NP-MRD: Showing NP-Card for 1-(acetyloxy)-13-hydroxy-3,6,6,10,14-pentamethyl-2-oxotricyclo[10.3.0.0⁵,⁷]pentadeca-3,10-dien-9-yl octa-2,4-dienoate (NP0195645)

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Record Information

Version

2.0

Created at

2022-09-04 13:32:55 UTC

Updated at

2022-09-04 13:32:55 UTC

NP-MRD ID

NP0195645

Secondary Accession Numbers

None

Natural Product Identification

Common Name

1-(acetyloxy)-13-hydroxy-3,6,6,10,14-pentamethyl-2-oxotricyclo[10.3.0.0⁵,⁷]pentadeca-3,10-dien-9-yl octa-2,4-dienoate

Description

Euphohelioscopin A belongs to the class of organic compounds known as diterpenoids. These are terpene compounds formed by four isoprene units. 1-(acetyloxy)-13-hydroxy-3,6,6,10,14-pentamethyl-2-oxotricyclo[10.3.0.0⁵,⁷]pentadeca-3,10-dien-9-yl octa-2,4-dienoate is found in Euphorbia helioscopia. 1-(acetyloxy)-13-hydroxy-3,6,6,10,14-pentamethyl-2-oxotricyclo[10.3.0.0⁵,⁷]pentadeca-3,10-dien-9-yl octa-2,4-dienoate was first documented in 2008 (PMID: 18452010). Based on a literature review a small amount of articles have been published on Euphohelioscopin A (PMID: 24417144) (PMID: 26882659) (PMID: 22921066).

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309042215322D          

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M  END

     RDKit          3D

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M  END


  Mrv1652309042215322D          

 36 38  0  0  0  0            999 V2000
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    1.8871    0.4140    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6037   -2.4086    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6037   -1.4622    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  4  3  1  4  0  0  0
  4  5  2  0  0  0  0
  6  5  1  4  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 15 14  1  4  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  2  0  0  0  0
 20 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  1  0  0  0  0
 20 30  1  0  0  0  0
 31 30  1  4  0  0  0
 31 32  2  0  0  0  0
 11 32  1  0  0  0  0
 32 33  1  0  0  0  0
 14 34  1  0  0  0  0
 13 34  1  0  0  0  0
 34 35  1  0  0  0  0
 34 36  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0195645

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CCCC=CC=CC(=O)OC1CC2C(C=C(C)C(=O)C3(CC(C)C(O)C3C=C1C)OC(C)=O)C2(C)C

> <INCHI_IDENTIFIER>
InChI=1S/C30H42O6/c1-8-9-10-11-12-13-26(32)35-25-16-23-22(29(23,6)7)15-19(3)28(34)30(36-21(5)31)17-20(4)27(33)24(30)14-18(25)2/h10-15,20,22-25,27,33H,8-9,16-17H2,1-7H3

> <INCHI_KEY>
LVWCGFQTAFKQBI-UHFFFAOYSA-N

> <FORMULA>
C30H42O6

> <MOLECULAR_WEIGHT>
498.66

> <EXACT_MASS>
498.298139072

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_ATOM_COUNT>
78

> <JCHEM_AVERAGE_POLARIZABILITY>
56.370564560435255

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
1-(acetyloxy)-13-hydroxy-3,6,6,10,14-pentamethyl-2-oxotricyclo[10.3.0.0^{5,7}]pentadeca-3,10-dien-9-yl octa-2,4-dienoate

