NP-MRD: Showing NP-Card for methyl 5-[4-hydroxy-5-(hydroxymethyl)-1,2,4a-trimethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl]-3-methylpent-2-enoate (NP0185775)

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Record Information

Version

2.0

Created at

2022-09-04 01:20:03 UTC

Updated at

2022-09-04 01:20:03 UTC

NP-MRD ID

NP0185775

Secondary Accession Numbers

None

Natural Product Identification

Common Name

methyl 5-[4-hydroxy-5-(hydroxymethyl)-1,2,4a-trimethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl]-3-methylpent-2-enoate

Description

Methyl 5-[4-hydroxy-5-(hydroxymethyl)-1,2,4a-trimethyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-yl]-3-methylpent-2-enoate belongs to the class of organic compounds known as colensane and clerodane diterpenoids. These are diterpenoids with a structure based on the clerodane or the colensane skeleton. Clerodanes arise from labdanes by two methyl migrations. methyl 5-[4-hydroxy-5-(hydroxymethyl)-1,2,4a-trimethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl]-3-methylpent-2-enoate is found in Pityrodia lepidota. Methyl 5-[4-hydroxy-5-(hydroxymethyl)-1,2,4a-trimethyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-yl]-3-methylpent-2-enoate is an extremely weak basic (essentially neutral) compound (based on its pKa).

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1533004251507072D          

 25 26  0  0  0  0            999 V2000
   -1.2747    4.8537    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7444    4.2217    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0266    3.4465    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8390    3.3032    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4963    2.8145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7784    2.0392    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5909    1.8960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2481    1.4072    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5303    0.6320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5303    0.6320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  5  3  1  4  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 10 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 17 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
M  END

     RDKit          3D

 59 60  0  0  0  0  0  0  0  0999 V2000
    7.2741   -1.0236    1.4983 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0008   -0.4585    1.2377 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8406   -1.2225    1.2019 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0270   -2.4662    1.4229 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5180   -0.7002    0.9418 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3258    0.5673    0.7133 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4597    1.5085    0.7139 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9573    1.1310    0.4371 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8901    0.0600    0.4585 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4493    0.6991    0.1757 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.5496    1.7164    1.3481 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4303    1.5241   -1.0691 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.4287    1.0086   -2.1958 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7662    1.8729   -1.6104 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8625    0.8719   -1.4124 C   0  0  2  0  0  0  0  0  0  0  0  0
   -3.7134    1.4384   -0.4314 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4452   -0.4547   -0.8948 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.7511   -1.3426   -1.8941 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6551   -1.2080   -0.4875 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8387   -1.2743   -1.3620 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4324   -0.0491   -1.6042 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7301   -1.9077    0.6639 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6498   -2.0150    1.6426 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3277   -1.5218    1.0261 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6162   -0.2037    0.3501 C   0  0  1  0  0  0  0  0  0  0  0  0
    7.7441   -0.5974    2.4128 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.2138   -2.1319    1.6257 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.9653   -0.8474    0.6571 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.6849   -1.3770    0.9406 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.2184    1.2774   -0.0717 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.0568    2.5439    0.5663 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.9432    1.5438    1.7182 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9486    1.7940   -0.4132 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.7713    1.7934    1.3374 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.9142   -0.3059    1.5083 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.1105   -0.8038   -0.1819 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1911    1.2462    2.2839 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0491    2.6531    1.1002 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6404    1.9263    1.4768 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.0587    2.5186   -0.8061 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.0330    0.1392   -1.9811 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1955    0.7560   -3.1082 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.1206    1.7955   -2.6229 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0838    2.9016   -1.2637 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6612    2.0265   -2.7263 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4806    0.7794   -2.3262 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6668    2.4329   -0.4659 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2416   -2.3586   -1.9977 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7132   -1.5768   -1.6729 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9012   -0.8892   -2.8949 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6529   -1.9166   -0.9273 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6190   -1.7735   -2.3402 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0915    0.1327   -0.8747 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6617   -2.4441    0.9038 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5368   -3.0530    2.0195 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8674   -1.3251    2.4829 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9462   -2.2841    0.3161 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6924   -1.4076    1.9236 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3954    0.2815    1.0273 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  2  0
  6  7  1  0
  6  8  1  0
  8  9  1  0
 10  9  1  1
 10 11  1  0
 10 12  1  0
 12 13  1  0
 12 14  1  0
 14 15  1  0
 15 16  1  0
 15 17  1  0
 17 18  1  6
 17 25  1  0
 25 24  1  0
 24 23  1  0
 23 22  1  0
 22 19  2  0
 19 20  1  0
 20 21  1  0
 25 10  1  0
 19 17  1  0
  1 26  1  0
  1 27  1  0
  1 28  1  0
  5 29  1  0
  7 30  1  0
  7 31  1  0
  7 32  1  0
  8 33  1  0
  8 34  1  0
  9 35  1  0
  9 36  1  0
 11 37  1  0
 11 38  1  0
 11 39  1  0
 12 40  1  1
 13 41  1  0
 13 42  1  0
 13 43  1  0
 14 44  1  0
 14 45  1  0
 15 46  1  6
 16 47  1  0
 18 48  1  0
 18 49  1  0
 18 50  1  0
 25 59  1  1
 24 57  1  0
 24 58  1  0
 23 55  1  0
 23 56  1  0
 22 54  1  0
 20 51  1  0
 20 52  1  0
 21 53  1  0
M  END


