NP-MRD: Showing NP-Card for 8-ethoxy-11-ethyl-6,16-dimethoxy-13-methyl-11-azahexacyclo[7.7.2.1²,⁵.0¹,¹⁰.0³,⁸.0¹³,¹⁷]nonadecan-4-ol (NP0202005)

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Record Information

Version

2.0

Created at

2022-09-04 21:08:40 UTC

Updated at

2022-09-04 21:08:40 UTC

NP-MRD ID

NP0202005

Secondary Accession Numbers

None

Natural Product Identification

Common Name

8-ethoxy-11-ethyl-6,16-dimethoxy-13-methyl-11-azahexacyclo[7.7.2.1²,⁵.0¹,¹⁰.0³,⁸.0¹³,¹⁷]nonadecan-4-ol

Description

8-Ethoxy-11-ethyl-6,16-dimethoxy-13-methyl-11-azahexacyclo[7.7.2.1²,⁵.0¹,¹⁰.0³,⁸.0¹³,¹⁷]Nonadecan-4-ol belongs to the class of organic compounds known as aconitane-type diterpenoid alkaloids. These are alkaloid diterpenoids with a structure based on the hexacyclic aconitane skeleton. These compounds have no oxygen functionality at the C7 atom. 8-ethoxy-11-ethyl-6,16-dimethoxy-13-methyl-11-azahexacyclo[7.7.2.1²,⁵.0¹,¹⁰.0³,⁸.0¹³,¹⁷]nonadecan-4-ol is found in Aconitum variegatum. Based on a literature review very few articles have been published on 8-ethoxy-11-ethyl-6,16-dimethoxy-13-methyl-11-azahexacyclo[7.7.2.1²,⁵.0¹,¹⁰.0³,⁸.0¹³,¹⁷]Nonadecan-4-ol.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309042223082D          

 30 35  0  0  0  0            999 V2000
    3.8578    4.4247    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8706    3.5998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1626    3.1763    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1755    2.3514    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0076    2.5653    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6521    2.0006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4414    2.2403    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0438    1.6766    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4223    1.1421    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5971    0.4436    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8102    1.0121    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2751    1.5505    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9465    0.8591    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8381    0.0412    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9859    1.4064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1336    0.5627    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9276    0.3389    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1309   -0.4607    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5811   -0.0636    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7800    0.1891    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5615    1.0150    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2187    0.7467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2277    1.7964    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6951    2.5190    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3487    3.2678    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4729    3.3423    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6423    2.3950    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2280    2.5637    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2096    2.2238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2890    1.3371    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  4 12  1  0  0  0  0
 12 13  1  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 11 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
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 21 23  1  0  0  0  0
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 15 27  1  0  0  0  0
 27 28  1  0  0  0  0
  4 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 21 30  1  0  0  0  0
 15 30  1  0  0  0  0
M  END

     RDKit          3D

 71 76  0  0  0  0  0  0  0  0999 V2000
    1.7845   -0.7152   -3.6497 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8743   -1.7769   -2.5720 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2850   -1.4658   -1.3844 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.1992    1.5231    0.5377 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3152    0.5596    1.6534 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.7300   -1.4003    0.2117 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8891   -1.2426   -0.8880 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8560   -2.3680   -1.7413 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.6879   -0.5402   -0.7654 C   0  0  2  0  0  0  0  0  0  0  0  0
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M  END


  Mrv1652309042223082D          

 30 35  0  0  0  0            999 V2000
    3.8578    4.4247    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8706    3.5998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
> <DATABASE_ID>
NP0202005

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CCOC12CC(OC)C3CC(C1C3O)C13C4CC2C1N(CC)CC4(C)CCC3OC

> <INCHI_IDENTIFIER>
InChI=1S/C25H41NO4/c1-6-26-13-23(3)9-8-19(29-5)25-15-10-14-17(28-4)12-24(30-7-2,20(15)21(14)27)16(22(25)26)11-18(23)25/h14-22,27H,6-13H2,1-5H3

> <INCHI_KEY>
JGYRCOIPRDVLMU-UHFFFAOYSA-N

> <FORMULA>
C25H41NO4

> <MOLECULAR_WEIGHT>
419.606

> <EXACT_MASS>
419.303558804

> <JCHEM_ACCEPTOR_COUNT>
5

> <JCHEM_ATOM_COUNT>
71

> <JCHEM_AVERAGE_POLARIZABILITY>
48.447559361878376

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
8-ethoxy-11-ethyl-6,16-dimethoxy-13-methyl-11-azahexacyclo[7.7.2.1^{2,5}.0^{1,10}.0^{3,8}.0^{13,17}]nonadecan-4-ol

