NP-MRD: Showing NP-Card for 23-hydroxy-10-isopropyl-1,6,9,14-tetramethyl-21-oxahexacyclo[18.2.1.0²,¹⁸.0⁵,¹⁷.0⁶,¹⁴.0⁹,¹³]tricosa-2(18),16-dien-22-one (NP0183191)

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Record Information

Version

2.0

Created at

2022-09-03 22:03:16 UTC

Updated at

2022-09-03 22:03:16 UTC

NP-MRD ID

NP0183191

Secondary Accession Numbers

None

Natural Product Identification

Common Name

23-hydroxy-10-isopropyl-1,6,9,14-tetramethyl-21-oxahexacyclo[18.2.1.0²,¹⁸.0⁵,¹⁷.0⁶,¹⁴.0⁹,¹³]tricosa-2(18),16-dien-22-one

Description

23-Hydroxy-1,6,9,14-tetramethyl-10-(propan-2-yl)-21-oxahexacyclo[18.2.1.0²,¹⁸.0⁵,¹⁷.0⁶,¹⁴.0⁹,¹³]Tricosa-2(18),16-dien-22-one belongs to the class of organic compounds known as steroids and steroid derivatives. Steroids and steroid derivatives are compounds based on the cyclopenta[a]phenanthrene carbon skeleton, partially or completely hydrogenated; there are usually methyl groups at C-10 and C-13, and often an alkyl group at C-17. By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred. 23-hydroxy-10-isopropyl-1,6,9,14-tetramethyl-21-oxahexacyclo[18.2.1.0²,¹⁸.0⁵,¹⁷.0⁶,¹⁴.0⁹,¹³]tricosa-2(18),16-dien-22-one is found in Lobaria kurokawae. 23-Hydroxy-1,6,9,14-tetramethyl-10-(propan-2-yl)-21-oxahexacyclo[18.2.1.0²,¹⁸.0⁵,¹⁷.0⁶,¹⁴.0⁹,¹³]Tricosa-2(18),16-dien-22-one is an extremely weak basic (essentially neutral) compound (based on its pKa).

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1533004241505252D          

 32 37  0  0  0  0            999 V2000
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M  END

     RDKit          3D

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M  END


  Mrv1533004241505252D          

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 17 18  2  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 17 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 20 26  1  0  0  0  0
 26 27  1  0  0  0  0
 18 28  1  0  0  0  0
 14 28  1  0  0  0  0
 28 29  2  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
  7 31  1  0  0  0  0
 12 31  1  0  0  0  0
 31 32  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0183191

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CC(C)C1CCC2C1(C)CCC1(C)C3CCC4=C(CC5OC(=O)C4(C)C5O)C3=CCC21C

> <INCHI_IDENTIFIER>
InChI=1S/C29H42O3/c1-16(2)19-9-10-23-26(19,3)13-14-27(4)20-7-8-21-18(17(20)11-12-28(23,27)5)15-22-24(30)29(21,6)25(31)32-22/h11,16,19-20,22-24,30H,7-10,12-15H2,1-6H3

> <INCHI_KEY>
FXKXNIOLULILLQ-UHFFFAOYSA-N

> <FORMULA>
C29H42O3

> <MOLECULAR_WEIGHT>
438.652

> <EXACT_MASS>
438.313395212

> <JCHEM_ACCEPTOR_COUNT>
2

> <JCHEM_ATOM_COUNT>
74

> <JCHEM_AVERAGE_POLARIZABILITY>
52.35252195737284

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
23-hydroxy-1,6,9,14-tetramethyl-10-(propan-2-yl)-21-oxahexacyclo[18.2.1.0²,¹⁸.0⁵,¹⁷.0⁶,¹⁴.0⁹,¹³]tricosa-2(18),16-dien-22-one

> <ALOGPS_LOGP>
6.21

> <JCHEM_LOGP>
5.422088501333334

> <ALOGPS_LOGS>
-5.28

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
6

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_ACIDIC>
13.410502511921273

> <JCHEM_PKA_STRONGEST_BASIC>
-3.4940462012856353

> <JCHEM_POLAR_SURFACE_AREA>
46.53

> <JCHEM_REFRACTIVITY>
127.67559999999999

> <JCHEM_ROTATABLE_BOND_COUNT>
1

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
2.30e-03 g/l

> <JCHEM_TRADITIONAL_IUPAC>
23-hydroxy-10-isopropyl-1,6,9,14-tetramethyl-21-oxahexacyclo[18.2.1.0²,¹⁸.0⁵,¹⁷.0⁶,¹⁴.0⁹,¹³]tricosa-2(18),16-dien-22-one

