NP-MRD: Showing NP-Card for (5e,7r,8r,9r)-4-(2-methoxy-2-oxoacetyl)-5-(2-methoxy-2-oxoethylidene)-7,8-dimethyl-2,13,15-trioxatetracyclo[8.6.1.0⁴,¹⁷.0¹²,¹⁶]heptadeca-1(17),10,12(16)-trien-9-yl (2z)-2-methylbut-2-enoate (NP0183957)

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Record Information

Version

2.0

Created at

2022-09-03 22:57:49 UTC

Updated at

2022-09-03 22:57:49 UTC

NP-MRD ID

NP0183957

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(5e,7r,8r,9r)-4-(2-methoxy-2-oxoacetyl)-5-(2-methoxy-2-oxoethylidene)-7,8-dimethyl-2,13,15-trioxatetracyclo[8.6.1.0⁴,¹⁷.0¹²,¹⁶]heptadeca-1(17),10,12(16)-trien-9-yl (2z)-2-methylbut-2-enoate

Description

Heteroclitin F belongs to the class of organic compounds known as benzodioxoles. These are organic compounds containing a benzene ring fused to either isomers of dioxole. Dioxole is a five-membered unsaturated ring of two oxygen atoms and three carbon atoms. (5e,7r,8r,9r)-4-(2-methoxy-2-oxoacetyl)-5-(2-methoxy-2-oxoethylidene)-7,8-dimethyl-2,13,15-trioxatetracyclo[8.6.1.0⁴,¹⁷.0¹²,¹⁶]heptadeca-1(17),10,12(16)-trien-9-yl (2z)-2-methylbut-2-enoate is found in Kadsura heteroclita and Kadsura interior. (5e,7r,8r,9r)-4-(2-methoxy-2-oxoacetyl)-5-(2-methoxy-2-oxoethylidene)-7,8-dimethyl-2,13,15-trioxatetracyclo[8.6.1.0⁴,¹⁷.0¹²,¹⁶]heptadeca-1(17),10,12(16)-trien-9-yl (2z)-2-methylbut-2-enoate was first documented in 2005 (PMID: 16041651). Based on a literature review a small amount of articles have been published on Heteroclitin F.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309042200572D          

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M  END

     RDKit          3D

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M  END


  Mrv1652309042200572D          

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 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
  9 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 15 22  1  0  0  0  0
 22 23  1  0  0  0  0
 13 23  1  0  0  0  0
 15 24  1  0  0  0  0
 24 25  2  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 24 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  6  0  0  0
 31 33  1  0  0  0  0
  8 33  1  0  0  0  0
 33 34  1  6  0  0  0
 12 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 11 37  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0183957

> <DATABASE_NAME>
NP-MRD

> <SMILES>
COC(=O)\C=C1/C[C@@H](C)[C@@H](C)[C@@H](OC(=O)C(\C)=C/C)C2=CC3=C(OCO3)C3=C2C1(CO3)C(=O)C(=O)OC

> <INCHI_IDENTIFIER>
InChI=1S/C27H30O10/c1-7-13(2)25(30)37-21-15(4)14(3)8-16(9-19(28)32-5)27(24(29)26(31)33-6)11-34-23-20(27)17(21)10-18-22(23)36-12-35-18/h7,9-10,14-15,21H,8,11-12H2,1-6H3/b13-7-,16-9+/t14-,15-,21-,27?/m1/s1

> <INCHI_KEY>
WZHLOZOCPVZWTE-JFKIBXCKSA-N

> <FORMULA>
C27H30O10

> <MOLECULAR_WEIGHT>
514.527

> <EXACT_MASS>
514.183897166

> <JCHEM_ACCEPTOR_COUNT>
7

> <JCHEM_ATOM_COUNT>
67

> <JCHEM_AVERAGE_POLARIZABILITY>
52.380595212146574

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
0

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(5E,7R,8R,9R)-4-(2-methoxy-2-oxoacetyl)-5-(2-methoxy-2-oxoethylidene)-7,8-dimethyl-2,13,15-trioxatetracyclo[8.6.1.0^{4,17}.0^{12,16}]heptadeca-1(17),10,12(16)-trien-9-yl (2Z)-2-methylbut-2-enoate

