NP-MRD: Showing NP-Card for methyl (15e)-15-ethylidene-18-hydroxy-3-methyl-19-oxa-3,13-diazahexacyclo[14.3.1.0²,¹⁰.0²,¹³.0⁴,⁹.0¹⁰,¹⁷]icosa-4,6,8-triene-17-carboxylate (NP0196083)

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Record Information

Version

2.0

Created at

2022-09-04 14:05:19 UTC

Updated at

2022-09-04 14:05:19 UTC

NP-MRD ID

NP0196083

Secondary Accession Numbers

None

Natural Product Identification

Common Name

methyl (15e)-15-ethylidene-18-hydroxy-3-methyl-19-oxa-3,13-diazahexacyclo[14.3.1.0²,¹⁰.0²,¹³.0⁴,⁹.0¹⁰,¹⁷]icosa-4,6,8-triene-17-carboxylate

Description

Corymine belongs to the class of organic compounds known as carbazoles. Carbazoles are compounds containing a three ring system containing a pyrrole ring fused on either side to a benzene ring. methyl (15e)-15-ethylidene-18-hydroxy-3-methyl-19-oxa-3,13-diazahexacyclo[14.3.1.0²,¹⁰.0²,¹³.0⁴,⁹.0¹⁰,¹⁷]icosa-4,6,8-triene-17-carboxylate is found in Hunteria zeylanica. methyl (15e)-15-ethylidene-18-hydroxy-3-methyl-19-oxa-3,13-diazahexacyclo[14.3.1.0²,¹⁰.0²,¹³.0⁴,⁹.0¹⁰,¹⁷]icosa-4,6,8-triene-17-carboxylate was first documented in 2003 (PMID: 12871110). Based on a literature review a small amount of articles have been published on Corymine (PMID: 31992040) (PMID: 28466505) (PMID: 23792896) (PMID: 15888962).

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309042216052D          

 28 33  0  0  0  0            999 V2000
    0.4117    1.2932    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6165    0.4940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4111    0.2719    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6576   -0.7120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5381   -1.0492    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4138   -0.1859    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9307    0.3668    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5361    0.0815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3849   -0.0134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9808    0.5572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7728    0.3265    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9691   -0.4748    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3732   -1.0454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5811   -0.8147    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8720   -1.2505    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8070   -2.0729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2252   -0.6958    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3126   -0.6663    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9189    0.1979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0913    0.9448    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9978    0.8606    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8122    0.9923    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3335    0.3528    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1054    1.7634    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9199    1.8951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2796    0.5458    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7616    1.1879    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7363   -0.2055    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
  9 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
  5 17  1  0  0  0  0
  8 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
  3 20  1  0  0  0  0
 20 21  1  0  0  0  0
  8 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 21 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
 18 28  1  0  0  0  0
M  END

     RDKit          3D

 54 59  0  0  0  0  0  0  0  0999 V2000
    4.0871   -0.2858   -0.7751 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0727   -1.2892   -1.1956 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9350   -1.4073   -0.5380 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0474   -2.4698   -1.0713 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3309   -2.2501   -0.8373 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8142   -1.5776   -2.0727 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2778   -0.1551   -1.8551 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5215    0.0711   -0.3921 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.7637    0.8158   -0.1577 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1151    2.1270   -0.2152 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3952    2.5304    0.0582 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3641    1.6297    0.3978 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0568    0.2909    0.4682 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7455   -0.0933    0.1847 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2229   -1.3974    0.1718 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9662   -2.6417    0.2000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7570   -1.3400    0.1238 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.3109   -1.4151    1.5298 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.1740   -1.4090    1.7263 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7262   -0.5193    0.6010 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.6497    0.5601    0.3809 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.2755    1.7965   -0.1174 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0966    2.3044   -1.2459 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1600    2.4876    0.7256 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7904    3.6834    0.2863 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1441    0.8128    1.7943 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.4160    2.0555    1.8743 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7575   -0.2188    2.1612 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8063    0.7473   -0.9884 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.0090   -0.4653   -1.4108 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.4632   -0.4601    0.2563 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2840   -1.9421   -2.0750 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.4364   -3.4234   -0.6456 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.2457   -2.5754   -2.1678 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8984   -1.6035   -2.1456 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020   -1.9925   -2.9627 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0071    0.4970   -2.4149 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.7248    0.0031   -2.2151 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3517    2.8817   -0.4995 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5997    3.6110   -0.0099 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3823    1.9780    0.6127 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8163   -0.4189    0.7346 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4612   -2.7921   -0.7659 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3132   -3.5037    0.4151 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7129   -2.6100    1.0338 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7968   -2.2650    2.0837 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.4954   -1.1027    2.7147 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.5886   -2.4360    1.5676 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.6307   -0.0144    0.9790 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.3232    3.9821   -0.6876 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.8612    3.4267    0.1289 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.6357    4.4456    1.0593 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.0395    0.8011    2.4832 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2456    2.5357    2.7091 H   0  0  0  0  0  0  0  0  0  0  0  0
 25 24  1  0
 24 22  1  0
 22 23  2  0
 21 22  1  6
 21 26  1  0
 26 27  1  0
 26 28  1  0
 28 18  1  0
 18 19  1  0
 19 20  1  0
 20  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  8  7  1  6
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  1  0
 17 15  1  1
  3  2  2  0
  2  1  1  0
 20 21  1  0
 17  5  1  0
  8 21  1  0
 17  8  1  0
 17 18  1  0
 14  9  1  0
 25 50  1  0
 25 51  1  0
 25 52  1  0
 26 53  1  1
 27 54  1  0
 18 46  1  1
 19 47  1  0
 19 48  1  0
 20 49  1  1
  4 33  1  0
  4 34  1  0
  6 35  1  0
  6 36  1  0
  7 37  1  0
  7 38  1  0
 10 39  1  0
 11 40  1  0
 12 41  1  0
 13 42  1  0
 16 43  1  0
 16 44  1  0
 16 45  1  0
  2 32  1  0
  1 29  1  0
  1 30  1  0
  1 31  1  0
M  END


