NP-MRD: Showing NP-Card for (1s,2r,5r,7s,11s,12s,15r,16s)-15-[(2s,3r,4r,5s)-3,4-dihydroxy-5,6-dimethylheptan-2-yl]-5-hydroxy-2,16-dimethyl-9-oxatetracyclo[9.7.0.0²,⁷.0¹²,¹⁶]octadecan-8-one (NP0208792)

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Record Information

Version

2.0

Created at

2022-09-05 05:56:33 UTC

Updated at

2022-09-05 05:56:33 UTC

NP-MRD ID

NP0208792

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(1s,2r,5r,7s,11s,12s,15r,16s)-15-[(2s,3r,4r,5s)-3,4-dihydroxy-5,6-dimethylheptan-2-yl]-5-hydroxy-2,16-dimethyl-9-oxatetracyclo[9.7.0.0²,⁷.0¹²,¹⁶]octadecan-8-one

Description

7-Oxatyphasterol, also known as 2-deoxybrassinolide, belongs to the class of organic compounds known as brassinolides and derivatives. These are cholestane based steroid lactones containing benzo[c]indeno[5,4-e]oxepin-3-one. Thus, 7-oxatyphasterol is considered to be a sterol. (1s,2r,5r,7s,11s,12s,15r,16s)-15-[(2s,3r,4r,5s)-3,4-dihydroxy-5,6-dimethylheptan-2-yl]-5-hydroxy-2,16-dimethyl-9-oxatetracyclo[9.7.0.0²,⁷.0¹²,¹⁶]octadecan-8-one was first documented in 2008 (PMID: 18685225). Based on a literature review very few articles have been published on 7-oxatyphasterol.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309052207562D          

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M  END

     RDKit          3D

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M  END


  Mrv1652309052207562D          

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    5.2328   -6.9307    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9779   -6.1461    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.3648   -6.6981    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  6  0  0  0
  4  6  1  0  0  0  0
  6  7  1  6  0  0  0
  6  8  1  0  0  0  0
  8  9  1  6  0  0  0
  8 10  1  0  0  0  0
 10 11  1  6  0  0  0
 12 10  1  1  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 15 14  1  1  0  0  0
 15 16  1  0  0  0  0
 16 17  1  6  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  1  0  0  0
 22 23  1  0  0  0  0
 23 24  1  6  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 21 27  1  0  0  0  0
 27 28  1  1  0  0  0
 27 29  1  0  0  0  0
 16 29  1  0  0  0  0
 29 30  1  1  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 15 32  1  0  0  0  0
 12 32  1  0  0  0  0
 32 33  1  1  0  0  0
M  END
> <DATABASE_ID>
NP0208792

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CC(C)[C@H](C)[C@@H](O)[C@H](O)[C@@H](C)[C@H]1CC[C@H]2[C@@H]3COC(=O)[C@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

> <INCHI_IDENTIFIER>
InChI=1S/C28H48O5/c1-15(2)16(3)24(30)25(31)17(4)20-7-8-21-19-14-33-26(32)23-13-18(29)9-11-28(23,6)22(19)10-12-27(20,21)5/h15-25,29-31H,7-14H2,1-6H3/t16-,17-,18+,19-,20+,21-,22-,23+,24+,25+,27+,28+/m0/s1

> <INCHI_KEY>
LLFIMDUWAVPJEJ-AVWWTISCSA-N

> <FORMULA>
C28H48O5

> <MOLECULAR_WEIGHT>
464.687

> <EXACT_MASS>
464.350174646

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_ATOM_COUNT>
81

> <JCHEM_AVERAGE_POLARIZABILITY>
54.474556145984934

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(1S,2R,5R,7S,11S,12S,15R,16S)-15-[(2S,3R,4R,5S)-3,4-dihydroxy-5,6-dimethylheptan-2-yl]-5-hydroxy-2,16-dimethyl-9-oxatetracyclo[9.7.0.0^{2,7}.0^{12,16}]octadecan-8-one

