NP-MRD: Showing NP-Card for 9-(3-hydroxy-3-methyl-2-oxobutoxy)-2h-[1,3]dioxolo[4,5-g]chromen-6-one (NP0191683)

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Record Information

Version

2.0

Created at

2022-09-04 08:43:15 UTC

Updated at

2022-09-04 08:43:15 UTC

NP-MRD ID

NP0191683

Secondary Accession Numbers

None

Natural Product Identification

Common Name

9-(3-hydroxy-3-methyl-2-oxobutoxy)-2h-[1,3]dioxolo[4,5-g]chromen-6-one

Description

CHEMBL3116091 belongs to the class of organic compounds known as coumarins and derivatives. These are polycyclic aromatic compounds containing a 1-benzopyran moiety with a ketone group at the C2 carbon atom (1-benzopyran-2-one). 9-(3-hydroxy-3-methyl-2-oxobutoxy)-2h-[1,3]dioxolo[4,5-g]chromen-6-one is found in Pterocaulon virgatum. Based on a literature review very few articles have been published on CHEMBL3116091.

Structure

MOL 3D MOL SDF PDB SMILES InChI

     RDKit          3D

 36 38  0  0  0  0  0  0  0  0999 V2000
    4.1633   -1.3834    0.2619 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4946   -0.0827   -0.1487 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3828    1.1103    0.1485 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1854   -0.1790   -1.4883 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2643    0.0791    0.6744 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3011    0.1839    1.8887 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9470    0.1124   -0.0266 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1212    0.2701    0.8799 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4084    0.3207    0.3992 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9466    1.5476    0.0590 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2353    1.5735   -0.4194 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9784    0.4002   -0.5581 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4436   -0.8136   -0.2206 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0917   -1.9493   -0.3286 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5739   -3.1102   -0.0035 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2362   -4.1773   -0.1247 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2834   -3.2017    0.4831 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5712   -2.0480    0.6127 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1600   -0.8516    0.2573 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5308    2.9060   -0.6822 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5982    3.7292   -0.0048 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4734    2.8596    0.0821 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7205   -1.7680   -0.6041 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.3547   -2.1162    0.5161 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.7941   -1.2775    1.1475 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.0607    1.6631    1.0378 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.4491    0.8564    0.1772 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.2538    1.8197   -0.7170 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.3071    0.6469   -2.0001 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.9063    0.9493   -0.7504 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.7954   -0.8214   -0.6027 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9906    0.4089   -0.9325 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8293   -4.1432    0.7594 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5561   -2.0240    0.9844 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9777    3.8495    1.0281 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3739    4.6609   -0.5222 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  2  5  1  0
  5  6  2  0
  5  7  1  0
  7  8  1  0
  8  9  1  0
  9 19  2  0
 19 18  1  0
 18 17  2  0
 17 15  1  0
 15 16  2  0
 15 14  1  0
 14 13  1  0
 13 12  2  0
 12 11  1  0
 11 10  2  0
 10 22  1  0
 22 21  1  0
 21 20  1  0
 10  9  1  0
 13 19  1  0
 20 11  1  0
  1 23  1  0
  1 24  1  0
  1 25  1  0
  3 26  1  0
  3 27  1  0
  3 28  1  0
  4 29  1  0
  7 30  1  0
  7 31  1  0
 18 34  1  0
 17 33  1  0
 12 32  1  0
 21 35  1  0
 21 36  1  0
M  END


  Mrv1652309042210432D          

 22 24  0  0  0  0            999 V2000
    4.2868    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1599    4.4270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9849    2.9980    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6425   -0.2549    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1274    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6425    1.0799    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 18 19  1  0  0  0  0
  9 19  2  0  0  0  0
 13 19  1  0  0  0  0
 11 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 10 22  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0191683

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CC(C)(O)C(=O)COC1=C2C=CC(=O)OC2=CC2=C1OCO2

