NP-MRD: Showing NP-Card for 1-[(1s,3as,5's,5ar,7s,9as,11as)-7-hydroxy-6,6-bis(hydroxymethyl)-3',3a,9a,11a-tetramethyl-2,3,4,5,5a,7,8,9,10,11-decahydrospiro[cyclopenta[a]phenanthrene-1,2'-oxolan]-5'-yl]propan-1-one (NP0213081)

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Record Information

Version

2.0

Created at

2022-09-05 11:56:44 UTC

Updated at

2022-09-05 11:56:44 UTC

NP-MRD ID

NP0213081

Secondary Accession Numbers

None

Natural Product Identification

Common Name

1-[(1s,3as,5's,5ar,7s,9as,11as)-7-hydroxy-6,6-bis(hydroxymethyl)-3',3a,9a,11a-tetramethyl-2,3,4,5,5a,7,8,9,10,11-decahydrospiro[cyclopenta[a]phenanthrene-1,2'-oxolan]-5'-yl]propan-1-one

Description

1-[(2S,2'S,5S,5'S,7'R,11'S,15'S)-5'-hydroxy-6',6'-bis(hydroxymethyl)-2',3,11',15'-tetramethylspiro[oxolane-2,14'-tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]Heptadecan]-1'(10')-en-5-yl]propan-1-one belongs to the class of organic compounds known as triterpenoids. These are terpene molecules containing six isoprene units. Based on a literature review very few articles have been published on 1-[(2S,2'S,5S,5'S,7'R,11'S,15'S)-5'-hydroxy-6',6'-bis(hydroxymethyl)-2',3,11',15'-tetramethylspiro[oxolane-2,14'-tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]Heptadecan]-1'(10')-en-5-yl]propan-1-one.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309052213562D          

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M  END

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M  END


  Mrv1652309052213562D          

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   -0.3096    2.4114    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0830    1.1506    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.4515    1.8887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2750    1.9387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5987    1.0522    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  5  3  1  6  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  1  0  0  0
 12 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 12 18  1  0  0  0  0
  9 18  1  0  0  0  0
 18 19  1  6  0  0  0
 15 20  1  0  0  0  0
 20 21  1  6  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  6  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 26 29  1  0  0  0  0
 29 30  1  0  0  0  0
 26 31  1  0  0  0  0
 20 31  1  0  0  0  0
 31 32  1  6  0  0  0
 32 33  1  0  0  0  0
 14 33  1  0  0  0  0
  9 34  1  1  0  0  0
  5 34  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0213081

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CCC(=O)[C@@H]1CC(C)[C@]2(CC[C@@]3(C)C4=C(CC[C@]23C)[C@@]2(C)CC[C@H](O)C(CO)(CO)[C@@H]2CC4)O1

> <INCHI_IDENTIFIER>
InChI=1S/C29H46O5/c1-6-21(32)22-15-18(2)29(34-22)14-13-26(4)20-7-8-23-25(3,19(20)9-12-27(26,29)5)11-10-24(33)28(23,16-30)17-31/h18,22-24,30-31,33H,6-17H2,1-5H3/t18?,22-,23+,24-,25+,26-,27-,29-/m0/s1

> <INCHI_KEY>
PGCCXLDWXXFVMP-VULJCXSWSA-N

> <FORMULA>
C29H46O5

> <MOLECULAR_WEIGHT>
474.682

> <EXACT_MASS>
474.334524581

> <JCHEM_ACCEPTOR_COUNT>
5

> <JCHEM_ATOM_COUNT>
80

> <JCHEM_AVERAGE_POLARIZABILITY>
55.47228773399003

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
1-[(2S,2'S,5S,5'S,7'R,11'S,15'S)-5'-hydroxy-6',6'-bis(hydroxymethyl)-2',3,11',15'-tetramethylspiro[oxolane-2,14'-tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan]-1'(10')-en-5-yl]propan-1-one

> <JCHEM_LOGP>
3.2937644839999987

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
5

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
14.92016625756398

> <JCHEM_PKA_STRONGEST_ACIDIC>
14.297359845042266

> <JCHEM_PKA_STRONGEST_BASIC>
-2.8201325690842687

> <JCHEM_POLAR_SURFACE_AREA>
86.99000000000001

> <JCHEM_REFRACTIVITY>
132.7701

> <JCHEM_ROTATABLE_BOND_COUNT>
4

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
1-[(2S,2'S,5S,5'S,7'R,11'S,15'S)-5'-hydroxy-6',6'-bis(hydroxymethyl)-2',3,11',15'-tetramethylspiro[oxolane-2,14'-tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan]-1'(10')-en-5-yl]propan-1-one

