NP-MRD: Showing NP-Card for (1s,1's,2's,5's,9's,10'r,13'r,14's)-5',10',14'-trimethyl-6',16'-dioxaspiro[cyclohexane-1,7'-pentacyclo[12.3.3.0¹,¹³.0²,¹⁰.0⁵,⁹]icosan]-3-ene-2,5,15'-trione (NP0206579)

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Record Information

Version

2.0

Created at

2022-09-05 02:52:44 UTC

Updated at

2022-09-05 02:52:44 UTC

NP-MRD ID

NP0206579

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(1s,1's,2's,5's,9's,10'r,13'r,14's)-5',10',14'-trimethyl-6',16'-dioxaspiro[cyclohexane-1,7'-pentacyclo[12.3.3.0¹,¹³.0²,¹⁰.0⁵,⁹]icosan]-3-ene-2,5,15'-trione

Description

(1S,1'S,2'S,5'S,9'S,10'R,13'R,14'S)-5',10',14'-trimethyl-6',16'-dioxaspiro[cyclohexane-1,7'-pentacyclo[12.3.3.0¹,¹³.0²,¹⁰.0⁵,⁹]Icosan]-3-ene-2,5,15'-trione belongs to the class of organic compounds known as oxosteroids. These are steroid derivatives carrying a C=O group attached to steroid skeleton. (1s,1's,2's,5's,9's,10'r,13'r,14's)-5',10',14'-trimethyl-6',16'-dioxaspiro[cyclohexane-1,7'-pentacyclo[12.3.3.0¹,¹³.0²,¹⁰.0⁵,⁹]icosan]-3-ene-2,5,15'-trione is found in Petrosia durissima. Based on a literature review very few articles have been published on (1S,1'S,2'S,5'S,9'S,10'R,13'R,14'S)-5',10',14'-trimethyl-6',16'-dioxaspiro[cyclohexane-1,7'-pentacyclo[12.3.3.0¹,¹³.0²,¹⁰.0⁵,⁹]Icosan]-3-ene-2,5,15'-trione.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309052204522D          

 31 36  0  0  1  0            999 V2000
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M  END

     RDKit          3D

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M  END


  Mrv1652309052204522D          

 31 36  0  0  1  0            999 V2000
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M  END
> <DATABASE_ID>
NP0206579

> <DATABASE_NAME>
NP-MRD

> <SMILES>
C[C@]12CC[C@H]3[C@@](C)(CC[C@H]4[C@]5(C)CCC[C@]34COC5=O)[C@@H]1C[C@@]1(CC(=O)C=CC1=O)O2

> <INCHI_IDENTIFIER>
InChI=1S/C26H34O5/c1-22-11-7-18-23(2)9-4-10-25(18,15-30-21(23)29)17(22)8-12-24(3)19(22)14-26(31-24)13-16(27)5-6-20(26)28/h5-6,17-19H,4,7-15H2,1-3H3/t17-,18-,19-,22+,23-,24-,25-,26+/m0/s1

> <INCHI_KEY>
CQCNPEVRQMVQSM-NYBKKNBDSA-N

> <FORMULA>
C26H34O5

> <MOLECULAR_WEIGHT>
426.553

> <EXACT_MASS>
426.240624195

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_ATOM_COUNT>
65

> <JCHEM_AVERAGE_POLARIZABILITY>
46.900107357175365

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
0

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(1S,1'S,2'S,5'S,9'S,10'R,13'R,14'S)-5',10',14'-trimethyl-6',16'-dioxaspiro[cyclohexane-1,7'-pentacyclo[12.3.3.0^{1,13}.0^{2,10}.0^{5,9}]icosan]-3-ene-2,5,15'-trione

> <JCHEM_LOGP>
4.403210556333334

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
6

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_ACIDIC>
16.298383220010965

> <JCHEM_PKA_STRONGEST_BASIC>
-4.266306960186067

> <JCHEM_POLAR_SURFACE_AREA>
69.67

> <JCHEM_REFRACTIVITY>
115.37289999999999

> <JCHEM_ROTATABLE_BOND_COUNT>
0

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
(1S,1'S,2'S,5'S,9'S,10'R,13'R,14'S)-5',10',14'-trimethyl-6',16'-dioxaspiro[cyclohexane-1,7'-pentacyclo[12.3.3.0^{1,13}.0^{2,10}.0^{5,9}]icosan]-3-ene-2,5,15'-trione