  Mrv1652309042216052D          

 28 33  0  0  0  0            999 V2000
    0.4117    1.2932    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6165    0.4940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4111    0.2719    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6576   -0.7120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5381   -1.0492    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4138   -0.1859    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9307    0.3668    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5361    0.0815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3849   -0.0134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9808    0.5572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7728    0.3265    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9691   -0.4748    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3732   -1.0454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5811   -0.8147    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8720   -1.2505    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8070   -2.0729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2252   -0.6958    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3126   -0.6663    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9189    0.1979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0913    0.9448    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9978    0.8606    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8122    0.9923    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3335    0.3528    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1054    1.7634    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9199    1.8951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2796    0.5458    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7616    1.1879    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7363   -0.2055    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
  9 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
  5 17  1  0  0  0  0
  8 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
  3 20  1  0  0  0  0
 20 21  1  0  0  0  0
  8 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 21 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
 18 28  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0196083

> <DATABASE_NAME>
NP-MRD

> <SMILES>
COC(=O)C12C(O)OC3CC1\C(CN1CCC22C4=CC=CC=C4N(C)C312)=C/C

> <INCHI_IDENTIFIER>
InChI=1S/C22H26N2O4/c1-4-13-12-24-10-9-20-14-7-5-6-8-16(14)23(2)22(20,24)17-11-15(13)21(20,18(25)27-3)19(26)28-17/h4-8,15,17,19,26H,9-12H2,1-3H3/b13-4-

> <INCHI_KEY>
KRTMWLRPHKYUJX-PQMHYQBVSA-N

> <FORMULA>
C22H26N2O4

> <MOLECULAR_WEIGHT>
382.46

> <EXACT_MASS>
382.189257325

> <JCHEM_ACCEPTOR_COUNT>
5

> <JCHEM_ATOM_COUNT>
54

> <JCHEM_AVERAGE_POLARIZABILITY>
40.037551768052396

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
methyl (15E)-15-ethylidene-18-hydroxy-3-methyl-19-oxa-3,13-diazahexacyclo[14.3.1.0^{2,10}.0^{2,13}.0^{4,9}.0^{10,17}]icosa-4,6,8-triene-17-carboxylate

