NP-MRD: Showing NP-Card for (3e)-3-[(3,4-dihydroxyphenyl)methylidene]-7-hydroxy-5-methoxy-2h-1-benzopyran-4-one (NP0207010)

Jump To Section:

Identification Spectra BioTaxonomy ChemoTaxonomy Physical properties Links References XML

Record Information

Version

2.0

Created at

2022-09-05 03:27:35 UTC

Updated at

2022-09-05 03:27:36 UTC

NP-MRD ID

NP0207010

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(3e)-3-[(3,4-dihydroxyphenyl)methylidene]-7-hydroxy-5-methoxy-2h-1-benzopyran-4-one

Description

CHEMBL4544044 belongs to the class of organic compounds known as homoisoflavonoids. These are naturally occurring oxygen heterocycles with a structure based on a 16-carbon skeleton including a chromanone, chromone or chromane system with a benzyl group at position C-3. (3e)-3-[(3,4-dihydroxyphenyl)methylidene]-7-hydroxy-5-methoxy-2h-1-benzopyran-4-one is found in Muscari neglectum. Based on a literature review very few articles have been published on CHEMBL4544044.

Structure

MOL 3D MOL SDF PDB SMILES InChI

     RDKit          3D

 37 39  0  0  0  0  0  0  0  0999 V2000
   -4.9125    1.4213    1.9232 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5857    1.1391    1.5202 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4038    0.4776    0.3195 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4430    0.0832   -0.4937 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2267   -0.5765   -1.6874 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3344   -0.9488   -2.4656 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9675   -0.8753   -2.1288 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8893   -0.4878   -1.3245 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1201    0.1708   -0.1346 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9779    0.5639    0.6799 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1795    1.1603    1.7605 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3676    0.2454    0.2028 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3869    0.2305    1.0451 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7655   -0.0765    0.6407 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5321   -0.9588    1.4088 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8328   -1.2476    1.0670 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4467   -0.6912   -0.0378 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7547   -0.9787   -0.3869 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6810    0.1750   -0.7838 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2974    0.7467   -1.9107 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3755    0.4791   -0.4595 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5263   -0.0767   -1.2381 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6113   -0.7610   -1.7150 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4804    1.9223    1.0933 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9397    2.0373    2.8471 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4038    0.4418    2.1166 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4533    0.3191   -0.1463 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7034   -1.8754   -2.2571 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7678   -1.3927   -3.0620 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.1653    0.4644    2.0981 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.0658   -1.4042    2.2774 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.4462   -1.9318    1.6510 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.1383   -0.5460   -1.1956 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.8117    1.3921   -2.5168 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.8087    1.1729   -1.0610 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.4403   -0.6997   -1.3974 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.5573    0.8856   -1.8006 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  5  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 10 12  1  0
 12 22  1  0
 22 23  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 17 19  1  0
 19 20  1  0
 19 21  2  0
  9  3  1  0
 21 14  1  0
 23  8  1  0
  1 24  1  0
  1 25  1  0
  1 26  1  0
  4 27  1  0
  6 28  1  0
  7 29  1  0
 22 36  1  0
 22 37  1  0
 13 30  1  0
 15 31  1  0
 16 32  1  0
 18 33  1  0
 20 34  1  0
 21 35  1  0
M  END


  Mrv1652309052205272D          

 23 25  0  0  0  0            999 V2000
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  3  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 14 21  1  0  0  0  0
 12 22  1  0  0  0  0
 22 23  1  0  0  0  0
  8 23  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0207010

> <DATABASE_NAME>
NP-MRD

> <SMILES>
COC1=CC(O)=CC2=C1C(=O)\C(CO2)=C\C1=CC=C(O)C(O)=C1

> <INCHI_IDENTIFIER>
InChI=1S/C17H14O6/c1-22-14-6-11(18)7-15-16(14)17(21)10(8-23-15)4-9-2-3-12(19)13(20)5-9/h2-7,18-20H,8H2,1H3/b10-4+

