NP-MRD: Showing NP-Card for (1r,2r,5r,6s,7s,8s,9s,10r)-8-hydroxy-10-[(4-hydroxydec-2-en-1-yl)oxy]-1,2,5,7,9-pentamethyl-3,11,12-trioxatricyclo[5.3.1.1²,⁶]dodecan-4-one (NP0196189)

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Record Information

Version

2.0

Created at

2022-09-04 14:13:25 UTC

Updated at

2022-09-04 14:13:26 UTC

NP-MRD ID

NP0196189

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(1r,2r,5r,6s,7s,8s,9s,10r)-8-hydroxy-10-[(4-hydroxydec-2-en-1-yl)oxy]-1,2,5,7,9-pentamethyl-3,11,12-trioxatricyclo[5.3.1.1²,⁶]dodecan-4-one

Description

5-Hydroxy-7-(4-hydroxydec-2(3)- enoyl) botrylactone belongs to the class of organic compounds known as fatty alcohols. These are aliphatic alcohols consisting of a chain of a least six carbon atoms. (1r,2r,5r,6s,7s,8s,9s,10r)-8-hydroxy-10-[(4-hydroxydec-2-en-1-yl)oxy]-1,2,5,7,9-pentamethyl-3,11,12-trioxatricyclo[5.3.1.1²,⁶]dodecan-4-one is found in Botrytis cinerea. Based on a literature review very few articles have been published on 5-hydroxy-7-(4-hydroxydec-2(3)- enoyl) botrylactone.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309042216132D          

 31 33  0  0  1  0            999 V2000
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M  END

     RDKit          3D

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M  END


  Mrv1652309042216132D          

 31 33  0  0  1  0            999 V2000
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M  END
> <DATABASE_ID>
NP0196189

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CCCCCCC(O)C=CCO[C@@H]1[C@@H](C)[C@H](O)[C@]2(C)O[C@@]1(C)[C@]1(C)O[C@H]2[C@@H](C)C(=O)O1

> <INCHI_IDENTIFIER>
InChI=1S/C24H40O7/c1-7-8-9-10-12-17(25)13-11-14-28-20-15(2)18(26)22(4)19-16(3)21(27)30-24(6,29-19)23(20,5)31-22/h11,13,15-20,25-26H,7-10,12,14H2,1-6H3/t15-,16+,17?,18-,19-,20+,22-,23+,24+/m0/s1

> <INCHI_KEY>
IWOGBRLVZBYBFT-TYOYNPPUSA-N

> <FORMULA>
C24H40O7

> <MOLECULAR_WEIGHT>
440.577

> <EXACT_MASS>
440.277403628

> <JCHEM_ACCEPTOR_COUNT>
6

> <JCHEM_ATOM_COUNT>
71

> <JCHEM_AVERAGE_POLARIZABILITY>
49.778164851890736

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(1R,2R,5R,6S,7S,8S,9S,10R)-8-hydroxy-10-[(4-hydroxydec-2-en-1-yl)oxy]-1,2,5,7,9-pentamethyl-3,11,12-trioxatricyclo[5.3.1.1^{2,6}]dodecan-4-one

> <JCHEM_LOGP>
3.7574964773333326

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
14.915089759597048

> <JCHEM_PKA_STRONGEST_ACIDIC>
13.609786806615414

> <JCHEM_PKA_STRONGEST_BASIC>
-2.8461317591652984

> <JCHEM_POLAR_SURFACE_AREA>
94.45000000000002

> <JCHEM_REFRACTIVITY>
116.23869999999997

> <JCHEM_ROTATABLE_BOND_COUNT>
9

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
(1R,2R,5R,6S,7S,8S,9S,10R)-8-hydroxy-10-[(4-hydroxydec-2-en-1-yl)oxy]-1,2,5,7,9-pentamethyl-3,11,12-trioxatricyclo[5.3.1.1^{2,6}]dodecan-4-one