> <JCHEM_LOGP>
2.4914813406666663

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
6

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_ACIDIC>
11.65423855151527

> <JCHEM_PKA_STRONGEST_BASIC>
6.321062934202363

> <JCHEM_POLAR_SURFACE_AREA>
62.24000000000001

> <JCHEM_REFRACTIVITY>
104.6986

> <JCHEM_ROTATABLE_BOND_COUNT>
2

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
methyl (15E)-15-ethylidene-18-hydroxy-3-methyl-19-oxa-3,13-diazahexacyclo[14.3.1.0^{2,10}.0^{2,13}.0^{4,9}.0^{10,17}]icosa-4,6,8-triene-17-carboxylate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 04-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   04-SEP-22         0                                  
HETATM    1  C   UNK     0       0.768   2.414   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       1.151   0.922   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       2.634   0.507   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       3.094  -1.329   0.000  0.00  0.00           C+0
HETATM    5  N   UNK     0       4.738  -1.958   0.000  0.00  0.00           N+0
HETATM    6  C   UNK     0       4.506  -0.347   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       5.471   0.685   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       6.601   0.152   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       8.185  -0.025   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       9.297   1.040   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0      10.776   0.609   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      11.142  -0.886   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      10.030  -1.951   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       8.551  -1.521   0.000  0.00  0.00           C+0
HETATM   15  N   UNK     0       7.228  -2.334   0.000  0.00  0.00           N+0
HETATM   16  C   UNK     0       7.106  -3.869   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       6.020  -1.299   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       4.317  -1.244   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       3.582   0.369   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       3.904   1.764   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       5.596   1.607   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       7.116   1.852   0.000  0.00  0.00           C+0
HETATM   23  O   UNK     0       8.089   0.659   0.000  0.00  0.00           O+0
HETATM   24  O   UNK     0       7.663   3.292   0.000  0.00  0.00           O+0
HETATM   25  C   UNK     0       9.184   3.538   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0       4.255   1.019   0.000  0.00  0.00           C+0
HETATM   27  O   UNK     0       3.288   2.217   0.000  0.00  0.00           O+0
HETATM   28  O   UNK     0       3.241  -0.384   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4   20                                                  
CONECT    4    3    5                                                       
CONECT    5    4    6   17                                                  
CONECT    6    5    7                                                       
CONECT    7    6    8                                                       
CONECT    8    7    9   17   21                                             
CONECT    9    8   10   14                                                  
CONECT   10    9   11                                                       
CONECT   11   10   12                                                       
CONECT   12   11   13                                                       
CONECT   13   12   14                                                       
CONECT   14   13    9   15                                                  
CONECT   15   14   16   17                                                  
CONECT   16   15                                                            
CONECT   17   15    5    8   18                                             
CONECT   18   17   19   28                                                  
CONECT   19   18   20                                                       
CONECT   20   19    3   21                                                  
CONECT   21   20    8   22   26                                             
CONECT   22   21   23   24                                                  
CONECT   23   22                                                            
CONECT   24   22   25                                                       
CONECT   25   24                                                            
CONECT   26   21   27   28                                                  
CONECT   27   26                                                            
CONECT   28   26   18                                                       
MASTER        0    0    0    0    0    0    0    0   28    0   66    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₂H₂₆N₂O₄

Average Mass

382.4600 Da

Monoisotopic Mass

382.18926 Da

IUPAC Name

methyl (15E)-15-ethylidene-18-hydroxy-3-methyl-19-oxa-3,13-diazahexacyclo[14.3.1.0^{2,10}.0^{2,13}.0^{4,9}.0^{10,17}]icosa-4,6,8-triene-17-carboxylate

Traditional Name

methyl (15E)-15-ethylidene-18-hydroxy-3-methyl-19-oxa-3,13-diazahexacyclo[14.3.1.0^{2,10}.0^{2,13}.0^{4,9}.0^{10,17}]icosa-4,6,8-triene-17-carboxylate

CAS Registry Number

Not Available

SMILES

COC(=O)C12C(O)OC3CC1\C(CN1CCC22C4=CC=CC=C4N(C)C312)=C/C

InChI Identifier

InChI=1S/C22H26N2O4/c1-4-13-12-24-10-9-20-14-7-5-6-8-16(14)23(2)22(20,24)17-11-15(13)21(20,18(25)27-3)19(26)28-17/h4-8,15,17,19,26H,9-12H2,1-3H3/b13-4-

InChI Key

KRTMWLRPHKYUJX-PQMHYQBVSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Hunteria zeylanica	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as carbazoles. Carbazoles are compounds containing a three ring system containing a pyrrole ring fused on either side to a benzene ring.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Indoles and derivatives

Sub Class

Carbazoles

Direct Parent

Carbazoles

Alternative Parents

Substituents

Carbazole
Pyrroloindole
Indole
Dialkylarylamine
Azepane
Beta-hydroxy acid
Hydroxy acid
Oxane
Benzenoid
N-alkylpyrrolidine
Pyrrole
Methyl ester
Pyrrolidine
Carboxylic acid ester
Hemiacetal
Monocarboxylic acid or derivatives
Carboxylic acid derivative
Oxacycle
Azacycle
Organooxygen compound
Organonitrogen compound
Hydrocarbon derivative
Organic oxide
Organic nitrogen compound
Carbonyl group
Organopnictogen compound
Organic oxygen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	2.49	ChemAxon
pKa (Strongest Acidic)	11.65	ChemAxon
pKa (Strongest Basic)	6.32	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	62.24 Å²	ChemAxon
Rotatable Bond Count	2	ChemAxon
Refractivity	104.7 m³·mol⁻¹	ChemAxon
Polarizability	40.04 Å³	ChemAxon
Number of Rings	6	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

