NP-MRD: Showing NP-Card for 17-(4,5-dimethyl-6-oxo-2,3-dihydropyran-2-yl)-14,18-dihydroxy-11,21-dimethyl-5,15-dioxahexacyclo[12.6.1.0²,¹².0⁴,⁶.0⁶,¹¹.0¹⁸,²¹]henicos-8-en-10-one (NP0184985)

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Record Information

Version

1.0

Created at

2022-09-04 00:15:38 UTC

Updated at

2022-09-04 00:15:38 UTC

NP-MRD ID

NP0184985

Secondary Accession Numbers

None

Natural Product Identification

Common Name

17-(4,5-dimethyl-6-oxo-2,3-dihydropyran-2-yl)-14,18-dihydroxy-11,21-dimethyl-5,15-dioxahexacyclo[12.6.1.0²,¹².0⁴,⁶.0⁶,¹¹.0¹⁸,²¹]henicos-8-en-10-one

Description

17-(4,5-Dimethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-14,18-dihydroxy-11,21-dimethyl-5,15-dioxahexacyclo[12.6.1.0²,¹².0⁴,⁶.0⁶,¹¹.0¹⁸,²¹]Henicos-8-en-10-one belongs to the class of organic compounds known as terpene lactones. These are prenol lipids containing a lactone ring. 17-(4,5-dimethyl-6-oxo-2,3-dihydropyran-2-yl)-14,18-dihydroxy-11,21-dimethyl-5,15-dioxahexacyclo[12.6.1.0²,¹².0⁴,⁶.0⁶,¹¹.0¹⁸,²¹]henicos-8-en-10-one is found in Jaborosa caulescens. 17-(4,5-Dimethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-14,18-dihydroxy-11,21-dimethyl-5,15-dioxahexacyclo[12.6.1.0²,¹².0⁴,⁶.0⁶,¹¹.0¹⁸,²¹]Henicos-8-en-10-one is an extremely weak basic (essentially neutral) compound (based on its pKa).

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1533004161507342D          

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M  END

     RDKit          3D

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M  END


  Mrv1533004161507342D          

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 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 16 27  1  0  0  0  0
 21 27  1  0  0  0  0
 27 28  1  0  0  0  0
 17 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 10 32  1  0  0  0  0
 32 33  1  0  0  0  0
 32 34  1  0  0  0  0
 13 34  1  0  0  0  0
 29 34  1  0  0  0  0
 34 35  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0184985

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CC1=C(C)C(=O)OC(C1)C1COC2(O)CC3C(CC4OC44CC=CC(=O)C34C)C3CCC1(O)C23C

> <INCHI_IDENTIFIER>
InChI=1S/C28H36O7/c1-14-10-20(34-23(30)15(14)2)19-13-33-28(32)12-18-16(17-7-9-26(19,31)25(17,28)4)11-22-27(35-22)8-5-6-21(29)24(18,27)3/h5-6,16-20,22,31-32H,7-13H2,1-4H3

> <INCHI_KEY>
JHGQZOZYOJZSAH-UHFFFAOYSA-N

> <FORMULA>
C28H36O7

> <MOLECULAR_WEIGHT>
484.589

> <EXACT_MASS>
484.246103499

> <JCHEM_ACCEPTOR_COUNT>
6

> <JCHEM_ATOM_COUNT>
71

> <JCHEM_AVERAGE_POLARIZABILITY>
52.53615799546289

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
17-(4,5-dimethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-14,18-dihydroxy-11,21-dimethyl-5,15-dioxahexacyclo[12.6.1.0²,¹².0⁴,⁶.0⁶,¹¹.0¹⁸,²¹]henicos-8-en-10-one

> <ALOGPS_LOGP>
1.67

> <JCHEM_LOGP>
3.0009059119999972

> <ALOGPS_LOGS>
-3.87

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
7

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
13.8834845409513

> <JCHEM_PKA_STRONGEST_ACIDIC>
11.576413281850193

> <JCHEM_PKA_STRONGEST_BASIC>
-3.2955322538250265

> <JCHEM_POLAR_SURFACE_AREA>
105.59000000000002

> <JCHEM_REFRACTIVITY>
126.79279999999999

> <JCHEM_ROTATABLE_BOND_COUNT>
1

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
6.48e-02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
17-(4,5-dimethyl-6-oxo-2,3-dihydropyran-2-yl)-14,18-dihydroxy-11,21-dimethyl-5,15-dioxahexacyclo[12.6.1.0²,¹².0⁴,⁶.0⁶,¹¹.0¹⁸,²¹]henicos-8-en-10-one

