r,11r,12s,14r,15r,18r)-6-(furan-3-yl)-14-hydroxy-10-(2-methoxy-2-oxoethyl)-7,9,11,15-tetramethyl-3,17-dioxapentacyclo[9.6.1.0²,⁹.0⁴,⁸.0¹⁵,¹⁸]octadec-7-en-12-yl 2,3-dimethylbut-2-enoate)