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 05-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   05-SEP-22         0                                  
HETATM    1  C   UNK     0      15.087  -0.823   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      13.549  -0.755   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      12.839   0.612   0.000  0.00  0.00           C+0
HETATM    4  O   UNK     0      13.667   1.910   0.000  0.00  0.00           O+0
HETATM    5  C   UNK     0      11.300   0.680   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      10.341  -0.525   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       9.043   0.178   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       7.614  -0.834   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       8.967   1.553   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       9.035   3.092   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       7.592   3.632   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       6.633   2.427   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       5.923   3.794   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       5.096   2.334   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       4.408   0.956   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       5.257  -0.328   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       6.794  -0.235   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       7.482   1.143   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       8.461  -0.046   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       2.871   0.863   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       3.720  -0.421   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       2.183  -0.515   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       0.646  -0.608   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0      -0.203   0.677   0.000  0.00  0.00           C+0
HETATM   25  O   UNK     0      -1.741   0.584   0.000  0.00  0.00           O+0
HETATM   26  C   UNK     0       0.484   2.055   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0      -0.992   2.493   0.000  0.00  0.00           C+0
HETATM   28  O   UNK     0      -1.351   3.990   0.000  0.00  0.00           O+0
HETATM   29  C   UNK     0       0.660   3.585   0.000  0.00  0.00           C+0
HETATM   30  O   UNK     0      -0.578   4.501   0.000  0.00  0.00           O+0
HETATM   31  C   UNK     0       2.022   2.148   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0       2.709   3.526   0.000  0.00  0.00           C+0
HETATM   33  C   UNK     0       4.247   3.619   0.000  0.00  0.00           C+0
HETATM   34  O   UNK     0      10.451   1.964   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4    5                                                  
CONECT    4    3                                                            
CONECT    5    3    6   34                                                  
CONECT    6    5    7                                                       
CONECT    7    6    8    9                                                  
CONECT    8    7                                                            
CONECT    9    7   10   18   34                                             
CONECT   10    9   11                                                       
CONECT   11   10   12                                                       
CONECT   12   11   13   14   18                                             
CONECT   13   12                                                            
CONECT   14   12   15   33                                                  
CONECT   15   14   16   20                                                  
CONECT   16   15   17                                                       
CONECT   17   16   18                                                       
CONECT   18   17   12    9   19                                             
CONECT   19   18                                                            
CONECT   20   15   21   22   31                                             
CONECT   21   20                                                            
CONECT   22   20   23                                                       
CONECT   23   22   24                                                       
CONECT   24   23   25   26                                                  
CONECT   25   24                                                            
CONECT   26   24   27   29   31                                             
CONECT   27   26   28                                                       
CONECT   28   27                                                            
CONECT   29   26   30                                                       
CONECT   30   29                                                            
CONECT   31   26   20   32                                                  
CONECT   32   31   33                                                       
CONECT   33   32   14                                                       
CONECT   34    9    5                                                       
MASTER        0    0    0    0    0    0    0    0   34    0   76    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₉H₄₆O₅

Average Mass

474.6820 Da

Monoisotopic Mass

474.33452 Da

IUPAC Name

1-[(2S,2'S,5S,5'S,7'R,11'S,15'S)-5'-hydroxy-6',6'-bis(hydroxymethyl)-2',3,11',15'-tetramethylspiro[oxolane-2,14'-tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan]-1'(10')-en-5-yl]propan-1-one

Traditional Name

1-[(2S,2'S,5S,5'S,7'R,11'S,15'S)-5'-hydroxy-6',6'-bis(hydroxymethyl)-2',3,11',15'-tetramethylspiro[oxolane-2,14'-tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan]-1'(10')-en-5-yl]propan-1-one

CAS Registry Number

Not Available

SMILES

CCC(=O)[C@@H]1CC(C)[C@]2(CC[C@@]3(C)C4=C(CC[C@]23C)[C@@]2(C)CC[C@H](O)C(CO)(CO)[C@@H]2CC4)O1

InChI Identifier

InChI=1S/C29H46O5/c1-6-21(32)22-15-18(2)29(34-22)14-13-26(4)20-7-8-23-25(3,19(20)9-12-27(26,29)5)11-10-24(33)28(23,16-30)17-31/h18,22-24,30-31,33H,6-17H2,1-5H3/t18?,22-,23+,24-,25+,26-,27-,29-/m0/s1

InChI Key

PGCCXLDWXXFVMP-VULJCXSWSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Not Available

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as triterpenoids. These are terpene molecules containing six isoprene units.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Triterpenoids