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 05-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   05-SEP-22         0                                  
HETATM    1  C   UNK     0       8.959   3.468   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       8.295   2.079   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       7.296   3.250   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       5.781   2.970   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       5.267   1.518   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       3.752   1.238   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       2.241   1.534   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       0.963   0.674   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       0.668  -0.838   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       1.528  -2.115   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       0.677  -3.399   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       3.039  -2.411   0.000  0.00  0.00           C+0
HETATM   13  O   UNK     0       3.345  -3.920   0.000  0.00  0.00           O+0
HETATM   14  O   UNK     0       4.234  -1.978   0.000  0.00  0.00           O+0
HETATM   15  C   UNK     0       4.612  -0.039   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       3.238  -0.213   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       4.238  -1.385   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       5.752  -1.105   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       6.266   0.347   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       7.266  -0.824   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       7.781   0.627   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       9.002  -0.311   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0      10.272   0.561   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0      11.443   1.561   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0      12.895   1.046   0.000  0.00  0.00           C+0
HETATM   26  O   UNK     0      14.066   2.046   0.000  0.00  0.00           O+0
HETATM   27  C   UNK     0      13.175  -0.468   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0      12.003  -1.468   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0      10.552  -0.953   0.000  0.00  0.00           C+0
HETATM   30  O   UNK     0       9.380  -1.953   0.000  0.00  0.00           O+0
HETATM   31  O   UNK     0       9.835   2.038   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3   21   31                                             
CONECT    3    2    4                                                       
CONECT    4    3    5                                                       
CONECT    5    4    6   19                                                  
CONECT    6    5    7   15   16                                             
CONECT    7    6    8                                                       
CONECT    8    7    9                                                       
CONECT    9    8   10                                                       
CONECT   10    9   11   12   16                                             
CONECT   11   10                                                            
CONECT   12   10   13   14                                                  
CONECT   13   12                                                            
CONECT   14   12   15                                                       
CONECT   15   14    6                                                       
CONECT   16   10    6   17                                                  
CONECT   17   16   18                                                       
CONECT   18   17   19                                                       
CONECT   19   18    5   20   21                                             
CONECT   20   19                                                            
CONECT   21   19    2   22                                                  
CONECT   22   21   23                                                       
CONECT   23   22   24   29   31                                             
CONECT   24   23   25                                                       
CONECT   25   24   26   27                                                  
CONECT   26   25                                                            
CONECT   27   25   28                                                       
CONECT   28   27   29                                                       
CONECT   29   28   23   30                                                  
CONECT   30   29                                                            
CONECT   31   23    2                                                       
MASTER        0    0    0    0    0    0    0    0   31    0   72    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₆H₃₄O₅

Average Mass

426.5530 Da

Monoisotopic Mass

426.24062 Da

IUPAC Name

(1S,1'S,2'S,5'S,9'S,10'R,13'R,14'S)-5',10',14'-trimethyl-6',16'-dioxaspiro[cyclohexane-1,7'-pentacyclo[12.3.3.0^{1,13}.0^{2,10}.0^{5,9}]icosan]-3-ene-2,5,15'-trione

Traditional Name

(1S,1'S,2'S,5'S,9'S,10'R,13'R,14'S)-5',10',14'-trimethyl-6',16'-dioxaspiro[cyclohexane-1,7'-pentacyclo[12.3.3.0^{1,13}.0^{2,10}.0^{5,9}]icosan]-3-ene-2,5,15'-trione

CAS Registry Number

Not Available

SMILES

C[C@]12CC[C@H]3[C@@](C)(CC[C@H]4[C@]5(C)CCC[C@]34COC5=O)[C@@H]1C[C@@]1(CC(=O)C=CC1=O)O2

InChI Identifier

InChI=1S/C26H34O5/c1-22-11-7-18-23(2)9-4-10-25(18,15-30-21(23)29)17(22)8-12-24(3)19(22)14-26(31-24)13-16(27)5-6-20(26)28/h5-6,17-19H,4,7-15H2,1-3H3/t17-,18-,19-,22+,23-,24-,25-,26+/m0/s1

InChI Key

CQCNPEVRQMVQSM-NYBKKNBDSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Petrosia durissima	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as oxosteroids. These are steroid derivatives carrying a C=O group attached to steroid skeleton.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Steroids and steroid derivatives