> <JCHEM_LOGP>
5.687995427333334

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_ACIDIC>
14.529764089144226

> <JCHEM_PKA_STRONGEST_BASIC>
-3.004481187408315

> <JCHEM_POLAR_SURFACE_AREA>
89.90000000000002

> <JCHEM_REFRACTIVITY>
142.92060000000004

> <JCHEM_ROTATABLE_BOND_COUNT>
8

> <JCHEM_RULE_OF_FIVE>
0

> <JCHEM_TRADITIONAL_IUPAC>
1-(acetyloxy)-13-hydroxy-3,6,6,10,14-pentamethyl-2-oxotricyclo[10.3.0.0^{5,7}]pentadeca-3,10-dien-9-yl octa-2,4-dienoate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 04-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   04-SEP-22         0                                  
HETATM    1  C   UNK     0      16.620   5.112   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      15.715   3.867   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      14.183   4.028   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      13.278   2.782   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      11.747   2.943   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      10.841   1.697   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       9.310   1.858   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       8.405   0.612   0.000  0.00  0.00           C+0
HETATM    9  O   UNK     0       9.031  -0.795   0.000  0.00  0.00           O+0
HETATM   10  O   UNK     0       6.873   0.773   0.000  0.00  0.00           O+0
HETATM   11  C   UNK     0       5.968  -0.473   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       6.444  -1.938   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       7.865  -2.843   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       7.865  -4.383   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       6.531  -5.153   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       5.198  -4.383   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       5.198  -2.843   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       3.864  -5.153   0.000  0.00  0.00           C+0
HETATM   19  O   UNK     0       3.864  -6.693   0.000  0.00  0.00           O+0
HETATM   20  C   UNK     0       2.530  -4.383   0.000  0.00  0.00           C+0
HETATM   21  O   UNK     0       2.369  -5.914   0.000  0.00  0.00           O+0
HETATM   22  C   UNK     0       0.963  -6.541   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       0.802  -8.072   0.000  0.00  0.00           C+0
HETATM   24  O   UNK     0      -0.283  -5.636   0.000  0.00  0.00           O+0
HETATM   25  C   UNK     0       1.066  -4.859   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0       0.161  -3.613   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0      -1.379  -3.613   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0       1.066  -2.367   0.000  0.00  0.00           C+0
HETATM   29  O   UNK     0       0.590  -0.902   0.000  0.00  0.00           O+0
HETATM   30  C   UNK     0       2.530  -2.843   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0       3.952  -1.938   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0       4.428  -0.473   0.000  0.00  0.00           C+0
HETATM   33  C   UNK     0       3.523   0.773   0.000  0.00  0.00           C+0
HETATM   34  C   UNK     0       9.199  -3.613   0.000  0.00  0.00           C+0
HETATM   35  C   UNK     0      10.460  -4.496   0.000  0.00  0.00           C+0
HETATM   36  C   UNK     0      10.460  -2.730   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4                                                       
CONECT    4    3    5                                                       
CONECT    5    4    6                                                       
CONECT    6    5    7                                                       
CONECT    7    6    8                                                       
CONECT    8    7    9   10                                                  
CONECT    9    8                                                            
CONECT   10    8   11                                                       
CONECT   11   10   12   32                                                  
CONECT   12   11   13                                                       
CONECT   13   12   14   34                                                  
CONECT   14   13   15   34                                                  
CONECT   15   14   16                                                       
CONECT   16   15   17   18                                                  
CONECT   17   16                                                            
CONECT   18   16   19   20                                                  
CONECT   19   18                                                            
CONECT   20   18   21   25   30                                             
CONECT   21   20   22                                                       
CONECT   22   21   23   24                                                  
CONECT   23   22                                                            
CONECT   24   22                                                            
CONECT   25   20   26                                                       
CONECT   26   25   27   28                                                  
CONECT   27   26                                                            
CONECT   28   26   29   30                                                  
CONECT   29   28                                                            
CONECT   30   28   20   31                                                  
CONECT   31   30   32                                                       
CONECT   32   31   11   33                                                  
CONECT   33   32                                                            
CONECT   34   14   13   35   36                                             
CONECT   35   34                                                            
CONECT   36   34                                                            
MASTER        0    0    0    0    0    0    0    0   36    0   76    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₃₀H₄₂O₆

Average Mass

498.6600 Da

Monoisotopic Mass

498.29814 Da

IUPAC Name

1-(acetyloxy)-13-hydroxy-3,6,6,10,14-pentamethyl-2-oxotricyclo[10.3.0.0^{5,7}]pentadeca-3,10-dien-9-yl octa-2,4-dienoate

Traditional Name

1-(acetyloxy)-13-hydroxy-3,6,6,10,14-pentamethyl-2-oxotricyclo[10.3.0.0^{5,7}]pentadeca-3,10-dien-9-yl octa-2,4-dienoate

CAS Registry Number

Not Available

SMILES

CCCC=CC=CC(=O)OC1CC2C(C=C(C)C(=O)C3(CC(C)C(O)C3C=C1C)OC(C)=O)C2(C)C

InChI Identifier

InChI=1S/C30H42O6/c1-8-9-10-11-12-13-26(32)35-25-16-23-22(29(23,6)7)15-19(3)28(34)30(36-21(5)31)17-20(4)27(33)24(30)14-18(25)2/h10-15,20,22-25,27,33H,8-9,16-17H2,1-7H3

InChI Key

LVWCGFQTAFKQBI-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Euphorbia helioscopia	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as diterpenoids. These are terpene compounds formed by four isoprene units.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Diterpenoids

Direct Parent

Diterpenoids

Alternative Parents

Substituents

Diterpenoid
Lathyrane diterpenoid
Alpha-acyloxy ketone
Fatty acid ester
Dicarboxylic acid or derivatives
Fatty acyl
Cyclic alcohol
Alpha,beta-unsaturated carboxylic ester
Enoate ester
Ketone
Carboxylic acid ester
Secondary alcohol
Carboxylic acid derivative
Hydrocarbon derivative
Organic oxide
Organic oxygen compound
Alcohol
Organooxygen compound
Carbonyl group
Aliphatic homopolycyclic compound

