NP-MRD: Showing NP-Card for (1ar,3as,4r,5r,5'r,7r,7ar,7bs)-5'-(furan-3-yl)-5,7a,7b-trimethyl-2'-oxo-hexahydro-1ah-spiro[naphtho[1,2-b]oxirene-4,3'-oxolan]-7-yl (2z)-2-methylbut-2-enoate (NP0210110)

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Record Information

Version

2.0

Created at

2022-09-05 07:47:36 UTC

Updated at

2022-09-05 07:47:36 UTC

NP-MRD ID

NP0210110

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(1ar,3as,4r,5r,5'r,7r,7ar,7bs)-5'-(furan-3-yl)-5,7a,7b-trimethyl-2'-oxo-hexahydro-1ah-spiro[naphtho[1,2-b]oxirene-4,3'-oxolan]-7-yl (2z)-2-methylbut-2-enoate

Description

(8R,9R,10beta,12R)-3alpha,4alpha:15,16-Diepoxy-6beta-[[(Z)-2-methyl-2-butenoyl]oxy]-12-hydroxyclerodane-13(16),14-diene-20-oic acid 20,12-lactone belongs to the class of organic compounds known as diterpene lactones. These are diterpenoids containing a lactone moiety. (1ar,3as,4r,5r,5'r,7r,7ar,7bs)-5'-(furan-3-yl)-5,7a,7b-trimethyl-2'-oxo-hexahydro-1ah-spiro[naphtho[1,2-b]oxirene-4,3'-oxolan]-7-yl (2z)-2-methylbut-2-enoate is found in Conyza pyrrhopappa. Based on a literature review very few articles have been published on (8R,9R,10beta,12R)-3alpha,4alpha:15,16-Diepoxy-6beta-[[(Z)-2-methyl-2-butenoyl]oxy]-12-hydroxyclerodane-13(16),14-diene-20-oic acid 20,12-lactone.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309052209472D          

 31 35  0  0  1  0            999 V2000
    2.1874   -6.0326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5464   -5.5133    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6756   -4.6984    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0346   -4.1791    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.0869   -4.9223    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5751   -3.5881    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.1638   -3.3643    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5228   -2.8450    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.2475   -3.1405    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6520   -2.0302    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.1449   -2.2435    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.6954   -1.2063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2147   -0.5653    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END

     RDKit          3D

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 31 63  1  0
M  END


  Mrv1652309052209472D          

 31 35  0  0  1  0            999 V2000
    2.1874   -6.0326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5464   -5.5133    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6756   -4.6984    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0346   -4.1791    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.0869   -4.9223    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
> <DATABASE_ID>
NP0210110

> <DATABASE_NAME>
NP-MRD

> <SMILES>
C\C=C(\C)C(=O)O[C@@H]1C[C@@H](C)[C@]2(C[C@@H](OC2=O)C2=COC=C2)[C@H]2CC[C@H]3O[C@@]3(C)[C@@]12C

> <INCHI_IDENTIFIER>
InChI=1S/C25H32O6/c1-6-14(2)21(26)30-20-11-15(3)25(12-17(29-22(25)27)16-9-10-28-13-16)18-7-8-19-24(5,31-19)23(18,20)4/h6,9-10,13,15,17-20H,7-8,11-12H2,1-5H3/b14-6-/t15-,17-,18+,19-,20-,23-,24-,25-/m1/s1

> <INCHI_KEY>
ZYYZPLNIGCEJBE-XABRHQLWSA-N

> <FORMULA>
C25H32O6

> <MOLECULAR_WEIGHT>
428.525

> <EXACT_MASS>
428.21988875

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_ATOM_COUNT>
63

> <JCHEM_AVERAGE_POLARIZABILITY>
46.24863299198776

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
0

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(1aS,1bR,2R,4R,5R,5'R,5aS,7aR)-5'-(furan-3-yl)-1a,1b,4-trimethyl-2'-oxo-octahydro-1aH-spiro[naphtho[1,2-b]oxirene-5,3'-oxolane]-2-yl (2Z)-2-methylbut-2-enoate