  Mrv1533004251507072D          

 25 26  0  0  0  0            999 V2000
   -1.2747    4.8537    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7444    4.2217    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0266    3.4465    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8390    3.3032    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4963    2.8145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7784    2.0392    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5909    1.8960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2481    1.4072    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5303    0.6320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5303    0.6320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  5  3  1  4  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 10 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 17 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0185775

> <DATABASE_NAME>
NP-MRD

> <SMILES>
COC(=O)C=C(C)CCC1(C)C(C)CC(O)C2(C)C1CCC=C2CO

> <INCHI_IDENTIFIER>
InChI=1S/C21H34O4/c1-14(11-19(24)25-5)9-10-20(3)15(2)12-18(23)21(4)16(13-22)7-6-8-17(20)21/h7,11,15,17-18,22-23H,6,8-10,12-13H2,1-5H3

> <INCHI_KEY>
JBUAQUFKSAIGHN-UHFFFAOYSA-N

> <FORMULA>
C21H34O4

> <MOLECULAR_WEIGHT>
350.499

> <EXACT_MASS>
350.245709575

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_ATOM_COUNT>
59

> <JCHEM_AVERAGE_POLARIZABILITY>
40.00041173382739

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
methyl 5-[4-hydroxy-5-(hydroxymethyl)-1,2,4a-trimethyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-yl]-3-methylpent-2-enoate

> <ALOGPS_LOGP>
3.76

> <JCHEM_LOGP>
3.2892964796666657

> <ALOGPS_LOGS>
-4.10

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
2

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
15.262424725452185

> <JCHEM_PKA_STRONGEST_ACIDIC>
14.510960452644806

> <JCHEM_PKA_STRONGEST_BASIC>
-2.7368231498133255

> <JCHEM_POLAR_SURFACE_AREA>
66.76

> <JCHEM_REFRACTIVITY>
101.05299999999998

> <JCHEM_ROTATABLE_BOND_COUNT>
6

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
2.79e-02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
methyl 5-[4-hydroxy-5-(hydroxymethyl)-1,2,4a-trimethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl]-3-methylpent-2-enoate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 25-APR-15   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   25-APR-15         0                                  
HETATM    1  C   UNK     0      -2.379   9.060   0.000  0.00  0.00           C+0
HETATM    2  O   UNK     0      -1.390   7.881   0.000  0.00  0.00           O+0
HETATM    3  C   UNK     0      -1.916   6.433   0.000  0.00  0.00           C+0
HETATM    4  O   UNK     0      -3.433   6.166   0.000  0.00  0.00           O+0
HETATM    5  C   UNK     0      -0.926   5.254   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      -1.453   3.807   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      -2.970   3.539   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      -0.463   2.627   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      -0.990   1.180   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       0.000  -0.000   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       0.990   1.180   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      -1.334  -0.770   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      -2.667  -0.000   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      -1.334  -2.310   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       0.000  -3.080   0.000  0.00  0.00           C+0
HETATM   16  O   UNK     0       0.000  -4.620   0.000  0.00  0.00           O+0
HETATM   17  C   UNK     0       1.334  -2.310   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       1.334  -3.850   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       1.334  -0.770   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       2.667  -0.000   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       4.001  -0.770   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       4.001  -2.310   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       2.667  -3.080   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0       2.667  -4.620   0.000  0.00  0.00           C+0
HETATM   25  O   UNK     0       4.001  -5.390   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4    5                                                  
CONECT    4    3                                                            
CONECT    5    3    6                                                       
CONECT    6    5    7    8                                                  
CONECT    7    6                                                            
CONECT    8    6    9                                                       
CONECT    9    8   10                                                       
CONECT   10    9   11   12   19                                             
CONECT   11   10                                                            
CONECT   12   10   13   14                                                  
CONECT   13   12                                                            
CONECT   14   12   15                                                       
CONECT   15   14   16   17                                                  
CONECT   16   15                                                            
CONECT   17   15   18   19   23                                             
CONECT   18   17                                                            
CONECT   19   17   10   20                                                  
CONECT   20   19   21                                                       
CONECT   21   20   22                                                       
CONECT   22   21   23                                                       
CONECT   23   22   17   24                                                  
CONECT   24   23   25                                                       
CONECT   25   24                                                            
MASTER        0    0    0    0    0    0    0    0   25    0   52    0
END

