NP-MRD: Showing NP-Card for (3r,7r,9s)-9-methoxy-4-methyl-11,16,18-trioxa-4-azapentacyclo[11.7.0.0²,¹⁰.0³,⁷.0¹⁵,¹⁹]icosa-1(20),2(10),13,15(19)-tetraen-12-one (NP0191239)

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Record Information

Version

2.0

Created at

2022-09-04 08:07:42 UTC

Updated at

2022-09-04 08:07:42 UTC

NP-MRD ID

NP0191239

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(3r,7r,9s)-9-methoxy-4-methyl-11,16,18-trioxa-4-azapentacyclo[11.7.0.0²,¹⁰.0³,⁷.0¹⁵,¹⁹]icosa-1(20),2(10),13,15(19)-tetraen-12-one

Description

Narseronine belongs to the class of organic compounds known as homolycorine-type amaryllidaceae alkaloids. These are amaryllidaceae alkaloids compounds containing the homolycorine skeleton, made up of a [3,4-g]benzopyranone ring due to the oxidation of the hydroxyl group at the C6. They are biogenetically formed through a restructuring of lycorine-type alkaloids. (3r,7r,9s)-9-methoxy-4-methyl-11,16,18-trioxa-4-azapentacyclo[11.7.0.0²,¹⁰.0³,⁷.0¹⁵,¹⁹]icosa-1(20),2(10),13,15(19)-tetraen-12-one is found in Narcissus serotinus. (3r,7r,9s)-9-methoxy-4-methyl-11,16,18-trioxa-4-azapentacyclo[11.7.0.0²,¹⁰.0³,⁷.0¹⁵,¹⁹]icosa-1(20),2(10),13,15(19)-tetraen-12-one was first documented in 2010 (PMID: 20948496). Based on a literature review very few articles have been published on Narseronine.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309042210072D          

 24 28  0  0  1  0            999 V2000
    0.9821    0.2912    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7942    0.4364    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3261   -0.1943    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.0458   -0.9702    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5776   -1.6009    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.4647   -2.4182    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2071   -2.7780    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7788   -2.1832    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5960   -2.2961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3897   -1.4557    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.6700   -0.6798    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1382   -0.0491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4185    0.7268    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2306    0.8721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5109    1.6480    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7624    0.2414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5745    0.3866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1064   -0.2441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8261   -1.0201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0139   -1.1653    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4821   -0.5346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4774   -1.5264    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1602   -1.0634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9309   -0.2709    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  3  2  1  6  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  6  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
 10  8  1  6  0  0  0
  5 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
  3 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 11 21  1  0  0  0  0
 16 21  1  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 18 24  1  0  0  0  0
M  END

     RDKit          3D

 43 47  0  0  0  0  0  0  0  0999 V2000
   -3.3985    3.4984   -0.0655 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7202    2.4027   -0.5824 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2790    1.5338    0.4316 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.8429    0.1973    0.1633 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1485   -0.9713    0.7772 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.5757   -2.1656   -0.0935 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5264   -2.0638   -1.1841 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3241   -2.0077   -0.3234 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3017   -3.3659    0.2565 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6631   -1.0058    0.6875 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.0525    0.3143    0.4498 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7985    1.4948    0.3272 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2269    2.6649    0.1093 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0513    2.8445   -0.0112 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5872    3.9683   -0.2197 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8812    1.7420    0.0944 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2641    1.9254   -0.0289 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0990    0.8382    0.0798 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5561   -0.4028    0.3071 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1827   -0.5554    0.4249 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3119    0.5075    0.3218 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6005   -1.3449    0.3795 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7697   -0.7390   -0.1435 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4758    0.6369    0.0157 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7121    4.0512    0.6046 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7135    4.1177   -0.9160 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2722    3.0829    0.5019 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6099    1.9860    1.3937 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9931    0.0859   -0.9405 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8960    0.1859    0.5762 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5300   -1.0982    1.8204 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6047   -2.0143   -0.4804 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4355   -3.0867    0.4615 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5513   -3.0084   -1.7500 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6239   -1.1868   -1.8121 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.7940   -3.6508    0.2287 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6098   -3.2789    1.3169 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8675   -4.0954   -0.3137 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3120   -1.4569    1.6609 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.6644    2.8963   -0.2048 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.8020   -1.5229    0.6056 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.8685   -0.9069   -1.2481 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.6813   -1.0465    0.4063 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  8 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 14 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 22  1  0
 22 23  1  0
 23 24  1  0
 19 20  1  0
 20 21  2  0
 12  3  1  0
 21 16  1  0
 10  5  1  0
 21 11  1  0
 24 18  1  0
  1 25  1  0
  1 26  1  0
  1 27  1  0
  3 28  1  1
  4 29  1  0
  4 30  1  0
  5 31  1  1
  6 32  1  0
  6 33  1  0
  7 34  1  0
  7 35  1  0
  9 36  1  0
  9 37  1  0
  9 38  1  0
 10 39  1  1
 17 40  1  0
 23 42  1  0
 23 43  1  0
 20 41  1  0
M  END