> <JCHEM_LOGP>
4.204970492

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
14.859298646706513

> <JCHEM_PKA_STRONGEST_ACIDIC>
13.644245350899563

> <JCHEM_PKA_STRONGEST_BASIC>
-2.698325938373002

> <JCHEM_POLAR_SURFACE_AREA>
86.99

> <JCHEM_REFRACTIVITY>
129.0451

> <JCHEM_ROTATABLE_BOND_COUNT>
5

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
(1S,2R,5R,7S,11S,12S,15R,16S)-15-[(2S,3R,4R,5S)-3,4-dihydroxy-5,6-dimethylheptan-2-yl]-5-hydroxy-2,16-dimethyl-9-oxatetracyclo[9.7.0.0^{2,7}.0^{12,16}]octadecan-8-one

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 05-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   05-SEP-22         0                                  
HETATM    1  C   UNK     0      -0.117 -10.846   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       1.217 -11.616   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       1.217 -13.156   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       2.550 -10.846   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       2.550  -9.306   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       3.884 -11.616   0.000  0.00  0.00           C+0
HETATM    7  O   UNK     0       3.884 -13.156   0.000  0.00  0.00           O+0
HETATM    8  C   UNK     0       5.218 -10.846   0.000  0.00  0.00           C+0
HETATM    9  O   UNK     0       5.218  -9.306   0.000  0.00  0.00           O+0
HETATM   10  C   UNK     0       6.551 -11.616   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       6.551 -13.156   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       7.885 -10.846   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       8.046  -9.315   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       9.552  -8.995   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      10.322 -10.328   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      11.829 -10.648   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      12.677  -9.363   0.000  0.00  0.00           C+0
HETATM   18  O   UNK     0      14.211  -9.225   0.000  0.00  0.00           O+0
HETATM   19  C   UNK     0      15.275 -10.338   0.000  0.00  0.00           C+0
HETATM   20  O   UNK     0      16.740  -9.862   0.000  0.00  0.00           O+0
HETATM   21  C   UNK     0      15.069 -11.864   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0      16.414 -12.614   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0      16.437 -14.154   0.000  0.00  0.00           C+0
HETATM   24  O   UNK     0      17.782 -14.904   0.000  0.00  0.00           O+0
HETATM   25  C   UNK     0      15.115 -14.944   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0      13.770 -14.194   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0      13.747 -12.654   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0      12.487 -13.541   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0      12.305 -12.113   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0      11.274 -13.257   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0       9.768 -12.937   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0       9.292 -11.473   0.000  0.00  0.00           C+0
HETATM   33  C   UNK     0       8.148 -12.503   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3    4                                                  
CONECT    3    2                                                            
CONECT    4    2    5    6                                                  
CONECT    5    4                                                            
CONECT    6    4    7    8                                                  
CONECT    7    6                                                            
CONECT    8    6    9   10                                                  
CONECT    9    8                                                            
CONECT   10    8   11   12                                                  
CONECT   11   10                                                            
CONECT   12   10   13   32                                                  
CONECT   13   12   14                                                       
CONECT   14   13   15                                                       
CONECT   15   14   16   32                                                  
CONECT   16   15   17   29                                                  
CONECT   17   16   18                                                       
CONECT   18   17   19                                                       
CONECT   19   18   20   21                                                  
CONECT   20   19                                                            
CONECT   21   19   22   27                                                  
CONECT   22   21   23                                                       
CONECT   23   22   24   25                                                  
CONECT   24   23                                                            
CONECT   25   23   26                                                       
CONECT   26   25   27                                                       
CONECT   27   26   21   28   29                                             
CONECT   28   27                                                            
CONECT   29   27   16   30                                                  
CONECT   30   29   31                                                       
CONECT   31   30   32                                                       
CONECT   32   31   15   12   33                                             
CONECT   33   32                                                            
MASTER        0    0    0    0    0    0    0    0   33    0   72    0
END