> <JCHEM_LOGP>
4.844068479333333

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_BASIC>
-4.552865639860604

> <JCHEM_POLAR_SURFACE_AREA>
123.66000000000001

> <JCHEM_REFRACTIVITY>
130.118

> <JCHEM_ROTATABLE_BOND_COUNT>
8

> <JCHEM_RULE_OF_FIVE>
0

> <JCHEM_TRADITIONAL_IUPAC>
(5E,7R,8R,9R)-4-(2-methoxy-2-oxoacetyl)-5-(2-methoxy-2-oxoethylidene)-7,8-dimethyl-2,13,15-trioxatetracyclo[8.6.1.0^{4,17}.0^{12,16}]heptadeca-1(17),10,12(16)-trien-9-yl (2Z)-2-methylbut-2-enoate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 04-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   04-SEP-22         0                                  
HETATM    1  C   UNK     0      -3.068  -6.224   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -1.535  -6.371   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      -0.641  -5.117   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       0.892  -5.265   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      -1.280  -3.716   0.000  0.00  0.00           C+0
HETATM    6  O   UNK     0      -2.813  -3.569   0.000  0.00  0.00           O+0
HETATM    7  O   UNK     0      -0.386  -2.462   0.000  0.00  0.00           O+0
HETATM    8  C   UNK     0      -1.024  -1.061   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       0.026   0.066   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       1.265  -0.728   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       2.612   0.019   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       2.639   1.558   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       1.319   2.351   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      -0.028   1.605   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      -1.154   2.655   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      -2.005   3.939   0.000  0.00  0.00           C+0
HETATM   17  O   UNK     0      -3.303   4.766   0.000  0.00  0.00           O+0
HETATM   18  C   UNK     0      -1.318   5.317   0.000  0.00  0.00           C+0
HETATM   19  O   UNK     0       0.220   5.411   0.000  0.00  0.00           O+0
HETATM   20  O   UNK     0      -2.168   6.601   0.000  0.00  0.00           O+0
HETATM   21  C   UNK     0      -1.481   7.979   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0      -0.504   4.051   0.000  0.00  0.00           C+0
HETATM   23  O   UNK     0       1.025   3.863   0.000  0.00  0.00           O+0
HETATM   24  C   UNK     0      -2.694   2.601   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0      -3.332   4.002   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0      -4.865   4.150   0.000  0.00  0.00           C+0
HETATM   27  O   UNK     0      -5.759   2.896   0.000  0.00  0.00           O+0
HETATM   28  O   UNK     0      -5.504   5.551   0.000  0.00  0.00           O+0
HETATM   29  C   UNK     0      -7.037   5.698   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0      -3.744   1.474   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0      -3.690  -0.065   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0      -5.091  -0.703   0.000  0.00  0.00           C+0
HETATM   33  C   UNK     0      -2.563  -1.115   0.000  0.00  0.00           C+0
HETATM   34  C   UNK     0      -3.103  -2.557   0.000  0.00  0.00           C+0
HETATM   35  O   UNK     0       4.112   2.009   0.000  0.00  0.00           O+0
HETATM   36  C   UNK     0       4.995   0.747   0.000  0.00  0.00           C+0
HETATM   37  O   UNK     0       4.068  -0.483   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4    5                                                  
CONECT    4    3                                                            
CONECT    5    3    6    7                                                  
CONECT    6    5                                                            
CONECT    7    5    8                                                       
CONECT    8    7    9   33                                                  
CONECT    9    8   10   14                                                  
CONECT   10    9   11                                                       
CONECT   11   10   12   37                                                  
CONECT   12   11   13   35                                                  
CONECT   13   12   14   23                                                  
CONECT   14   13    9   15                                                  
CONECT   15   14   16   22   24                                             
CONECT   16   15   17   18                                                  
CONECT   17   16                                                            
CONECT   18   16   19   20                                                  
CONECT   19   18                                                            
CONECT   20   18   21                                                       
CONECT   21   20                                                            
CONECT   22   15   23                                                       
CONECT   23   22   13                                                       
CONECT   24   15   25   30                                                  
CONECT   25   24   26                                                       
CONECT   26   25   27   28                                                  
CONECT   27   26                                                            
CONECT   28   26   29                                                       
CONECT   29   28                                                            
CONECT   30   24   31                                                       
CONECT   31   30   32   33                                                  
CONECT   32   31                                                            
CONECT   33   31    8   34                                                  
CONECT   34   33                                                            
CONECT   35   12   36                                                       
CONECT   36   35   37                                                       
CONECT   37   36   11                                                       
MASTER        0    0    0    0    0    0    0    0   37    0   80    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₇H₃₀O₁₀