  Mrv1652309042210072D          

 24 28  0  0  1  0            999 V2000
    0.9821    0.2912    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7942    0.4364    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3261   -0.1943    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.0458   -0.9702    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5776   -1.6009    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.4647   -2.4182    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2071   -2.7780    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7788   -2.1832    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5960   -2.2961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3897   -1.4557    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.6700   -0.6798    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1382   -0.0491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4185    0.7268    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2306    0.8721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5109    1.6480    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7624    0.2414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5745    0.3866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1064   -0.2441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8261   -1.0201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0139   -1.1653    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4821   -0.5346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4774   -1.5264    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1602   -1.0634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9309   -0.2709    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  3  2  1  6  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  6  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
 10  8  1  6  0  0  0
  5 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
  3 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 11 21  1  0  0  0  0
 16 21  1  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 18 24  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0191239

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CO[C@H]1C[C@H]2CCN(C)[C@H]2C2=C1OC(=O)C1=CC3=C(OCO3)C=C21

> <INCHI_IDENTIFIER>
InChI=1S/C18H19NO5/c1-19-4-3-9-5-14(21-2)17-15(16(9)19)10-6-12-13(23-8-22-12)7-11(10)18(20)24-17/h6-7,9,14,16H,3-5,8H2,1-2H3/t9-,14+,16-/m1/s1

> <INCHI_KEY>
DJKWIYGRPQRQRV-WKFLNTIRSA-N

> <FORMULA>
C18H19NO5

> <MOLECULAR_WEIGHT>
329.352

> <EXACT_MASS>
329.126322716

> <JCHEM_ACCEPTOR_COUNT>
5

> <JCHEM_ATOM_COUNT>
43

> <JCHEM_AVERAGE_POLARIZABILITY>
34.166758176575804

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
0

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(3R,7R,9S)-9-methoxy-4-methyl-11,16,18-trioxa-4-azapentacyclo[11.7.0.0^{2,10}.0^{3,7}.0^{15,19}]icosa-1(20),2(10),13,15(19)-tetraen-12-one

> <JCHEM_LOGP>
1.619054578666666

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
5

> <JCHEM_PHYSIOLOGICAL_CHARGE>
1

> <JCHEM_PKA_STRONGEST_BASIC>
8.666531728238464

> <JCHEM_POLAR_SURFACE_AREA>
57.230000000000004

> <JCHEM_REFRACTIVITY>
86.7718

> <JCHEM_ROTATABLE_BOND_COUNT>
1

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
(3R,7R,9S)-9-methoxy-4-methyl-11,16,18-trioxa-4-azapentacyclo[11.7.0.0^{2,10}.0^{3,7}.0^{15,19}]icosa-1(20),2(10),13,15(19)-tetraen-12-one