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 16-APR-15   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   16-APR-15         0                                  
HETATM    1  C   UNK     0      -1.795  -2.525   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -1.555  -1.003   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      -2.753  -0.035   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      -4.190  -0.588   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      -2.513   1.486   0.000  0.00  0.00           C+0
HETATM    6  O   UNK     0      -3.711   2.454   0.000  0.00  0.00           O+0
HETATM    7  O   UNK     0      -1.076   2.039   0.000  0.00  0.00           O+0
HETATM    8  C   UNK     0       0.122   1.071   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      -0.118  -0.450   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       1.559   1.624   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       1.799   3.145   0.000  0.00  0.00           C+0
HETATM   12  O   UNK     0       3.236   3.698   0.000  0.00  0.00           O+0
HETATM   13  C   UNK     0       4.433   2.730   0.000  0.00  0.00           C+0
HETATM   14  O   UNK     0       4.884   4.203   0.000  0.00  0.00           O+0
HETATM   15  C   UNK     0       6.265   2.889   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       7.235   1.693   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       6.685   0.255   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       7.655  -0.941   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       9.176  -0.699   0.000  0.00  0.00           C+0
HETATM   20  O   UNK     0      10.696  -0.457   0.000  0.00  0.00           O+0
HETATM   21  C   UNK     0       9.726   0.739   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0      11.247   0.981   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0      11.798   2.419   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0      10.828   3.615   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0       9.307   3.373   0.000  0.00  0.00           C+0
HETATM   26  O   UNK     0       8.337   4.569   0.000  0.00  0.00           O+0
HETATM   27  C   UNK     0       8.756   1.935   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0       7.786   3.131   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0       5.164   0.013   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0       4.326  -1.280   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0       2.838  -0.882   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0       2.756   0.656   0.000  0.00  0.00           C+0
HETATM   33  O   UNK     0       1.385  -0.045   0.000  0.00  0.00           O+0
HETATM   34  C   UNK     0       4.194   1.209   0.000  0.00  0.00           C+0
HETATM   35  C   UNK     0       5.681   1.608   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3    9                                                  
CONECT    3    2    4    5                                                  
CONECT    4    3                                                            
CONECT    5    3    6    7                                                  
CONECT    6    5                                                            
CONECT    7    5    8                                                       
CONECT    8    7    9   10                                                  
CONECT    9    8    2                                                       
CONECT   10    8   11   32                                                  
CONECT   11   10   12                                                       
CONECT   12   11   13                                                       
CONECT   13   12   14   15   34                                             
CONECT   14   13                                                            
CONECT   15   13   16                                                       
CONECT   16   15   17   27                                                  
CONECT   17   16   18   29                                                  
CONECT   18   17   19                                                       
CONECT   19   18   20   21                                                  
CONECT   20   19   21                                                       
CONECT   21   20   19   22   27                                             
CONECT   22   21   23                                                       
CONECT   23   22   24                                                       
CONECT   24   23   25                                                       
CONECT   25   24   26   27                                                  
CONECT   26   25                                                            
CONECT   27   25   16   21   28                                             
CONECT   28   27                                                            
CONECT   29   17   30   34                                                  
CONECT   30   29   31                                                       
CONECT   31   30   32                                                       
CONECT   32   31   10   33   34                                             
CONECT   33   32                                                            
CONECT   34   32   13   29   35                                             
CONECT   35   34                                                            
MASTER        0    0    0    0    0    0    0    0   35    0   82    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₈H₃₆O₇

Average Mass

484.5890 Da

Monoisotopic Mass

484.24610 Da

IUPAC Name

17-(4,5-dimethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-14,18-dihydroxy-11,21-dimethyl-5,15-dioxahexacyclo[12.6.1.0²,¹².0⁴,⁶.0⁶,¹¹.0¹⁸,²¹]henicos-8-en-10-one

Traditional Name

17-(4,5-dimethyl-6-oxo-2,3-dihydropyran-2-yl)-14,18-dihydroxy-11,21-dimethyl-5,15-dioxahexacyclo[12.6.1.0²,¹².0⁴,⁶.0⁶,¹¹.0¹⁸,²¹]henicos-8-en-10-one

CAS Registry Number

Not Available

SMILES

CC1=C(C)C(=O)OC(C1)C1COC2(O)CC3C(CC4OC44CC=CC(=O)C34C)C3CCC1(O)C23C

InChI Identifier

InChI=1S/C28H36O7/c1-14-10-20(34-23(30)15(14)2)19-13-33-28(32)12-18-16(17-7-9-26(19,31)25(17,28)4)11-22-27(35-22)8-5-6-21(29)24(18,27)3/h5-6,16-20,22,31-32H,7-13H2,1-4H3

InChI Key

JHGQZOZYOJZSAH-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Jaborosa caulescens	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as terpene lactones. These are prenol lipids containing a lactone ring.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Terpene lactones

