NP-MRD: Showing NP-Card for (1r,4z,7r)-4-ethylidene-7-hydroxy-7,14-dimethyl-6-methylidene-2,9-dioxa-14-azabicyclo[9.5.1]heptadec-11-ene-3,8,17-trione (NP0199395)

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Record Information

Version

2.0

Created at

2022-09-04 18:01:55 UTC

Updated at

2022-09-04 18:01:55 UTC

NP-MRD ID

NP0199395

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(1r,4z,7r)-4-ethylidene-7-hydroxy-7,14-dimethyl-6-methylidene-2,9-dioxa-14-azabicyclo[9.5.1]heptadec-11-ene-3,8,17-trione

Description

(1R,4Z,7R)-4-ethylidene-7-hydroxy-7,14-dimethyl-6-methylidene-2,9-dioxa-14-azabicyclo[9.5.1]Heptadec-11-ene-3,8,17-trione belongs to the class of organic compounds known as alpha-acyloxy ketones. These are ketones that have an acyloxy substituent alpha to the carbonyl group. They have the general structure R4C(=O)OC(R2)(R3)C(R1)=O (R1=organyl, R4=H or organyl; R2,R3 = any atom). (1r,4z,7r)-4-ethylidene-7-hydroxy-7,14-dimethyl-6-methylidene-2,9-dioxa-14-azabicyclo[9.5.1]heptadec-11-ene-3,8,17-trione is found in Jacobaea carniolica. Based on a literature review very few articles have been published on (1R,4Z,7R)-4-ethylidene-7-hydroxy-7,14-dimethyl-6-methylidene-2,9-dioxa-14-azabicyclo[9.5.1]Heptadec-11-ene-3,8,17-trione.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309042220012D          

 26 27  0  0  1  0            999 V2000
    5.9737    1.9495    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0964    2.0124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6947    1.2918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8698    1.2794    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5968    2.2965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7978    2.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4680    0.5588    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8689   -0.2216    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6431    0.5464    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2200    1.2546    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.4626    0.9275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6957    1.2318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3686    1.9891    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4938    1.9761    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6729    2.7560    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4302    3.0831    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1985    2.6834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6002    3.4040    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4252    3.4164    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8483    2.7082    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8596    1.8214    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6732    2.7206    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.8283    3.6422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4979    3.1066    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6217    1.9752    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3555    1.7769    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  4  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  6  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 16 15  1  4  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
  2 22  1  0  0  0  0
 22 23  1  1  0  0  0
 22 24  1  6  0  0  0
 17 25  1  0  0  0  0
 10 25  1  0  0  0  0
 25 26  2  0  0  0  0
M  END