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 24-APR-15   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   24-APR-15         0                                  
HETATM    1  C   UNK     0      -3.672  -7.009   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -2.224  -6.484   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      -1.955  -4.968   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      -1.046  -7.476   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      -1.156  -9.012   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       0.271  -9.591   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       1.263  -8.412   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       0.449  -7.105   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      -0.498  -5.890   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       1.174  -5.747   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       2.713  -5.695   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       3.527  -7.002   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       4.252  -5.643   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       5.066  -6.951   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       5.791  -5.592   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       7.330  -5.540   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       8.144  -6.847   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       7.420  -8.206   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       8.030  -9.620   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       9.516 -10.024   0.000  0.00  0.00           C+0
HETATM   21  O   UNK     0      10.758  -9.115   0.000  0.00  0.00           O+0
HETATM   22  C   UNK     0      10.822  -7.576   0.000  0.00  0.00           C+0
HETATM   23  O   UNK     0      12.236  -6.966   0.000  0.00  0.00           O+0
HETATM   24  C   UNK     0       9.659  -6.567   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0      10.063  -5.081   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0      10.019  -8.314   0.000  0.00  0.00           C+0
HETATM   27  O   UNK     0      11.558  -8.377   0.000  0.00  0.00           O+0
HETATM   28  C   UNK     0       5.880  -8.258   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0       5.156  -9.616   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0       3.616  -9.668   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0       2.802  -8.361   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0       2.077  -9.720   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3    4                                                  
CONECT    3    2                                                            
CONECT    4    2    5    8                                                  
CONECT    5    4    6                                                       
CONECT    6    5    7                                                       
CONECT    7    6    8   31                                                  
CONECT    8    7    4    9   10                                             
CONECT    9    8                                                            
CONECT   10    8   11                                                       
CONECT   11   10   12                                                       
CONECT   12   11   13   14   31                                             
CONECT   13   12                                                            
CONECT   14   12   15   28                                                  
CONECT   15   14   16                                                       
CONECT   16   15   17                                                       
CONECT   17   16   18   24                                                  
CONECT   18   17   19   28                                                  
CONECT   19   18   20                                                       
CONECT   20   19   21   26                                                  
CONECT   21   20   22                                                       
CONECT   22   21   23   24                                                  
CONECT   23   22                                                            
CONECT   24   22   17   25   26                                             
CONECT   25   24                                                            
CONECT   26   24   20   27                                                  
CONECT   27   26                                                            
CONECT   28   18   14   29                                                  
CONECT   29   28   30                                                       
CONECT   30   29   31                                                       
CONECT   31   30    7   12   32                                             
CONECT   32   31                                                            
MASTER        0    0    0    0    0    0    0    0   32    0   74    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₉H₄₂O₃

Average Mass

438.6520 Da

Monoisotopic Mass

438.31340 Da

IUPAC Name

23-hydroxy-1,6,9,14-tetramethyl-10-(propan-2-yl)-21-oxahexacyclo[18.2.1.0²,¹⁸.0⁵,¹⁷.0⁶,¹⁴.0⁹,¹³]tricosa-2(18),16-dien-22-one

Traditional Name

23-hydroxy-10-isopropyl-1,6,9,14-tetramethyl-21-oxahexacyclo[18.2.1.0²,¹⁸.0⁵,¹⁷.0⁶,¹⁴.0⁹,¹³]tricosa-2(18),16-dien-22-one

CAS Registry Number

Not Available

SMILES

CC(C)C1CCC2C1(C)CCC1(C)C3CCC4=C(CC5OC(=O)C4(C)C5O)C3=CCC21C

InChI Identifier

InChI=1S/C29H42O3/c1-16(2)19-9-10-23-26(19,3)13-14-27(4)20-7-8-21-18(17(20)11-12-28(23,27)5)15-22-24(30)29(21,6)25(31)32-22/h11,16,19-20,22-24,30H,7-10,12-15H2,1-6H3

InChI Key

FXKXNIOLULILLQ-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Lobaria kurokawae	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as steroids and steroid derivatives. Steroids and steroid derivatives are compounds based on the cyclopenta[a]phenanthrene carbon skeleton, partially or completely hydrogenated; there are usually methyl groups at C-10 and C-13, and often an alkyl group at C-17. By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Steroids and steroid derivatives

