NP-MRD: Showing NP-Card for 4-hydroxy-2-methyl-n-(5-methyl-1,3-thiazol-2-yl)-1,1-dioxo-1λ⁶,2-benzothiazine-3-carboximidic acid (NP0200784)

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Record Information

Version

2.0

Created at

2022-09-04 19:42:00 UTC

Updated at

2022-09-04 19:42:00 UTC

NP-MRD ID

NP0200784

Secondary Accession Numbers

None

Natural Product Identification

Common Name

4-hydroxy-2-methyl-n-(5-methyl-1,3-thiazol-2-yl)-1,1-dioxo-1λ⁶,2-benzothiazine-3-carboximidic acid

Description

Meloxicam, also known as mobic or unii-VG2QF83CGL, belongs to the class of organic compounds known as benzothiazines. These are organic compounds containing a benzene fused to a thiazine ring (a six-membered ring with four carbon atoms, one nitrogen atom and one sulfur atom). Meloxicam is an extremely weak basic (essentially neutral) compound (based on its pKa). In humans, meloxicam is involved in meloxicam action pathway. 4-hydroxy-2-methyl-n-(5-methyl-1,3-thiazol-2-yl)-1,1-dioxo-1λ⁶,2-benzothiazine-3-carboximidic acid is found in Apis cerana. 4-hydroxy-2-methyl-n-(5-methyl-1,3-thiazol-2-yl)-1,1-dioxo-1λ⁶,2-benzothiazine-3-carboximidic acid was first documented in 1999 (PMID: 10092958). Meloxicam is a potentially toxic compound (PMID: 12387696) (PMID: 16197363) (PMID: 16623613) (PMID: 16863437).

Structure

MOL 3D MOL SDF PDB SMILES InChI

     RDKit          3D

 36 38  0  0  0  0  0  0  0  0999 V2000
    7.1173    0.1092   -0.7473 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6263    0.1074   -0.5167 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9665    0.3272    0.6676 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6737    0.2818    0.6522 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0400    0.0296   -0.4834 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5921   -0.0623   -0.7018 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7833    0.1393    0.4170 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3510    0.3883    1.5477 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6771    0.0866    0.3927 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3454   -0.1648   -0.6991 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6134   -0.3645   -1.9022 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7884   -0.2841   -0.8432 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3222   -0.4562   -2.1345 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6882   -0.4788   -2.2685 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5658   -0.3446   -1.2251 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9825   -0.1789    0.0292 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6412   -0.1508    0.2166 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9938   -0.0450    1.8218 S   0  0  0  0  0  6  0  0  0  0  0  0
   -3.6943    0.9923    2.6512 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1502   -1.4219    2.4465 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3180    0.3185    1.6684 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6100    0.8752    2.8072 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3226   -0.1541   -1.5902 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.5018    1.0128   -0.2376 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.2959    0.2370   -1.8320 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.5731   -0.8172   -0.3720 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.5357    0.5368    1.6040 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.3496   -0.2667   -1.6657 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8175   -1.2083   -2.4101 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6743   -0.5662   -2.9853 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1185   -0.6109   -3.2595 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.6401   -0.3660   -1.3670 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6333   -0.0673    0.8957 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0284    1.7744    2.5963 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4295    1.2569    3.5114 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.0033    0.1351    3.3159 H   0  0  0  0  0  0  0  0  0  0  0  0
 22 21  1  0
 21  9  1  0
  9  7  1  0
  7  8  2  0
  7  6  1  0
  6  5  1  0
  5  4  2  0
  4  3  1  0
  3  2  2  0
  2  1  1  0
  2 23  1  0
  9 10  2  0
 10 11  1  0
 10 12  1  0
 12 17  2  0
 17 16  1  0
 16 15  2  0
 15 14  1  0
 14 13  2  0
 17 18  1  0
 18 19  2  0
 18 20  2  0
 18 21  1  0
 23  5  1  0
 13 12  1  0
 22 34  1  0
 22 35  1  0
 22 36  1  0
  6 28  1  0
  3 27  1  0
  1 24  1  0
  1 25  1  0
  1 26  1  0
 11 29  1  0
 16 33  1  0
 15 32  1  0
 14 31  1  0
 13 30  1  0
M  END