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 04-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   04-SEP-22         0                                  
HETATM    1  C   UNK     0       1.833   0.544   0.000  0.00  0.00           C+0
HETATM    2  O   UNK     0       3.349   0.815   0.000  0.00  0.00           O+0
HETATM    3  C   UNK     0       4.342  -0.363   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       3.819  -1.811   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       4.811  -2.988   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       4.601  -4.514   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       5.987  -5.186   0.000  0.00  0.00           C+0
HETATM    8  N   UNK     0       7.054  -4.075   0.000  0.00  0.00           N+0
HETATM    9  C   UNK     0       8.579  -4.286   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       6.327  -2.717   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       6.851  -1.269   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       5.858  -0.092   0.000  0.00  0.00           C+0
HETATM   13  O   UNK     0       6.381   1.357   0.000  0.00  0.00           O+0
HETATM   14  C   UNK     0       7.897   1.628   0.000  0.00  0.00           C+0
HETATM   15  O   UNK     0       8.420   3.076   0.000  0.00  0.00           O+0
HETATM   16  C   UNK     0       8.890   0.451   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      10.406   0.722   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      11.399  -0.456   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0      10.875  -1.904   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       9.359  -2.175   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       8.367  -0.998   0.000  0.00  0.00           C+0
HETATM   22  O   UNK     0      12.091  -2.849   0.000  0.00  0.00           O+0
HETATM   23  C   UNK     0      13.366  -1.985   0.000  0.00  0.00           C+0
HETATM   24  O   UNK     0      12.938  -0.506   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4   12                                                  
CONECT    4    3    5                                                       
CONECT    5    4    6   10                                                  
CONECT    6    5    7                                                       
CONECT    7    6    8                                                       
CONECT    8    7    9   10                                                  
CONECT    9    8                                                            
CONECT   10    8    5   11                                                  
CONECT   11   10   12   21                                                  
CONECT   12   11    3   13                                                  
CONECT   13   12   14                                                       
CONECT   14   13   15   16                                                  
CONECT   15   14                                                            
CONECT   16   14   17   21                                                  
CONECT   17   16   18                                                       
CONECT   18   17   19   24                                                  
CONECT   19   18   20   22                                                  
CONECT   20   19   21                                                       
CONECT   21   20   11   16                                                  
CONECT   22   19   23                                                       
CONECT   23   22   24                                                       
CONECT   24   23   18                                                       
MASTER        0    0    0    0    0    0    0    0   24    0   56    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₁₈H₁₉NO₅

Average Mass

329.3520 Da

Monoisotopic Mass

329.12632 Da

IUPAC Name

(3R,7R,9S)-9-methoxy-4-methyl-11,16,18-trioxa-4-azapentacyclo[11.7.0.0^{2,10}.0^{3,7}.0^{15,19}]icosa-1(20),2(10),13,15(19)-tetraen-12-one

Traditional Name

(3R,7R,9S)-9-methoxy-4-methyl-11,16,18-trioxa-4-azapentacyclo[11.7.0.0^{2,10}.0^{3,7}.0^{15,19}]icosa-1(20),2(10),13,15(19)-tetraen-12-one

CAS Registry Number

Not Available

SMILES

CO[C@H]1C[C@H]2CCN(C)[C@H]2C2=C1OC(=O)C1=CC3=C(OCO3)C=C21

InChI Identifier

InChI=1S/C18H19NO5/c1-19-4-3-9-5-14(21-2)17-15(16(9)19)10-6-12-13(23-8-22-12)7-11(10)18(20)24-17/h6-7,9,14,16H,3-5,8H2,1-2H3/t9-,14+,16-/m1/s1

InChI Key

DJKWIYGRPQRQRV-WKFLNTIRSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Narcissus serotinus	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as homolycorine-type amaryllidaceae alkaloids. These are amaryllidaceae alkaloids compounds containing the homolycorine skeleton, made up of a [3,4-g]benzopyranone ring due to the oxidation of the hydroxyl group at the C6. They are biogenetically formed through a restructuring of lycorine-type alkaloids.

Kingdom

Organic compounds

Super Class

Alkaloids and derivatives

Class

Amaryllidaceae alkaloids

Sub Class

Homolycorine-type amaryllidaceae alkaloids

Direct Parent

Homolycorine-type amaryllidaceae alkaloids

Alternative Parents

Substituents

Homolycorine skeleton
Isocoumarin
Benzopyran
2-benzopyran
Benzodioxole
Indole or derivatives
Pyranone
Aralkylamine
Pyran
N-alkylpyrrolidine
Benzenoid
Heteroaromatic compound
Pyrrolidine
Lactone
Tertiary aliphatic amine
Tertiary amine
Azacycle
Organoheterocyclic compound
Acetal
Dialkyl ether
Ether
Oxacycle
Organic oxygen compound
Amine
Organic nitrogen compound
Organonitrogen compound
Organooxygen compound
Organic oxide
Hydrocarbon derivative
Organopnictogen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	1.62	ChemAxon
pKa (Strongest Basic)	8.67	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	57.23 Å²	ChemAxon
Rotatable Bond Count	1	ChemAxon
Refractivity	86.77 m³·mol⁻¹	ChemAxon
Polarizability	34.17 Å³	ChemAxon
Number of Rings	5	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