     RDKit          3D

 51 52  0  0  0  0  0  0  0  0999 V2000
   -2.7718   -0.7841   -1.2849 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6671   -0.7326    0.0210 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5445    0.5713    0.7030 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3275    1.7259   -0.1945 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2017    2.7430   -0.1342 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0414    3.9267   -1.0043 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2163    1.8123   -1.1325 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4417    2.4992   -2.1903 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0441    1.1959   -0.8708 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8686    1.3204    0.1642 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.2552    1.5208   -0.4706 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3362    0.7883    0.2991 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0771   -0.0523   -0.5913 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4586    0.3203   -0.6088 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0065   -1.4730   -0.2767 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5886   -1.8775   -0.0057 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4097   -1.2884    0.2313 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4368   -2.1966   -0.4140 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4361   -2.9060    0.3785 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7845   -3.0388    0.3900 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3162   -4.1203    0.0161 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6877   -1.9629    0.8287 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.4783   -1.6206    2.2952 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0465   -2.4056    0.7732 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0385   -0.0442    0.8618 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7946    0.1392    2.0732 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7760    0.0924   -1.9324 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8605   -1.7523   -1.7645 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8137    0.5450    1.5396 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5378    0.7170    1.2248 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0369    2.6641    0.5822 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0159    4.3472   -0.9206 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3751    3.7663   -2.0511 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6942    4.7331   -0.5510 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.7104    2.1103    0.8909 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.1872    1.1000   -1.4930 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4200    2.6038   -0.5555 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.0221    1.6128    0.6640 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.9856    0.3048    1.2191 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.6412    1.2095   -1.2728 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.1397   -0.5129   -0.8695 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.7408    0.6448    0.4170 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.6276   -1.6750    0.6059 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.4022   -2.0288   -1.1225 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4913   -2.9373   -0.0081 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0420   -1.6083   -1.2433 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.9807   -3.0068   -1.0138 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0160   -0.7056    2.5908 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7579   -2.4803    2.9522 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3964   -1.4502    2.4395 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2915   -2.3541   -0.1844 H   0  0  0  0  0  0  0  0  0  0  0  0
  6  5  1  0
  5  4  2  0
  4  3  1  0
  3  2  1  0
  2  1  2  3
  2 22  1  0
 22 23  1  0
 22 24  1  1
 22 20  1  0
 20 21  2  0
 20 19  1  0
 19 18  1  0
 18 17  1  0
 17 16  2  0
 16 15  1  0
 15 13  1  0
 13 14  1  0
 13 12  1  0
 12 11  1  0
 11 10  1  0
 10  9  1  0
  9  7  1  0
  7  8  2  0
 10 25  1  0
 25 26  2  0
  7  4  1  0
 25 17  1  0
  6 32  1  0
  6 33  1  0
  6 34  1  0
  5 31  1  0
  3 29  1  0
  3 30  1  0
  1 27  1  0
  1 28  1  0
 23 48  1  0
 23 49  1  0
 23 50  1  0
 24 51  1  0
 18 46  1  0
 18 47  1  0
 16 45  1  0
 15 43  1  0
 15 44  1  0
 14 40  1  0
 14 41  1  0
 14 42  1  0
 12 38  1  0
 12 39  1  0
 11 36  1  0
 11 37  1  0
 10 35  1  1
M  END


  Mrv1652309042220012D          

 26 27  0  0  1  0            999 V2000
    5.9737    1.9495    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0964    2.0124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6947    1.2918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8698    1.2794    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5968    2.2965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7978    2.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4680    0.5588    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8689   -0.2216    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6431    0.5464    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2200    1.2546    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.4626    0.9275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6957    1.2318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3686    1.9891    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4938    1.9761    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6729    2.7560    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4302    3.0831    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1985    2.6834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6002    3.4040    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4252    3.4164    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8483    2.7082    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8596    1.8214    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6732    2.7206    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.8283    3.6422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4979    3.1066    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6217    1.9752    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3555    1.7769    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  4  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  6  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 16 15  1  4  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
  2 22  1  0  0  0  0
 22 23  1  1  0  0  0
 22 24  1  6  0  0  0
 17 25  1  0  0  0  0
 10 25  1  0  0  0  0
 25 26  2  0  0  0  0
M  END
> <DATABASE_ID>
NP0199395

> <DATABASE_NAME>
NP-MRD

> <SMILES>
C\C=C1\CC(=C)[C@@](C)(O)C(=O)OCC2=CCN(C)CC[C@@H](OC1=O)C2=O

> <INCHI_IDENTIFIER>
InChI=1S/C19H25NO6/c1-5-13-10-12(2)19(3,24)18(23)25-11-14-6-8-20(4)9-7-15(16(14)21)26-17(13)22/h5-6,15,24H,2,7-11H2,1,3-4H3/b13-5-,14-6?/t15-,19-/m1/s1

> <INCHI_KEY>
GRQOJAAONJAOJH-HFTZCKCTSA-N

> <FORMULA>
C19H25NO6

> <MOLECULAR_WEIGHT>
363.41

> <EXACT_MASS>
363.168187529

> <JCHEM_ACCEPTOR_COUNT>
5

> <JCHEM_ATOM_COUNT>
51

> <JCHEM_AVERAGE_POLARIZABILITY>
37.5373756884476

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(1R,4Z,7R)-4-ethylidene-7-hydroxy-7,14-dimethyl-6-methylidene-2,9-dioxa-14-azabicyclo[9.5.1]heptadec-11-ene-3,8,17-trione