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 04-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   04-SEP-22         0                                  
HETATM    1  C   UNK     0     -14.793  -1.015   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0     -13.460  -0.245   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0     -12.126  -1.015   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0     -10.792  -0.245   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      -9.459  -1.015   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      -8.125  -0.245   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      -6.791  -1.015   0.000  0.00  0.00           C+0
HETATM    8  O   UNK     0      -6.791  -2.555   0.000  0.00  0.00           O+0
HETATM    9  C   UNK     0      -5.458  -0.245   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      -4.124  -1.015   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0      -2.790  -0.245   0.000  0.00  0.00           C+0
HETATM   12  O   UNK     0      -2.790   1.295   0.000  0.00  0.00           O+0
HETATM   13  C   UNK     0      -1.457   2.065   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      -0.110   1.182   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      -0.097  -0.358   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       1.182   2.062   0.000  0.00  0.00           C+0
HETATM   17  O   UNK     0       2.538   1.332   0.000  0.00  0.00           O+0
HETATM   18  C   UNK     0       1.205   3.666   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       2.733   3.479   0.000  0.00  0.00           C+0
HETATM   20  O   UNK     0      -0.317   3.711   0.000  0.00  0.00           O+0
HETATM   21  C   UNK     0      -1.555   3.798   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0      -3.091   3.913   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0      -1.195   5.517   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0      -2.713   5.775   0.000  0.00  0.00           C+0
HETATM   25  O   UNK     0      -0.979   7.176   0.000  0.00  0.00           O+0
HETATM   26  C   UNK     0       0.426   7.972   0.000  0.00  0.00           C+0
HETATM   27  O   UNK     0       0.531   9.508   0.000  0.00  0.00           O+0
HETATM   28  C   UNK     0       1.721   6.981   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0       3.127   7.609   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0       1.591   5.316   0.000  0.00  0.00           C+0
HETATM   31  O   UNK     0       0.289   5.486   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4                                                       
CONECT    4    3    5                                                       
CONECT    5    4    6                                                       
CONECT    6    5    7                                                       
CONECT    7    6    8    9                                                  
CONECT    8    7                                                            
CONECT    9    7   10                                                       
CONECT   10    9   11                                                       
CONECT   11   10   12                                                       
CONECT   12   11   13                                                       
CONECT   13   12   14   21                                                  
CONECT   14   13   15   16                                                  
CONECT   15   14                                                            
CONECT   16   14   17   18                                                  
CONECT   17   16                                                            
CONECT   18   16   19   20   30                                             
CONECT   19   18                                                            
CONECT   20   18   21                                                       
CONECT   21   20   13   22   23                                             
CONECT   22   21                                                            
CONECT   23   21   24   25   31                                             
CONECT   24   23                                                            
CONECT   25   23   26                                                       
CONECT   26   25   27   28                                                  
CONECT   27   26                                                            
CONECT   28   26   29   30                                                  
CONECT   29   28                                                            
CONECT   30   28   18   31                                                  
CONECT   31   30   23                                                       
MASTER        0    0    0    0    0    0    0    0   31    0   66    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₄H₄₀O₇

Average Mass

440.5770 Da

Monoisotopic Mass

440.27740 Da

IUPAC Name

(1R,2R,5R,6S,7S,8S,9S,10R)-8-hydroxy-10-[(4-hydroxydec-2-en-1-yl)oxy]-1,2,5,7,9-pentamethyl-3,11,12-trioxatricyclo[5.3.1.1^{2,6}]dodecan-4-one

Traditional Name

(1R,2R,5R,6S,7S,8S,9S,10R)-8-hydroxy-10-[(4-hydroxydec-2-en-1-yl)oxy]-1,2,5,7,9-pentamethyl-3,11,12-trioxatricyclo[5.3.1.1^{2,6}]dodecan-4-one

CAS Registry Number

Not Available

SMILES

CCCCCCC(O)C=CCO[C@@H]1[C@@H](C)[C@H](O)[C@]2(C)O[C@@]1(C)[C@]1(C)O[C@H]2[C@@H](C)C(=O)O1

InChI Identifier

InChI=1S/C24H40O7/c1-7-8-9-10-12-17(25)13-11-14-28-20-15(2)18(26)22(4)19-16(3)21(27)30-24(6,29-19)23(20,5)31-22/h11,13,15-20,25-26H,7-10,12,14H2,1-6H3/t15-,16+,17?,18-,19-,20+,22-,23+,24+/m0/s1

InChI Key

IWOGBRLVZBYBFT-TYOYNPPUSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Botrytis cinerea	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as fatty alcohols. These are aliphatic alcohols consisting of a chain of a least six carbon atoms.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Fatty Acyls