> <INCHI_KEY>
HZEFXIWDWIWKPZ-ONNFQVAWSA-N

> <FORMULA>
C17H14O6

> <MOLECULAR_WEIGHT>
314.293

> <EXACT_MASS>
314.079038171

> <JCHEM_ACCEPTOR_COUNT>
6

> <JCHEM_ATOM_COUNT>
37

> <JCHEM_AVERAGE_POLARIZABILITY>
31.69090675660688

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(3E)-3-[(3,4-dihydroxyphenyl)methylidene]-7-hydroxy-5-methoxy-3,4-dihydro-2H-1-benzopyran-4-one

> <JCHEM_LOGP>
2.2976432139999994

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
8.999068873209685

> <JCHEM_PKA_STRONGEST_ACIDIC>
7.894718785482849

> <JCHEM_PKA_STRONGEST_BASIC>
-4.615376040449837

> <JCHEM_POLAR_SURFACE_AREA>
96.22000000000001

> <JCHEM_REFRACTIVITY>
83.61659999999999

> <JCHEM_ROTATABLE_BOND_COUNT>
2

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
(3E)-3-[(3,4-dihydroxyphenyl)methylidene]-7-hydroxy-5-methoxy-2H-1-benzopyran-4-one

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 05-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   05-SEP-22         0                                  
HETATM    1  C   UNK     0       1.334   2.310   0.000  0.00  0.00           C+0
HETATM    2  O   UNK     0       0.000   1.540   0.000  0.00  0.00           O+0
HETATM    3  C   UNK     0       0.000  -0.000   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      -1.334  -0.770   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      -1.334  -2.310   0.000  0.00  0.00           C+0
HETATM    6  O   UNK     0      -2.667  -3.080   0.000  0.00  0.00           O+0
HETATM    7  C   UNK     0       0.000  -3.080   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       1.334  -2.310   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       1.334  -0.770   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       2.667  -0.000   0.000  0.00  0.00           C+0
HETATM   11  O   UNK     0       2.667   1.540   0.000  0.00  0.00           O+0
HETATM   12  C   UNK     0       4.001  -0.770   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       5.335  -0.000   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       6.668  -0.770   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       8.002  -0.000   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       9.336  -0.770   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       9.336  -2.310   0.000  0.00  0.00           C+0
HETATM   18  O   UNK     0      10.669  -3.080   0.000  0.00  0.00           O+0
HETATM   19  C   UNK     0       8.002  -3.080   0.000  0.00  0.00           C+0
HETATM   20  O   UNK     0       8.002  -4.620   0.000  0.00  0.00           O+0
HETATM   21  C   UNK     0       6.668  -2.310   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       4.001  -2.310   0.000  0.00  0.00           C+0
HETATM   23  O   UNK     0       2.667  -3.080   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4    9                                                  
CONECT    4    3    5                                                       
CONECT    5    4    6    7                                                  
CONECT    6    5                                                            
CONECT    7    5    8                                                       
CONECT    8    7    9   23                                                  
CONECT    9    8    3   10                                                  
CONECT   10    9   11   12                                                  
CONECT   11   10                                                            
CONECT   12   10   13   22                                                  
CONECT   13   12   14                                                       
CONECT   14   13   15   21                                                  
CONECT   15   14   16                                                       
CONECT   16   15   17                                                       
CONECT   17   16   18   19                                                  
CONECT   18   17                                                            
CONECT   19   17   20   21                                                  
CONECT   20   19                                                            
CONECT   21   19   14                                                       
CONECT   22   12   23                                                       
CONECT   23   22    8                                                       
MASTER        0    0    0    0    0    0    0    0   23    0   50    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₁₇H₁₄O₆

Average Mass

314.2930 Da

Monoisotopic Mass

314.07904 Da

IUPAC Name

(3E)-3-[(3,4-dihydroxyphenyl)methylidene]-7-hydroxy-5-methoxy-3,4-dihydro-2H-1-benzopyran-4-one