Average Mass

514.5270 Da

Monoisotopic Mass

514.18390 Da

IUPAC Name

(5E,7R,8R,9R)-4-(2-methoxy-2-oxoacetyl)-5-(2-methoxy-2-oxoethylidene)-7,8-dimethyl-2,13,15-trioxatetracyclo[8.6.1.0^{4,17}.0^{12,16}]heptadeca-1(17),10,12(16)-trien-9-yl (2Z)-2-methylbut-2-enoate

Traditional Name

(5E,7R,8R,9R)-4-(2-methoxy-2-oxoacetyl)-5-(2-methoxy-2-oxoethylidene)-7,8-dimethyl-2,13,15-trioxatetracyclo[8.6.1.0^{4,17}.0^{12,16}]heptadeca-1(17),10,12(16)-trien-9-yl (2Z)-2-methylbut-2-enoate

CAS Registry Number

Not Available

SMILES

COC(=O)\C=C1/C[C@@H](C)[C@@H](C)[C@@H](OC(=O)C(\C)=C/C)C2=CC3=C(OCO3)C3=C2C1(CO3)C(=O)C(=O)OC

InChI Identifier

InChI=1S/C27H30O10/c1-7-13(2)25(30)37-21-15(4)14(3)8-16(9-19(28)32-5)27(24(29)26(31)33-6)11-34-23-20(27)17(21)10-18-22(23)36-12-35-18/h7,9-10,14-15,21H,8,11-12H2,1-6H3/b13-7-,16-9+/t14-,15-,21-,27?/m1/s1

InChI Key

WZHLOZOCPVZWTE-JFKIBXCKSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Kadsura heteroclita	LOTUS Database	35616633
Kadsura interior	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as benzodioxoles. These are organic compounds containing a benzene ring fused to either isomers of dioxole. Dioxole is a five-membered unsaturated ring of two oxygen atoms and three carbon atoms.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Benzodioxoles

Sub Class

Not Available

Direct Parent

Benzodioxoles

Alternative Parents

Substituents

Coumaran
Benzodioxole
Tricarboxylic acid or derivatives
Alkyl aryl ether
Fatty acid ester
Alpha-keto acid
Fatty acyl
Benzenoid
Keto acid
Alpha,beta-unsaturated carboxylic ester
Enoate ester
Methyl ester
Carboxylic acid ester
Ketone
Oxacycle
Ether
Acetal
Carboxylic acid derivative
Carbonyl group
Hydrocarbon derivative
Organic oxide
Organic oxygen compound
Organooxygen compound
Aldehyde
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	4.84	ChemAxon
pKa (Strongest Basic)	-4.6	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	7	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	123.66 Å²	ChemAxon
Rotatable Bond Count	8	ChemAxon
Refractivity	130.12 m³·mol⁻¹	ChemAxon
Polarizability	52.38 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

C00024181

Chemspider ID

24718556

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

44575996

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Kuo YH, Wu MD, Huang RL, Kuo LM, Hsu YW, Liaw CC, Hung CC, Shen YC, Ong CW: Antihepatitis activity (anti-HBsAg and anti-HBeAg) of C19 homolignans and six novel C18 dibenzocyclooctadiene lignans from Kadsura japonica. Planta Med. 2005 Jul;71(7):646-53. doi: 10.1055/s-2005-871271. [PubMed:16041651 ]
LOTUS database [Link]

Showing NP-Card for (5e,7r,8r,9r)-4-(2-methoxy-2-oxoacetyl)-5-(2-methoxy-2-oxoethylidene)-7,8-dimethyl-2,13,15-trioxatetracyclo[8.6.1.0⁴,¹⁷.0¹²,¹⁶]heptadeca-1(17),10,12(16)-trien-9-yl (2z)-2-methylbut-2-enoate (NP0183957)