28289017

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

54597956

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Pigni NB, Berkov S, Elamrani A, Benaissa M, Viladomat F, Codina C, Bastida J: Two new alkaloids from Narcissus serotinus L. Molecules. 2010 Oct 14;15(10):7083-9. doi: 10.3390/molecules15107083. [PubMed:20948496 ]
LOTUS database [Link]

Showing NP-Card for (3r,7r,9s)-9-methoxy-4-methyl-11,16,18-trioxa-4-azapentacyclo[11.7.0.0²,¹⁰.0³,⁷.0¹⁵,¹⁹]icosa-1(20),2(10),13,15(19)-tetraen-12-one (NP0191239)

MOL for NP0191239 ((3r,7r,9s)-9-methoxy-4-methyl-11,16,18-trioxa-4-azapentacyclo[11.7.0.0²,¹⁰.0³,⁷.0¹⁵,¹⁹]icosa-1(20),2(10),13,15(19)-tetraen-12-one)

3D MOL for NP0191239 ((3r,7r,9s)-9-methoxy-4-methyl-11,16,18-trioxa-4-azapentacyclo[11.7.0.0²,¹⁰.0³,⁷.0¹⁵,¹⁹]icosa-1(20),2(10),13,15(19)-tetraen-12-one)

3D SDF for NP0191239 ((3r,7r,9s)-9-methoxy-4-methyl-11,16,18-trioxa-4-azapentacyclo[11.7.0.0²,¹⁰.0³,⁷.0¹⁵,¹⁹]icosa-1(20),2(10),13,15(19)-tetraen-12-one)

3D-SDF for NP0191239 ((3r,7r,9s)-9-methoxy-4-methyl-11,16,18-trioxa-4-azapentacyclo[11.7.0.0²,¹⁰.0³,⁷.0¹⁵,¹⁹]icosa-1(20),2(10),13,15(19)-tetraen-12-one)

PDB for NP0191239 ((3r,7r,9s)-9-methoxy-4-methyl-11,16,18-trioxa-4-azapentacyclo[11.7.0.0²,¹⁰.0³,⁷.0¹⁵,¹⁹]icosa-1(20),2(10),13,15(19)-tetraen-12-one)

3D PDB for NP0191239 ((3r,7r,9s)-9-methoxy-4-methyl-11,16,18-trioxa-4-azapentacyclo[11.7.0.0²,¹⁰.0³,⁷.0¹⁵,¹⁹]icosa-1(20),2(10),13,15(19)-tetraen-12-one)

SMILES for NP0191239 ((3r,7r,9s)-9-methoxy-4-methyl-11,16,18-trioxa-4-azapentacyclo[11.7.0.0²,¹⁰.0³,⁷.0¹⁵,¹⁹]icosa-1(20),2(10),13,15(19)-tetraen-12-one)

INCHI for NP0191239 ((3r,7r,9s)-9-methoxy-4-methyl-11,16,18-trioxa-4-azapentacyclo[11.7.0.0²,¹⁰.0³,⁷.0¹⁵,¹⁹]icosa-1(20),2(10),13,15(19)-tetraen-12-one)

Structure for NP0191239 ((3r,7r,9s)-9-methoxy-4-methyl-11,16,18-trioxa-4-azapentacyclo[11.7.0.0²,¹⁰.0³,⁷.0¹⁵,¹⁹]icosa-1(20),2(10),13,15(19)-tetraen-12-one)

3D Structure for NP0191239 ((3r,7r,9s)-9-methoxy-4-methyl-11,16,18-trioxa-4-azapentacyclo[11.7.0.0²,¹⁰.0³,⁷.0¹⁵,¹⁹]icosa-1(20),2(10),13,15(19)-tetraen-12-one)