 
  Mrv0541 02231215012D          
 
 23 25  0  0  0  0            999 V2000
   17.2936  -10.3134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.2797  -11.1354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.0115   -9.9111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.5825   -9.8868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.9837  -11.5550    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   16.5617  -11.5377    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.7155  -10.3342    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.0254   -9.0857    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   15.8647  -10.2960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.7017  -11.1562    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   18.6114  -12.1411    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   17.2832  -12.1828    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   15.8543  -11.1215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.4369   -9.9319    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.4161  -11.5793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   20.1479  -10.3585    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   19.4508   -9.1064    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   20.8693   -9.9561    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   21.6591  -10.1868    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   20.8452   -9.1265    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   22.1258   -9.5071    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   21.6250   -8.8524    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   21.8535   -8.0574    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  1  0  0  0  0
  1  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  2  0  0  0  0
  3  8  1  0  0  0  0
  4  9  2  0  0  0  0
  5 10  1  0  0  0  0
  5 11  2  0  0  0  0
  5 12  2  0  0  0  0
  6 13  2  0  0  0  0
  7 14  1  0  0  0  0
 10 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
  7 10  1  0  0  0  0
  9 13  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
> <DATABASE_ID>
NP0200784

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CN1C(C(=O)NC2=NC=C(C)S2)=C(O)C2=C(C=CC=C2)S1(=O)=O

> <INCHI_IDENTIFIER>
InChI=1S/C14H13N3O4S2/c1-8-7-15-14(22-8)16-13(19)11-12(18)9-5-3-4-6-10(9)23(20,21)17(11)2/h3-7,18H,1-2H3,(H,15,16,19)

> <INCHI_KEY>
ZRVUJXDFFKFLMG-UHFFFAOYSA-N

> <FORMULA>
C14H13N3O4S2

> <MOLECULAR_WEIGHT>
351.401

> <EXACT_MASS>
351.034747299

> <JCHEM_ACCEPTOR_COUNT>
5

> <JCHEM_AVERAGE_POLARIZABILITY>
34.25368290810468

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
4-hydroxy-2-methyl-N-(5-methyl-1,3-thiazol-2-yl)-1,1-dioxo-2H-1λ⁶,2-benzothiazine-3-carboxamide

> <ALOGPS_LOGP>
2.28

> <JCHEM_LOGP>
1.6005813606666672

> <ALOGPS_LOGS>
-3.36

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-1

> <JCHEM_PKA>
10.641769387409953

> <JCHEM_PKA_STRONGEST_ACIDIC>
4.471159895191359

> <JCHEM_PKA_STRONGEST_BASIC>
0.4736328830676666

> <JCHEM_POLAR_SURFACE_AREA>
99.60000000000001

> <JCHEM_REFRACTIVITY>
88.6249

> <JCHEM_ROTATABLE_BOND_COUNT>
2

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.54e-01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
meloxicam