> <INCHI_IDENTIFIER>
InChI=1S/C15H14O7/c1-15(2,18)11(16)6-19-13-8-3-4-12(17)22-9(8)5-10-14(13)21-7-20-10/h3-5,18H,6-7H2,1-2H3

> <INCHI_KEY>
ILIBQXWLXBNMBF-UHFFFAOYSA-N

> <FORMULA>
C15H14O7

> <MOLECULAR_WEIGHT>
306.27

> <EXACT_MASS>
306.073952791

> <JCHEM_ACCEPTOR_COUNT>
6

> <JCHEM_ATOM_COUNT>
36

> <JCHEM_AVERAGE_POLARIZABILITY>
29.49131361491154

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
9-(3-hydroxy-3-methyl-2-oxobutoxy)-2H,6H-[1,3]dioxolo[4,5-g]chromen-6-one

> <JCHEM_LOGP>
1.240812730666667

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
18.83356098581629

> <JCHEM_PKA_STRONGEST_ACIDIC>
13.472617885085675

> <JCHEM_PKA_STRONGEST_BASIC>
-3.466873627523265

> <JCHEM_POLAR_SURFACE_AREA>
91.29000000000002

> <JCHEM_REFRACTIVITY>
74.32380000000002

> <JCHEM_ROTATABLE_BOND_COUNT>
4

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
9-(3-hydroxy-3-methyl-2-oxobutoxy)-2H-[1,3]dioxolo[4,5-g]chromen-6-one

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 04-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   04-SEP-22         0                                  
HETATM    1  C   UNK     0       8.002   7.700   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       6.668   6.930   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       5.898   8.264   0.000  0.00  0.00           C+0
HETATM    4  O   UNK     0       7.438   5.596   0.000  0.00  0.00           O+0
HETATM    5  C   UNK     0       5.335   6.160   0.000  0.00  0.00           C+0
HETATM    6  O   UNK     0       4.001   6.930   0.000  0.00  0.00           O+0
HETATM    7  C   UNK     0       5.335   4.620   0.000  0.00  0.00           C+0
HETATM    8  O   UNK     0       4.001   3.850   0.000  0.00  0.00           O+0
HETATM    9  C   UNK     0       4.001   2.310   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       5.335   1.540   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       5.335   0.000   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       4.001  -0.770   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       2.667   0.000   0.000  0.00  0.00           C+0
HETATM   14  O   UNK     0       1.334  -0.770   0.000  0.00  0.00           O+0
HETATM   15  C   UNK     0      -0.000   0.000   0.000  0.00  0.00           C+0
HETATM   16  O   UNK     0      -1.334  -0.770   0.000  0.00  0.00           O+0
HETATM   17  C   UNK     0       0.000   1.540   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       1.334   2.310   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       2.667   1.540   0.000  0.00  0.00           C+0
HETATM   20  O   UNK     0       6.799  -0.476   0.000  0.00  0.00           O+0
HETATM   21  C   UNK     0       7.705   0.770   0.000  0.00  0.00           C+0
HETATM   22  O   UNK     0       6.799   2.016   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3    4    5                                             
CONECT    3    2                                                            
CONECT    4    2                                                            
CONECT    5    2    6    7                                                  
CONECT    6    5                                                            
CONECT    7    5    8                                                       
CONECT    8    7    9                                                       
CONECT    9    8   10   19                                                  
CONECT   10    9   11   22                                                  
CONECT   11   10   12   20                                                  
CONECT   12   11   13                                                       
CONECT   13   12   14   19                                                  
CONECT   14   13   15                                                       
CONECT   15   14   16   17                                                  
CONECT   16   15                                                            
CONECT   17   15   18                                                       
CONECT   18   17   19                                                       
CONECT   19   18    9   13                                                  
CONECT   20   11   21                                                       
CONECT   21   20   22                                                       
CONECT   22   21   10                                                       
MASTER        0    0    0    0    0    0    0    0   22    0   48    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₁₅H₁₄O₇