Traditional Name

(3E)-3-[(3,4-dihydroxyphenyl)methylidene]-7-hydroxy-5-methoxy-2H-1-benzopyran-4-one

CAS Registry Number

Not Available

SMILES

COC1=CC(O)=CC2=C1C(=O)\C(CO2)=C\C1=CC=C(O)C(O)=C1

InChI Identifier

InChI=1S/C17H14O6/c1-22-14-6-11(18)7-15-16(14)17(21)10(8-23-15)4-9-2-3-12(19)13(20)5-9/h2-7,18-20H,8H2,1H3/b10-4+

InChI Key

HZEFXIWDWIWKPZ-ONNFQVAWSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Muscari neglectum	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as homoisoflavonoids. These are naturally occurring oxygen heterocycles with a structure based on a 16-carbon skeleton including a chromanone, chromone or chromane system with a benzyl group at position C-3.

Kingdom

Organic compounds

Super Class

Phenylpropanoids and polyketides

Class

Homoisoflavonoids

Sub Class

Not Available

Direct Parent

Homoisoflavonoids

Alternative Parents

Substituents

Homoisoflavonoid
Chromone
Chromane
Benzopyran
1-benzopyran
Anisole
Aryl ketone
Catechol
1-hydroxy-4-unsubstituted benzenoid
1-hydroxy-2-unsubstituted benzenoid
Alkyl aryl ether
Phenol
Monocyclic benzene moiety
Benzenoid
Ketone
Oxacycle
Organoheterocyclic compound
Ether
Organic oxygen compound
Hydrocarbon derivative
Organic oxide
Organooxygen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	2.3	ChemAxon
pKa (Strongest Acidic)	7.89	ChemAxon
pKa (Strongest Basic)	-4.6	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	6	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	96.22 Å²	ChemAxon
Rotatable Bond Count	2	ChemAxon
Refractivity	83.62 m³·mol⁻¹	ChemAxon
Polarizability	31.69 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

14779759

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for (3e)-3-[(3,4-dihydroxyphenyl)methylidene]-7-hydroxy-5-methoxy-2h-1-benzopyran-4-one (NP0207010)

MOL for NP0207010 ((3e)-3-[(3,4-dihydroxyphenyl)methylidene]-7-hydroxy-5-methoxy-2h-1-benzopyran-4-one)

3D MOL for NP0207010 ((3e)-3-[(3,4-dihydroxyphenyl)methylidene]-7-hydroxy-5-methoxy-2h-1-benzopyran-4-one)

3D SDF for NP0207010 ((3e)-3-[(3,4-dihydroxyphenyl)methylidene]-7-hydroxy-5-methoxy-2h-1-benzopyran-4-one)

3D-SDF for NP0207010 ((3e)-3-[(3,4-dihydroxyphenyl)methylidene]-7-hydroxy-5-methoxy-2h-1-benzopyran-4-one)

PDB for NP0207010 ((3e)-3-[(3,4-dihydroxyphenyl)methylidene]-7-hydroxy-5-methoxy-2h-1-benzopyran-4-one)

3D PDB for NP0207010 ((3e)-3-[(3,4-dihydroxyphenyl)methylidene]-7-hydroxy-5-methoxy-2h-1-benzopyran-4-one)

SMILES for NP0207010 ((3e)-3-[(3,4-dihydroxyphenyl)methylidene]-7-hydroxy-5-methoxy-2h-1-benzopyran-4-one)

INCHI for NP0207010 ((3e)-3-[(3,4-dihydroxyphenyl)methylidene]-7-hydroxy-5-methoxy-2h-1-benzopyran-4-one)

Structure for NP0207010 ((3e)-3-[(3,4-dihydroxyphenyl)methylidene]-7-hydroxy-5-methoxy-2h-1-benzopyran-4-one)

3D Structure for NP0207010 ((3e)-3-[(3,4-dihydroxyphenyl)methylidene]-7-hydroxy-5-methoxy-2h-1-benzopyran-4-one)