Direct Parent

Triterpenoids

Alternative Parents

Substituents

Triterpenoid
14-alpha-methylsteroid
3-beta-hydroxysteroid
Hydroxysteroid
3-hydroxysteroid
Steroid
Tetrahydrofuran
Cyclic alcohol
Secondary alcohol
Ketone
Oxacycle
Organoheterocyclic compound
Ether
Dialkyl ether
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Primary alcohol
Organooxygen compound
Carbonyl group
Alcohol
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	3.29	ChemAxon
pKa (Strongest Acidic)	14.3	ChemAxon
pKa (Strongest Basic)	-2.8	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	86.99 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	132.77 m³·mol⁻¹	ChemAxon
Polarizability	55.47 Å³	ChemAxon
Number of Rings	5	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

57641890

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

163070554

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for 1-[(1s,3as,5's,5ar,7s,9as,11as)-7-hydroxy-6,6-bis(hydroxymethyl)-3',3a,9a,11a-tetramethyl-2,3,4,5,5a,7,8,9,10,11-decahydrospiro[cyclopenta[a]phenanthrene-1,2'-oxolan]-5'-yl]propan-1-one (NP0213081)

MOL for NP0213081 (1-[(1s,3as,5's,5ar,7s,9as,11as)-7-hydroxy-6,6-bis(hydroxymethyl)-3',3a,9a,11a-tetramethyl-2,3,4,5,5a,7,8,9,10,11-decahydrospiro[cyclopenta[a]phenanthrene-1,2'-oxolan]-5'-yl]propan-1-one)

3D MOL for NP0213081 (1-[(1s,3as,5's,5ar,7s,9as,11as)-7-hydroxy-6,6-bis(hydroxymethyl)-3',3a,9a,11a-tetramethyl-2,3,4,5,5a,7,8,9,10,11-decahydrospiro[cyclopenta[a]phenanthrene-1,2'-oxolan]-5'-yl]propan-1-one)

3D SDF for NP0213081 (1-[(1s,3as,5's,5ar,7s,9as,11as)-7-hydroxy-6,6-bis(hydroxymethyl)-3',3a,9a,11a-tetramethyl-2,3,4,5,5a,7,8,9,10,11-decahydrospiro[cyclopenta[a]phenanthrene-1,2'-oxolan]-5'-yl]propan-1-one)

3D-SDF for NP0213081 (1-[(1s,3as,5's,5ar,7s,9as,11as)-7-hydroxy-6,6-bis(hydroxymethyl)-3',3a,9a,11a-tetramethyl-2,3,4,5,5a,7,8,9,10,11-decahydrospiro[cyclopenta[a]phenanthrene-1,2'-oxolan]-5'-yl]propan-1-one)

PDB for NP0213081 (1-[(1s,3as,5's,5ar,7s,9as,11as)-7-hydroxy-6,6-bis(hydroxymethyl)-3',3a,9a,11a-tetramethyl-2,3,4,5,5a,7,8,9,10,11-decahydrospiro[cyclopenta[a]phenanthrene-1,2'-oxolan]-5'-yl]propan-1-one)

3D PDB for NP0213081 (1-[(1s,3as,5's,5ar,7s,9as,11as)-7-hydroxy-6,6-bis(hydroxymethyl)-3',3a,9a,11a-tetramethyl-2,3,4,5,5a,7,8,9,10,11-decahydrospiro[cyclopenta[a]phenanthrene-1,2'-oxolan]-5'-yl]propan-1-one)

SMILES for NP0213081 (1-[(1s,3as,5's,5ar,7s,9as,11as)-7-hydroxy-6,6-bis(hydroxymethyl)-3',3a,9a,11a-tetramethyl-2,3,4,5,5a,7,8,9,10,11-decahydrospiro[cyclopenta[a]phenanthrene-1,2'-oxolan]-5'-yl]propan-1-one)

INCHI for NP0213081 (1-[(1s,3as,5's,5ar,7s,9as,11as)-7-hydroxy-6,6-bis(hydroxymethyl)-3',3a,9a,11a-tetramethyl-2,3,4,5,5a,7,8,9,10,11-decahydrospiro[cyclopenta[a]phenanthrene-1,2'-oxolan]-5'-yl]propan-1-one)

Structure for NP0213081 (1-[(1s,3as,5's,5ar,7s,9as,11as)-7-hydroxy-6,6-bis(hydroxymethyl)-3',3a,9a,11a-tetramethyl-2,3,4,5,5a,7,8,9,10,11-decahydrospiro[cyclopenta[a]phenanthrene-1,2'-oxolan]-5'-yl]propan-1-one)

3D Structure for NP0213081 (1-[(1s,3as,5's,5ar,7s,9as,11as)-7-hydroxy-6,6-bis(hydroxymethyl)-3',3a,9a,11a-tetramethyl-2,3,4,5,5a,7,8,9,10,11-decahydrospiro[cyclopenta[a]phenanthrene-1,2'-oxolan]-5'-yl]propan-1-one)