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 23-FEB-12   NONE
TITLE     NULL                                                        
COMPND    MOLECULE:                                                   
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   23-FEB-12         0                                  
HETATM    1  C   UNK     0      32.281 -19.252   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      32.255 -20.786   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      33.621 -18.501   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      30.954 -18.455   0.000  0.00  0.00           C+0
HETATM    5  S   UNK     0      33.570 -21.569   0.000  0.00  0.00           S+0
HETATM    6  C   UNK     0      30.915 -21.537   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      34.936 -19.291   0.000  0.00  0.00           C+0
HETATM    8  O   UNK     0      33.647 -16.960   0.000  0.00  0.00           O+0
HETATM    9  C   UNK     0      29.614 -19.219   0.000  0.00  0.00           C+0
HETATM   10  N   UNK     0      34.910 -20.825   0.000  0.00  0.00           N+0
HETATM   11  O   UNK     0      34.741 -22.663   0.000  0.00  0.00           O+0
HETATM   12  O   UNK     0      32.262 -22.741   0.000  0.00  0.00           O+0
HETATM   13  C   UNK     0      29.595 -20.760   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      36.282 -18.540   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      36.243 -21.615   0.000  0.00  0.00           C+0
HETATM   16  N   UNK     0      37.609 -19.336   0.000  0.00  0.00           N+0
HETATM   17  O   UNK     0      36.308 -16.999   0.000  0.00  0.00           O+0
HETATM   18  C   UNK     0      38.956 -18.585   0.000  0.00  0.00           C+0
HETATM   19  N   UNK     0      40.430 -19.015   0.000  0.00  0.00           N+0
HETATM   20  S   UNK     0      38.911 -17.036   0.000  0.00  0.00           S+0
HETATM   21  C   UNK     0      41.301 -17.747   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0      40.367 -16.524   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0      40.793 -15.040   0.000  0.00  0.00           C+0
CONECT    1    2    3    4                                                  
CONECT    2    1    5    6                                                  
CONECT    3    1    7    8                                                  
CONECT    4    1    9                                                       
CONECT    5    2   10   11   12                                             
CONECT    6    2   13                                                       
CONECT    7    3   14   10                                                  
CONECT    8    3                                                            
CONECT    9    4   13                                                       
CONECT   10    5   15    7                                                  
CONECT   11    5                                                            
CONECT   12    5                                                            
CONECT   13    6    9                                                       
CONECT   14    7   16   17                                                  
CONECT   15   10                                                            
CONECT   16   14   18                                                       
CONECT   17   14                                                            
CONECT   18   16   19   20                                                  
CONECT   19   18   21                                                       
CONECT   20   18   22                                                       
CONECT   21   19   22                                                       
CONECT   22   20   23   21                                                  
CONECT   23   22                                                            
MASTER        0    0    0    0    0    0    0    0   23    0   50    0
END

View in JSmol

Synonyms

Value	Source
Meloxicamum	ChEBI
Mobic	ChEBI
UNII-VG2QF83CGL	ChEBI
Masflex	HMDB
Mobicox	HMDB
Movalis	HMDB
Movicox	HMDB
Mobec	HMDB
Uticox	HMDB
Parocin	HMDB
Miloxicam	HMDB
Reumoxicam	HMDB

Chemical Formula

C₁₄H₁₃N₃O₄S₂

Average Mass

351.4010 Da

Monoisotopic Mass

351.03475 Da

IUPAC Name

4-hydroxy-2-methyl-N-(5-methyl-1,3-thiazol-2-yl)-1,1-dioxo-2H-1λ⁶,2-benzothiazine-3-carboxamide

Traditional Name

meloxicam

CAS Registry Number

Not Available

SMILES

CN1C(C(=O)NC2=NC=C(C)S2)=C(O)C2=C(C=CC=C2)S1(=O)=O

InChI Identifier

InChI=1S/C14H13N3O4S2/c1-8-7-15-14(22-8)16-13(19)11-12(18)9-5-3-4-6-10(9)23(20,21)17(11)2/h3-7,18H,1-2H3,(H,15,16,19)

InChI Key

ZRVUJXDFFKFLMG-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Apis cerana	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as benzothiazines. These are organic compounds containing a benzene fused to a thiazine ring (a six-membered ring with four carbon atoms, one nitrogen atom and one sulfur atom).

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Benzothiazines

Sub Class

Not Available

Direct Parent

Benzothiazines

Alternative Parents

Substituents

Alpha-amino acid or derivatives
Benzothiazine
N-arylamide
2,5-disubstituted 1,3-thiazole
Ortho-thiazine
Benzenoid
Organosulfonic acid amide
Azole
Heteroaromatic compound
Vinylogous acid
Thiazole
Organosulfonic acid or derivatives
Organic sulfonic acid or derivatives
Carboxamide group
Secondary carboxylic acid amide
Azacycle
Carboxylic acid derivative
Organic oxygen compound
Organic nitrogen compound
Carbonyl group
Hydrocarbon derivative
Organic oxide
Organopnictogen compound
Organonitrogen compound
Organooxygen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

monocarboxylic acid amide (CHEBI:6741 )
1,3-thiazole (CHEBI:6741 )
benzothiazine (CHEBI:6741 )

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	2.28	ALOGPS
logP	1.6	ChemAxon
logS	-3.4	ALOGPS
pKa (Strongest Acidic)	4.47	ChemAxon
pKa (Strongest Basic)	0.47	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	99.6 Å²	ChemAxon
Rotatable Bond Count	2	ChemAxon
Refractivity	88.62 m³·mol⁻¹	ChemAxon
Polarizability	34.25 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