> <JCHEM_LOGP>
1.3674802036666653

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
6

> <JCHEM_PHYSIOLOGICAL_CHARGE>
1

> <JCHEM_PKA_STRONGEST_ACIDIC>
14.51204979934598

> <JCHEM_PKA_STRONGEST_BASIC>
10.521562949586269

> <JCHEM_POLAR_SURFACE_AREA>
51.160000000000004

> <JCHEM_REFRACTIVITY>
116.01129999999995

> <JCHEM_ROTATABLE_BOND_COUNT>
5

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
8-ethoxy-11-ethyl-6,16-dimethoxy-13-methyl-11-azahexacyclo[7.7.2.1^{2,5}.0^{1,10}.0^{3,8}.0^{13,17}]nonadecan-4-ol

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 04-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   04-SEP-22         0                                  
HETATM    1  C   UNK     0       7.201   8.260   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       7.225   6.720   0.000  0.00  0.00           C+0
HETATM    3  O   UNK     0       5.904   5.929   0.000  0.00  0.00           O+0
HETATM    4  C   UNK     0       5.928   4.389   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       7.481   4.788   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       8.684   3.734   0.000  0.00  0.00           C+0
HETATM    7  O   UNK     0      10.157   4.182   0.000  0.00  0.00           O+0
HETATM    8  C   UNK     0      11.282   3.130   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       8.255   2.132   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       6.715   0.828   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       5.246   1.889   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       6.113   2.894   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       7.367   1.604   0.000  0.00  0.00           C+0
HETATM   14  O   UNK     0       7.165   0.077   0.000  0.00  0.00           O+0
HETATM   15  C   UNK     0       3.707   2.625   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       3.983   1.050   0.000  0.00  0.00           C+0
HETATM   17  O   UNK     0       5.465   0.633   0.000  0.00  0.00           O+0
HETATM   18  C   UNK     0       5.844  -0.860   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       2.951  -0.119   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       1.456   0.353   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       1.048   1.895   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0      -0.408   1.394   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       0.425   3.353   0.000  0.00  0.00           C+0
HETATM   24  N   UNK     0       1.297   4.702   0.000  0.00  0.00           N+0
HETATM   25  C   UNK     0       0.651   6.100   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0      -0.883   6.239   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0       3.066   4.471   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0       4.159   4.786   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0       2.258   4.151   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0       2.406   2.496   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4                                                       
CONECT    4    3    5   12   28                                             
CONECT    5    4    6                                                       
CONECT    6    5    7    9                                                  
CONECT    7    6    8                                                       
CONECT    8    7                                                            
CONECT    9    6   10   13                                                  
CONECT   10    9   11                                                       
CONECT   11   10   12   15                                                  
CONECT   12   11    4   13                                                  
CONECT   13   12    9   14                                                  
CONECT   14   13                                                            
CONECT   15   11   16   27   30                                             
CONECT   16   15   17   19                                                  
CONECT   17   16   18                                                       
CONECT   18   17                                                            
CONECT   19   16   20                                                       
CONECT   20   19   21                                                       
CONECT   21   20   22   23   30                                             
CONECT   22   21                                                            
CONECT   23   21   24                                                       
CONECT   24   23   25   27                                                  
CONECT   25   24   26                                                       
CONECT   26   25                                                            
CONECT   27   24   15   28                                                  
CONECT   28   27    4   29                                                  
CONECT   29   28   30                                                       
CONECT   30   29   21   15                                                  
MASTER        0    0    0    0    0    0    0    0   30    0   70    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₅H₄₁NO₄

Average Mass

419.6060 Da

Monoisotopic Mass

419.30356 Da

IUPAC Name

8-ethoxy-11-ethyl-6,16-dimethoxy-13-methyl-11-azahexacyclo[7.7.2.1^{2,5}.0^{1,10}.0^{3,8}.0^{13,17}]nonadecan-4-ol

Traditional Name

8-ethoxy-11-ethyl-6,16-dimethoxy-13-methyl-11-azahexacyclo[7.7.2.1^{2,5}.0^{1,10}.0^{3,8}.0^{13,17}]nonadecan-4-ol