Sub Class

Oxosteroids

Direct Parent

Oxosteroids

Alternative Parents

Substituents

Oxosteroid
3-oxo-5-alpha-steroid
Naphthopyran
Naphthofuran
Naphthalene
Cyclohexenone
Delta valerolactone
Delta_valerolactone
Oxane
Pyran
Tetrahydrofuran
Cyclic ketone
Lactone
Ketone
Carboxylic acid ester
Monocarboxylic acid or derivatives
Organoheterocyclic compound
Ether
Dialkyl ether
Oxacycle
Carboxylic acid derivative
Hydrocarbon derivative
Organooxygen compound
Organic oxide
Carbonyl group
Organic oxygen compound
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	4.4	ChemAxon
pKa (Strongest Acidic)	16.3	ChemAxon
pKa (Strongest Basic)	-4.3	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	69.67 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	115.37 m³·mol⁻¹	ChemAxon
Polarizability	46.9 Å³	ChemAxon
Number of Rings	6	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

29215773

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

14564370

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for (1s,1's,2's,5's,9's,10'r,13'r,14's)-5',10',14'-trimethyl-6',16'-dioxaspiro[cyclohexane-1,7'-pentacyclo[12.3.3.0¹,¹³.0²,¹⁰.0⁵,⁹]icosan]-3-ene-2,5,15'-trione (NP0206579)

MOL for NP0206579 ((1s,1's,2's,5's,9's,10'r,13'r,14's)-5',10',14'-trimethyl-6',16'-dioxaspiro[cyclohexane-1,7'-pentacyclo[12.3.3.0¹,¹³.0²,¹⁰.0⁵,⁹]icosan]-3-ene-2,5,15'-trione)

3D MOL for NP0206579 ((1s,1's,2's,5's,9's,10'r,13'r,14's)-5',10',14'-trimethyl-6',16'-dioxaspiro[cyclohexane-1,7'-pentacyclo[12.3.3.0¹,¹³.0²,¹⁰.0⁵,⁹]icosan]-3-ene-2,5,15'-trione)

3D SDF for NP0206579 ((1s,1's,2's,5's,9's,10'r,13'r,14's)-5',10',14'-trimethyl-6',16'-dioxaspiro[cyclohexane-1,7'-pentacyclo[12.3.3.0¹,¹³.0²,¹⁰.0⁵,⁹]icosan]-3-ene-2,5,15'-trione)

3D-SDF for NP0206579 ((1s,1's,2's,5's,9's,10'r,13'r,14's)-5',10',14'-trimethyl-6',16'-dioxaspiro[cyclohexane-1,7'-pentacyclo[12.3.3.0¹,¹³.0²,¹⁰.0⁵,⁹]icosan]-3-ene-2,5,15'-trione)

PDB for NP0206579 ((1s,1's,2's,5's,9's,10'r,13'r,14's)-5',10',14'-trimethyl-6',16'-dioxaspiro[cyclohexane-1,7'-pentacyclo[12.3.3.0¹,¹³.0²,¹⁰.0⁵,⁹]icosan]-3-ene-2,5,15'-trione)

3D PDB for NP0206579 ((1s,1's,2's,5's,9's,10'r,13'r,14's)-5',10',14'-trimethyl-6',16'-dioxaspiro[cyclohexane-1,7'-pentacyclo[12.3.3.0¹,¹³.0²,¹⁰.0⁵,⁹]icosan]-3-ene-2,5,15'-trione)

SMILES for NP0206579 ((1s,1's,2's,5's,9's,10'r,13'r,14's)-5',10',14'-trimethyl-6',16'-dioxaspiro[cyclohexane-1,7'-pentacyclo[12.3.3.0¹,¹³.0²,¹⁰.0⁵,⁹]icosan]-3-ene-2,5,15'-trione)

INCHI for NP0206579 ((1s,1's,2's,5's,9's,10'r,13'r,14's)-5',10',14'-trimethyl-6',16'-dioxaspiro[cyclohexane-1,7'-pentacyclo[12.3.3.0¹,¹³.0²,¹⁰.0⁵,⁹]icosan]-3-ene-2,5,15'-trione)

Structure for NP0206579 ((1s,1's,2's,5's,9's,10'r,13'r,14's)-5',10',14'-trimethyl-6',16'-dioxaspiro[cyclohexane-1,7'-pentacyclo[12.3.3.0¹,¹³.0²,¹⁰.0⁵,⁹]icosan]-3-ene-2,5,15'-trione)

3D Structure for NP0206579 ((1s,1's,2's,5's,9's,10'r,13'r,14's)-5',10',14'-trimethyl-6',16'-dioxaspiro[cyclohexane-1,7'-pentacyclo[12.3.3.0¹,¹³.0²,¹⁰.0⁵,⁹]icosan]-3-ene-2,5,15'-trione)