View in JSmol

Synonyms

Value	Source
(1S,2R,5R,7S,11S,12S,15R,16S)-15-[(2S,3R,4R,5S)-3,4-Dihydroxy-5,6-dimethylheptan-2-yl]-5-hydroxy-2,16-dimethyl-9-oxatetracyclo[9.7.0.0(2,7).0(12,16)]octadecan-8-one	ChEBI
(22R,23R,24S)-3alpha,22,23-Trihydroxy-7-oxa-5alpha-ergostane-6-one	ChEBI
2-Deoxybrassinolide	ChEBI
3alpha,22R,23R-Trihydroxy-6,7-seco-5alpha-campestano-6,7-lactone	ChEBI
7-Oxotyphasterol	ChEBI
(22R,23R,24S)-3a,22,23-Trihydroxy-7-oxa-5a-ergostane-6-one	Generator
(22R,23R,24S)-3Α,22,23-trihydroxy-7-oxa-5α-ergostane-6-one	Generator
3a,22R,23R-Trihydroxy-6,7-seco-5a-campestano-6,7-lactone	Generator
3Α,22R,23R-trihydroxy-6,7-seco-5α-campestano-6,7-lactone	Generator

Chemical Formula

C₂₈H₄₈O₅

Average Mass

464.6870 Da

Monoisotopic Mass

464.35017 Da

IUPAC Name

Not Available

Traditional Name

Not Available

CAS Registry Number

Not Available

SMILES

CC(C)[C@H](C)[C@@H](O)[C@H](O)[C@@H](C)[C@H]1CC[C@H]2[C@@H]3COC(=O)[C@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI Identifier

InChI=1S/C28H48O5/c1-15(2)16(3)24(30)25(31)17(4)20-7-8-21-19-14-33-26(32)23-13-18(29)9-11-28(23,6)22(19)10-12-27(20,21)5/h15-25,29-31H,7-14H2,1-6H3/t16-,17-,18+,19-,20+,21-,22-,23+,24+,25+,27+,28+/m0/s1

InChI Key

LLFIMDUWAVPJEJ-AVWWTISCSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Not Available

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as brassinolides and derivatives. These are cholestane based steroid lactones containing benzo[c]indeno[5,4-e]oxepin-3-one.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Steroids and steroid derivatives

Sub Class

Steroid lactones

Direct Parent

Brassinolides and derivatives

Alternative Parents

Substituents

Brassinolide-skeleton
Caprolactone
Oxepane
Cyclic alcohol
Carboxylic acid ester
Lactone
Secondary alcohol
Carboxylic acid derivative
Oxacycle
Organoheterocyclic compound
Monocarboxylic acid or derivatives
Hydrocarbon derivative
Alcohol
Carbonyl group
Organic oxygen compound
Organic oxide
Organooxygen compound
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Brassinolides and derivatives (LMST01140003 )

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

C00055380

Chemspider ID

103882371

KEGG Compound ID

Not Available

BioCyc ID

CPD-12497

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

14153907

PDB ID

Not Available

ChEBI ID

185407

Good Scents ID

rw1889861

References

General References

Katsumata T, Hasegawa A, Fujiwara T, Komatsu T, Notomi M, Abe H, Natsume M, Kawaide H: Arabidopsis CYP85A2 catalyzes lactonization reactions in the biosynthesis of 2-deoxy-7-oxalactone brassinosteroids. Biosci Biotechnol Biochem. 2008 Aug;72(8):2110-7. doi: 10.1271/bbb.80192. Epub 2008 Aug 7. [PubMed:18685225 ]
LOTUS database [Link]

Showing NP-Card for (1s,2r,5r,7s,11s,12s,15r,16s)-15-[(2s,3r,4r,5s)-3,4-dihydroxy-5,6-dimethylheptan-2-yl]-5-hydroxy-2,16-dimethyl-9-oxatetracyclo[9.7.0.0²,⁷.0¹²,¹⁶]octadecan-8-one (NP0208792)