> <JCHEM_LOGP>
4.748225256666665

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
5

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_BASIC>
-2.8691829632446124

> <JCHEM_POLAR_SURFACE_AREA>
78.27000000000001

> <JCHEM_REFRACTIVITY>
113.0517

> <JCHEM_ROTATABLE_BOND_COUNT>
4

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
(1aS,1bR,2R,4R,5R,5'R,5aS,7aR)-5'-(furan-3-yl)-1a,1b,4-trimethyl-2'-oxo-hexahydro-2H-spiro[naphtho[1,2-b]oxirene-5,3'-oxolane]-2-yl (2Z)-2-methylbut-2-enoate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 05-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   05-SEP-22         0                                  
HETATM    1  C   UNK     0       4.083 -11.261   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       2.887 -10.291   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       3.128  -8.770   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       1.931  -7.801   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       4.566  -8.219   0.000  0.00  0.00           C+0
HETATM    6  O   UNK     0       5.762  -9.188   0.000  0.00  0.00           O+0
HETATM    7  O   UNK     0       4.807  -6.698   0.000  0.00  0.00           O+0
HETATM    8  C   UNK     0       3.610  -5.728   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       2.172  -6.280   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       0.976  -5.311   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0      -0.462  -5.862   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       1.217  -3.790   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      -0.271  -4.188   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      -1.109  -2.896   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      -2.647  -2.815   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      -3.616  -4.012   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      -5.054  -3.460   0.000  0.00  0.00           C+0
HETATM   18  O   UNK     0      -4.973  -1.922   0.000  0.00  0.00           O+0
HETATM   19  C   UNK     0      -3.485  -1.524   0.000  0.00  0.00           C+0
HETATM   20  O   UNK     0      -0.140  -1.700   0.000  0.00  0.00           O+0
HETATM   21  C   UNK     0       1.298  -2.252   0.000  0.00  0.00           C+0
HETATM   22  O   UNK     0       2.267  -1.055   0.000  0.00  0.00           O+0
HETATM   23  C   UNK     0       2.655  -3.238   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0       2.896  -1.717   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0       4.334  -1.165   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0       5.531  -2.135   0.000  0.00  0.00           C+0
HETATM   27  O   UNK     0       6.727  -3.104   0.000  0.00  0.00           O+0
HETATM   28  C   UNK     0       5.289  -3.656   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0       5.841  -5.094   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0       3.852  -4.207   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0       5.048  -5.177   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4    5                                                  
CONECT    4    3                                                            
CONECT    5    3    6    7                                                  
CONECT    6    5                                                            
CONECT    7    5    8                                                       
CONECT    8    7    9   30                                                  
CONECT    9    8   10                                                       
CONECT   10    9   11   12                                                  
CONECT   11   10                                                            
CONECT   12   10   13   21   23                                             
CONECT   13   12   14                                                       
CONECT   14   13   15   20                                                  
CONECT   15   14   16   19                                                  
CONECT   16   15   17                                                       
CONECT   17   16   18                                                       
CONECT   18   17   19                                                       
CONECT   19   18   15                                                       
CONECT   20   14   21                                                       
CONECT   21   20   12   22                                                  
CONECT   22   21                                                            
CONECT   23   12   24   30                                                  
CONECT   24   23   25                                                       
CONECT   25   24   26                                                       
CONECT   26   25   27   28                                                  
CONECT   27   26   28                                                       
CONECT   28   27   26   29   30                                             
CONECT   29   28                                                            
CONECT   30   28   23    8   31                                             
CONECT   31   30                                                            
MASTER        0    0    0    0    0    0    0    0   31    0   70    0
END