View in JSmol

Synonyms

Value	Source
Methyl 5-[4-hydroxy-5-(hydroxymethyl)-1,2,4a-trimethyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-yl]-3-methylpent-2-enoic acid	Generator

Chemical Formula

C₂₁H₃₄O₄

Average Mass

350.4990 Da

Monoisotopic Mass

350.24571 Da

IUPAC Name

methyl 5-[4-hydroxy-5-(hydroxymethyl)-1,2,4a-trimethyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-yl]-3-methylpent-2-enoate

Traditional Name

methyl 5-[4-hydroxy-5-(hydroxymethyl)-1,2,4a-trimethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl]-3-methylpent-2-enoate

CAS Registry Number

Not Available

SMILES

COC(=O)C=C(C)CCC1(C)C(C)CC(O)C2(C)C1CCC=C2CO

InChI Identifier

InChI=1S/C21H34O4/c1-14(11-19(24)25-5)9-10-20(3)15(2)12-18(23)21(4)16(13-22)7-6-8-17(20)21/h7,11,15,17-18,22-23H,6,8-10,12-13H2,1-5H3

InChI Key

JBUAQUFKSAIGHN-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Pityrodia lepidota	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as colensane and clerodane diterpenoids. These are diterpenoids with a structure based on the clerodane or the colensane skeleton. Clerodanes arise from labdanes by two methyl migrations.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Diterpenoids

Direct Parent

Colensane and clerodane diterpenoids

Alternative Parents

Substituents

Clerodane diterpenoid
Fatty acid ester
Fatty acyl
Cyclic alcohol
Methyl ester
Alpha,beta-unsaturated carboxylic ester
Enoate ester
Carboxylic acid ester
Secondary alcohol
Monocarboxylic acid or derivatives
Carboxylic acid derivative
Primary alcohol
Organooxygen compound
Organic oxide
Organic oxygen compound
Alcohol
Carbonyl group
Hydrocarbon derivative
Aliphatic homopolycyclic compound

Molecular Framework

Aliphatic homopolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	3.76	ALOGPS
logP	3.29	ChemAxon
logS	-4.1	ALOGPS
pKa (Strongest Acidic)	14.51	ChemAxon
pKa (Strongest Basic)	-2.7	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	66.76 Å²	ChemAxon
Rotatable Bond Count	6	ChemAxon
Refractivity	101.05 m³·mol⁻¹	ChemAxon
Polarizability	40 Å³	ChemAxon
Number of Rings	2	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

Not Available

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for methyl 5-[4-hydroxy-5-(hydroxymethyl)-1,2,4a-trimethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl]-3-methylpent-2-enoate (NP0185775)

MOL for NP0185775 (methyl 5-[4-hydroxy-5-(hydroxymethyl)-1,2,4a-trimethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl]-3-methylpent-2-enoate)

3D MOL for NP0185775 (methyl 5-[4-hydroxy-5-(hydroxymethyl)-1,2,4a-trimethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl]-3-methylpent-2-enoate)

3D SDF for NP0185775 (methyl 5-[4-hydroxy-5-(hydroxymethyl)-1,2,4a-trimethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl]-3-methylpent-2-enoate)

3D-SDF for NP0185775 (methyl 5-[4-hydroxy-5-(hydroxymethyl)-1,2,4a-trimethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl]-3-methylpent-2-enoate)

PDB for NP0185775 (methyl 5-[4-hydroxy-5-(hydroxymethyl)-1,2,4a-trimethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl]-3-methylpent-2-enoate)

3D PDB for NP0185775 (methyl 5-[4-hydroxy-5-(hydroxymethyl)-1,2,4a-trimethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl]-3-methylpent-2-enoate)

SMILES for NP0185775 (methyl 5-[4-hydroxy-5-(hydroxymethyl)-1,2,4a-trimethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl]-3-methylpent-2-enoate)

INCHI for NP0185775 (methyl 5-[4-hydroxy-5-(hydroxymethyl)-1,2,4a-trimethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl]-3-methylpent-2-enoate)

Structure for NP0185775 (methyl 5-[4-hydroxy-5-(hydroxymethyl)-1,2,4a-trimethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl]-3-methylpent-2-enoate)

3D Structure for NP0185775 (methyl 5-[4-hydroxy-5-(hydroxymethyl)-1,2,4a-trimethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl]-3-methylpent-2-enoate)