> <JCHEM_LOGP>
1.622958857666667

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
2

> <JCHEM_PHYSIOLOGICAL_CHARGE>
1

> <JCHEM_PKA>
16.461913974572337

> <JCHEM_PKA_STRONGEST_ACIDIC>
12.037704465724074

> <JCHEM_PKA_STRONGEST_BASIC>
6.959296184726099

> <JCHEM_POLAR_SURFACE_AREA>
93.13999999999999

> <JCHEM_REFRACTIVITY>
96.67679999999999

> <JCHEM_ROTATABLE_BOND_COUNT>
0

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
(1R,4Z,7R)-4-ethylidene-7-hydroxy-7,14-dimethyl-6-methylidene-2,9-dioxa-14-azabicyclo[9.5.1]heptadec-11-ene-3,8,17-trione

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 04-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   04-SEP-22         0                                  
HETATM    1  C   UNK     0      11.151   3.639   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       9.513   3.756   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       8.763   2.411   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       7.224   2.388   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       6.714   4.287   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       5.223   4.826   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       6.474   1.043   0.000  0.00  0.00           C+0
HETATM    8  O   UNK     0       7.222  -0.414   0.000  0.00  0.00           O+0
HETATM    9  O   UNK     0       4.934   1.020   0.000  0.00  0.00           O+0
HETATM   10  C   UNK     0       4.144   2.342   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       2.730   1.731   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       1.299   2.299   0.000  0.00  0.00           C+0
HETATM   13  N   UNK     0       0.688   3.713   0.000  0.00  0.00           N+0
HETATM   14  C   UNK     0      -0.922   3.689   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       1.256   5.145   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       2.670   5.755   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       4.104   5.009   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       4.854   6.354   0.000  0.00  0.00           C+0
HETATM   19  O   UNK     0       6.394   6.377   0.000  0.00  0.00           O+0
HETATM   20  C   UNK     0       7.184   5.055   0.000  0.00  0.00           C+0
HETATM   21  O   UNK     0       7.205   3.400   0.000  0.00  0.00           O+0
HETATM   22  C   UNK     0       8.723   5.078   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       9.013   6.799   0.000  0.00  0.00           C+0
HETATM   24  O   UNK     0      10.263   5.799   0.000  0.00  0.00           O+0
HETATM   25  C   UNK     0       4.894   3.687   0.000  0.00  0.00           C+0
HETATM   26  O   UNK     0       6.264   3.317   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3   22                                                  
CONECT    3    2    4                                                       
CONECT    4    3    5    7                                                  
CONECT    5    4    6                                                       
CONECT    6    5                                                            
CONECT    7    4    8    9                                                  
CONECT    8    7                                                            
CONECT    9    7   10                                                       
CONECT   10    9   11   25                                                  
CONECT   11   10   12                                                       
CONECT   12   11   13                                                       
CONECT   13   12   14   15                                                  
CONECT   14   13                                                            
CONECT   15   13   16                                                       
CONECT   16   15   17                                                       
CONECT   17   16   18   25                                                  
CONECT   18   17   19                                                       
CONECT   19   18   20                                                       
CONECT   20   19   21   22                                                  
CONECT   21   20                                                            
CONECT   22   20    2   23   24                                             
CONECT   23   22                                                            
CONECT   24   22                                                            
CONECT   25   17   10   26                                                  
CONECT   26   25                                                            
MASTER        0    0    0    0    0    0    0    0   26    0   54    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₁₉H₂₅NO₆

Average Mass

363.4100 Da

Monoisotopic Mass

363.16819 Da

IUPAC Name

(1R,4Z,7R)-4-ethylidene-7-hydroxy-7,14-dimethyl-6-methylidene-2,9-dioxa-14-azabicyclo[9.5.1]heptadec-11-ene-3,8,17-trione

Traditional Name

(1R,4Z,7R)-4-ethylidene-7-hydroxy-7,14-dimethyl-6-methylidene-2,9-dioxa-14-azabicyclo[9.5.1]heptadec-11-ene-3,8,17-trione

CAS Registry Number

Not Available

SMILES

C\C=C1\CC(=C)[C@@](C)(O)C(=O)OCC2=CCN(C)CC[C@@H](OC1=O)C2=O

InChI Identifier

InChI=1S/C19H25NO6/c1-5-13-10-12(2)19(3,24)18(23)25-11-14-6-8-20(4)9-7-15(16(14)21)26-17(13)22/h5-6,15,24H,2,7-11H2,1,3-4H3/b13-5-,14-6?/t15-,19-/m1/s1

InChI Key

GRQOJAAONJAOJH-HFTZCKCTSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Jacobaea carniolica	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as alpha-acyloxy ketones. These are ketones that have an acyloxy substituent alpha to the carbonyl group. They have the general structure R4C(=O)OC(R2)(R3)C(R1)=O (R1=organyl, R4=H or organyl; R2,R3 = any atom).