Molecular Framework

Aliphatic homopolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	5.69	ChemAxon
pKa (Strongest Acidic)	14.53	ChemAxon
pKa (Strongest Basic)	-3	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	89.9 Å²	ChemAxon
Rotatable Bond Count	8	ChemAxon
Refractivity	142.92 m³·mol⁻¹	ChemAxon
Polarizability	56.37 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

C00030230

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

137796515

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Mu SZ, Shang S, Yan C, Yang FM, Hao XJ: [Study on chemical constituents of Euphorbia helioscopia and their antitumor activities]. Zhong Yao Cai. 2013 Jul;36(7):1092-6. [PubMed:24417144 ]
Hua J, Liu YC, Jing SX, Luo SH, Li SH: Macrocyclic Diterpenoids from the Latex of Euphorbia helioscopia. Nat Prod Commun. 2015 Dec;10(12):2037-9. [PubMed:26882659 ]
de Lichtervelde L, Antal CE, Boitano AE, Wang Y, Krastel P, Petersen F, Newton AC, Cooke MP, Schultz PG: Euphohelioscopin A is a PKC activator capable of inducing macrophage differentiation. Chem Biol. 2012 Aug 24;19(8):994-1000. doi: 10.1016/j.chembiol.2012.06.010. [PubMed:22921066 ]
Barile E, Borriello M, Di Pietro A, Doreau A, Fattorusso C, Fattorusso E, Lanzotti V: Discovery of a new series of jatrophane and lathyrane diterpenes as potent and specific P-glycoprotein modulators. Org Biomol Chem. 2008 May 21;6(10):1756-62. doi: 10.1039/b800485d. Epub 2008 Mar 28. [PubMed:18452010 ]
LOTUS database [Link]

Showing NP-Card for 1-(acetyloxy)-13-hydroxy-3,6,6,10,14-pentamethyl-2-oxotricyclo[10.3.0.0⁵,⁷]pentadeca-3,10-dien-9-yl octa-2,4-dienoate (NP0195645)

MOL for NP0195645 (1-(acetyloxy)-13-hydroxy-3,6,6,10,14-pentamethyl-2-oxotricyclo[10.3.0.0⁵,⁷]pentadeca-3,10-dien-9-yl octa-2,4-dienoate)

3D MOL for NP0195645 (1-(acetyloxy)-13-hydroxy-3,6,6,10,14-pentamethyl-2-oxotricyclo[10.3.0.0⁵,⁷]pentadeca-3,10-dien-9-yl octa-2,4-dienoate)

3D SDF for NP0195645 (1-(acetyloxy)-13-hydroxy-3,6,6,10,14-pentamethyl-2-oxotricyclo[10.3.0.0⁵,⁷]pentadeca-3,10-dien-9-yl octa-2,4-dienoate)

3D-SDF for NP0195645 (1-(acetyloxy)-13-hydroxy-3,6,6,10,14-pentamethyl-2-oxotricyclo[10.3.0.0⁵,⁷]pentadeca-3,10-dien-9-yl octa-2,4-dienoate)

PDB for NP0195645 (1-(acetyloxy)-13-hydroxy-3,6,6,10,14-pentamethyl-2-oxotricyclo[10.3.0.0⁵,⁷]pentadeca-3,10-dien-9-yl octa-2,4-dienoate)

3D PDB for NP0195645 (1-(acetyloxy)-13-hydroxy-3,6,6,10,14-pentamethyl-2-oxotricyclo[10.3.0.0⁵,⁷]pentadeca-3,10-dien-9-yl octa-2,4-dienoate)

SMILES for NP0195645 (1-(acetyloxy)-13-hydroxy-3,6,6,10,14-pentamethyl-2-oxotricyclo[10.3.0.0⁵,⁷]pentadeca-3,10-dien-9-yl octa-2,4-dienoate)

INCHI for NP0195645 (1-(acetyloxy)-13-hydroxy-3,6,6,10,14-pentamethyl-2-oxotricyclo[10.3.0.0⁵,⁷]pentadeca-3,10-dien-9-yl octa-2,4-dienoate)

Structure for NP0195645 (1-(acetyloxy)-13-hydroxy-3,6,6,10,14-pentamethyl-2-oxotricyclo[10.3.0.0⁵,⁷]pentadeca-3,10-dien-9-yl octa-2,4-dienoate)

3D Structure for NP0195645 (1-(acetyloxy)-13-hydroxy-3,6,6,10,14-pentamethyl-2-oxotricyclo[10.3.0.0⁵,⁷]pentadeca-3,10-dien-9-yl octa-2,4-dienoate)