4528148

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

5379626

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Ramirez A, Garcia-Rubio S: Current progress in the chemistry and pharmacology of akuammiline alkaloids. Curr Med Chem. 2003 Sep;10(18):1891-915. doi: 10.2174/0929867033457016. [PubMed:12871110 ]
Zhang B, Wang X, Li C: Enantioselective Total Synthesis of (+)-Corymine and (-)-Deformylcorymine. J Am Chem Soc. 2020 Feb 12;142(6):3269-3274. doi: 10.1021/jacs.0c00302. Epub 2020 Jan 31. [PubMed:31992040 ]
Zhang B, Wang X, Cheng C, Sun D, Li C: Total Synthesis of (+/-)-Corymine. Angew Chem Int Ed Engl. 2017 Jun 19;56(26):7484-7487. doi: 10.1002/anie.201704086. Epub 2017 May 23. [PubMed:28466505 ]
Wang W, Cheng MH, Wang XH: Monoterpenoid indole alkaloids from Alstonia rupestris with cytotoxic, anti-inflammatory and antifungal activities. Molecules. 2013 Jun 21;18(6):7309-22. doi: 10.3390/molecules18067309. [PubMed:23792896 ]
Leewanich P, Tohda M, Takayama H, Sophasan S, Watanabe H, Matsumoto K: Corymine potentiates NMDA-induced currents in Xenopus oocytes expressing NR1a/NR2B glutamate receptors. J Pharmacol Sci. 2005 May;98(1):58-65. doi: 10.1254/jphs.fp0050023. Epub 2005 May 12. [PubMed:15888962 ]
LOTUS database [Link]

Showing NP-Card for methyl (15e)-15-ethylidene-18-hydroxy-3-methyl-19-oxa-3,13-diazahexacyclo[14.3.1.0²,¹⁰.0²,¹³.0⁴,⁹.0¹⁰,¹⁷]icosa-4,6,8-triene-17-carboxylate (NP0196083)

MOL for NP0196083 (methyl (15e)-15-ethylidene-18-hydroxy-3-methyl-19-oxa-3,13-diazahexacyclo[14.3.1.0²,¹⁰.0²,¹³.0⁴,⁹.0¹⁰,¹⁷]icosa-4,6,8-triene-17-carboxylate)

3D MOL for NP0196083 (methyl (15e)-15-ethylidene-18-hydroxy-3-methyl-19-oxa-3,13-diazahexacyclo[14.3.1.0²,¹⁰.0²,¹³.0⁴,⁹.0¹⁰,¹⁷]icosa-4,6,8-triene-17-carboxylate)

3D SDF for NP0196083 (methyl (15e)-15-ethylidene-18-hydroxy-3-methyl-19-oxa-3,13-diazahexacyclo[14.3.1.0²,¹⁰.0²,¹³.0⁴,⁹.0¹⁰,¹⁷]icosa-4,6,8-triene-17-carboxylate)

3D-SDF for NP0196083 (methyl (15e)-15-ethylidene-18-hydroxy-3-methyl-19-oxa-3,13-diazahexacyclo[14.3.1.0²,¹⁰.0²,¹³.0⁴,⁹.0¹⁰,¹⁷]icosa-4,6,8-triene-17-carboxylate)

PDB for NP0196083 (methyl (15e)-15-ethylidene-18-hydroxy-3-methyl-19-oxa-3,13-diazahexacyclo[14.3.1.0²,¹⁰.0²,¹³.0⁴,⁹.0¹⁰,¹⁷]icosa-4,6,8-triene-17-carboxylate)

3D PDB for NP0196083 (methyl (15e)-15-ethylidene-18-hydroxy-3-methyl-19-oxa-3,13-diazahexacyclo[14.3.1.0²,¹⁰.0²,¹³.0⁴,⁹.0¹⁰,¹⁷]icosa-4,6,8-triene-17-carboxylate)

SMILES for NP0196083 (methyl (15e)-15-ethylidene-18-hydroxy-3-methyl-19-oxa-3,13-diazahexacyclo[14.3.1.0²,¹⁰.0²,¹³.0⁴,⁹.0¹⁰,¹⁷]icosa-4,6,8-triene-17-carboxylate)

INCHI for NP0196083 (methyl (15e)-15-ethylidene-18-hydroxy-3-methyl-19-oxa-3,13-diazahexacyclo[14.3.1.0²,¹⁰.0²,¹³.0⁴,⁹.0¹⁰,¹⁷]icosa-4,6,8-triene-17-carboxylate)

Structure for NP0196083 (methyl (15e)-15-ethylidene-18-hydroxy-3-methyl-19-oxa-3,13-diazahexacyclo[14.3.1.0²,¹⁰.0²,¹³.0⁴,⁹.0¹⁰,¹⁷]icosa-4,6,8-triene-17-carboxylate)

3D Structure for NP0196083 (methyl (15e)-15-ethylidene-18-hydroxy-3-methyl-19-oxa-3,13-diazahexacyclo[14.3.1.0²,¹⁰.0²,¹³.0⁴,⁹.0¹⁰,¹⁷]icosa-4,6,8-triene-17-carboxylate)