Average Mass

306.2700 Da

Monoisotopic Mass

306.07395 Da

IUPAC Name

9-(3-hydroxy-3-methyl-2-oxobutoxy)-2H,6H-[1,3]dioxolo[4,5-g]chromen-6-one

Traditional Name

9-(3-hydroxy-3-methyl-2-oxobutoxy)-2H-[1,3]dioxolo[4,5-g]chromen-6-one

CAS Registry Number

Not Available

SMILES

CC(C)(O)C(=O)COC1=C2C=CC(=O)OC2=CC2=C1OCO2

InChI Identifier

InChI=1S/C15H14O7/c1-15(2,18)11(16)6-19-13-8-3-4-12(17)22-9(8)5-10-14(13)21-7-20-10/h3-5,18H,6-7H2,1-2H3

InChI Key

ILIBQXWLXBNMBF-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Pterocaulon virgatum	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as coumarins and derivatives. These are polycyclic aromatic compounds containing a 1-benzopyran moiety with a ketone group at the C2 carbon atom (1-benzopyran-2-one).

Kingdom

Organic compounds

Super Class

Phenylpropanoids and polyketides

Class

Coumarins and derivatives

Sub Class

Not Available

Direct Parent

Coumarins and derivatives

Alternative Parents

Substituents

Coumarin
Benzopyran
1-benzopyran
Benzodioxole
Alkyl aryl ether
Pyranone
Acyloin
Benzenoid
Pyran
Monosaccharide
Alpha-hydroxy ketone
Heteroaromatic compound
Tertiary alcohol
Ketone
Lactone
Ether
Organoheterocyclic compound
Oxacycle
Acetal
Organooxygen compound
Carbonyl group
Hydrocarbon derivative
Organic oxide
Aldehyde
Alcohol
Organic oxygen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	1.24	ChemAxon
pKa (Strongest Acidic)	13.47	ChemAxon
pKa (Strongest Basic)	-3.5	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	6	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	91.29 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	74.32 m³·mol⁻¹	ChemAxon
Polarizability	29.49 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

31137454

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

76321600

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for 9-(3-hydroxy-3-methyl-2-oxobutoxy)-2h-[1,3]dioxolo[4,5-g]chromen-6-one (NP0191683)

MOL for NP0191683 (9-(3-hydroxy-3-methyl-2-oxobutoxy)-2h-[1,3]dioxolo[4,5-g]chromen-6-one)

3D MOL for NP0191683 (9-(3-hydroxy-3-methyl-2-oxobutoxy)-2h-[1,3]dioxolo[4,5-g]chromen-6-one)

3D SDF for NP0191683 (9-(3-hydroxy-3-methyl-2-oxobutoxy)-2h-[1,3]dioxolo[4,5-g]chromen-6-one)

3D-SDF for NP0191683 (9-(3-hydroxy-3-methyl-2-oxobutoxy)-2h-[1,3]dioxolo[4,5-g]chromen-6-one)

PDB for NP0191683 (9-(3-hydroxy-3-methyl-2-oxobutoxy)-2h-[1,3]dioxolo[4,5-g]chromen-6-one)

3D PDB for NP0191683 (9-(3-hydroxy-3-methyl-2-oxobutoxy)-2h-[1,3]dioxolo[4,5-g]chromen-6-one)

SMILES for NP0191683 (9-(3-hydroxy-3-methyl-2-oxobutoxy)-2h-[1,3]dioxolo[4,5-g]chromen-6-one)

INCHI for NP0191683 (9-(3-hydroxy-3-methyl-2-oxobutoxy)-2h-[1,3]dioxolo[4,5-g]chromen-6-one)

Structure for NP0191683 (9-(3-hydroxy-3-methyl-2-oxobutoxy)-2h-[1,3]dioxolo[4,5-g]chromen-6-one)

3D Structure for NP0191683 (9-(3-hydroxy-3-methyl-2-oxobutoxy)-2h-[1,3]dioxolo[4,5-g]chromen-6-one)