CAS Registry Number

Not Available

SMILES

CCOC12CC(OC)C3CC(C1C3O)C13C4CC2C1N(CC)CC4(C)CCC3OC

InChI Identifier

InChI=1S/C25H41NO4/c1-6-26-13-23(3)9-8-19(29-5)25-15-10-14-17(28-4)12-24(30-7-2,20(15)21(14)27)16(22(25)26)11-18(23)25/h14-22,27H,6-13H2,1-5H3

InChI Key

JGYRCOIPRDVLMU-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Aconitum variegatum	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as aconitane-type diterpenoid alkaloids. These are alkaloid diterpenoids with a structure based on the hexacyclic aconitane skeleton. These compounds have no oxygen functionality at the C7 atom.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Diterpenoids

Direct Parent

Aconitane-type diterpenoid alkaloids

Alternative Parents

Substituents

Aconitane-type diterpenoid alkaloid
Quinolidine
Alkaloid or derivatives
Azepane
Piperidine
Cyclic alcohol
Secondary alcohol
Tertiary amine
Tertiary aliphatic amine
Ether
Dialkyl ether
Azacycle
Organoheterocyclic compound
Amine
Alcohol
Organopnictogen compound
Organooxygen compound
Organonitrogen compound
Organic oxygen compound
Organic nitrogen compound
Hydrocarbon derivative
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	1.37	ChemAxon
pKa (Strongest Acidic)	14.51	ChemAxon
pKa (Strongest Basic)	10.52	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	51.16 Å²	ChemAxon
Rotatable Bond Count	5	ChemAxon
Refractivity	116.01 m³·mol⁻¹	ChemAxon
Polarizability	48.45 Å³	ChemAxon
Number of Rings	6	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

73804011

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for 8-ethoxy-11-ethyl-6,16-dimethoxy-13-methyl-11-azahexacyclo[7.7.2.1²,⁵.0¹,¹⁰.0³,⁸.0¹³,¹⁷]nonadecan-4-ol (NP0202005)

MOL for NP0202005 (8-ethoxy-11-ethyl-6,16-dimethoxy-13-methyl-11-azahexacyclo[7.7.2.1²,⁵.0¹,¹⁰.0³,⁸.0¹³,¹⁷]nonadecan-4-ol)

3D MOL for NP0202005 (8-ethoxy-11-ethyl-6,16-dimethoxy-13-methyl-11-azahexacyclo[7.7.2.1²,⁵.0¹,¹⁰.0³,⁸.0¹³,¹⁷]nonadecan-4-ol)

3D SDF for NP0202005 (8-ethoxy-11-ethyl-6,16-dimethoxy-13-methyl-11-azahexacyclo[7.7.2.1²,⁵.0¹,¹⁰.0³,⁸.0¹³,¹⁷]nonadecan-4-ol)

3D-SDF for NP0202005 (8-ethoxy-11-ethyl-6,16-dimethoxy-13-methyl-11-azahexacyclo[7.7.2.1²,⁵.0¹,¹⁰.0³,⁸.0¹³,¹⁷]nonadecan-4-ol)

PDB for NP0202005 (8-ethoxy-11-ethyl-6,16-dimethoxy-13-methyl-11-azahexacyclo[7.7.2.1²,⁵.0¹,¹⁰.0³,⁸.0¹³,¹⁷]nonadecan-4-ol)

3D PDB for NP0202005 (8-ethoxy-11-ethyl-6,16-dimethoxy-13-methyl-11-azahexacyclo[7.7.2.1²,⁵.0¹,¹⁰.0³,⁸.0¹³,¹⁷]nonadecan-4-ol)

SMILES for NP0202005 (8-ethoxy-11-ethyl-6,16-dimethoxy-13-methyl-11-azahexacyclo[7.7.2.1²,⁵.0¹,¹⁰.0³,⁸.0¹³,¹⁷]nonadecan-4-ol)

INCHI for NP0202005 (8-ethoxy-11-ethyl-6,16-dimethoxy-13-methyl-11-azahexacyclo[7.7.2.1²,⁵.0¹,¹⁰.0³,⁸.0¹³,¹⁷]nonadecan-4-ol)

Structure for NP0202005 (8-ethoxy-11-ethyl-6,16-dimethoxy-13-methyl-11-azahexacyclo[7.7.2.1²,⁵.0¹,¹⁰.0³,⁸.0¹³,¹⁷]nonadecan-4-ol)

3D Structure for NP0202005 (8-ethoxy-11-ethyl-6,16-dimethoxy-13-methyl-11-azahexacyclo[7.7.2.1²,⁵.0¹,¹⁰.0³,⁸.0¹³,¹⁷]nonadecan-4-ol)