Direct Parent

Terpene lactones

Alternative Parents

Substituents

Terpene lactone
Naphthopyran
Iridoid-skeleton
Monoterpenoid
Naphthalene
Dihydropyranone
Cyclohexenone
Oxepane
Oxane
Pyran
Cyclic alcohol
Alpha,beta-unsaturated carboxylic ester
Enoate ester
Tertiary alcohol
Carboxylic acid ester
Hemiacetal
Ketone
Lactone
Ether
Oxirane
Dialkyl ether
Carboxylic acid derivative
Monocarboxylic acid or derivatives
Oxacycle
Organoheterocyclic compound
Organooxygen compound
Organic oxide
Carbonyl group
Organic oxygen compound
Alcohol
Hydrocarbon derivative
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	1.67	ALOGPS
logP	3	ChemAxon
logS	-3.9	ALOGPS
pKa (Strongest Acidic)	11.58	ChemAxon
pKa (Strongest Basic)	-3.3	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	6	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	105.59 Å²	ChemAxon
Rotatable Bond Count	1	ChemAxon
Refractivity	126.79 m³·mol⁻¹	ChemAxon
Polarizability	52.54 Å³	ChemAxon
Number of Rings	7	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

73306511

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for 17-(4,5-dimethyl-6-oxo-2,3-dihydropyran-2-yl)-14,18-dihydroxy-11,21-dimethyl-5,15-dioxahexacyclo[12.6.1.0²,¹².0⁴,⁶.0⁶,¹¹.0¹⁸,²¹]henicos-8-en-10-one (NP0184985)

MOL for NP0184985 (17-(4,5-dimethyl-6-oxo-2,3-dihydropyran-2-yl)-14,18-dihydroxy-11,21-dimethyl-5,15-dioxahexacyclo[12.6.1.0²,¹².0⁴,⁶.0⁶,¹¹.0¹⁸,²¹]henicos-8-en-10-one)

3D MOL for NP0184985 (17-(4,5-dimethyl-6-oxo-2,3-dihydropyran-2-yl)-14,18-dihydroxy-11,21-dimethyl-5,15-dioxahexacyclo[12.6.1.0²,¹².0⁴,⁶.0⁶,¹¹.0¹⁸,²¹]henicos-8-en-10-one)

3D SDF for NP0184985 (17-(4,5-dimethyl-6-oxo-2,3-dihydropyran-2-yl)-14,18-dihydroxy-11,21-dimethyl-5,15-dioxahexacyclo[12.6.1.0²,¹².0⁴,⁶.0⁶,¹¹.0¹⁸,²¹]henicos-8-en-10-one)

3D-SDF for NP0184985 (17-(4,5-dimethyl-6-oxo-2,3-dihydropyran-2-yl)-14,18-dihydroxy-11,21-dimethyl-5,15-dioxahexacyclo[12.6.1.0²,¹².0⁴,⁶.0⁶,¹¹.0¹⁸,²¹]henicos-8-en-10-one)

PDB for NP0184985 (17-(4,5-dimethyl-6-oxo-2,3-dihydropyran-2-yl)-14,18-dihydroxy-11,21-dimethyl-5,15-dioxahexacyclo[12.6.1.0²,¹².0⁴,⁶.0⁶,¹¹.0¹⁸,²¹]henicos-8-en-10-one)

3D PDB for NP0184985 (17-(4,5-dimethyl-6-oxo-2,3-dihydropyran-2-yl)-14,18-dihydroxy-11,21-dimethyl-5,15-dioxahexacyclo[12.6.1.0²,¹².0⁴,⁶.0⁶,¹¹.0¹⁸,²¹]henicos-8-en-10-one)

SMILES for NP0184985 (17-(4,5-dimethyl-6-oxo-2,3-dihydropyran-2-yl)-14,18-dihydroxy-11,21-dimethyl-5,15-dioxahexacyclo[12.6.1.0²,¹².0⁴,⁶.0⁶,¹¹.0¹⁸,²¹]henicos-8-en-10-one)

INCHI for NP0184985 (17-(4,5-dimethyl-6-oxo-2,3-dihydropyran-2-yl)-14,18-dihydroxy-11,21-dimethyl-5,15-dioxahexacyclo[12.6.1.0²,¹².0⁴,⁶.0⁶,¹¹.0¹⁸,²¹]henicos-8-en-10-one)

Structure for NP0184985 (17-(4,5-dimethyl-6-oxo-2,3-dihydropyran-2-yl)-14,18-dihydroxy-11,21-dimethyl-5,15-dioxahexacyclo[12.6.1.0²,¹².0⁴,⁶.0⁶,¹¹.0¹⁸,²¹]henicos-8-en-10-one)

3D Structure for NP0184985 (17-(4,5-dimethyl-6-oxo-2,3-dihydropyran-2-yl)-14,18-dihydroxy-11,21-dimethyl-5,15-dioxahexacyclo[12.6.1.0²,¹².0⁴,⁶.0⁶,¹¹.0¹⁸,²¹]henicos-8-en-10-one)