Sub Class

Not Available

Direct Parent

Steroids and steroid derivatives

Alternative Parents

Substituents

Steroid
Gamma butyrolactone
Tetrahydrofuran
Carboxylic acid ester
Lactone
Secondary alcohol
Carboxylic acid derivative
Monocarboxylic acid or derivatives
Oxacycle
Organoheterocyclic compound
Hydrocarbon derivative
Organic oxide
Organic oxygen compound
Organooxygen compound
Carbonyl group
Alcohol
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	6.21	ALOGPS
logP	5.42	ChemAxon
logS	-5.3	ALOGPS
pKa (Strongest Acidic)	13.41	ChemAxon
pKa (Strongest Basic)	-3.5	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	2	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	46.53 Å²	ChemAxon
Rotatable Bond Count	1	ChemAxon
Refractivity	127.68 m³·mol⁻¹	ChemAxon
Polarizability	52.35 Å³	ChemAxon
Number of Rings	6	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

Not Available

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for 23-hydroxy-10-isopropyl-1,6,9,14-tetramethyl-21-oxahexacyclo[18.2.1.0²,¹⁸.0⁵,¹⁷.0⁶,¹⁴.0⁹,¹³]tricosa-2(18),16-dien-22-one (NP0183191)

MOL for NP0183191 (23-hydroxy-10-isopropyl-1,6,9,14-tetramethyl-21-oxahexacyclo[18.2.1.0²,¹⁸.0⁵,¹⁷.0⁶,¹⁴.0⁹,¹³]tricosa-2(18),16-dien-22-one)

3D MOL for NP0183191 (23-hydroxy-10-isopropyl-1,6,9,14-tetramethyl-21-oxahexacyclo[18.2.1.0²,¹⁸.0⁵,¹⁷.0⁶,¹⁴.0⁹,¹³]tricosa-2(18),16-dien-22-one)

3D SDF for NP0183191 (23-hydroxy-10-isopropyl-1,6,9,14-tetramethyl-21-oxahexacyclo[18.2.1.0²,¹⁸.0⁵,¹⁷.0⁶,¹⁴.0⁹,¹³]tricosa-2(18),16-dien-22-one)

3D-SDF for NP0183191 (23-hydroxy-10-isopropyl-1,6,9,14-tetramethyl-21-oxahexacyclo[18.2.1.0²,¹⁸.0⁵,¹⁷.0⁶,¹⁴.0⁹,¹³]tricosa-2(18),16-dien-22-one)

PDB for NP0183191 (23-hydroxy-10-isopropyl-1,6,9,14-tetramethyl-21-oxahexacyclo[18.2.1.0²,¹⁸.0⁵,¹⁷.0⁶,¹⁴.0⁹,¹³]tricosa-2(18),16-dien-22-one)

3D PDB for NP0183191 (23-hydroxy-10-isopropyl-1,6,9,14-tetramethyl-21-oxahexacyclo[18.2.1.0²,¹⁸.0⁵,¹⁷.0⁶,¹⁴.0⁹,¹³]tricosa-2(18),16-dien-22-one)

SMILES for NP0183191 (23-hydroxy-10-isopropyl-1,6,9,14-tetramethyl-21-oxahexacyclo[18.2.1.0²,¹⁸.0⁵,¹⁷.0⁶,¹⁴.0⁹,¹³]tricosa-2(18),16-dien-22-one)

INCHI for NP0183191 (23-hydroxy-10-isopropyl-1,6,9,14-tetramethyl-21-oxahexacyclo[18.2.1.0²,¹⁸.0⁵,¹⁷.0⁶,¹⁴.0⁹,¹³]tricosa-2(18),16-dien-22-one)

Structure for NP0183191 (23-hydroxy-10-isopropyl-1,6,9,14-tetramethyl-21-oxahexacyclo[18.2.1.0²,¹⁸.0⁵,¹⁷.0⁶,¹⁴.0⁹,¹³]tricosa-2(18),16-dien-22-one)

3D Structure for NP0183191 (23-hydroxy-10-isopropyl-1,6,9,14-tetramethyl-21-oxahexacyclo[18.2.1.0²,¹⁸.0⁵,¹⁷.0⁶,¹⁴.0⁹,¹³]tricosa-2(18),16-dien-22-one)