View in JSmol

Synonyms

Value	Source
(8R,9R,10b,12R)-3a,4Alpha:15,16-diepoxy-6b-[[(Z)-2-methyl-2-butenoyl]oxy]-12-hydroxyclerodane-13(16),14-diene-20-Oate 20,12-lactone	Generator
(8R,9R,10b,12R)-3a,4Alpha:15,16-diepoxy-6b-[[(Z)-2-methyl-2-butenoyl]oxy]-12-hydroxyclerodane-13(16),14-diene-20-Oic acid 20,12-lactone	Generator
(8R,9R,10beta,12R)-3alpha,4Alpha:15,16-diepoxy-6beta-[[(Z)-2-methyl-2-butenoyl]oxy]-12-hydroxyclerodane-13(16),14-diene-20-Oate 20,12-lactone	Generator
(8R,9R,10Β,12R)-3α,4alpha:15,16-diepoxy-6β-[[(Z)-2-methyl-2-butenoyl]oxy]-12-hydroxyclerodane-13(16),14-diene-20-Oate 20,12-lactone	Generator
(8R,9R,10Β,12R)-3α,4alpha:15,16-diepoxy-6β-[[(Z)-2-methyl-2-butenoyl]oxy]-12-hydroxyclerodane-13(16),14-diene-20-Oic acid 20,12-lactone	Generator

Chemical Formula

C₂₅H₃₂O₆

Average Mass

428.5250 Da

Monoisotopic Mass

428.21989 Da

IUPAC Name

(1aS,1bR,2R,4R,5R,5'R,5aS,7aR)-5'-(furan-3-yl)-1a,1b,4-trimethyl-2'-oxo-octahydro-1aH-spiro[naphtho[1,2-b]oxirene-5,3'-oxolane]-2-yl (2Z)-2-methylbut-2-enoate

Traditional Name

(1aS,1bR,2R,4R,5R,5'R,5aS,7aR)-5'-(furan-3-yl)-1a,1b,4-trimethyl-2'-oxo-hexahydro-2H-spiro[naphtho[1,2-b]oxirene-5,3'-oxolane]-2-yl (2Z)-2-methylbut-2-enoate

CAS Registry Number

Not Available

SMILES

C\C=C(\C)C(=O)O[C@@H]1C[C@@H](C)[C@]2(C[C@@H](OC2=O)C2=COC=C2)[C@H]2CC[C@H]3O[C@@]3(C)[C@@]12C

InChI Identifier

InChI=1S/C25H32O6/c1-6-14(2)21(26)30-20-11-15(3)25(12-17(29-22(25)27)16-9-10-28-13-16)18-7-8-19-24(5,31-19)23(18,20)4/h6,9-10,13,15,17-20H,7-8,11-12H2,1-5H3/b14-6-/t15-,17-,18+,19-,20-,23-,24-,25-/m1/s1

InChI Key

ZYYZPLNIGCEJBE-XABRHQLWSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Conyza pyrrhopappa	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as diterpene lactones. These are diterpenoids containing a lactone moiety.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Terpene lactones

Direct Parent

Diterpene lactones

Alternative Parents

Substituents

Diterpene lactone
Diterpenoid
Clerodane diterpenoid
Fatty acid ester
Oxepane
Dicarboxylic acid or derivatives
Gamma butyrolactone
Fatty acyl
Heteroaromatic compound
Furan
Oxolane
Alpha,beta-unsaturated carboxylic ester
Enoate ester
Lactone
Carboxylic acid ester
Oxacycle
Ether
Oxirane
Organoheterocyclic compound
Carboxylic acid derivative
Dialkyl ether
Carbonyl group
Hydrocarbon derivative
Organic oxide
Organic oxygen compound
Organooxygen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	4.75	ChemAxon
pKa (Strongest Basic)	-2.9	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	78.27 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	113.05 m³·mol⁻¹	ChemAxon
Polarizability	46.25 Å³	ChemAxon
Number of Rings	5	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