HMDB0014952

DrugBank ID

DB00814

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

10442740

KEGG Compound ID

C08169

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Meloxicam

METLIN ID

Not Available

PubChem Compound

54677470

PDB ID

Not Available

ChEBI ID

6741

Good Scents ID

Not Available

References

General References

Davies NM, Skjodt NM: Clinical pharmacokinetics of meloxicam. A cyclo-oxygenase-2 preferential nonsteroidal anti-inflammatory drug. Clin Pharmacokinet. 1999 Feb;36(2):115-26. doi: 10.2165/00003088-199936020-00003. [PubMed:10092958 ]
Fleischmann R, Iqbal I, Slobodin G: Meloxicam. Expert Opin Pharmacother. 2002 Oct;3(10):1501-12. doi: 10.1517/14656566.3.10.1501. [PubMed:12387696 ]
Gates BJ, Nguyen TT, Setter SM, Davies NM: Meloxicam: a reappraisal of pharmacokinetics, efficacy and safety. Expert Opin Pharmacother. 2005 Oct;6(12):2117-40. doi: 10.1517/14656566.6.12.2117. [PubMed:16197363 ]
Curtiss FR: Relative value of the NSAIDs, including COX-2 inhibitors and meloxicam. J Manag Care Pharm. 2006 Apr;12(3):265-8. doi: 10.18553/jmcp.2006.12.3.265. [PubMed:16623613 ]
Ahmed M, Khanna D, Furst DE: Meloxicam in rheumatoid arthritis. Expert Opin Drug Metab Toxicol. 2005 Dec;1(4):739-51. doi: 10.1517/17425255.1.4.739. [PubMed:16863437 ]
LOTUS database [Link]

Showing NP-Card for 4-hydroxy-2-methyl-n-(5-methyl-1,3-thiazol-2-yl)-1,1-dioxo-1λ⁶,2-benzothiazine-3-carboximidic acid (NP0200784)

MOL for NP0200784 (4-hydroxy-2-methyl-n-(5-methyl-1,3-thiazol-2-yl)-1,1-dioxo-1λ⁶,2-benzothiazine-3-carboximidic acid)

3D MOL for NP0200784 (4-hydroxy-2-methyl-n-(5-methyl-1,3-thiazol-2-yl)-1,1-dioxo-1λ⁶,2-benzothiazine-3-carboximidic acid)

3D SDF for NP0200784 (4-hydroxy-2-methyl-n-(5-methyl-1,3-thiazol-2-yl)-1,1-dioxo-1λ⁶,2-benzothiazine-3-carboximidic acid)

3D-SDF for NP0200784 (4-hydroxy-2-methyl-n-(5-methyl-1,3-thiazol-2-yl)-1,1-dioxo-1λ⁶,2-benzothiazine-3-carboximidic acid)

PDB for NP0200784 (4-hydroxy-2-methyl-n-(5-methyl-1,3-thiazol-2-yl)-1,1-dioxo-1λ⁶,2-benzothiazine-3-carboximidic acid)

3D PDB for NP0200784 (4-hydroxy-2-methyl-n-(5-methyl-1,3-thiazol-2-yl)-1,1-dioxo-1λ⁶,2-benzothiazine-3-carboximidic acid)

SMILES for NP0200784 (4-hydroxy-2-methyl-n-(5-methyl-1,3-thiazol-2-yl)-1,1-dioxo-1λ⁶,2-benzothiazine-3-carboximidic acid)

INCHI for NP0200784 (4-hydroxy-2-methyl-n-(5-methyl-1,3-thiazol-2-yl)-1,1-dioxo-1λ⁶,2-benzothiazine-3-carboximidic acid)

Structure for NP0200784 (4-hydroxy-2-methyl-n-(5-methyl-1,3-thiazol-2-yl)-1,1-dioxo-1λ⁶,2-benzothiazine-3-carboximidic acid)

3D Structure for NP0200784 (4-hydroxy-2-methyl-n-(5-methyl-1,3-thiazol-2-yl)-1,1-dioxo-1λ⁶,2-benzothiazine-3-carboximidic acid)