MOL for NP0183957 ((5e,7r,8r,9r)-4-(2-methoxy-2-oxoacetyl)-5-(2-methoxy-2-oxoethylidene)-7,8-dimethyl-2,13,15-trioxatetracyclo[8.6.1.0⁴,¹⁷.0¹²,¹⁶]heptadeca-1(17),10,12(16)-trien-9-yl (2z)-2-methylbut-2-enoate)

3D MOL for NP0183957 ((5e,7r,8r,9r)-4-(2-methoxy-2-oxoacetyl)-5-(2-methoxy-2-oxoethylidene)-7,8-dimethyl-2,13,15-trioxatetracyclo[8.6.1.0⁴,¹⁷.0¹²,¹⁶]heptadeca-1(17),10,12(16)-trien-9-yl (2z)-2-methylbut-2-enoate)

3D SDF for NP0183957 ((5e,7r,8r,9r)-4-(2-methoxy-2-oxoacetyl)-5-(2-methoxy-2-oxoethylidene)-7,8-dimethyl-2,13,15-trioxatetracyclo[8.6.1.0⁴,¹⁷.0¹²,¹⁶]heptadeca-1(17),10,12(16)-trien-9-yl (2z)-2-methylbut-2-enoate)

3D-SDF for NP0183957 ((5e,7r,8r,9r)-4-(2-methoxy-2-oxoacetyl)-5-(2-methoxy-2-oxoethylidene)-7,8-dimethyl-2,13,15-trioxatetracyclo[8.6.1.0⁴,¹⁷.0¹²,¹⁶]heptadeca-1(17),10,12(16)-trien-9-yl (2z)-2-methylbut-2-enoate)

PDB for NP0183957 ((5e,7r,8r,9r)-4-(2-methoxy-2-oxoacetyl)-5-(2-methoxy-2-oxoethylidene)-7,8-dimethyl-2,13,15-trioxatetracyclo[8.6.1.0⁴,¹⁷.0¹²,¹⁶]heptadeca-1(17),10,12(16)-trien-9-yl (2z)-2-methylbut-2-enoate)

3D PDB for NP0183957 ((5e,7r,8r,9r)-4-(2-methoxy-2-oxoacetyl)-5-(2-methoxy-2-oxoethylidene)-7,8-dimethyl-2,13,15-trioxatetracyclo[8.6.1.0⁴,¹⁷.0¹²,¹⁶]heptadeca-1(17),10,12(16)-trien-9-yl (2z)-2-methylbut-2-enoate)

SMILES for NP0183957 ((5e,7r,8r,9r)-4-(2-methoxy-2-oxoacetyl)-5-(2-methoxy-2-oxoethylidene)-7,8-dimethyl-2,13,15-trioxatetracyclo[8.6.1.0⁴,¹⁷.0¹²,¹⁶]heptadeca-1(17),10,12(16)-trien-9-yl (2z)-2-methylbut-2-enoate)

INCHI for NP0183957 ((5e,7r,8r,9r)-4-(2-methoxy-2-oxoacetyl)-5-(2-methoxy-2-oxoethylidene)-7,8-dimethyl-2,13,15-trioxatetracyclo[8.6.1.0⁴,¹⁷.0¹²,¹⁶]heptadeca-1(17),10,12(16)-trien-9-yl (2z)-2-methylbut-2-enoate)

Structure for NP0183957 ((5e,7r,8r,9r)-4-(2-methoxy-2-oxoacetyl)-5-(2-methoxy-2-oxoethylidene)-7,8-dimethyl-2,13,15-trioxatetracyclo[8.6.1.0⁴,¹⁷.0¹²,¹⁶]heptadeca-1(17),10,12(16)-trien-9-yl (2z)-2-methylbut-2-enoate)

3D Structure for NP0183957 ((5e,7r,8r,9r)-4-(2-methoxy-2-oxoacetyl)-5-(2-methoxy-2-oxoethylidene)-7,8-dimethyl-2,13,15-trioxatetracyclo[8.6.1.0⁴,¹⁷.0¹²,¹⁶]heptadeca-1(17),10,12(16)-trien-9-yl (2z)-2-methylbut-2-enoate)