MOL for NP0208792 ((1s,2r,5r,7s,11s,12s,15r,16s)-15-[(2s,3r,4r,5s)-3,4-dihydroxy-5,6-dimethylheptan-2-yl]-5-hydroxy-2,16-dimethyl-9-oxatetracyclo[9.7.0.0²,⁷.0¹²,¹⁶]octadecan-8-one)

3D MOL for NP0208792 ((1s,2r,5r,7s,11s,12s,15r,16s)-15-[(2s,3r,4r,5s)-3,4-dihydroxy-5,6-dimethylheptan-2-yl]-5-hydroxy-2,16-dimethyl-9-oxatetracyclo[9.7.0.0²,⁷.0¹²,¹⁶]octadecan-8-one)

3D SDF for NP0208792 ((1s,2r,5r,7s,11s,12s,15r,16s)-15-[(2s,3r,4r,5s)-3,4-dihydroxy-5,6-dimethylheptan-2-yl]-5-hydroxy-2,16-dimethyl-9-oxatetracyclo[9.7.0.0²,⁷.0¹²,¹⁶]octadecan-8-one)

3D-SDF for NP0208792 ((1s,2r,5r,7s,11s,12s,15r,16s)-15-[(2s,3r,4r,5s)-3,4-dihydroxy-5,6-dimethylheptan-2-yl]-5-hydroxy-2,16-dimethyl-9-oxatetracyclo[9.7.0.0²,⁷.0¹²,¹⁶]octadecan-8-one)

PDB for NP0208792 ((1s,2r,5r,7s,11s,12s,15r,16s)-15-[(2s,3r,4r,5s)-3,4-dihydroxy-5,6-dimethylheptan-2-yl]-5-hydroxy-2,16-dimethyl-9-oxatetracyclo[9.7.0.0²,⁷.0¹²,¹⁶]octadecan-8-one)

3D PDB for NP0208792 ((1s,2r,5r,7s,11s,12s,15r,16s)-15-[(2s,3r,4r,5s)-3,4-dihydroxy-5,6-dimethylheptan-2-yl]-5-hydroxy-2,16-dimethyl-9-oxatetracyclo[9.7.0.0²,⁷.0¹²,¹⁶]octadecan-8-one)

SMILES for NP0208792 ((1s,2r,5r,7s,11s,12s,15r,16s)-15-[(2s,3r,4r,5s)-3,4-dihydroxy-5,6-dimethylheptan-2-yl]-5-hydroxy-2,16-dimethyl-9-oxatetracyclo[9.7.0.0²,⁷.0¹²,¹⁶]octadecan-8-one)

INCHI for NP0208792 ((1s,2r,5r,7s,11s,12s,15r,16s)-15-[(2s,3r,4r,5s)-3,4-dihydroxy-5,6-dimethylheptan-2-yl]-5-hydroxy-2,16-dimethyl-9-oxatetracyclo[9.7.0.0²,⁷.0¹²,¹⁶]octadecan-8-one)

Structure for NP0208792 ((1s,2r,5r,7s,11s,12s,15r,16s)-15-[(2s,3r,4r,5s)-3,4-dihydroxy-5,6-dimethylheptan-2-yl]-5-hydroxy-2,16-dimethyl-9-oxatetracyclo[9.7.0.0²,⁷.0¹²,¹⁶]octadecan-8-one)

3D Structure for NP0208792 ((1s,2r,5r,7s,11s,12s,15r,16s)-15-[(2s,3r,4r,5s)-3,4-dihydroxy-5,6-dimethylheptan-2-yl]-5-hydroxy-2,16-dimethyl-9-oxatetracyclo[9.7.0.0²,⁷.0¹²,¹⁶]octadecan-8-one)