102208938

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for (1ar,3as,4r,5r,5'r,7r,7ar,7bs)-5'-(furan-3-yl)-5,7a,7b-trimethyl-2'-oxo-hexahydro-1ah-spiro[naphtho[1,2-b]oxirene-4,3'-oxolan]-7-yl (2z)-2-methylbut-2-enoate (NP0210110)

MOL for NP0210110 ((1ar,3as,4r,5r,5'r,7r,7ar,7bs)-5'-(furan-3-yl)-5,7a,7b-trimethyl-2'-oxo-hexahydro-1ah-spiro[naphtho[1,2-b]oxirene-4,3'-oxolan]-7-yl (2z)-2-methylbut-2-enoate)

3D MOL for NP0210110 ((1ar,3as,4r,5r,5'r,7r,7ar,7bs)-5'-(furan-3-yl)-5,7a,7b-trimethyl-2'-oxo-hexahydro-1ah-spiro[naphtho[1,2-b]oxirene-4,3'-oxolan]-7-yl (2z)-2-methylbut-2-enoate)

3D SDF for NP0210110 ((1ar,3as,4r,5r,5'r,7r,7ar,7bs)-5'-(furan-3-yl)-5,7a,7b-trimethyl-2'-oxo-hexahydro-1ah-spiro[naphtho[1,2-b]oxirene-4,3'-oxolan]-7-yl (2z)-2-methylbut-2-enoate)

3D-SDF for NP0210110 ((1ar,3as,4r,5r,5'r,7r,7ar,7bs)-5'-(furan-3-yl)-5,7a,7b-trimethyl-2'-oxo-hexahydro-1ah-spiro[naphtho[1,2-b]oxirene-4,3'-oxolan]-7-yl (2z)-2-methylbut-2-enoate)

PDB for NP0210110 ((1ar,3as,4r,5r,5'r,7r,7ar,7bs)-5'-(furan-3-yl)-5,7a,7b-trimethyl-2'-oxo-hexahydro-1ah-spiro[naphtho[1,2-b]oxirene-4,3'-oxolan]-7-yl (2z)-2-methylbut-2-enoate)

3D PDB for NP0210110 ((1ar,3as,4r,5r,5'r,7r,7ar,7bs)-5'-(furan-3-yl)-5,7a,7b-trimethyl-2'-oxo-hexahydro-1ah-spiro[naphtho[1,2-b]oxirene-4,3'-oxolan]-7-yl (2z)-2-methylbut-2-enoate)

SMILES for NP0210110 ((1ar,3as,4r,5r,5'r,7r,7ar,7bs)-5'-(furan-3-yl)-5,7a,7b-trimethyl-2'-oxo-hexahydro-1ah-spiro[naphtho[1,2-b]oxirene-4,3'-oxolan]-7-yl (2z)-2-methylbut-2-enoate)

INCHI for NP0210110 ((1ar,3as,4r,5r,5'r,7r,7ar,7bs)-5'-(furan-3-yl)-5,7a,7b-trimethyl-2'-oxo-hexahydro-1ah-spiro[naphtho[1,2-b]oxirene-4,3'-oxolan]-7-yl (2z)-2-methylbut-2-enoate)

Structure for NP0210110 ((1ar,3as,4r,5r,5'r,7r,7ar,7bs)-5'-(furan-3-yl)-5,7a,7b-trimethyl-2'-oxo-hexahydro-1ah-spiro[naphtho[1,2-b]oxirene-4,3'-oxolan]-7-yl (2z)-2-methylbut-2-enoate)

3D Structure for NP0210110 ((1ar,3as,4r,5r,5'r,7r,7ar,7bs)-5'-(furan-3-yl)-5,7a,7b-trimethyl-2'-oxo-hexahydro-1ah-spiro[naphtho[1,2-b]oxirene-4,3'-oxolan]-7-yl (2z)-2-methylbut-2-enoate)