Sub Class

Fatty alcohols

Direct Parent

Fatty alcohols

Alternative Parents

Substituents

Fatty alcohol
Ketal
Oxane
Para-dioxane
Meta-dioxane
Secondary alcohol
Lactone
Carboxylic acid ester
Oxacycle
Organoheterocyclic compound
Monocarboxylic acid or derivatives
Ether
Dialkyl ether
Carboxylic acid derivative
Acetal
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Organooxygen compound
Carbonyl group
Alcohol
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	3.76	ChemAxon
pKa (Strongest Acidic)	13.61	ChemAxon
pKa (Strongest Basic)	-2.8	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	6	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	94.45 Å²	ChemAxon
Rotatable Bond Count	9	ChemAxon
Refractivity	116.24 m³·mol⁻¹	ChemAxon
Polarizability	49.78 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

139583877

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for (1r,2r,5r,6s,7s,8s,9s,10r)-8-hydroxy-10-[(4-hydroxydec-2-en-1-yl)oxy]-1,2,5,7,9-pentamethyl-3,11,12-trioxatricyclo[5.3.1.1²,⁶]dodecan-4-one (NP0196189)

MOL for NP0196189 ((1r,2r,5r,6s,7s,8s,9s,10r)-8-hydroxy-10-[(4-hydroxydec-2-en-1-yl)oxy]-1,2,5,7,9-pentamethyl-3,11,12-trioxatricyclo[5.3.1.1²,⁶]dodecan-4-one)

3D MOL for NP0196189 ((1r,2r,5r,6s,7s,8s,9s,10r)-8-hydroxy-10-[(4-hydroxydec-2-en-1-yl)oxy]-1,2,5,7,9-pentamethyl-3,11,12-trioxatricyclo[5.3.1.1²,⁶]dodecan-4-one)

3D SDF for NP0196189 ((1r,2r,5r,6s,7s,8s,9s,10r)-8-hydroxy-10-[(4-hydroxydec-2-en-1-yl)oxy]-1,2,5,7,9-pentamethyl-3,11,12-trioxatricyclo[5.3.1.1²,⁶]dodecan-4-one)

3D-SDF for NP0196189 ((1r,2r,5r,6s,7s,8s,9s,10r)-8-hydroxy-10-[(4-hydroxydec-2-en-1-yl)oxy]-1,2,5,7,9-pentamethyl-3,11,12-trioxatricyclo[5.3.1.1²,⁶]dodecan-4-one)

PDB for NP0196189 ((1r,2r,5r,6s,7s,8s,9s,10r)-8-hydroxy-10-[(4-hydroxydec-2-en-1-yl)oxy]-1,2,5,7,9-pentamethyl-3,11,12-trioxatricyclo[5.3.1.1²,⁶]dodecan-4-one)

3D PDB for NP0196189 ((1r,2r,5r,6s,7s,8s,9s,10r)-8-hydroxy-10-[(4-hydroxydec-2-en-1-yl)oxy]-1,2,5,7,9-pentamethyl-3,11,12-trioxatricyclo[5.3.1.1²,⁶]dodecan-4-one)

SMILES for NP0196189 ((1r,2r,5r,6s,7s,8s,9s,10r)-8-hydroxy-10-[(4-hydroxydec-2-en-1-yl)oxy]-1,2,5,7,9-pentamethyl-3,11,12-trioxatricyclo[5.3.1.1²,⁶]dodecan-4-one)

INCHI for NP0196189 ((1r,2r,5r,6s,7s,8s,9s,10r)-8-hydroxy-10-[(4-hydroxydec-2-en-1-yl)oxy]-1,2,5,7,9-pentamethyl-3,11,12-trioxatricyclo[5.3.1.1²,⁶]dodecan-4-one)

Structure for NP0196189 ((1r,2r,5r,6s,7s,8s,9s,10r)-8-hydroxy-10-[(4-hydroxydec-2-en-1-yl)oxy]-1,2,5,7,9-pentamethyl-3,11,12-trioxatricyclo[5.3.1.1²,⁶]dodecan-4-one)

3D Structure for NP0196189 ((1r,2r,5r,6s,7s,8s,9s,10r)-8-hydroxy-10-[(4-hydroxydec-2-en-1-yl)oxy]-1,2,5,7,9-pentamethyl-3,11,12-trioxatricyclo[5.3.1.1²,⁶]dodecan-4-one)