Kingdom

Organic compounds

Super Class

Organic oxygen compounds

Class

Organooxygen compounds

Sub Class

Carbonyl compounds

Direct Parent

Alpha-acyloxy ketones

Alternative Parents

Substituents

Alpha-acyloxy ketone
Dicarboxylic acid or derivatives
Alpha,beta-unsaturated carboxylic ester
Enoate ester
Tertiary alcohol
Tertiary aliphatic amine
Tertiary amine
Lactone
Ketone
Carboxylic acid ester
Amino acid or derivatives
Oxacycle
Azacycle
Organoheterocyclic compound
Carboxylic acid derivative
Organic nitrogen compound
Organopnictogen compound
Organic oxide
Hydrocarbon derivative
Organonitrogen compound
Amine
Alcohol
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	1.62	ChemAxon
pKa (Strongest Acidic)	12.04	ChemAxon
pKa (Strongest Basic)	6.96	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	93.14 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	96.68 m³·mol⁻¹	ChemAxon
Polarizability	37.54 Å³	ChemAxon
Number of Rings	2	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

163078082

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for (1r,4z,7r)-4-ethylidene-7-hydroxy-7,14-dimethyl-6-methylidene-2,9-dioxa-14-azabicyclo[9.5.1]heptadec-11-ene-3,8,17-trione (NP0199395)

MOL for NP0199395 ((1r,4z,7r)-4-ethylidene-7-hydroxy-7,14-dimethyl-6-methylidene-2,9-dioxa-14-azabicyclo[9.5.1]heptadec-11-ene-3,8,17-trione)

3D MOL for NP0199395 ((1r,4z,7r)-4-ethylidene-7-hydroxy-7,14-dimethyl-6-methylidene-2,9-dioxa-14-azabicyclo[9.5.1]heptadec-11-ene-3,8,17-trione)

3D SDF for NP0199395 ((1r,4z,7r)-4-ethylidene-7-hydroxy-7,14-dimethyl-6-methylidene-2,9-dioxa-14-azabicyclo[9.5.1]heptadec-11-ene-3,8,17-trione)

3D-SDF for NP0199395 ((1r,4z,7r)-4-ethylidene-7-hydroxy-7,14-dimethyl-6-methylidene-2,9-dioxa-14-azabicyclo[9.5.1]heptadec-11-ene-3,8,17-trione)

PDB for NP0199395 ((1r,4z,7r)-4-ethylidene-7-hydroxy-7,14-dimethyl-6-methylidene-2,9-dioxa-14-azabicyclo[9.5.1]heptadec-11-ene-3,8,17-trione)

3D PDB for NP0199395 ((1r,4z,7r)-4-ethylidene-7-hydroxy-7,14-dimethyl-6-methylidene-2,9-dioxa-14-azabicyclo[9.5.1]heptadec-11-ene-3,8,17-trione)

SMILES for NP0199395 ((1r,4z,7r)-4-ethylidene-7-hydroxy-7,14-dimethyl-6-methylidene-2,9-dioxa-14-azabicyclo[9.5.1]heptadec-11-ene-3,8,17-trione)

INCHI for NP0199395 ((1r,4z,7r)-4-ethylidene-7-hydroxy-7,14-dimethyl-6-methylidene-2,9-dioxa-14-azabicyclo[9.5.1]heptadec-11-ene-3,8,17-trione)

Structure for NP0199395 ((1r,4z,7r)-4-ethylidene-7-hydroxy-7,14-dimethyl-6-methylidene-2,9-dioxa-14-azabicyclo[9.5.1]heptadec-11-ene-3,8,17-trione)

3D Structure for NP0199395 ((1r,4z,7r)-4-ethylidene-7-hydroxy-7,14-dimethyl-6-methylidene-2,9-dioxa-14-azabicyclo[9.5.1]heptadec-11-ene-3,8,17-trione)